Protein Description

Gene Symbol HNRNPA2B1
Entrez ID 3181
Uniprot ID P22626
Description heterogeneous nuclear ribonucleoprotein A2/B1
Chromosomal Location chr7: 26,189,927-26,201,529
Ontology GO ID GO Term Definition Evidence

BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IEA

BP

GO:0000398

mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

IC|IMP|TAS

BP

GO:0006397

mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

IDA

BP

GO:0006406

mRNA export from nucleus

The directed movement of mRNA from the nucleus to the cytoplasm.

IDA

BP

GO:0010467

gene expression

The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

TAS

BP

GO:0031053

primary miRNA processing

Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.

IDA

BP

GO:0048025

negative regulation of mRNA splicing, via spliceosome

Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.

IEA

BP

GO:0050658

RNA transport

The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IDA

BP

GO:1990428

miRNA transport

The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005681

spliceosomal complex

Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0030529

intracellular ribonucleoprotein complex

An intracellular macromolecular complex containing both protein and RNA molecules.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0071013

catalytic step 2 spliceosome

A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.

IDA

MF

GO:0000166

nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

IEA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

IDA

MF

GO:0003730

mRNA 3'-UTR binding

Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0035198

miRNA binding

Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.

IDA

MF

GO:0043047

single-stranded telomeric DNA binding

Interacting selectively and non-covalently with single-stranded telomere-associated DNA.

IDA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0097157

pre-mRNA intronic binding

Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).

IEA

MF

GO:1990247

N6-methyladenosine-containing RNA binding

Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.

IDA

Domain ID Description

IPR000504

RNA recognition motif domain

IPR034486

hnRNP A2/B1, RNA recognition motif 1

IPR034489

hnRNP A2/B1

Pathway ID Pathway Term Pathway Source

WP411

mRNA Processing

WikiPathways

UMLS CUI UMLS Term

C0023493

Adult T-Cell Lymphoma/Leukemia

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bone marrow

hematopoietic cells

breast

adipocytes

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

caudate

neuronal cells

cerebellum

cells in molecular layer

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

glandular cells

colon

peripheral nerve/ganglion

duodenum

glandular cells

endometrium

cells in endometrial stroma

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

bile duct cells

lung

macrophages

lung

pneumocytes

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

parathyroid gland

glandular cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

soft tissue

adipocytes

soft tissue

fibroblasts

soft tissue

peripheral nerve

spleen

cells in red pulp

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

thyroid gland

glandular cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

15291743

Diao et al.

2004

The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray

17557764

Ma et al.

