Protein Description

Gene Symbol HSP90AB1
Entrez ID 3326
Uniprot ID P08238
Description heat shock protein 90kDa alpha family class B member 1
Chromosomal Location chr6: 44,246,166-44,253,888
Ontology GO ID GO Term Definition Evidence

BP

GO:0001890

placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

IEA

BP

GO:0006457

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

IEA

BP

GO:0006986

response to unfolded protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

NAS

BP

GO:0009651

response to salt stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

IEA

BP

GO:0019062

virion attachment to host cell

The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.

IMP

BP

GO:0031396

regulation of protein ubiquitination

Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.

IDA

BP

GO:0032092

positive regulation of protein binding

Any process that activates or increases the frequency, rate or extent of protein binding.

IEA

BP

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

IMP

BP

GO:0032516

positive regulation of phosphoprotein phosphatase activity

Any process that activates or increases the activity of a phosphoprotein phosphatase.

IDA

BP

GO:0033160

positive regulation of protein import into nucleus, translocation

Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.

IEA

BP

GO:0035690

cellular response to drug

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.

TAS

BP

GO:0042220

response to cocaine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.

IEA

BP

GO:0043524

negative regulation of neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

IEA

BP

GO:0045429

positive regulation of nitric oxide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

ISS

BP

GO:0045793

positive regulation of cell size

Any process that increases cell size.

IEA

BP

GO:0050821

protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

TAS

BP

GO:0060334

regulation of interferon-gamma-mediated signaling pathway

Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.

IMP

BP

GO:0060338

regulation of type I interferon-mediated signaling pathway

Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.

IMP

BP

GO:0071353

cellular response to interleukin-4

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.

IEA

BP

GO:0071407

cellular response to organic cyclic compound

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

IEA

BP

GO:0071902

positive regulation of protein serine/threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.

IEA

BP

GO:0097435

fibril organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins.

IMP

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

BP

GO:1900034

regulation of cellular response to heat

Any process that modulates the frequency, rate or extent of cellular response to heat.

TAS

BP

GO:1903660

negative regulation of complement-dependent cytotoxicity

Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity.

IEA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005765

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0008180

COP9 signalosome

A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.

IDA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016234

inclusion body

A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.

IEA

CC

GO:0016323

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

IEA

CC

GO:0016324

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

IEA

CC

GO:0031526

brush border membrane

The portion of the plasma membrane surrounding the brush border.

IEA

CC

GO:0042470

melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:1990913

sperm head plasma membrane

The plasma membrane that is part of the head section of a sperm cell.

IEA

CC

GO:1990917

ooplasm

The cytoplasm of an ovum.

IEA

MF

GO:0001948

glycoprotein binding

Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.

IEA

MF

GO:0002134

UTP binding

Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate.

IEA

MF

GO:0002135

CTP binding

Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate.

IEA

MF

GO:0003725

double-stranded RNA binding

Interacting selectively and non-covalently with double-stranded RNA.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0005525

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

IEA

MF

GO:0008144

drug binding

Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

IEA

MF

GO:0017098

sulfonylurea receptor binding

Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.

IEA

MF

GO:0019887

protein kinase regulator activity

Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.

IEA

MF

GO:0019900

kinase binding

Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IEA

MF

GO:0023026

MHC class II protein complex binding

Interacting selectively and non-covalently with the class II major histocompatibility complex.

IDA

MF

GO:0030235

nitric-oxide synthase regulator activity

Modulates the activity of nitric oxide synthase.

ISS

MF

GO:0030911

TPR domain binding

Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.

ISS

MF

GO:0032564

dATP binding

Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate.

IEA

MF

GO:0042826

histone deacetylase binding

Interacting selectively and non-covalently with the enzyme histone deacetylase.

IPI

MF

GO:0044325

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0051082

unfolded protein binding

Interacting selectively and non-covalently with an unfolded protein.

