| Gene Symbol | HNRNPL |
| Entrez ID | 3191 |
| Uniprot ID | P14866 |
| Description | heterogeneous nuclear ribonucleoprotein L |
| Chromosomal Location | chr19: 38,836,388-38,852,347 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
IMP |
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
TAS |
|
BP |
GO:0006396 |
RNA processing |
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
TAS |
|
BP |
GO:0010467 |
gene expression |
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
TAS |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IEA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0030529 |
intracellular ribonucleoprotein complex |
An intracellular macromolecular complex containing both protein and RNA molecules. |
IDA |
|
CC |
GO:0035770 |
ribonucleoprotein granule |
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. |
IDA |
|
CC |
GO:0045120 |
pronucleus |
The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. |
IEA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0044212 |
transcription regulatory region DNA binding |
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
IDA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:0097157 |
pre-mRNA intronic binding |
Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA). |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000504 |
RNA recognition motif domain |
|
IPR006536 |
HnRNP-L/PTB |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP411 |
mRNA Processing |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0038356 |
Stomach Neoplasms |
|
C0242656 |
Disease Progression |
|
C1458155 |
Mammary Neoplasms |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
keratinocytes |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
DHX15 |
1665 |
O43143 |
0.49 |
|
HSPA9 |
3313 |
P38646 |
0.49 |
|
IL7R |
3575 |
P16871 |
0.49 |
|
LPP |
4026 |
Q93052 |
0.49 |
|
MPV17 |
4358 |
P39210 |
0.49 |
|
HNRNPM |
4670 |
P52272 |
0.49 |
|
NARS |
4677 |
O43776 |
0.49 |
|
SNU13 |
4809 |
P55769 |
0.49 |
|
PDHA1 |
5160 |
P08559 |
0.49 |
|
PLEC |
5339 |
Q15149 |
0.49 |
|
SFPQ |
6421 |
P23246 |
0.49 |
|
TUFM |
7284 |
P49411 |
0.49 |
|
EIF4H |
7458 |
Q15056 |
0.49 |
|
YWHAE |
7531 |
P62258 |
0.49 |
|
SF1 |
7536 |
Q15637 |
0.49 |
|
ACTR3 |
10096 |
P61158 |
0.49 |
|
HNRNPR |
10236 |
O43390 |
0.49 |
|
SYNCRIP |
10492 |
O60506 |
0.49 |
|
HNRNPA0 |
10949 |
Q13151 |
0.49 |
|
HSPBP1 |
23640 |
Q9NZL4 |
0.49 |
|
LSM14A |
26065 |
Q8ND56 |
0.49 |
|
DPH5 |
51611 |
Q9H2P9 |
0.49 |
|
MRPL41 |
64975 |
Q8IXM3 |
0.49 |
|
NAA50 |
80218 |
Q9GZZ1 |
0.49 |
|
HNRNPA3 |
220988 |
P51991 |
0.49 |
|
ATP6V1F |
9296 |
Q16864 |
0.59 |
|
NPLOC4 |
55666 |
Q8TAT6 |
0.59 |
|
VEGFA |
7422 |
P15692 |
0.63 |
|
ZNF143 |
7702 |
P52747 |
0.63 |
|
HMG20B |
10362 |
Q9P0W2 |
0.63 |
|
PJA1 |
64219 |
Q8NG27 |
0.63 |
|
ILF3 |
3609 |
Q12906 |
0.68 |
|
APEX1 |
328 |
P27695 |
0.76 |
|
HNRNPL |
3191 |
P14866 |
0.78 |
|
HNRNPA2B1 |
3181 |
P22626 |
0.86 |
|
HNRNPK |
3190 |
P61978 |
0.89 |
|
PTBP1 |
5725 |
P26599 |
0.89 |
|
PCBP2 |
5094 |
Q15366 |
0.99 |