2007

Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ATP1B1

481

P05026

0.49

SERPINH1

871

P50454

0.49

EIF4EBP2

1979

Q13542

0.49

HNRNPF

3185

P52597

0.49

ITPA

3704

Q9BY32

0.49

MAX

4149

P61244

0.49

PGK1

5230

P00558

0.49

RPS7

6201

P62081

0.49

RPS19

6223

P39019

0.49

RPS27A

6233

P62979

0.49

SRSF2

6427

Q01130

0.49

SRSF3

6428

P84103

0.49

SRSF5

6430

Q13243

0.49

SNRPD1

6632

P62314

0.49

TPR

7175

P12270

0.49

UBA52

7311

P62987

0.49

SRSF9

8683

Q13242

0.49

SQSTM1

8878

Q13501

0.49

ACAA2

10449

P42765

0.49

TIMM13

26517

Q9Y5L4

0.49

SLIRP

81892

Q9GZT3

0.49

S100A16

140576

Q96FQ6

0.49

HNRNPA3

220988

P51991

0.49

SNRNP70

6625

P08621

0.52

HNRNPAB

3182

Q99729

0.59

HNRNPA2B1

3181

P22626

0.63

IARS

3376

P41252

0.63

MRE11A

4361

P49959

0.63

PSMA4

5685

P25789

0.63

PSMA5

5686

P28066

0.63

RBM3

5935

P98179

0.63

SNRPB2

6629

P08579

0.63

RN7SK

125050

N/A

0.63

ZMAT3

64393

Q9HA38

0.76

HNRNPH2

3188

P55795

0.82

VHL

7428

P40337

0.84

CSNK2A1

1457

P68400

0.89

ATP5B

506

P06576

0.49

ELAVL1

1994

Q15717

0.49

HSD17B10

3028

Q99714

0.49

HSPD1

3329

P10809

0.49

LMNA

4000

P02545

0.49

SFPQ

6421

P23246

0.49

HIST3H3

8290

Q16695

0.49

HIPK3

10114

Q9H422

0.49

ACTB

60

P60709

0.55

PPP2R2B

5521

Q00005

0.56

HNRNPH3

3189

P31942

0.59

HNRNPDL

9987

O14979

0.59

ABCF1

23

Q8NE71

0.63

ADRB2

154

P07550

0.63

ARRB2

409

P32121

0.63

BRCA1

672

P38398

0.63

CD4

920

P01730

0.63

CD81

975

P60033

0.63

CDC5L

988

Q99459

0.63

CDKN1A

1026

P38936

0.63

AP2M1

1173

Q96CW1

0.63

CSF2

1437

P04141

0.63

CSNK1A1

1452

P48729

0.63

CTNNB1

1499

P35222

0.63

DDX1

1653

Q92499

0.63

DHX9

1660

Q08211

0.63

DYNC1LI2

1783

O43237

0.63

ERBB3

2065

P21860

0.63

FKBP3

2287

Q00688

0.63

FN1

2335

P02751

0.63

NR5A1

2516

Q13285

0.63

NR4A1

3164

P22736

0.63

HSPA5

3309

P11021

0.63

HSPB1

3315

P04792

0.63

ICAM1

3383

P05362

0.63

IGF1R

3480

P08069

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

LDHB

3945

P07195

0.63

LIG4

3981

P49917

0.63

MBNL1

4154

Q9NR56

0.63

MCM2

4171

P49736

0.63

MCM5

4174

P33992

0.63

MDM2

4193

Q00987

0.63

MGMT

4255

P16455

0.63

NFKB1

4790

P19838

0.63

NFX1

4799

Q12986

0.63

NTRK1

4914

P04629

0.63

PA2G4

5036

Q9UQ80

0.63

PAFAH1B2

5049

P68402

0.63

PARK2

5071

O60260

0.63

PHKG2

5261

P15735

0.63

PSMA6

5687

P60900

0.63

PSMB1

5689

P20618

0.63

PSMB4

5692

P28070

0.63

PSMD13

5719

Q9UNM6

0.63

QARS

5859

P47897

0.63

MAP4K2

5871

Q12851

0.63

RAD51

5888

Q06609

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

RPL27A

6157

P46776

0.63

RPL39

6170

P62891

0.63

RPS6KB2

6199

Q9UBS0

0.63

RPS28

6234

P62857

0.63

SHC1

6464

P29353

0.63

SUMO3

6612

P55854

0.63

STAU1

6780

O95793

0.63

STK4

6789

Q13043

0.63

AURKA

6790

O14965

0.63

TP53

7157

P04637

0.63

YWHAE

7531

P62258

0.63

YWHAZ

7534

P63104

0.63

ZFP36

7538

P26651

