BP

GO:0001916

positive regulation of T cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

IDA

BP

GO:0002250

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

IDA

BP

GO:0002474

antigen processing and presentation of peptide antigen via MHC class I

The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

IBA|TAS

BP

GO:0002476

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

IDA

BP

GO:0002479

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.

TAS

BP

GO:0002480

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.

TAS

BP

GO:0002715

regulation of natural killer cell mediated immunity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.

IDA

BP

GO:0002717

positive regulation of natural killer cell mediated immunity

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.

IDA

BP

GO:0019731

antibacterial humoral response

An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.

IDA

BP

GO:0032736

positive regulation of interleukin-13 production

Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.

IDA

BP

GO:0032753

positive regulation of interleukin-4 production

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

IDA

BP

GO:0032759

positive regulation of TRAIL production

Any process that activates or increases the frequency, rate, or extent of TRAIL production.

IDA

BP

GO:0032760

positive regulation of tumor necrosis factor production

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.

IDA

BP

GO:0036037

CD8-positive, alpha-beta T cell activation

The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

IDA

BP

GO:0042270

protection from natural killer cell mediated cytotoxicity

The process of protecting a cell from natural killer cell mediated cytotoxicity.

IDA

BP

GO:0045087

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

TAS

BP

GO:0050776

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

TAS

BP

GO:0050830

defense response to Gram-positive bacterium

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.

IDA

BP

GO:0051024

positive regulation of immunoglobulin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

IDA

BP

GO:0060333

interferon-gamma-mediated signaling pathway

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

TAS

BP

GO:0060337

type I interferon signaling pathway

A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

TAS

BP

GO:2000566

positive regulation of CD8-positive, alpha-beta T cell proliferation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.

IDA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0012507

ER to Golgi transport vesicle membrane

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.

TAS

CC

GO:0030670

phagocytic vesicle membrane

The lipid bilayer surrounding a phagocytic vesicle.

TAS

CC

GO:0031901

early endosome membrane

The lipid bilayer surrounding an early endosome.

TAS

CC

GO:0032398

MHC class Ib protein complex

A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.

IDA

CC

GO:0042612

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0071556

integral component of lumenal side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.

TAS

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IPI

MF

GO:0030881

beta-2-microglobulin binding

Interacting selectively and non-covalently with beta-2-microglobulin.

IDA|IMP

MF

GO:0042288

MHC class I protein binding

Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

IDA

MF

GO:0042605

peptide antigen binding

Interacting selectively and non-covalently with an antigen peptide.

IDA|IMP

MF

GO:0046703

natural killer cell lectin-like receptor binding

Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.

IPI