Gene Symbol | HNRNPA2B1 |
Entrez ID | 3181 |
Uniprot ID | P22626 |
Description | heterogeneous nuclear ribonucleoprotein A2/B1 |
Chromosomal Location | chr7: 26,189,927-26,201,529 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IC|IMP|TAS |
BP |
GO:0006397 |
mRNA processing |
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
IDA |
BP |
GO:0006406 |
mRNA export from nucleus |
The directed movement of mRNA from the nucleus to the cytoplasm. |
IDA |
BP |
GO:0010467 |
gene expression |
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
TAS |
BP |
GO:0031053 |
primary miRNA processing |
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
IDA |
BP |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. |
IEA |
BP |
GO:0050658 |
RNA transport |
The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IDA |
BP |
GO:1990428 |
miRNA transport |
The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
CC |
GO:0005681 |
spliceosomal complex |
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0030529 |
intracellular ribonucleoprotein complex |
An intracellular macromolecular complex containing both protein and RNA molecules. |
IDA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
CC |
GO:0071013 |
catalytic step 2 spliceosome |
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
IDA |
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
IDA |
MF |
GO:0003730 |
mRNA 3'-UTR binding |
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0035198 |
miRNA binding |
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
IDA |
MF |
GO:0043047 |
single-stranded telomeric DNA binding |
Interacting selectively and non-covalently with single-stranded telomere-associated DNA. |
IDA |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
MF |
GO:0097157 |
pre-mRNA intronic binding |
Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA). |
IEA |
MF |
GO:1990247 |
N6-methyladenosine-containing RNA binding |
Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. |
IDA |
Domain ID | Description |
---|---|
IPR000504 |
RNA recognition motif domain |
IPR034486 |
hnRNP A2/B1, RNA recognition motif 1 |
IPR034489 |
hnRNP A2/B1 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP411 |
mRNA Processing |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0023493 |
Adult T-Cell Lymphoma/Leukemia |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bone marrow |
hematopoietic cells |
breast |
adipocytes |
breast |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
caudate |
glial cells |
caudate |
neuronal cells |
cerebellum |
cells in molecular layer |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
cervix, uterine |
squamous epithelial cells |
colon |
glandular cells |
colon |
peripheral nerve/ganglion |
