Gene Symbol | HBA1 |
Entrez ID | 3039 |
Uniprot ID | P69905 |
Description | hemoglobin subunit alpha 1 |
Chromosomal Location | chr16: 176,680-177,522 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006898 |
receptor-mediated endocytosis |
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. |
TAS |
BP |
GO:0010942 |
positive regulation of cell death |
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. |
IDA |
BP |
GO:0015671 |
oxygen transport |
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
TAS |
BP |
GO:0015701 |
bicarbonate transport |
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
TAS |
BP |
GO:0042542 |
response to hydrogen peroxide |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
IDA |
BP |
GO:0042744 |
hydrogen peroxide catabolic process |
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). |
IDA |
BP |
GO:0051291 |
protein heterooligomerization |
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
IDA |
BP |
GO:0098869 |
cellular oxidant detoxification |
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. |
IEA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
TAS |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005833 |
hemoglobin complex |
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. |
IDA|TAS |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0022627 |
cytosolic small ribosomal subunit |
The small subunit of a ribosome located in the cytosol. |
IDA |
CC |
GO:0031838 |
haptoglobin-hemoglobin complex |
A protein complex formed by the stable binding of a haptoglobin to hemoglobin. |
IDA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
CC |
GO:0071682 |
endocytic vesicle lumen |
The volume enclosed by the membrane of an endocytic vesicle. |
TAS |
CC |
GO:0072562 |
blood microparticle |
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. |
IDA |
MF |
GO:0004601 |
peroxidase activity |
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. |
IDA |
MF |
GO:0005344 |
oxygen transporter activity |
Enables the directed movement of oxygen into, out of or within a cell, or between cells. |
IEA |
MF |
GO:0005506 |
iron ion binding |
Interacting selectively and non-covalently with iron (Fe) ions. |
IEA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0019825 |
oxygen binding |
Interacting selectively and non-covalently with oxygen (O2). |
IEA |
MF |
GO:0020037 |
heme binding |
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
IEA |
MF |
GO:0031720 |
haptoglobin binding |
Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. |
IDA |
Domain ID | Description |
---|---|
IPR000971 |
Globin |
IPR002338 |
Haemoglobin, alpha-type |
IPR002339 |
Haemoglobin, pi |
IPR009050 |
Globin-like |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa05143 |
African trypanosomiasis |
KEGG |
hsa05144 |
Malaria |
KEGG |
WP1533 |
Vitamin B12 Metabolism |
WikiPathways |
WP15 |
Selenium Micronutrient Network |
WikiPathways |
WP176 |
Folate Metabolism |
WikiPathways |
WP1995 |
Effects of Nitric Oxide |
WikiPathways |