IEA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR001404

Heat shock protein Hsp90 family

IPR003594

Histidine kinase-like ATPase, C-terminal domain

IPR019805

Heat shock protein Hsp90, conserved site

IPR020568

Ribosomal protein S5 domain 2-type fold

IPR020575

Heat shock protein Hsp90, N-terminal

Pathway ID Pathway Term Pathway Source

hsa04141

Protein processing in endoplasmic reticulum

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04612

Antigen processing and presentation

KEGG

hsa04621

NOD-like receptor signaling pathway

KEGG

hsa04657

IL-17 signaling pathway

KEGG

hsa04659

Th17 cell differentiation

KEGG

hsa04914

Progesterone-mediated oocyte maturation

KEGG

hsa04915

Estrogen signaling pathway

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05215

Prostate cancer

KEGG

hsa05418

Fluid shear stress and atherosclerosis

KEGG

WP2884

NRF2 pathway

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

UMLS CUI UMLS Term

C0019693

HIV Infections

C0033578

Prostatic Neoplasms

Tissue Cell Type

adrenal gland

glandular cells

bone marrow

hematopoietic cells

bronchus

respiratory epithelial cells

cerebellum

cells in molecular layer

colon

peripheral nerve/ganglion

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

lymph node

germinal center cells

lymph node

non-germinal center cells

placenta

decidual cells

placenta

trophoblastic cells

prostate

glandular cells

soft tissue

chondrocytes

testis

cells in seminiferous ducts

tonsil

germinal center cells

tonsil

non-germinal center cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ATP6V1B2