|
DYNC1H1 |
1778 |
Q14204 |
0.49 |
|
EEF1A1 |
1915 |
P68104 |
0.49 |
|
EEF2 |
1938 |
P13639 |
0.49 |
|
HNRNPD |
3184 |
Q14103 |
0.49 |
|
HSPA5 |
3309 |
P11021 |
0.49 |
|
LGALS1 |
3956 |
P09382 |
0.49 |
|
ABCC1 |
4363 |
P33527 |
0.49 |
|
HIST3H3 |
8290 |
Q16695 |
0.49 |
|
HNRNPDL |
9987 |
O14979 |
0.49 |
|
DDX17 |
10521 |
Q92841 |
0.49 |
|
GCN1 |
10985 |
Q92616 |
0.49 |
|
PPP2R2B |
5521 |
Q00005 |
0.56 |
|
HNRNPH1 |
3187 |
P31943 |
0.59 |
|
CRY1 |
1407 |
Q16526 |
0.63 |
|
CSNK1E |
1454 |
P49674 |
0.63 |
|
DAB2 |
1601 |
P98082 |
0.63 |
|
DFFA |
1676 |
O00273 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
FGFR3 |
2261 |
P22607 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MAGOH |
4116 |
P61326 |
0.63 |
|
MBNL1 |
4154 |
Q9NR56 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PIK3CB |
5291 |
P42338 |
0.63 |
|
EIF2AK2 |
5610 |
P19525 |
0.63 |
|
RARA |
5914 |
P10276 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
RPA1 |
6117 |
P27694 |
0.63 |
|
RPA2 |
6118 |
P15927 |
0.63 |
|
RPA3 |
6119 |
P35244 |
0.63 |
|
SGK1 |
6446 |
O00141 |
0.63 |
|
SUMO3 |
6612 |
P55854 |
0.63 |
|
TIAL1 |
7073 |
Q01085 |
0.63 |
|
TP53 |
7157 |
P04637 |
0.63 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
|
WHSC1 |
7468 |
O96028 |
0.63 |
|
UBL4A |
8266 |
P11441 |
0.63 |
|
HIST1H3A |
8350 |
P68431 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
TNFRSF14 |
8764 |
Q92956 |
0.63 |
|
CFLAR |
8837 |
O15519 |
0.63 |
|
ISG15 |
9636 |
P05161 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
EIF4A3 |
9775 |
P38919 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
|
TOPORS |
10210 |
Q9NS56 |
0.63 |
|
SSSCA1 |
10534 |
O60232 |
0.63 |
|
IVNS1ABP |
10625 |
Q9Y6Y0 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
SRRM2 |
23524 |
Q9UQ35 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
AGO1 |
26523 |
Q9UL18 |
0.63 |
|
DDX41 |
51428 |
Q9UJV9 |
0.63 |
|
TMBIM4 |
51643 |
Q9HC24 |
0.63 |
|
TRIM68 |
55128 |
Q6AZZ1 |
0.63 |
|
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
SMARCAD1 |
56916 |
Q9H4L7 |
0.63 |
|
SMYD2 |
56950 |
Q9NRG4 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
|
UNK |
85451 |
Q9C0B0 |
0.63 |
|
SCARNA22 |
677770 |
N/A |
0.63 |
|
SUMO4 |
387082 |
Q6EEV6 |
0.65 |
|
NEDD4 |
4734 |
P46934 |
0.68 |
|
TOP1 |
7150 |
P11387 |
0.68 |
|
ITCH |
83737 |
Q96J02 |
0.68 |
|
CSNK2A1 |
1457 |
P68400 |
0.70 |
|
FOXE1 |
2304 |
O00358 |
0.72 |
|
HMGA1 |
3159 |
P17096 |
0.72 |
|
HNRNPU |
3192 |
Q00839 |
0.72 |
|
IFIT2 |
3433 |
P09913 |
0.72 |
|
IFIT3 |
3437 |
O14879 |
0.72 |
|
TP63 |
8626 |
Q9H3D4 |
0.72 |
|
MATR3 |
9782 |
P43243 |
0.72 |
|
KHDRBS2 |
202559 |
Q5VWX1 |
0.72 |
|
CSE1L |
1434 |
P55060 |
0.73 |
|
FUS |
2521 |
P35637 |
0.73 |
|
VHL |
7428 |
P40337 |
0.73 |
|
SUMO2 |
6613 |
P61956 |
0.74 |
|
EIF2B1 |
1967 |
Q14232 |
0.76 |
|
YWHAZ |
7534 |
P63104 |
0.76 |
|
DOCK4 |
9732 |
Q8N1I0 |
0.76 |
|
PUF60 |
22827 |
Q9UHX1 |
0.76 |
|
SUMO1 |
7341 |
P63165 |
0.78 |
|
YBX1 |
4904 |
P67809 |
0.82 |
|
VCAM1 |
7412 |
P19320 |
0.82 |
|
HNRNPA1 |
3178 |
P09651 |
0.87 |