Protein Description

Gene Symbol ANXA3
Entrez ID 306
Uniprot ID P12429
Description annexin A3
Chromosomal Location chr4: 78,551,519-78,610,451
Ontology GO ID GO Term Definition Evidence

BP

GO:0006909

phagocytosis

An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.

IDA

BP

GO:0010595

positive regulation of endothelial cell migration

Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

IDA

BP

GO:0021766

hippocampus development

The progression of the hippocampus over time from its initial formation until its mature state.

IEA

BP

GO:0031100

animal organ regeneration

The regrowth of a lost or destroyed animal organ.

IEA

BP

GO:0042742

defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

IDA

BP

GO:0043086

negative regulation of catalytic activity

Any process that stops or reduces the activity of an enzyme.

IEA

BP

GO:0043312

neutrophil degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.

IDA

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

IDA

BP

GO:0051054

positive regulation of DNA metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.

IEA

BP

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IDA

BP

GO:0051384

response to glucocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

IEA

BP

GO:0070848

response to growth factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0030424

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

IEA

CC

GO:0030425

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

IEA

CC

GO:0030670

phagocytic vesicle membrane

The lipid bilayer surrounding a phagocytic vesicle.

IDA

CC

GO:0042581

specific granule

Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

IDA

CC

GO:0043025

neuronal cell body

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IEA

MF

GO:0005544

calcium-dependent phospholipid binding

Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.

IDA

MF

GO:0019834

phospholipase A2 inhibitor activity

Stops, prevents or reduces the activity of the enzyme phospholipase A2.

IEA

MF

GO:0048306

calcium-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.

IPI

Domain ID Description

IPR001464

Annexin

IPR002390

Annexin A3

IPR018252

Annexin repeat, conserved site

IPR018502

Annexin repeat

Pathway ID Pathway Term Pathway Source

WP98

Prostaglandin Synthesis and Regulation

WikiPathways

UMLS CUI UMLS Term

C0003873

Rheumatoid Arthritis

C0024141

Lupus Erythematosus, Systemic

C0033578

Prostatic Neoplasms

C0919267

Ovarian Neoplasm

No tissues found.

No databases found.

Pubmed ID Author Year Title

12734205

Wood et al.

2003

The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ANXA4

307

P09525

0.49

STX4

6810

Q12846

0.49

STXBP2

6813

Q15833

0.49

SSNA1

8636

O43805

0.49

SNAP23

8773

O00161

0.49

UNC119

9094

Q13432

0.63

EMG1

10436

Q92979

0.63

IGSF21

84966

Q96ID5

0.63

UBR1

197131

Q8IWV7

0.63

TP53

7157

P04637

0.73

ANXA11

311

P50995

0.49

PPP2R4

5524

Q15257

0.49

ISG15

9636

P05161

0.63

REG3A

5068

Q06141

0.65

ATF2

1386

P15336

0.72