526

P21281

0.49

AXL

558

P30530

0.49

PRDM1

639

O75626

0.49

BMX

660

P51813

0.49

CALR

811

P27797

0.49

CAMK2A

815

Q9UQM7

0.49

CAMK2B

816

Q13554

0.49

CEBPE

1053

Q15744

0.49

RCBTB2

1102

O95199

0.49

CLK2

1196

P49760

0.49

CLK3

1198

P49761

0.49

CSF1R

1436

P07333

0.49

DAPK3

1613

O43293

0.49

DDOST

1650

P39656

0.49

EPHA1

2041

P21709

0.49

EPHB1

2047

P54762

0.49

FOXM1

2305

Q08050

0.49

HCK

3055

P08631

0.49

HMGA1

3159

P17096

0.49

IGF1R

3480

P08069

0.49

IRAK2

3656

O43187

0.49

IRF2

3660

P14316

0.49

ITK

3702

Q08881

0.49

JAK1

3716

P23458

0.49

LYN

4067

P07948

0.49

MAFG

4097

O15525

0.49

MAX

4149

P61244

0.49

MDM4

4194

O15151

0.49

MAP3K5

4217

Q99683

0.49

MOS

4342

P00540

0.49

MYL6

4637

P60660

0.49

RPL10A

4736

P62906

0.49

NFIC

4782

P08651

0.49

NFRKB

4798

Q6P4R8

0.49

NTRK3

4916

Q16288

0.49

P4HB

5034

P07237

0.49

PDGFRB

5159

P09619

0.49

PPARG

5468

P37231

0.49

PRKCA

5578

P17252

0.49

PRKCG

5582

P05129

0.49

PKN2

5586

Q16513

0.49

PRKG2

5593

Q13237

0.49

MAP2K7

5609

O14733

0.49

MAP4K2

5871

Q12851

0.49

RAPSN

5913

Q13702

0.49

RGS7

6000

P49802

0.49

RPL3

6122

P39023

0.49

RPL7A

6130

P62424

0.49

RPL17

6139

P18621

0.49

RPL32

6161

P62910

0.49

RPS2

6187

P15880

0.49

RPS6KA2

6196

Q15349

0.49

RPS6KA3

6197

P51812

0.49

RPS6KB1

6198

P23443

0.49

RPS16

6217

P62249

0.49

RPS23

6228

P62266

0.49

RPS26

6231

P62854

0.49

SKP2

6502

Q13309

0.49

SNRPD1

6632

P62314

0.49

SSR4

6748

P51571

0.49

STAT2

6773

P52630

0.49

TESK1

7016

Q15569

0.49

TIE1

7075

P35590

0.49

TNFAIP3

7128

P21580

0.49

TYRO3

7301

Q06418

0.49

UQCRC2

7385

P22695

0.49

MAP3K12

7786

Q12852

0.49

DYRK2

8445

Q92630

0.49

BTRC

8945

Q9Y297

0.49

RPL14

9045

P50914

0.49

MAP3K6

9064

O95382

0.49

RPS6KA5

9252

O75582

0.49

MAP4K4

9448

O95819

0.49

RNF40

9810

O75150

0.49

AREL1

9870

O15033

0.49

ZBED4

9889

O75132

0.49

SGK2

10110

Q9HBY8

0.49

PCGF3

10336

Q3KNV8

0.49

NPM3

10360

O75607

0.49

MERTK

10461

Q12866

0.49

KAT5

10524

Q92993

0.49

MAP3K2

10746

Q9Y2U5

0.49

FASTK

10922

Q14296

0.49

TCF25

22980

Q9BQ70

0.49

FBXW11

23291

Q9UKB1

0.49

TRIM2

23321

Q9C040

0.49

TSSK2

23617

Q96PF2

0.49

FBXO9

26268

Q9UK97

0.49

FBXO4

26272

Q9UKT5

0.49

FBXO3

26273

Q9UK99

0.49

RPS6KC1

26750

Q96S38

0.49

PRPF19

27339

Q9UMS4

0.49

CXXC1

30827

Q9P0U4

0.49

STOML2

30968

Q9UJZ1

0.49

TRIM17

51127

Q9Y577

0.49

TAOK3

51347

Q9H2K8

0.49

FBXW5

54461

Q969U6

0.49

FBXL12

54850

Q9NXK8

0.49

SARS2

54938

Q9NP81

0.49

RFWD3

55159

Q6PCD5

0.49

FBXL8

55336

Q96CD0

0.49

TRIM36

55521

Q9NQ86

0.49

PAK6

56924

Q9NQU5

0.49

HES4

57801

Q9HCC6

0.49

WNK4

65266

Q96J92

0.49

HECTD3

79654

Q5T447

0.49

SPSB1

80176

Q96BD6

0.49

FBXO38

81545

Q6PIJ6

0.49

TSSK3

81629

Q96PN8

0.49

TRIM7

81786

Q9C029

0.49

NUAK2

81788

Q9H093

0.49

TRIM56

81844

Q9BRZ2

0.49

LNX1

84708

Q8TBB1

0.49

PCGF1

84759

Q9BSM1

0.49

FBXO18

84893

Q8NFZ0

0.49

MYLK2

85366

Q9H1R3