duodenum |
glandular cells |
endometrium |
cells in endometrial stroma |
endometrium |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
hippocampus |
glial cells |
hippocampus |
neuronal cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
liver |
bile duct cells |
lung |
macrophages |
lung |
pneumocytes |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
oral mucosa |
squamous epithelial cells |
pancreas |
exocrine glandular cells |
pancreas |
islets of Langerhans |
parathyroid gland |
glandular cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
seminal vesicle |
glandular cells |
skeletal muscle |
myocytes |
skin |
fibroblasts |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
soft tissue |
adipocytes |
soft tissue |
fibroblasts |
soft tissue |
peripheral nerve |
spleen |
cells in red pulp |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
thyroid gland |
glandular cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15291743 |
Diao et al. |
2004 |
The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray |
17557764 |
Ma et al. |
2007 |
Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ATP1B1 |
481 |
P05026 |
0.49 |
SERPINH1 |
871 |
P50454 |
0.49 |
EIF4EBP2 |
1979 |
Q13542 |
0.49 |
HNRNPF |
3185 |
P52597 |
0.49 |
ITPA |
3704 |
Q9BY32 |
0.49 |
MAX |
4149 |
P61244 |
0.49 |
PGK1 |
5230 |
P00558 |
0.49 |
RPS7 |
6201 |
P62081 |
0.49 |
RPS19 |
6223 |
P39019 |
0.49 |
RPS27A |
6233 |
P62979 |
0.49 |
SRSF2 |
6427 |
Q01130 |
0.49 |
SRSF3 |
6428 |
P84103 |
0.49 |
SRSF5 |
6430 |
Q13243 |
0.49 |
SNRPD1 |
6632 |
P62314 |
0.49 |
TPR |
7175 |
P12270 |
0.49 |
UBA52 |
7311 |
P62987 |
0.49 |
SRSF9 |
8683 |
Q13242 |
0.49 |
SQSTM1 |
8878 |
Q13501 |
0.49 |
ACAA2 |
10449 |
P42765 |
0.49 |
TIMM13 |
26517 |
Q9Y5L4 |
0.49 |
SLIRP |
81892 |
Q9GZT3 |
0.49 |
S100A16 |
140576 |
Q96FQ6 |
0.49 |
HNRNPA3 |
220988 |
P51991 |
0.49 |
SNRNP70 |
6625 |
P08621 |
0.52 |
HNRNPAB |
3182 |
Q99729 |
0.59 |
HNRNPA2B1 |
3181 |
P22626 |
0.63 |
IARS |
3376 |
P41252 |
0.63 |
MRE11A |
4361 |
P49959 |
0.63 |
PSMA4 |
5685 |
P25789 |
0.63 |
PSMA5 |
5686 |
P28066 |
0.63 |
RBM3 |
5935 |
P98179 |
0.63 |
SNRPB2 |
6629 |
P08579 |
0.63 |
RN7SK |
125050 |
N/A |
0.63 |
ZMAT3 |
64393 |
Q9HA38 |
0.76 |
HNRNPH2 |
3188 |
P55795 |
0.82 |
VHL |
7428 |
P40337 |
0.84 |
CSNK2A1 |
1457 |
P68400 |
0.89 |
ATP5B |
506 |
P06576 |
0.49 |
ELAVL1 |
1994 |
Q15717 |
0.49 |
HSD17B10 |
3028 |
Q99714 |
0.49 |
HSPD1 |
3329 |
P10809 |
0.49 |
LMNA |
4000 |
P02545 |
0.49 |
SFPQ |
6421 |
P23246 |
0.49 |
HIST3H3 |
8290 |
Q16695 |
0.49 |
HIPK3 |
10114 |
Q9H422 |
0.49 |
ACTB |
60 |
P60709 |
0.55 |
PPP2R2B |
5521 |
Q00005 |
0.56 |
HNRNPH3 |
3189 |
P31942 |
0.59 |
HNRNPDL |
9987 |
O14979 |
0.59 |
ABCF1 |
23 |
Q8NE71 |
0.63 |
ADRB2 |
154 |
P07550 |
0.63 |
ARRB2 |
409 |
