Protein Description

Gene Symbol HOXA1
Entrez ID 3198
Uniprot ID P49639
Description homeobox A1
Chromosomal Location chr7: 27,092,993-27,095,996
Ontology GO ID GO Term Definition Evidence

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0006355

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

IEA

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0007605

sensory perception of sound

The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

IDA

BP

GO:0007634

optokinetic behavior

The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.

IDA

BP

GO:0009653

anatomical structure morphogenesis

The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

IMP

BP

GO:0021599

abducens nerve formation

The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.

IMP

BP

GO:0042473

outer ear morphogenesis

The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull.

IDA

BP

GO:0048702

embryonic neurocranium morphogenesis

The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.

IMP

BP

GO:0048839

inner ear development

The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.

IMP

BP

GO:0048844

artery morphogenesis

The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.

IMP

BP

GO:0050795

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.

IDA

BP

GO:0050890

cognition

The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

IDA

BP

GO:0050905

neuromuscular process

Any process pertaining to the functions of the nervous and muscular systems of an organism.

IDA

BP

GO:0060840

artery development

The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.

IMP

BP

GO:0060876

semicircular canal formation

The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes.

IMP

BP

GO:0090102

cochlea development

The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.

IMP

BP

GO:0090103

cochlea morphogenesis

The process in which the cochlea is generated and organized.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0043565

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

IEA

Domain ID Description

IPR001356

Homeobox domain

IPR009057

Homeobox domain-like

IPR017970

Homeobox, conserved site

IPR020479

Homeobox domain, metazoa

Pathway ID Pathway Term Pathway Source

WP2064

Neural Crest Differentiation

WikiPathways

WP2853

Endoderm Differentiation

WikiPathways

UMLS CUI UMLS Term

C0004352

Autistic Disorder

C0018798

Congenital Heart Defects

C0376634

Craniofacial Abnormalities

C0497552

Congenital Neurologic Anomalies

No tissues found.

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

TCF3

6929

P15923

0.52

KRT31

3881

Q15323

0.63

PBX1

5087

P40424

0.63

PBX2

5089

P40425

0.63

PCSK5

5125

Q92824

0.63

SDCBP

6386

O00560

0.63

TLE1

7088

Q04724

0.63

TRAF1

7185

Q13077

0.63

BLZF1

8548

Q9H2G9

0.63

CHRD

8646

Q9H2X0

0.63

KRT38

8687

O76015

0.63

CHIC2

26511

Q9UKJ5

0.63

RGS17

26575

Q9UGC6

0.63

ALG13

79868

Q9NP73

0.63

CCDC33

80125

Q8N5R6

0.63

ZNF703

80139

Q9H7S9

0.63

KRTAP9-2

83899

Q9BYQ4

0.63

PRRC2B

84726

Q5JSZ5

0.63

ZNF503

84858

Q96F45

0.63

KRTAP9-4

85280

Q9BYQ2

0.63

KRTAP4-2

85291

Q9BYR5

0.63

KRT40

125115

Q6A162

0.63

HSFY1

159119

Q96LI6

0.63

LCE4A

199834

Q5TA78

0.63

TRIM42

287015

Q8IWZ5

0.63

LCE1B

353132

Q5T7P3

0.63

LCE3E

353145

Q5T5B0

0.63

KRTAP12-2

353323

P59991

0.63

KRTAP12-1

353332

P59990

0.63

TBC1D10C

374403

Q8IV04

0.63

KRTAP10-9

386676

P60411

0.63

KRTAP10-1

386677

P60331

0.63

KRTAP10-11

386678

P60412

0.63

KRTAP10-5

386680

P60370

0.63

KRTAP10-8

386681

P60410

0.63

KRTAP10-3

386682

P60369

0.63

KRTAP12-4

386684

P60329

0.63

NOTCH2NL

388677

Q7Z3S9

0.63

KRTAP5-6

440023

Q6L8G9

0.63

KRTAP4-11

653240

Q9BYQ6

0.63

DUSP22

56940

Q9NRW4

0.63

KDM1A

23028

O60341

0.72

PRMT6

55170

Q96LA8

0.72

SPRY1

10252

O43609

0.73

KRTAP3-2

83897

Q9BYR7

0.82

KRTAP26-1

388818

Q6PEX3

0.82

HOXA1

3198

P49639

0.83

PLSCR1

5359

O15162

0.83

TRIP6

7205

Q15654

0.83

PKNOX1

5316

P55347

0.84

LPXN

9404

O60711

0.86

TRAPPC6A

79090

O75865

0.86

MDFI

4188

Q99750

0.87

EFEMP2

30008

O95967

0.87

KRTAP4-12

83755

Q9BQ66

0.87

KRTAP4-7

100132476

Q9BYR0

0.63

TRIM23

373

P36406

0.63

GATA1

2623

P15976

0.63

PIK3R1

5295

P27986

0.63

TRAF2

7186

Q12933

0.63

ZBTB16

7704

Q05516

0.63

PDLIM7

9260

Q9NR12

0.63

RBCK1

10616

Q9BYM8

0.63

KDM5B

10765

Q9UGL1

0.63

ZBTB32

27033

Q9Y2Y4

0.63

SMOC1

64093

Q9H4F8

0.63

HOXD3

3232

P31249

0.72

KRT81

3887

Q14533

0.72

LIMS1

3987

P48059

0.72

PITX2

5308

Q99697

0.72

RAB33A

9363

Q14088

0.72

FHL5

9457

Q5TD97

0.72

PDCD6IP

10015

Q8WUM4

0.72

IKZF2

22807

Q9UKS7

0.72

ZZZ3

26009

Q8IYH5

0.72

PLSCR4

57088

Q9NRQ2

0.72

ABHD17A

81926

Q96GS6

0.72

CRACR2A

84766

Q9BSW2

0.72

C1orf94

84970

Q6P1W5

0.72

SAXO1

158297

Q8IYX7

0.72

LNX2

222484

Q8N448

0.72

GP9

2815

P14770

0.73

GRN

2896

P28799

0.74

SUV39H1

6839

O43463

0.76

PRNP

5621

P04156

0.78

RGS20

8601

O76081

0.82

N4BP2L2

10443

Q92802

0.82

RBPMS

11030

Q93062

0.82

KRTAP5-9

3846

P26371

0.86

LGALS13

29124

Q9UHV8

0.86

ADAMTSL4

54507

Q6UY14

0.86

MGAT5B

146664

Q3V5L5

0.86