0.49

LRSAM1

90678

Q6UWE0

0.49

SLFN11

91607

Q7Z7L1

0.49

FOXP2

93986

O15409

0.49

DCLK2

166614

Q8N568

0.49

TUBB

203068

P07437

0.49

RPLP0P6

220717

Q8NHW5

0.49

STK32C

282974

Q86UX6

0.49

MAP3K15

389840

Q6ZN16

0.49

STAT3

6774

P40763

0.52

EIF4A1

1973

P60842

0.56

HSPA4

3308

P34932

0.56

HSPA8

3312

P11142

0.56

HSPE1

3336

P61604

0.56

RPL6

6128

Q02878

0.56

UBA52

7311

P62987

0.56

DNAJA2

10294

O60884

0.56

IPO7

10527

O95373

0.56

ECD

11319

O95905

0.56

SRPK3

26576

Q9UPE1

0.56

WASL

8976

O00401

0.62

ACVR1B

91

P36896

0.63

AKT2

208

P31751

0.63

ARHGAP1

392

Q07960

0.63

CAMK2G

818

Q13555

0.63

CYP17A1

1586

P05093

0.63

EPHA2

1969

P29317

0.63

FLT4

2324

P35916

0.63

IRF3

3661

Q14653

0.63

LCK

3932

P06239

0.63

MET

4233

P08581

0.63

DDR2

4921

Q16832

0.63

PIM1

5292

P11309

0.63

PMP2

5375

P02689

0.63

PRKCZ

5590

Q05513

0.63

MAPK4

5596

P31152

0.63

MAPK6

5597

Q16659

0.63

SGTA

6449

O43765

0.63

SKP1

6500

P63208

0.63

STAT1

6772

P42224

0.63

TYK2

7297

P29597

0.63

XDH

7498

P47989

0.63

NELFE

7936

P18615

0.63

CDK10

8558

Q15131

0.63

MKNK1

8569

Q9BUB5

0.63

NR1I2

8856

O75469

0.63

FCHSD2

9873

O94868

0.63

MVP

9961

Q14764

0.63

EIF3M

10480

Q7L2H7

0.63

STK38

11329

Q15208

0.63

ICK

22858

Q9UPZ9

0.63

ITGB1BP2

26548

Q9UKP3

0.63

COPS4

51138

Q9BT78

0.63

ANKMY2

57037

Q8IV38

0.63

DDX24

57062

Q9GZR7

0.63

POGK

57645

Q9P215

0.63

GSG2

83903

Q8TF76

0.63

NEK9

91754

Q8TD19

0.63

HGH1

51236

Q9BTY7

0.72

AARS

16

P49588

0.72

ACTN1

87

P12814

0.72

ALDOA

226

P04075

0.72

ESRRB

2103

O95718

0.72

FASN

2194

P49327

0.72

HSF1

3297

Q00613

0.72

RPSA

3921

P08865

0.72

LDHA

3939

P00338

0.72

MDH1

4190

P40925

0.72

MTHFD1

4522

P11586

0.72

NUMA1

4926

Q14980

0.72

PKM

5315

P14618

0.72

PRKDC

5591

P78527

0.72

PSMB5

5693

P28074

0.72

PSMD1

5707

Q99460

0.72

RPL5

6125

P46777

0.72

RPL7

6129

P18124

0.72

RPLP0

6175

P05388

0.72

RPS3A

6189

P61247

0.72

RPS4X

6191

P62701

0.72

SPTAN1

6709

Q13813

0.72

TCP1

6950

P17987

0.72

TPM3

7170

P06753

0.72

UBA1

7317

P22314

0.72

XPO1

7514

O14980

0.72

TUBA1A

7846

Q71U36

0.72

EIF3H

8667

O15372

0.72

KEAP1

9817

Q14145

0.72

TOMM34

10953

Q15785

0.72

RHOBTB2

23221

Q9BYZ6

0.72

CACYBP

27101

Q9HB71

0.72

TMOD4

29765

Q9NZQ9

0.72

PSAT1

29968

Q9Y617

0.72

NANS

54187

Q9NR45

0.72

IARS2

55699

Q9NSE4

0.72

AKT1

207

P31749

0.73

CSNK1A1

1452

P48729

0.73

ILK

3611

Q13418

0.73

MCM2

4171

P49736

0.73

NTRK1

4914

P04629

0.73

EIF2AK2

5610

P19525

0.73

GAN

8139

Q9H2C0

0.73

CUL4B

8450

Q13620

0.73

CUL4A

8451

Q13619

0.73

FBXL2

25827

Q9UKC9

0.73

FBXW2

26190

Q9UKT8

0.73

PINK1

65018

Q9BXM7

0.73

MCM5

4174

P33992

0.74

ESR1

2099

P03372

0.76

TP53

7157

P04637

0.78

ACTG1

71

P63261

0.79

EEF2

1938

P13639

0.79

HSP90AB1

3326

P08238

0.79

MAPT

4137

P10636

0.79

PGK1

5230

P00558

0.79

HSPH1

10808

Q92598

0.79

C12orf10

60314

Q9HB07

0.79

TTC4

7268

O95801

0.81

CSNK1E