0.63

CUL5

8065

Q93034

0.63

SF3A2

8175

Q15428

0.63

UBL4A

8266

P11441

0.63

STK24

8428

Q9Y6E0

0.63

CUL4B

8450

Q13620

0.63

CUL4A

8451

Q13619

0.63

CUL3

8452

Q13618

0.63

CUL2

8453

Q13617

0.63

CUL1

8454

Q13616

0.63

CAMK1

8536

Q14012

0.63

DENR

8562

O43583

0.63

EED

8726

O75530

0.63

EIF2B2

8892

P49770

0.63

PAPSS2

9060

O95340

0.63

EEF1E1

9521

O43324

0.63

BRE

9577

Q9NXR7

0.63

ISG15

9636

P05161

0.63

CEP57

9702

Q86XR8

0.63

ULK2

9706

Q8IYT8

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

RB1CC1

9821

Q8TDY2

0.63

PAN2

9924

Q504Q3

0.63

AKT3

10000

Q9Y243

0.63

HDAC5

10014

Q9UQL6

0.63

ABCF2

10061

Q9UG63

0.63

HUWE1

10075

Q7Z6Z7

0.63

TOB1

10140

P50616

0.63

NXF1

10482

Q9UBU9

0.63

STK25

10494

O00506

0.63

UBD

10537

O15205

0.63

AHSA1

10598

O95433

0.63

IGF2BP3

10643

O00425

0.63

YWHAQ

10971

P27348

0.63

COPS6

10980

Q7L5N1

0.63

COPS5

10987

Q92905

0.63

GABARAP

11337

O95166

0.63

GABARAPL2

11345

P60520

0.63

SNW1

22938

Q13573

0.63

UNC13A

23025

Q9UPW8

0.63

FAM175B

23172

Q15018

0.63

OBSL1

23363

O75147

0.63

TARDBP

23435

Q13148

0.63

SRRM2

23524

Q9UQ35

0.63

GABARAPL1

23710

Q9H0R8

0.63

FBXO6

26270

Q9NRD1

0.63

DIMT1

27292

Q9UNQ2

0.63

EEF2K

29904

O00418

0.63

DDX41

51428

Q9UJV9

0.63

ASB2

51676

Q96Q27

0.63

DCUN1D1

54165

Q96GG9

0.63

LARP1B

55132

Q659C4

0.63

MAP1S

55201

Q66K74

0.63

RIOK2

55781

Q9BVS4

0.63

CAND1

55832

Q86VP6

0.63

USE1

55850

Q9NZ43

0.63

LIN37

55957

Q96GY3

0.63

YAE1D1

57002

Q9NRH1

0.63

SMURF1

57154

Q9HCE7

0.63

MTA3

57504

Q9BTC8

0.63

TXNDC16

57544

Q9P2K2

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

PHF6

84295

Q8IWS0

0.63

MAP1LC3A

84557

Q9H492

0.63

MAEL

84944

Q96JY0

0.63

UBASH3B

84959

Q8TF42

0.63

IGSF8

93185

Q969P0

0.63

HAUS1

115106

Q96CS2

0.63

NEDD1

121441

Q8NHV4

0.63

LIN54

132660

Q6MZP7

0.63

SREK1

140890

Q8WXA9

0.63

MAP1LC3C

440738

Q9BXW4

0.63

HIST1H2AB; HIST1H2AE

3012

P04908

0.63

TTF2

8458

Q9UNY4

0.65

CDKN2A

1029

P42771

0.68

PSMA3

5684

P25788

0.68

H2AFX

3014

P16104

0.72

HDGF

3068

P51858

0.72

HNRNPU

3192

Q00839

0.72

IFIT2

3433

P09913

0.72

IFIT3

3437

O14879

0.72

PPP1CB

5500

P62140

0.72

PPP1CC

5501

P36873

0.72

XRCC3

7517

O43542

0.72

IQCB1

9657

Q15051

0.72

EMC2

9694

Q15006

0.72

MATR3

9782

P43243

0.72

MEPCE

56257

Q7L2J0

0.72

MMGT1

93380

Q8N4V1

0.72

KHDRBS2

202559

Q5VWX1

0.72

SMN1; SMN2

6606

Q16637

0.72

NEDD8

4738

Q15843

0.73

PTBP1

5725

P26599

0.73

SUMO2

6613

P61956

0.73

SUMO1

7341

P63165

0.73

FBXW11

23291

Q9UKB1

0.73

CSNK2B

1460

P67870

0.75

TOP1

7150

P11387

0.75

ZMYM2

7750

Q9UBW7

0.77

ERG

2078

P11308

0.78

GRB2

2885

P62993

0.78

ESR1

2099

P03372

0.79

CDK9

1025

P50750

0.82

VCAM1

7412

P19320

0.82

HNRNPD

3184

Q14103

0.83

HNRNPH1

3187

P31943

0.83

HNRNPL

3191

P14866

0.86

HNRNPA1

3178

P09651

0.87

YBX1

4904

P67809

0.87