P32121 |
0.63 |
BRCA1 |
672 |
P38398 |
0.63 |
CD4 |
920 |
P01730 |
0.63 |
CD81 |
975 |
P60033 |
0.63 |
CDC5L |
988 |
Q99459 |
0.63 |
CDKN1A |
1026 |
P38936 |
0.63 |
AP2M1 |
1173 |
Q96CW1 |
0.63 |
CSF2 |
1437 |
P04141 |
0.63 |
CSNK1A1 |
1452 |
P48729 |
0.63 |
CTNNB1 |
1499 |
P35222 |
0.63 |
DDX1 |
1653 |
Q92499 |
0.63 |
DHX9 |
1660 |
Q08211 |
0.63 |
DYNC1LI2 |
1783 |
O43237 |
0.63 |
ERBB3 |
2065 |
P21860 |
0.63 |
FKBP3 |
2287 |
Q00688 |
0.63 |
FN1 |
2335 |
P02751 |
0.63 |
NR5A1 |
2516 |
Q13285 |
0.63 |
NR4A1 |
3164 |
P22736 |
0.63 |
HSPA5 |
3309 |
P11021 |
0.63 |
HSPB1 |
3315 |
P04792 |
0.63 |
ICAM1 |
3383 |
P05362 |
0.63 |
IGF1R |
3480 |
P08069 |
0.63 |
ITGA4 |
3676 |
P13612 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
LDHB |
3945 |
P07195 |
0.63 |
LIG4 |
3981 |
P49917 |
0.63 |
MBNL1 |
4154 |
Q9NR56 |
0.63 |
MCM2 |
4171 |
P49736 |
0.63 |
MCM5 |
4174 |
P33992 |
0.63 |
MDM2 |
4193 |
Q00987 |
0.63 |
MGMT |
4255 |
P16455 |
0.63 |
NFKB1 |
4790 |
P19838 |
0.63 |
NFX1 |
4799 |
Q12986 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PA2G4 |
5036 |
Q9UQ80 |
0.63 |
PAFAH1B2 |
5049 |
P68402 |
0.63 |
PARK2 |
5071 |
O60260 |
0.63 |
PHKG2 |
5261 |
P15735 |
0.63 |
PSMA6 |
5687 |
P60900 |
0.63 |
PSMB1 |
5689 |
P20618 |
0.63 |
PSMB4 |
5692 |
P28070 |
0.63 |
PSMD13 |
5719 |
Q9UNM6 |
0.63 |
QARS |
5859 |
P47897 |
0.63 |
MAP4K2 |
5871 |
Q12851 |
0.63 |
RAD51 |
5888 |
Q06609 |
0.63 |
RPA1 |
6117 |
P27694 |
0.63 |
RPA2 |
6118 |
P15927 |
0.63 |
RPA3 |
6119 |
P35244 |
0.63 |
RPL27A |
6157 |
P46776 |
0.63 |
RPL39 |
6170 |
P62891 |
0.63 |
RPS6KB2 |
6199 |
Q9UBS0 |
0.63 |
RPS28 |
6234 |
P62857 |
0.63 |
SHC1 |
6464 |
P29353 |
0.63 |
SUMO3 |
6612 |
P55854 |
0.63 |
STAU1 |
6780 |
O95793 |
0.63 |
STK4 |
6789 |
Q13043 |
0.63 |
AURKA |
6790 |
O14965 |
0.63 |
TP53 |
7157 |
P04637 |
0.63 |
YWHAE |
7531 |
P62258 |
0.63 |
YWHAZ |
7534 |
P63104 |
0.63 |
ZFP36 |
7538 |
P26651 |
0.63 |
CUL5 |
8065 |
Q93034 |
0.63 |
SF3A2 |
8175 |
Q15428 |
0.63 |
UBL4A |
8266 |
P11441 |
0.63 |
STK24 |
8428 |
Q9Y6E0 |
0.63 |
CUL4B |
8450 |
Q13620 |
0.63 |
CUL4A |
8451 |
Q13619 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
CUL2 |
8453 |
Q13617 |
0.63 |
CUL1 |
8454 |
Q13616 |
0.63 |
CAMK1 |
8536 |
Q14012 |
0.63 |
DENR |
8562 |
O43583 |
0.63 |
EED |
8726 |
O75530 |
0.63 |
EIF2B2 |
8892 |
P49770 |
0.63 |
PAPSS2 |
9060 |
O95340 |
0.63 |
EEF1E1 |
9521 |
O43324 |
0.63 |
BRE |
9577 |
Q9NXR7 |
0.63 |
ISG15 |
9636 |
P05161 |
0.63 |
CEP57 |
9702 |
Q86XR8 |
0.63 |
ULK2 |
9706 |
Q8IYT8 |
0.63 |
KIAA0101 |
9768 |
Q15004 |
0.63 |
CUL7 |
9820 |
Q14999 |
0.63 |
RB1CC1 |
9821 |
Q8TDY2 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
AKT3 |
10000 |
Q9Y243 |
0.63 |
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
ABCF2 |
10061 |
Q9UG63 |
0.63 |