1454

P49674

0.82

ERBB2

2064

P04626

0.82

HSPA1A

3303

P0DMV8

0.82

HSPA1B

3304

P0DMV9

0.82

PRKACB

5567

P22694

0.82

RPS6

6194

P62753

0.82

CUL3

8452

Q13618

0.82

CDK15

65061

Q96Q40

0.82

CCDC117

150275

Q8IWD4

0.82

GNAI2

2771

P04899

0.83

MYH9

4627

P35579

0.87

FLNA

2316

P21333

0.88

GAPDH

2597

P04406

0.88

STIP1

10963

P31948

0.92

AHSA1

10598

O95433

0.94

PPP5C

5536

P53041

0.96

AICDA

57379

Q9GZX7

0.07

ABL1

25

P00519

0.49

ACVR2B

93

Q13705

0.49

ATF3

467

P18847

0.49

BLK

640

P51451

0.49

BMPR1A

657

P36894

0.49

CAMK4

814

Q16566

0.49

CAMK2D

817

Q13557

0.49

DLX6

1750

P56179

0.49

DMPK

1760

Q09013

0.49

EPHA4

2043

P54764

0.49

EPHB6

2051

O15197

0.49

PTK2B

2185

Q14289

0.49

FER

2241

P16591

0.49

FES

2242

P07332

0.49

FGFR1

2260

P11362

0.49

FRK

2444

P42685

0.49

GRK4

2868

P32298

0.49

HADHB

3032

P55084

0.49

HSPA5

3309

P11021

0.49

HSP90AA2P

3324

Q14568

0.49

INSRR

3645

P14616

0.49

KCNA5

3741

P22460

0.49

KCNA6

3742

P17658

0.49

KCNG1

3755

Q9UIX4

0.49

KCNS3

3790

Q9BQ31

0.49

LIMK1

3984

P53667

0.49

TRIM37

4591

O94972

0.49

NPR2

4882

P20594

0.49

NTRK2

4915

Q16620

0.49

PPARD

5467

Q03181

0.49

PRKAA2

5563

P54646

0.49

PRKCB

5579

P05771

0.49

PRKCH

5583

P24723

0.49

PRKCI

5584

P41743

0.49

PKN1

5585

Q16512

0.49

PRKCQ

5588

Q04759

0.49

MAP2K5

5607

Q13163

0.49

PRKY

5616

O43930

0.49

PTK2

5747

Q05397

0.49

PTK6

5753

Q13882

0.49

RAG1

5896

P15918

0.49

SGK1

6446

O00141

0.49

SIM2

6493

Q14190

0.49

SREBF1

6720

P36956

0.49

SRPK1

6732

Q96SB4

0.49

TADA2A

6871

O75478

0.49

YES1

7525

P07947

0.49

ZNF74

7625

Q16587

0.49

ZBTB17

7709

Q13105

0.49

ZNF215

7762

Q9UL58

0.49

TEAD2

8463

Q15562

0.49

ENC1

8507

O14682

0.49

TNK1

8711

Q13470

0.49

RGS11

8786

O94810

0.49

RGS9

8787

O75916

0.49

DYRK4

8798

Q9NR20

0.49

DYRK1B

9149

Q9Y463

0.49

SOCS6

9306

O14544

0.49

SETDB1

9869

Q15047

0.49

RHOBTB1

9886

O94844

0.49

RNF10

9921

Q8N5U6

0.49

NR1I3

9970

Q14994

0.49

NR1H3

10062

Q13133

0.49

TRIM10

10107

Q9UDY6

0.49

PREB

10113

Q9HCU5

0.49

TNK2

10188

Q07912

0.49

DCTN2

10540

Q13561

0.49

CAMKK2

10645

Q96RR4

0.49

PIM2

11040

Q9P1W9

0.49

WWP1

11059

Q9H0M0

0.49

MAP4K1

11184

Q92918

0.49

IRAK3

11213

Q9Y616

0.49

TRIM32

22954

Q13049

0.49

STK38L

23012

Q9Y2H1

0.49

MAST2

23139

Q6P0Q8

0.49

PASK

23178

Q96RG2

0.49

LARP4B

23185

Q92615

0.49

FBXO28

23219

Q9NVF7

0.49

DTX4

23220

Q9Y2E6

0.49

ZC3H7B

23264

Q9UGR2

0.49

SF3B3

23450

Q15393

0.49

SGK3

23678

Q96BR1

0.49

PRKD2

25865

Q9BZL6

0.49

C20orf194

25943

Q5TEA3

0.49

HERC4

26091

Q5GLZ8

0.49

ZBTB20

26137

Q9HC78

0.49

FBXL3

26224

Q9UKT7

0.49

FBXO25

26260

Q8TCJ0

0.49

FBXO10

26267

Q9UK96

0.49

VPS41

27072

P49754

0.49

EIF2AK1

27102

Q9BQI3

0.49

RPS6KA6

27330

Q9UK32

0.49

ANAPC2

29882

Q9UJX6

0.49

MINK1

50488

Q8N4C8

0.49

HP1BP3

50809

Q5SSJ5

0.49

TBX22

50945

Q9Y458

0.49

THAP4

51078

Q8WY91

0.49

ASB3

51130

Q9Y575

0.49

TFDP3

51270

