PCOSBase

Protein Description

Gene Symbol	HNRNPH1
Entrez ID	3187
Uniprot ID	P31943
Description	heterogeneous nuclear ribonucleoprotein H1 (H)
Chromosomal Location	chr5: 179,614,178-179,634,784

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000398	mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	IC\|TAS
BP	GO:0006396	RNA processing	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.	TAS
BP	GO:0008543	fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.	TAS
BP	GO:0010467	gene expression	The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	TAS
BP	GO:0043484	regulation of RNA splicing	Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	TAS
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0071013	catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.	IDA
MF	GO:0000166	nucleotide binding	Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.	IEA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0008266	poly(U) RNA binding	Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.	TAS
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000504	RNA recognition motif domain
IPR012996	Zinc finger, CHHC-type

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Pathway ID	Pathway Term	Pathway Source
WP3584	MECP2 and Associated Rett Syndrome	WikiPathways
WP411	mRNA Processing	WikiPathways

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UMLS CUI	UMLS Term
C0033578	Prostatic Neoplasms

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
breast	glandular cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
17148555	Wood et al.	2007	Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

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Gene Symbol	Entrez ID	Uniprot ID	Score
TPP1	1200	O14773	0.49
HNRNPAB	3182	Q99729	0.49
ILF2	3608	Q12905	0.49
RAB5C	5878	P51148	0.49
RANBP2	5903	P49792	0.49
RBM4	5936	Q9BWF3	0.49
RPS6KA3	6197	P51812	0.49
SNRNP70	6625	P08621	0.49
YES1	7525	P07947	0.49
USP7	7874	Q93009	0.49
NUP58	9818	Q9BVL2	0.49
PDCD6	10016	O75340	0.49
NAMPT	10135	P43490	0.49
HNRNPR	10236	O43390	0.49
BASP1	10409	P80723	0.49
RBM14	10432	Q96PK6	0.49
PGRMC1	10857	O00264	0.49
HNRNPA0	10949	Q13151	0.49
HNRNPUL1	11100	Q9BUJ2	0.49
U2AF2	11338	P26368	0.49
LSM14A	26065	Q8ND56	0.49
RBMX	27316	P38159	0.49
SCOC	60592	Q9UIL1	0.49
IKBIP	121457	Q70UQ0	0.49
PTRF	284119	Q6NZI2	0.49
HNRNPL	3191	P14866	0.59
HNRNPA3	220988	P51991	0.59
CRMP1	1400	Q14194	0.63
MTNR1A	4543	P48039	0.63
PPP2CA	5515	P67775	0.63
TOM1L1	10040	O75674	0.63
TOB1	10140	P50616	0.63
HNRNPD	3184	Q14103	0.72
HNRNPK	3190	P61978	0.72
HNRNPU	3192	Q00839	0.72
HSPD1	3329	P10809	0.72
KPNA2	3838	P52292	0.72
CPNE1	8904	Q99829	0.72
RQCD1	9125	Q92600	0.72
SYNCRIP	10492	O60506	0.72
DDX17	10521	Q92841	0.72
CCT4	10575	P50991	0.72
YKT6	10652	O15498	0.72
CCT5	22948	P48643	0.72
YTHDF2	51441	Q9Y5A9	0.72
HNRNPH3	3189	P31942	0.73
NCBP1	4686	Q09161	0.76
HNRNPM	4670	P52272	0.79
HNRNPA2B1	3181	P22626	0.83
HNRNPH2	3188	P55795	0.83
DDX5	1655	P17844	0.87
CPS1	1373	P31327	0.49
EEF2	1938	P13639	0.49
GTF2I	2969	P78347	0.49
HADHA	3030	P40939	0.49
HSPB1	3315	P04792	0.49
TSTA3	7264	Q13630	0.49
RTCA	8634	O00442	0.49
CPNE3	8895	O75131	0.49
HNRNPDL	9987	O14979	0.49
HIPK3	10114	Q9H422	0.49
ECM29	23392	Q5VYK3	0.49
HIBCH	26275	Q6NVY1	0.49
SAR1B	51128	Q9Y6B6	0.49
RTCB	51493	Q9Y3I0	0.49
C9orf78	51759	Q9NZ63	0.49
DDX43	55510	Q9NXZ2	0.49
