BP

GO:0002503

peptide antigen assembly with MHC class II protein complex

The binding of a peptide to the antigen binding groove of an MHC class II protein complex.

IDA

BP

GO:0002504

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.

IDA

BP

GO:0002506

polysaccharide assembly with MHC class II protein complex

The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex.

IDA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

NAS

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.

TAS

BP

GO:0031295

T cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.

TAS

BP

GO:0050852

T cell receptor signaling pathway

A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

TAS

BP

GO:0050890

cognition

The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

IMP

BP

GO:0060333

interferon-gamma-mediated signaling pathway

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

TAS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005764

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

IDA

CC

GO:0005765

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

IDA|TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

NAS

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0012507

ER to Golgi transport vesicle membrane

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.

TAS

CC

GO:0030658

transport vesicle membrane

The lipid bilayer surrounding a transport vesicle.

TAS

CC

GO:0030666

endocytic vesicle membrane

The lipid bilayer surrounding an endocytic vesicle.

TAS

CC

GO:0030669

clathrin-coated endocytic vesicle membrane

The lipid bilayer surrounding a clathrin-coated endocytic vesicle.

TAS

CC

GO:0031902

late endosome membrane

The lipid bilayer surrounding a late endosome.

IDA

CC

GO:0032588

trans-Golgi network membrane

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

TAS

CC

GO:0042613

MHC class II protein complex

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0071556

integral component of lumenal side of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.

TAS

MF

GO:0023026

MHC class II protein complex binding

Interacting selectively and non-covalently with the class II major histocompatibility complex.

IDA

MF

GO:0032395

MHC class II receptor activity

Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

NAS

MF

GO:0042605

peptide antigen binding

Interacting selectively and non-covalently with an antigen peptide.

IDA