Q5H9I0

0.49

ASB4

51666

Q9Y574

0.49

ASB2

51676

Q96Q27

0.49

FBXO40

51725

Q9UH90

0.49

RNF111

54778

Q6ZNA4

0.49

HERC6

55008

Q8IVU3

0.49

FBXO34

55030

Q9NWN3

0.49

DET1

55070

Q7L5Y6

0.49

RCBTB1

55213

Q8NDN9

0.49

FBXW7

55294

Q969H0

0.49

KLHL26

55295

Q53HC5

0.49

STK32B

55351

Q9NY57

0.49

STYK1

55359

Q6J9G0

0.49

G2E3

55632

Q7L622

0.49

KBTBD4

55709

Q9NVX7

0.49

WSB2

55884

Q9NYS7

0.49

BBX

56987

Q8WY36

0.49

TRIM49

57093

P0CI25

0.49

NUP107

57122

P57740

0.49

CAMK1G

57172

Q96NX5

0.49

KLHL14

57565

Q9P2G3

0.49

VPS18

57617

Q9P253

0.49

KLHL1

57626

Q9NR64

0.49

DMRTA1

63951

Q5VZB9

0.49

KLHL25

64410

Q9H0H3

0.49

CAMKV

79012

Q8NCB2

0.49

FBXL15

79176

Q9H469

0.49

KLHL36

79786

Q8N4N3

0.49

ARMC5

79798

Q96C12

0.49

NEK11

79858

Q8NG66

0.49

NUP85

79902

Q9BW27

0.49

FBXL18

80028

Q96ME1

0.49

ALPK1

80216

Q96QP1

0.49

KLHL15

80311

Q96M94

0.49

RPS6KL1

83694

Q9Y6S9

0.49

TSSK1B

83942

Q9BXA7

0.49

KBTBD7

84078

Q8WVZ9

0.49

PCGF6

84108

Q9BYE7

0.49

GTF2IRD2

84163

Q86UP8

0.49

CAMKK1

84254

Q8N5S9

0.49

KLHL22

84861

Q53GT1

0.49

KLHL6

89857

Q8WZ60

0.49

KLHL13

90293

Q9P2N7

0.49

SPSB3

90864

Q6PJ21

0.49

TRIM41

90933

Q8WV44

0.49

ISX

91464

Q2M1V0

0.49

MYLK3

91807

Q32MK0

0.49

MARCH9

92979

Q86YJ5

0.49

KLHL32

114792

Q96NJ5

0.49

KLHL29

114818

Q96CT2

0.49

FBXO27

126433

Q8NI29

0.49

ASB17

127247

Q8WXJ9

0.49

RNF19B

127544

Q6ZMZ0

0.49

ACVR1C

130399

Q8NER5

0.49

GRK7

131890

Q8WTQ7

0.49

ASB6

140459

Q9NWX5

0.49

MYO3B

140469

Q8WXR4

0.49

RAB40A

142684

Q8WXH6

0.49

FBXL14

144699

Q8N1E6

0.49

HIPK4

147746

Q8NE63

0.49

PDIK1L

149420

Q8N165

0.49

KLHL23

151230

Q8NBE8

0.49

SH3RF2

153769

Q8TEC5

0.49

SGK223

157285

Q86YV5

0.49

ZBTB49

166793

Q6ZSB9

0.49

FBXL13

222235

Q8NEE6

0.49

MAPK15

225689

Q8TD08

0.49

KLHL34

257240

Q8N239

0.49

NPHP4

261734

O75161

0.49

MKX

283078

Q8IYA7

0.49

KSR2

283455

Q6VAB6

0.49

NEK8

284086

Q86SG6

0.49

KLHL10

317719

Q6JEL2

0.49

TRIM73

375593

Q86UV7

0.49

TRIM74

378108

Q86UV6

0.49

NHLRC1

378884

Q6VVB1

0.49

KCTD8

386617

Q6ZWB6

0.49

PIM3

415116

Q86V86

0.49

FOXD4L6

653404

Q3SYB3

0.49

CDK11A

728642

Q9UQ88

0.49

ATP5B

506

P06576

0.56

CD247

919

P20963

0.56

NR3C2

4306

P08235

0.56

ROCK1

6093

Q13464

0.56

UBE3A

7337

Q05086

0.56

KSR1

8844

Q8IVT5

0.56

CCT2

10576

P78371

0.56

HSP90AA5P

730211

Q58FG0

0.56

ATP5A1

498

P25705

0.59

ACTB

60

P60709

0.62

NR2C2

7182

P49116

0.62

HLA-DRB4

3126

P13762

0.63

ALK

238

Q9UM73

0.63

AMHR2

269

Q16671

0.63

AIRE

326

O43918

0.63

BTK

695

Q06187

0.63

CD4

920

P01730

0.63

CDC5L

988

Q99459

0.63

CDK6

1021

Q00534

0.63

ATF2

1386

P15336

0.63

CRK

1398

P46108

0.63

CRY2

1408

Q49AN0

0.63

CSK

1445

P41240

0.63

CSNK2A2

1459

P19784

0.63

CTNNB1

1499

P35222

0.63

EIF4EBP1

1978

Q13541

0.63

ERBB4

2066

Q15303

0.63

FGR

2268

P09769

0.63

FN1

2335

P02751

0.63

FUS

2521

P35637

0.63

FYN

2534

P06241

0.63

GJA1

2697

P17302

0.63

GRK5

2869

