| Gene Symbol | ANXA3 |
| Entrez ID | 306 |
| Uniprot ID | P12429 |
| Description | annexin A3 |
| Chromosomal Location | chr4: 78,551,519-78,610,451 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006909 |
phagocytosis |
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
IDA |
|
BP |
GO:0010595 |
positive regulation of endothelial cell migration |
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
IDA |
|
BP |
GO:0021766 |
hippocampus development |
The progression of the hippocampus over time from its initial formation until its mature state. |
IEA |
|
BP |
GO:0031100 |
animal organ regeneration |
The regrowth of a lost or destroyed animal organ. |
IEA |
|
BP |
GO:0042742 |
defense response to bacterium |
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
IDA |
|
BP |
GO:0043086 |
negative regulation of catalytic activity |
Any process that stops or reduces the activity of an enzyme. |
IEA |
|
BP |
GO:0043312 |
neutrophil degranulation |
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil. |
IDA |
|
BP |
GO:0045766 |
positive regulation of angiogenesis |
Any process that activates or increases angiogenesis. |
IDA |
|
BP |
GO:0051054 |
positive regulation of DNA metabolic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. |
IEA |
|
BP |
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
IDA |
|
BP |
GO:0051384 |
response to glucocorticoid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
IEA |
|
BP |
GO:0070848 |
response to growth factor |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0030424 |
axon |
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
IEA |
|
CC |
GO:0030425 |
dendrite |
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
IEA |
|
CC |
GO:0030670 |
phagocytic vesicle membrane |
The lipid bilayer surrounding a phagocytic vesicle. |
IDA |
|
CC |
GO:0042581 |
specific granule |
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
IDA |
|
CC |
GO:0043025 |
neuronal cell body |
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
IEA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0005509 |
calcium ion binding |
Interacting selectively and non-covalently with calcium ions (Ca2+). |
IEA |
|
MF |
GO:0005544 |
calcium-dependent phospholipid binding |
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
IDA |
|
MF |
GO:0019834 |
phospholipase A2 inhibitor activity |
Stops, prevents or reduces the activity of the enzyme phospholipase A2. |
IEA |
|
MF |
GO:0048306 |
calcium-dependent protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. |
IPI |
| Domain ID | Description |
|---|---|
|
IPR001464 |
Annexin |
|
IPR002390 |
Annexin A3 |
|
IPR018252 |
Annexin repeat, conserved site |
|
IPR018502 |
Annexin repeat |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP98 |
Prostaglandin Synthesis and Regulation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0003873 |
Rheumatoid Arthritis |
|
C0024141 |
Lupus Erythematosus, Systemic |
|
C0033578 |
Prostatic Neoplasms |
|
C0919267 |
Ovarian Neoplasm |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ANXA4 |
307 |
P09525 |
0.49 |
|
STX4 |
6810 |
Q12846 |
0.49 |
|
STXBP2 |
6813 |
Q15833 |
0.49 |
|
SSNA1 |
8636 |
O43805 |
0.49 |
|
SNAP23 |
8773 |
O00161 |
0.49 |
|
UNC119 |
9094 |
Q13432 |
0.63 |
|
EMG1 |
10436 |
Q92979 |
0.63 |
|
IGSF21 |
84966 |
Q96ID5 |
0.63 |
|
UBR1 |
197131 |
Q8IWV7 |
0.63 |
|
TP53 |
7157 |
P04637 |
0.73 |
|
ANXA11 |
311 |
P50995 |
0.49 |
|
PPP2R4 |
5524 |
Q15257 |
0.49 |
|
ISG15 |
9636 |
P05161 |
0.63 |
|
REG3A |
5068 |
Q06141 |
0.65 |
|
ATF2 |
1386 |
P15336 |
0.72 |