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
TOB1 |
10140 |
P50616 |
0.63 |
NXF1 |
10482 |
Q9UBU9 |
0.63 |
STK25 |
10494 |
O00506 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
AHSA1 |
10598 |
O95433 |
0.63 |
IGF2BP3 |
10643 |
O00425 |
0.63 |
YWHAQ |
10971 |
P27348 |
0.63 |
COPS6 |
10980 |
Q7L5N1 |
0.63 |
COPS5 |
10987 |
Q92905 |
0.63 |
GABARAP |
11337 |
O95166 |
0.63 |
GABARAPL2 |
11345 |
P60520 |
0.63 |
SNW1 |
22938 |
Q13573 |
0.63 |
UNC13A |
23025 |
Q9UPW8 |
0.63 |
FAM175B |
23172 |
Q15018 |
0.63 |
OBSL1 |
23363 |
O75147 |
0.63 |
TARDBP |
23435 |
Q13148 |
0.63 |
SRRM2 |
23524 |
Q9UQ35 |
0.63 |
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
DIMT1 |
27292 |
Q9UNQ2 |
0.63 |
EEF2K |
29904 |
O00418 |
0.63 |
DDX41 |
51428 |
Q9UJV9 |
0.63 |
ASB2 |
51676 |
Q96Q27 |
0.63 |
DCUN1D1 |
54165 |
Q96GG9 |
0.63 |
LARP1B |
55132 |
Q659C4 |
0.63 |
MAP1S |
55201 |
Q66K74 |
0.63 |
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
CAND1 |
55832 |
Q86VP6 |
0.63 |
USE1 |
55850 |
Q9NZ43 |
0.63 |
LIN37 |
55957 |
Q96GY3 |
0.63 |
YAE1D1 |
57002 |
Q9NRH1 |
0.63 |
SMURF1 |
57154 |
Q9HCE7 |
0.63 |
MTA3 |
57504 |
Q9BTC8 |
0.63 |
TXNDC16 |
57544 |
Q9P2K2 |
0.63 |
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
PHF6 |
84295 |
Q8IWS0 |
0.63 |
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
MAEL |
84944 |
Q96JY0 |
0.63 |
UBASH3B |
84959 |
Q8TF42 |
0.63 |
IGSF8 |
93185 |
Q969P0 |
0.63 |
HAUS1 |
115106 |
Q96CS2 |
0.63 |
NEDD1 |
121441 |
Q8NHV4 |
0.63 |
LIN54 |
132660 |
Q6MZP7 |
0.63 |
SREK1 |
140890 |
Q8WXA9 |
0.63 |
MAP1LC3C |
440738 |
Q9BXW4 |
0.63 |
HIST1H2AB; HIST1H2AE |
3012 |
P04908 |
0.63 |
TTF2 |
8458 |
Q9UNY4 |
0.65 |
CDKN2A |
1029 |
P42771 |
0.68 |
PSMA3 |
5684 |
P25788 |
0.68 |
H2AFX |
3014 |
P16104 |
0.72 |
HDGF |
3068 |
P51858 |
0.72 |
HNRNPU |
3192 |
Q00839 |
0.72 |
IFIT2 |
3433 |
P09913 |
0.72 |
IFIT3 |
3437 |
O14879 |
0.72 |
PPP1CB |
5500 |
P62140 |
0.72 |
PPP1CC |
5501 |
P36873 |
0.72 |
XRCC3 |
7517 |
O43542 |
0.72 |
IQCB1 |
9657 |
Q15051 |
0.72 |
EMC2 |
9694 |
Q15006 |
0.72 |
MATR3 |
9782 |
P43243 |
0.72 |
MEPCE |
56257 |
Q7L2J0 |
0.72 |
MMGT1 |
93380 |
Q8N4V1 |
0.72 |
KHDRBS2 |
202559 |
Q5VWX1 |
0.72 |
SMN1; SMN2 |
6606 |
Q16637 |
0.72 |
NEDD8 |
4738 |
Q15843 |
0.73 |
PTBP1 |
5725 |
P26599 |
0.73 |
SUMO2 |
6613 |
P61956 |
0.73 |
SUMO1 |
7341 |
P63165 |
0.73 |
FBXW11 |
23291 |
Q9UKB1 |
0.73 |
CSNK2B |
1460 |
P67870 |
0.75 |
TOP1 |
7150 |
P11387 |
0.75 |
ZMYM2 |
7750 |
Q9UBW7 |
0.77 |
ERG |
2078 |
P11308 |
0.78 |
GRB2 |
2885 |
P62993 |
0.78 |
ESR1 |
2099 |
P03372 |
0.79 |
CDK9 |
1025 |
P50750 |
0.82 |
VCAM1 |
7412 |
P19320 |
0.82 |
HNRNPD |
3184 |
Q14103 |
0.83 |
HNRNPH1 |
3187 |
P31943 |
0.83 |
HNRNPL |
3191 |
P14866 |
0.86 |
HNRNPA1 |
3178 |
P09651 |
0.87 |
YBX1 |
4904 |
P67809 |
0.87 |