P34947

0.63

GSK3A

2931

P49840

0.63

GSK3B

2932

P49841

0.63

HTT

3064

P42858

0.63

HLA-DRA

3122

P01903

0.63

HLA-DRB1

3123

P04229

0.63

HLA-DRB3

3125

P79483

0.63

HLA-DRB5

3127

Q30154

0.63

NR4A1

3164

P22736

0.63

HSPB1

3315

P04792

0.63

HTR7

3363

P34969

0.63

INPPL1

3636

O15357

0.63

ITGA4

3676

P13612

0.63

JAK2

3717

O60674

0.63

JUN

3725

P05412

0.63

KPNA2

3838

P52292

0.63

LGALS3

3958

P17931

0.63

LIMK2

3985

P53671

0.63

MATK

4145

P42679

0.63

MCM6

4175

Q14566

0.63

MGMT

4255

P16455

0.63

MAP3K9

4293

P80192

0.63

MAP3K11

4296

Q16584

0.63

MUSK

4593

O15146

0.63

NFKBIB

4793

Q15653

0.63

NFKBIE

4794

O00221

0.63

NOS2

4843

P35228

0.63

NPM1

4869

P06748

0.63

ROR2

4920

Q01974

0.63

PCBP1

5093

Q15365

0.63

CDK14

5218

O94921

0.63

PHKG2

5261

P15735

0.63

PRKCD

5580

Q05655

0.63

PRKD1

5587

Q15139

0.63

PRKX

5613

P51817

0.63

PSKH1

5681

P11801

0.63

PSMA2

5683

P25787

0.63

PSMA3

5684

P25788

0.63

RAD21

5885

O60216

0.63

RPS6KB2

6199

Q9UBS0

0.63

SHC1

6464

P29353

0.63

SKI

6497

P12755

0.63

SLC34A1

6569

Q06495

0.63

STK3

6788

Q13188

0.63

STK4

6789

Q13043

0.63

AURKA

6790

O14965

0.63

STK11

6794

Q15831

0.63

TNNT1

7138

P13805

0.63

VCP

7415

P55072

0.63

WHSC1

7468

O96028

0.63

YWHAE

7531

P62258

0.63

CUL5

8065

Q93034

0.63

UBL4A

8266

P11441

0.63

STK24

8428

Q9Y6E0

0.63

CAMK1

8536

Q14012

0.63

CDK13

8621

Q14004

0.63

EED

8726

O75530

0.63

LATS1

9113

O95835

0.63

RGS6

9628

P49758

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

PAN2

9924

Q504Q3

0.63

OXSR1

9943

O95747

0.63

HDAC5

10014

Q9UQL6

0.63

HUWE1

10075

Q7Z6Z7

0.63

TESK2

10420

Q96S53

0.63

TUBGCP3

10426

Q96CW5

0.63

HAX1

10456

O00165

0.63

NXF1

10482

Q9UBU9

0.63

CAP1

10487

Q01518

0.63

STK25

10494

O00506

0.63

UBD

10537

O15205

0.63

IVNS1ABP

10625

Q9Y6Y0

0.63

TUBGCP2

10844

Q9BSJ2

0.63

MAGED2

10916

Q9UNF1

0.63

COPS5

10987

Q92905

0.63

CEP250

11190

Q9BV73

0.63

GABARAP

11337

O95166

0.63

GABARAPL2

11345

P60520

0.63

SNW1

22938

Q13573

0.63

OBSL1

23363

O75147

0.63

GABARAPL1

23710

Q9H0R8

0.63

FKBP8

23770

Q14318

0.63

METTL21B

25895

Q96AZ1

0.63

CLIC4

25932

Q9Y696

0.63

LATS2

26524

Q9NRM7

0.63

AGO2

27161

Q9UKV8

0.63

IP6K2

51447

Q9UHH9

0.63

REV1

51455

Q9UBZ9

0.63

DCUN1D1

54165

Q96GG9

0.63

PPP6R3

55291

Q5H9R7

0.63

CAND1

55832

Q86VP6

0.63

PBK

55872

Q96KB5

0.63

UNC45A

55898

Q9H3U1

0.63

SMYD3

64754

Q9H7B4

0.63

STK33

65975

Q9BYT3

0.63

METTL22

79091

Q9BUU2

0.63

TAF1D

79101

Q9H5J8

0.63

LRRK1

79705

Q38SD2

0.63

CAMKMT

79823

Q7Z624

0.63

CEP76

79959

Q8TAP6

0.63

TTI2

80185

Q6NXR4

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

CRISPLD2

83716

Q9H0B8

0.63

CCDC8

83987

Q9H0W5

0.63

MAP1LC3A

84557

Q9H492

0.63

UBASH3B

84959

Q8TF42

0.63

UNK

85451

Q9C0B0

0.63

FBXO33

254170

Q7Z6M2

0.63

CDKL4

344387

Q5MAI5

0.63

SCARNA22

677770

N/A

0.63

HSPD1

3329

P10809

0.65

STARD13

90627

Q9Y3M8

0.65

YWHAZ

7534

P63104

0.68