IARS2	55699	Q9NSE4	0.49
C21orf59	56683	P57076	0.49
ELAC2	60528	Q9BQ52	0.49
AHNAK	79026	Q09666	0.49
HNRNPA1L2	144983	Q32P51	0.49
ACTB	60	P60709	0.55
CD247	919	P20963	0.56
GRB2	2885	P62993	0.56
PPP2R2B	5521	Q00005	0.56
SUN2	25777	Q9UH99	0.56
PARP1	142	P09874	0.63
ADRB2	154	P07550	0.63
CD4	920	P01730	0.63
CD81	975	P60033	0.63
CDC5L	988	Q99459	0.63
CDK4	1019	P11802	0.63
CRY1	1407	Q16526	0.63
CSNK1E	1454	P49674	0.63
ELAVL1	1994	Q15717	0.63
FN1	2335	P02751	0.63
FUS	2521	P35637	0.63
ICAM1	3383	P05362	0.63
ILK	3611	Q13418	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
MDM2	4193	Q00987	0.63
NEDD8	4738	Q15843	0.63
NFKB1	4790	P19838	0.63
NFX1	4799	Q12986	0.63
NPM1	4869	P06748	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
PHKG2	5261	P15735	0.63
PPP3CA	5530	Q08209	0.63
PRKAA1	5562	Q13131	0.63
EIF2AK2	5610	P19525	0.63
PSMD9	5715	O00233	0.63
REL	5966	Q04864	0.63
RPA1	6117	P27694	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
RPS6KA1	6195	Q15418	0.63
SHC1	6464	P29353	0.63
SUMO3	6612	P55854	0.63
STAU1	6780	O95793	0.63
TP53	7157	P04637	0.63
VCP	7415	P55072	0.63
VHL	7428	P40337	0.63
WHSC1	7468	O96028	0.63
SF1	7536	Q15637	0.63
CUL5	8065	Q93034	0.63
GAN	8139	Q9H2C0	0.63
UBL4A	8266	P11441	0.63
CUL4B	8450	Q13620	0.63
CUL4A	8451	Q13619	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
EED	8726	O75530	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
PTBP3	9991	O95758	0.63
HUWE1	10075	Q7Z6Z7	0.63
SF3B4	10262	Q15427	0.63
TUBGCP3	10426	Q96CW5	0.63
UBD	10537	O15205	0.63
AHSA1	10598	O95433	0.63
CELF1	10658	Q92879	0.63
COPS6	10980	Q7L5N1	0.63
COPS5	10987	Q92905	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
SNW1	22938	Q13573	0.63
PEG10	23089	Q86TG7	0.63
FBXW11	23291	Q9UKB1	0.63
OBSL1	23363	O75147	0.63
TARDBP	23435	Q13148	0.63
PRAME	23532	P78395	0.63
TNPO3	23534	Q9Y5L0	0.63
GABARAPL1	23710	Q9H0R8	0.63
FBXO6	26270	Q9NRD1	0.63
EEF2K	29904	O00418	0.63
IPO11	51194	Q9UI26	0.63
DDX41	51428	Q9UJV9	0.63
SIRT6	51548	Q8N6T7	0.63
ASB2	51676	Q96Q27	0.63
DCUN1D1	54165	Q96GG9	0.63
DGCR8	54487	Q8WYQ5	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
SMARCAD1	56916	Q9H4L7	0.63
SMURF1	57154	Q9HCE7	0.63
AASDHPPT	60496	Q9NRN7	0.63
CEP76	79959	Q8TAP6	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
CCDC8	83987	Q9H0W5	0.63
UNK	85451	Q9C0B0	0.63
IGSF8	93185	Q969P0	0.63
TP53RK	112858	Q96S44	0.63
MYSM1	114803	Q5VVJ2	0.63
SREK1	140890	Q8WXA9	0.63
ALKBH3	221120	Q96Q83	0.63
SCARNA22	677770	N/A	0.63
SUMO4	387082	Q6EEV6	0.65
APBB1	322	O00213	0.68
ERG	2078	P11308	0.68
PIN1	5300	Q13526	0.68
YWHAQ	10971	P27348	0.68
ARRB1	408	P49407	0.72
ARRB2	409	P32121	0.72
CDK9	1025	P50750	0.72
ATF2	1386	P15336	0.72
MAGOH	4116	P61326	0.72
MAP3K3	4215	Q99759	0.72
NFKB2	4791	Q00653	0.72
TYK2	7297	P29597	0.72
IKBKE	9641	Q14164	0.72
EIF4A3	9775	P38919	0.72
MATR3	9782	P43243	0.72
RIPK3	11035	Q9Y572	0.72
ZWINT	11130	O95229	0.72
GPN1	11321	Q9HCN4	0.72
TAB2	23118	Q9NYJ8	0.72
MEPCE	56257	Q7L2J0	0.72
KHDRBS2	202559	Q5VWX1	0.72
SMN1; SMN2	6606	Q16637	0.72
SUMO1	7341	P63165	0.73
YWHAG	7532	P61981	0.73
NDRG1	10397	Q92597	0.73
TCERG1	10915	O14776	0.73
RALY	22913	Q9UKM9	0.73
SRRM2	23524	Q9UQ35	0.73
NCBP2	22916	P52298	0.75
SUMO2	6613	P61956	0.79
MBNL1	4154	Q9NR56	0.82
VCAM1	7412	P19320	0.82
MAP1LC3A	84557	Q9H492	0.82
HNRNPF	3185	P52597	0.85
EGFR	1956	P00533	0.87
HNRNPA1	3178	P09651	0.88
KHSRP	8570	Q92945	0.88