BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0001892

embryonic placenta development

The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

IEA

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IEA

BP

GO:0006952

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

IEA

BP

GO:0007143

female meiotic division

A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.

IEA

BP

GO:0007283

spermatogenesis

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

IEA

BP

GO:0007584

response to nutrient

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

IEA

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IEA

BP

GO:0009299

mRNA transcription

The cellular synthesis of messenger RNA (mRNA) from a DNA template.

IDA

BP

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.

IEA

BP

GO:0014823

response to activity

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.

IEA

BP

GO:0032720

negative regulation of tumor necrosis factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.

IEA

BP

GO:0033574

response to testosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.

IEA

BP

GO:0034605

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

IDA

BP

GO:0035865

cellular response to potassium ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.

IEA

BP

GO:0040018

positive regulation of multicellular organism growth

Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.

IEA

BP

GO:0042517

positive regulation of tyrosine phosphorylation of Stat3 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

IEA

BP

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

IEA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0060136

embryonic process involved in female pregnancy

A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.

IEA

BP

GO:0070301

cellular response to hydrogen peroxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

IEA

BP

GO:0071222

cellular response to lipopolysaccharide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IEA

BP

GO:0071392

cellular response to estradiol stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

IEA

BP

GO:0071478

cellular response to radiation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

IEA

BP

GO:0090084

negative regulation of inclusion body assembly

Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.

IEA

BP

GO:0090261

positive regulation of inclusion body assembly

Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.

IEA

BP

GO:1900034

regulation of cellular response to heat

Any process that modulates the frequency, rate or extent of cellular response to heat.

TAS

BP

GO:1901215

negative regulation of neuron death

Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.

IEA

BP

GO:1902512

positive regulation of apoptotic DNA fragmentation

Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.

IEA

BP

GO:1904385

cellular response to angiotensin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.

IEA

BP

GO:1904528

positive regulation of microtubule binding

Any process that activates or increases the frequency, rate or extent of microtubule binding.

IEA

BP

GO:1904843

cellular response to nitroglycerin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus.

IEA

BP

GO:1904845

cellular response to L-glutamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus.

IEA

BP

GO:1990910

response to hypobaric hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).

IEA

BP

GO:1990911

response to psychosocial stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.

IEA

CC

GO:0000791

euchromatin

A dispersed and relatively uncompacted form of chromatin.

IEA

CC

GO:0000792

heterochromatin

A compact and highly condensed form of chromatin.

IEA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IEA

CC

GO:0045120

pronucleus

The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.

IEA

MF

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.

IDA

MF

GO:0000979

RNA polymerase II core promoter sequence-specific DNA binding

Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.

IEA

MF

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

MF

GO:0001162

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.

IDA

MF

GO:0003700

transcription factor activity, sequence-specific DNA binding

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0031072

heat shock protein binding

Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.

IEA

MF

GO:0097677

STAT family protein binding

Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.

IEA

MF

GO:0098847

sequence-specific single stranded DNA binding

Interacting selectively and non-covalently with single-stranded DNA of a specific nucleotide composition.

IEA

MF

GO:1990841

promoter-specific chromatin binding

Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.

IEA