TRIM8

81603

Q9BZR9

0.68

CSNK2A1

1457

P68400

0.70

ENO1

2023

P06733

0.70

SUMO3

6612

P55854

0.70

HDAC6

10013

Q9UBN7

0.70

ADRBK1

156

P25098

0.72

ARRB2

409

P32121

0.72

CDK5

1020

Q00535

0.72

CFTR

1080

P13569

0.72

DBN1

1627

Q16643

0.72

FKBP4

2288

Q02790

0.72

FKBP5

2289

Q13451

0.72

GTF2E2

2961

P29084

0.72

IFIT1

3434

P09914

0.72

MAP3K1

4214

Q13233

0.72

NFKB2

4791

Q00653

0.72

PRKACA

5566

P17612

0.72

RELA

5970

Q04206

0.72

TAF10

6881

Q12962

0.72

MAP3K7

6885

O43318

0.72

DNAJC7

7266

Q99615

0.72

XRCC3

7517

O43542

0.72

FKBP6

8468

O75344

0.72

TP63

8626

Q9H3D4

0.72

TRADD

8717

Q15628

0.72

IQGAP1

8826

P46940

0.72

TAB1

10454

Q15750

0.72

RIPK3

11035

Q9Y572

0.72

GPN1

11321

Q9HCN4

0.72

MAPRE1

22919

Q15691

0.72

TRAF3IP1

26146

Q8TDR0

0.72

MEPCE

56257

Q7L2J0

0.72

FKBPL

63943

Q9UIM3

0.72

MYO19

80179

Q96H55

0.72

TUBA1C

84790

Q9BQE3

0.72

UNC45B

146862

Q8IWX7

0.72

AGO3

192669

Q9H9G7

0.72

AGO4

192670

Q9HCK5

0.72

KHDRBS2

202559

Q5VWX1

0.72

USP50

373509

Q70EL3

0.72

ARAF

369

P10398

0.73

CDK3

1018

Q00526

0.73

CHUK

1147

O15111

0.73

ERBB3

2065

P21860

0.73

LGALS3BP

3959

Q08380

0.73

MDM2

4193

Q00987

0.73

MAP3K3

4215

Q99759

0.73

PARK2

5071

O60260

0.73

CDK18

5129

Q07002

0.73

PHB

5245

P35232

0.73

MAPK7

5598

Q13164

0.73

AURKC

6795

Q9UQB9

0.73

TERF1

7013

P54274

0.73

CUL2

8453

Q13617

0.73

CUL1

8454

Q13616

0.73

BAG3

9531

O95817

0.73

ISG15

9636

P05161

0.73

POT1

25913

Q9NUX5

0.73

FBXO24

26261

O75426

0.73

FBXO6

26270

Q9NRD1

0.73

TINF2

26277

Q9BSI4

0.73

AGO1

26523

Q9UL18

0.73

ACD

65057

Q96AP0

0.73

PSKH2

85481

Q96QS6

0.73

TP53RK

112858

Q96S44

0.73

MYLK4

340156

Q86YV6

0.73

KLHL38

340359

Q2WGJ6

0.73

FAM162A

26355

Q96A26

0.74

TSSK6

83983

Q9BXA6

0.75

CHEK1

1111

O14757

0.78

GRB2

2885

P62993

0.78

PTEN

5728

P60484

0.78

SUMO1

7341

P63165

0.79

SLC33A1

9197

O00400

0.79

RPAP3

79657

Q9H6T3

0.79

YWHAB

7529

P31946

0.80

BRAF

673

P15056

0.82

CDK2

1017

P24941

0.82

MAP3K8

1326

P41279

0.82

FGFR3

2261

P22607

0.82

GRK6

2870

P43250

0.82

HNRNPA1

3178

P09651

0.82

MCM7

4176

P33993

0.82

PRKCE

5581

Q02156

0.82

RPS6KA1

6195

Q15418

0.82

TUBG1

7283

P23258

0.82

VCAM1

7412

P19320

0.82

RIPK1

8737

Q13546

0.82

AIP

9049

O00170

0.82

CDK7

1022

P50613

0.83

RAF1

5894

P04049

0.83

TRAF2

7186

Q12933

0.83

MAP3K14

9020

Q99558

0.83

AURKB

9212

Q96GD4

0.83

IKBKE

9641

Q14164

0.83

TBK1

29110

Q9UHD2

0.83

LRRK2

120892

Q5S007

0.83

IKBKB

3551

O14920

0.84

NFKB1

4790

P19838

0.84

CDKN2A

1029

P42771

0.85

SUGT1

10910

Q9Y2Z0

0.85

PRKAA1

5562

Q13131

0.86

SUMO2

6613

P61956

0.86

CDK4

1019

P11802

0.87

CDK9

1025

P50750

0.87

PTGES3

10728

Q15185

0.88

HIF1A

3091

Q16665

0.89

IKBKG

8517

Q9Y6K9

0.89

STUB1

10273

Q9UNE7

0.89

CHORDC1

26973

Q9UHD1

0.89

EGFR

1956

P00533

0.90

CDC37L1

55664

Q7L3B6

0.94

HSP90AA1

3320

P07900

0.96

CDC37

11140

Q16543

0.96

PPID

5481

Q08752

0.98