h_ahspPathway |
Hemoglobin's Chaperone |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0002312 |
Alpha-Thalassemia |
C0007785 |
Cerebral Infarction |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0024667 |
Animal Mammary Neoplasms |
C0024668 |
Mammary Neoplasms, Experimental |
C0025637 |
Methemoglobinemia |
C0032461 |
Polycythemia |
C0032463 |
Polycythemia Vera |
C0263454 |
Chloracne |
C0455988 |
Hydrops Fetalis, Non-Immune |
C1261502 |
Finding Of Mean Corpuscular Hemoglobin |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
spleen |
cells in red pulp |
Database Name |
---|
DGA |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
HBG1 |
3047 |
P69891 |
0.00 |
CRYAB |
1410 |
P02511 |
0.56 |
DAXX |
1616 |
Q9UER7 |
0.63 |
HBA1 HBA2 |
3039 |
P69905 |
0.63 |
HBD |
3045 |
P02042 |
0.63 |
NAP1L1 |
4673 |
P55209 |
0.63 |
PTEN |
5728 |
P60484 |
0.63 |
TSC1 |
7248 |
Q92574 |
0.63 |
KRT40 |
125115 |
Q6A162 |
0.63 |
CCDC57 |
284001 |
Q2TAC2 |
0.63 |
HBB |
3043 |
P68871 |
0.96 |
CPM |
1368 |
P14384 |
0.52 |
UCHL5 |
51377 |
Q9Y5K5 |
0.56 |
ADRBK1 |
156 |
P25098 |
0.63 |
AGA |
175 |
P20933 |
0.63 |
AKT2 |
208 |
P31751 |
0.63 |
ALB |
213 |
P02768 |
0.63 |
ATP6AP1 |
537 |
Q15904 |
0.63 |
CDK2 |
1017 |
P24941 |
0.63 |
CDK5 |
1020 |
Q00535 |
0.63 |
CLU |
1191 |
P10909 |
0.63 |
ATF2 |
1386 |
P15336 |
0.63 |
MAPK14 |
1432 |
Q16539 |
0.63 |
CSK |
1445 |
P41240 |
0.63 |
CSNK1A1 |
1452 |
P48729 |
0.63 |
CSNK1E |
1454 |
P49674 |
0.63 |
CSNK2A2 |
1459 |
P19784 |
0.63 |
EGFR |
1956 |
P00533 |
0.63 |
FN1 |
2335 |
P02751 |
0.63 |
GSK3B |
2932 |
P49841 |
0.63 |
HLA-B |
3106 |
P30480 |
0.63 |
HLA-DPA1 |
3113 |
P20036 |
0.63 |
ILK |
3611 |
Q13418 |
0.63 |
ITGA4 |
3676 |
P13612 |
0.63 |
PHKG2 |
5261 |
P15735 |
0.63 |
PRKAA1 |
5562 |
Q13131 |
0.63 |
PRKACA |
5566 |
P17612 |
0.63 |
PRKCD |
5580 |
Q05655 |
0.63 |
EIF2AK2 |
5610 |
P19525 |
0.63 |
RPS6KA1 |
6195 |
Q15418 |
0.63 |
SLC4A1 |
6521 |
P02730 |
0.63 |
SPP1 |
6696 |
P10451 |
0.63 |
STK3 |
6788 |
Q13188 |
0.63 |
UBE3A |
7337 |
Q05086 |
0.63 |
VRK1 |
7443 |
Q99986 |
0.63 |
STK24 |
8428 |
Q9Y6E0 |
0.63 |
CAMK1 |
8536 |
Q14012 |
0.63 |
CUL7 |
9820 |
Q14999 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
OXSR1 |
9943 |
O95747 |
0.63 |
DHRS2 |
10202 |
Q13268 |
0.63 |
STK25 |
10494 |
O00506 |
0.63 |
CEP250 |
11190 |
Q9BV73 |
0.63 |
NXPH2 |
11249 |
O95156 |
0.63 |
OBSL1 |
23363 |
O75147 |
0.63 |
NUFIP1 |
26747 |
Q9UHK0 |
0.63 |
MED4 |
29079 |
Q9NPJ6 |
0.63 |
EEF2K |
29904 |
O00418 |
0.63 |
STK26 |
51765 |
Q9P289 |
0.63 |
PGPEP1 |
54858 |
Q9NXJ5 |
0.63 |
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
PBK |
55872 |
Q96KB5 |
0.63 |
NDUFAF5 |
79133 |
Q5TEU4 |
0.63 |
SPINK7 |
84651 |
P58062 |
0.63 |
IGSF8 |
93185 |
Q969P0 |
0.63 |
TP53RK |
112858 |
Q96S44 |
0.63 |
GDPD1 |
284161 |
Q8N9F7 |
0.63 |
CTSD |
1509 |
P07339 |
0.68 |
APOA1 |
335 |
P02647 |
0.72 |
HBG2 |
3048 |
P69892 |
0.72 |
IQCB1 |
9657 |
Q15051 |
0.72 |
SYNCRIP |
10492 |
O60506 |
0.72 |
HBE1 |
3046 |
P02100 |
0.75 |
VCAM1 |
7412 |
P19320 |
0.82 |
AHSP |
51327 |
Q9NZD4 |
0.87 |