PCOSBase

Protein Description

Gene Symbol	HDGF
Entrez ID	3068
Uniprot ID	P51858
Description	hepatoma-derived growth factor
Chromosomal Location	chr1: 156,742,107-156,766,925

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IDA
BP	GO:0006351	transcription, DNA-templated	The cellular synthesis of RNA on a template of DNA.	IEA
BP	GO:0007165	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	NAS
BP	GO:0008283	cell proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.	TAS
BP	GO:0036498	IRE1-mediated unfolded protein response	A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.	TAS
CC	GO:0005615	extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IEA
CC	GO:0017053	transcriptional repressor complex	A protein complex that possesses activity that prevents or downregulates transcription.	IDA
MF	GO:0000166	nucleotide binding	Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.	IEA
MF	GO:0001106	RNA polymerase II transcription corepressor activity	Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.	IDA
MF	GO:0001222	transcription corepressor binding	Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.	IPI
MF	GO:0003677	DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	IEA
MF	GO:0008083	growth factor activity	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.	IEA
MF	GO:0008201	heparin binding	Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.	IEA
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000313	PWWP domain

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No pathways found.

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UMLS CUI	UMLS Term
C0019693	HIV Infections

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
cerebellum	cells in granular layer
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
endometrium	cells in endometrial stroma
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
kidney	cells in glomeruli
kidney	cells in tubules
lung	pneumocytes
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
soft tissue	fibroblasts
soft tissue	peripheral nerve
stomach	glandular cells
testis	Leydig cells
thyroid gland	glandular cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
15598877	Wood et al.	2005	Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects
15820804	Oksjoki et al.	2005	Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

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Gene Symbol	Entrez ID	Uniprot ID	Score
SMAD4	4089	Q13485	0.52
ACTL6A	86	O96019	0.63
RCC1	1104	P18754	0.63
MAPK14	1432	Q16539	0.63
EEF2	1938	P13639	0.63
H1F0	3005	P07305	0.63
HSD17B10	3028	Q99714	0.63
HMGN1	3150	P05114	0.63
DNAJA1	3301	P31689	0.63
HSPA9	3313	P38646	0.63
JUN	3725	P05412	0.63
KRT1	3848	P04264	0.63
KRT2	3849	P35908	0.63
KRT10	3858	P13645	0.63
MAGEB2	4113	O15479	0.63
MAP4	4134	P27816	0.63
MPG	4350	P29372	0.63
DRG1	4733	Q9Y295	0.63
PLS3	5358	P13797	0.63
EIF2AK2	5610	P19525	0.63
PRSS3	5646	P35030	0.63
RAN	5901	P62826	0.63
RFC3	5983	P40938	0.63
RPL10	6134	P27635	0.63
SNRPF	6636	P62306	0.63
SRP68	6730	Q9UHB9	0.63
SRP72	6731	O76094	0.63
SSB	6741	P05455	0.63
UBA52	7311	P62987	0.63
XBP1	7494	P17861	0.63
DEK	7913	P35659	0.63
HMGA2	8091	P52926	0.63
HIST2H2BE	8349	Q16778	0.63
SMARCA5	8467	O60264	0.63
RUVBL1	8607	Q9Y265	0.63
EIF2S2	8894	P20042	0.63
BAZ1B	9031	Q9UIG0	0.63
BUB3	9184	O43684	0.63
ZRANB2	9406	O95218	0.63
H2AFY	9555	O75367	0.63
RCL1	10171	Q9Y2P8	0.63
PRMT5	10419	O14744	0.63
RPP38	10557	P78345	0.63
NUDC	10726	Q9Y266	0.63
CKAP4	10970	Q07065	0.63
CBX3	11335	Q13185	0.63
U2AF2	11338	P26368	0.63
MRPS27	23107	Q92552	0.63
RBMX	27316	P38159	0.63
HP1BP3	50809	Q5SSJ5	0.63
TRMT10C	54931	Q7L0Y3	0.63
H2AFY2	55506	Q9P0M6	0.63
LYAR	55646	Q9NX58	0.63
MRPS22	56945	P82650	0.63
PHF6	84295	Q8IWS0	0.63
THOC3	84321	Q96J01	0.63
ASB6	140459	Q9NWX5	0.63
RNA18S5	100008588	N/A	0.63
RNA28S5	100008589	N/A	0.63
ABCF1	23	Q8NE71	0.72
SLC25A5	292	P05141	0.72
CDK1	983	P06493	0.72
CDC5L	988	Q99459	0.72
DDX1	1653	Q92499	0.72
DHX9	1660	Q08211	0.72
DHX15	1665	O43143	0.72
EIF2S1	1965	P05198	0.72
EIF2S3	1968	P41091	0.72
FBL	2091	P22087	0.72
XRCC6	2547	P12956	0.72
HIST1H1C	3006	P16403	0.72
HIST1H1D	3007	P16402	0.72
HIST1H1E	3008	P10412	0.72
HIST1H2BD	3017	P58876	0.72
HDAC2	3066	Q92769	0.72
HNRNPA2B1	3181	P22626	0.72
HNRNPU	3192	Q00839	0.72
KIF2A	3796	O00139	0.72
KPNA2	3838	P52292	0.72
NACA	4666	Q13765	0.72
NCL	4691	P19338	0.72
NOP2	4839	P46087	0.72
SLC25A3	5250	Q00325	0.72
EXOSC10	5394	Q01780	0.72
POLRMT	5442	O00411	0.72
PWP2	5822	Q15269	0.72
RBBP4	5928	Q09028	0.72
RFC1	5981	P35251	0.72
RFC4	5984	P35249	0.72
RFC5	5985	P40937	0.72
RPA1	6117	P27694	0.72
RPL17	6139	P18621	0.72
RPL19	6143	P84098	0.72
RPL22	6146	P35268	0.72
RPL32	6161	P62910	0.72
RPL34	6164	P49207	0.72
RPL35A	6165	P18077	0.72
RPS11	6205	P62280	0.72
RPS15A	6210	P62244	0.72
RPS23	6228	P62266	0.72
SRSF2	6427	Q01130	0.72
SRSF3	6428	P84103	0.72
SRSF5	6430	Q13243	0.72
SRSF7	6432	Q16629	0.72
SNRPD1	6632	P62314	0.72
SRPK1	6732	Q96SB4	0.72
SSR1	6745	P43307	0.72
STAU1	6780	O95793	0.72
TMPO	7112	P42166	0.72
TOP1	7150	P11387	0.72
U2AF1	7307	Q01081	0.72
XRCC5	7520	P13010	0.72
H1FX	8971	Q92522	0.72
SMC3	9126	Q9UQE7	0.72
DDX21	9188	Q9NR30	0.72
EFTUD2	9343	Q15029	0.72
GTPBP1	9567	O00178	0.72
RBM39	9584	Q14498	0.72
EIF5B	9669	O60841	0.72
BMS1	9790	Q14692	0.72
FARSB	10056	Q9NSD9	0.72
ALYREF	10189	Q86V81	0.72
MYBBP1A	10514	Q9BQG0	0.72
DDX17	10521	Q92841	0.72
SUB1	10923	P53999	0.72
EBNA1BP2	10969	Q99848	0.72
WDR5	11091	P61964	0.72
PSIP1	11168	O75475	0.72
SUPT16H	11198	Q9Y5B9	0.72
RPL35	11224	P42766	0.72
DHX30	22907	Q7L2E3	0.72
RRP1B	23076	Q14684	0.72
EXOSC2	23404	Q13868	0.72
RSL1D1	26156	O76021	0.72
GNL3	26354	Q9BVP2	0.72
DIMT1	27292	Q9UNQ2	0.72
EXOSC3	51010	Q9NQT5	0.72
MRTO4	51154	Q9UKD2	0.72
DDX47	51202	Q9H0S4	0.72
INTS10	55174	Q9NVR2	0.72
ATAD3A	55210	Q9NVI7	0.72
BRIX1	55299	Q8TDN6	0.72
LRRC59	55379	Q96AG4	0.72
TSR1	55720	Q2NL82	0.72
ASUN	55726	Q9NVM9	0.72
RCC2	55920	Q9P258	0.72
ZC3HAV1	56829	Q7Z2W4	0.72
C8orf33	65265	Q9H7E9	0.72
DDX50	79009	Q9BQ39	0.72
C7orf26	79034	Q96N11	0.72
VWA9	81556	Q96SY0	0.72
GRWD1	83743	Q9BQ67	0.72
POLDIP3	84271	Q9BY77	0.72
C7orf50	84310	Q9BRJ6	0.72
HIST1H2BK	85236	O60814	0.72
EXOSC6	118460	Q5RKV6	0.72
HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4	121504	P62805	0.72
WDR36	134430	Q8NI36	0.72
PGAM5	192111	Q96HS1	0.72
HNRNPA3	220988	P51991	0.72
PARP1	142	P09874	0.75
DDX5	1655	P17844	0.75
HDAC1	3065	Q13547	0.75
PRKDC	5591	P78527	0.75
SRSF1	6426	Q07955	0.75
SSRP1	6749	Q08945	0.75
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI	8339	P62807	0.82
HIST1H3A	8350	P68431	0.82
EWSR1	2130	Q01844	0.49
MSH6	2956	P52701	0.49
PSME3	10197	P61289	0.49
APP	351	P05067	0.56
AHCY	191	P23526	0.63
ENO1	2023	P06733	0.63
KAT2A	2648	Q92830	0.63
MDM2	4193	Q00987	0.63
MOV10	4343	Q9HCE1	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
SUMO2	6613	P61956	0.63
SUMO1	7341	P63165	0.63
CROCC	9696	Q5TZA2	0.63
NXF1	10482	Q9UBU9	0.63
KAT5	10524	Q92993	0.63
MCTS1	28985	Q9ULC4	0.63
OLA1	29789	Q9NTK5	0.63
UBR7	55148	Q8N806	0.63
OTUB1	55611	Q96FW1	0.63
SH2D4A	63898	Q9H788	0.63
EMD	2010	P50402	0.82