Protein Description

Gene Symbol HBA1
Entrez ID 3039
Uniprot ID P69905
Description hemoglobin subunit alpha 1
Chromosomal Location chr16: 176,680-177,522
Ontology GO ID GO Term Definition Evidence

BP

GO:0006898

receptor-mediated endocytosis

An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

TAS

BP

GO:0010942

positive regulation of cell death

Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

IDA

BP

GO:0015671

oxygen transport

The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TAS

BP

GO:0015701

bicarbonate transport

The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TAS

BP

GO:0042542

response to hydrogen peroxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

IDA

BP

GO:0042744

hydrogen peroxide catabolic process

The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).

IDA

BP

GO:0051291

protein heterooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IDA

BP

GO:0098869

cellular oxidant detoxification

Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005833

hemoglobin complex

An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.

IDA|TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0022627

cytosolic small ribosomal subunit

The small subunit of a ribosome located in the cytosol.

IDA

CC

GO:0031838

haptoglobin-hemoglobin complex

A protein complex formed by the stable binding of a haptoglobin to hemoglobin.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0071682

endocytic vesicle lumen

The volume enclosed by the membrane of an endocytic vesicle.

TAS

CC

GO:0072562

blood microparticle

A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.

IDA

MF

GO:0004601

peroxidase activity

Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.

IDA

MF

GO:0005344

oxygen transporter activity

Enables the directed movement of oxygen into, out of or within a cell, or between cells.

IEA

MF

GO:0005506

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019825

oxygen binding

Interacting selectively and non-covalently with oxygen (O2).

IEA

MF

GO:0020037

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

IEA

MF

GO:0031720

haptoglobin binding

Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.

IDA

Domain ID Description

IPR000971

Globin

IPR002338

Haemoglobin, alpha-type

IPR002339

Haemoglobin, pi

IPR009050

Globin-like

Pathway ID Pathway Term Pathway Source

hsa05143

African trypanosomiasis

KEGG

hsa05144

Malaria

KEGG

WP1533

Vitamin B12 Metabolism

WikiPathways

WP15

Selenium Micronutrient Network

WikiPathways

WP176

Folate Metabolism

WikiPathways

WP1995

Effects of Nitric Oxide

WikiPathways

h_ahspPathway

Hemoglobin's Chaperone

BioCarta

UMLS CUI UMLS Term

C0002312

Alpha-Thalassemia

C0007785

Cerebral Infarction

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0024667

Animal Mammary Neoplasms

C0024668

Mammary Neoplasms, Experimental

C0025637

Methemoglobinemia

C0032461

Polycythemia

C0032463

Polycythemia Vera

C0263454

Chloracne

C0455988

Hydrops Fetalis, Non-Immune

C1261502

Finding Of Mean Corpuscular Hemoglobin

Tissue Cell Type

bone marrow

hematopoietic cells

spleen

cells in red pulp

Database Name

DGA

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

HBG1

3047

P69891

0.00

CRYAB

1410

P02511

0.56

DAXX

1616

Q9UER7

0.63

HBA1 HBA2

3039

P69905

0.63

HBD

3045

P02042

0.63

NAP1L1

4673

P55209

0.63

PTEN

5728

P60484

0.63

TSC1

7248

Q92574

0.63

KRT40

125115

Q6A162

0.63

CCDC57

284001

Q2TAC2

0.63

HBB

3043

P68871

0.96

CPM

1368

P14384

0.52

UCHL5

51377

Q9Y5K5

0.56

ADRBK1

156

P25098

0.63

AGA

175

P20933

0.63

AKT2

208

P31751

0.63

ALB

213

P02768

0.63

ATP6AP1

537

Q15904

0.63

CDK2

1017

P24941

0.63

CDK5

1020

Q00535

0.63

CLU

1191

P10909

0.63

ATF2

1386

P15336

0.63

MAPK14

1432

Q16539

0.63

CSK

1445

P41240

0.63

CSNK1A1

1452

P48729

0.63

CSNK1E

1454

P49674

0.63

CSNK2A2

1459

P19784

0.63

EGFR

1956

P00533

0.63

FN1

2335

P02751

0.63

GSK3B

2932

P49841

0.63

HLA-B

3106

P30480

0.63

HLA-DPA1

3113

P20036

0.63

ILK

3611

Q13418

0.63

ITGA4

3676

P13612

0.63

PHKG2

5261

P15735

0.63

PRKAA1

5562

Q13131

0.63

PRKACA

5566

P17612

0.63

PRKCD

5580

Q05655

0.63

EIF2AK2

5610

P19525

0.63

RPS6KA1

6195

Q15418

0.63

SLC4A1

6521

P02730

0.63

SPP1

6696

P10451

0.63

STK3

6788

Q13188

0.63

UBE3A

7337

Q05086

0.63

VRK1

7443

Q99986

0.63

STK24

8428

Q9Y6E0

0.63

CAMK1

8536

Q14012

0.63

CUL7

9820

Q14999

0.63

PAN2

9924

Q504Q3

0.63

OXSR1

9943

O95747

0.63

DHRS2

10202

Q13268

0.63

STK25

10494

O00506

0.63

CEP250

11190

Q9BV73

0.63

NXPH2

11249

O95156

0.63

OBSL1

23363

O75147

0.63

NUFIP1

26747

Q9UHK0

0.63

MED4

29079

Q9NPJ6

0.63

EEF2K

29904

O00418

0.63

STK26

51765

Q9P289

0.63

PGPEP1

54858

Q9NXJ5

0.63

RIOK2

55781

Q9BVS4

0.63

PBK

55872

Q96KB5

0.63

NDUFAF5

79133

Q5TEU4

0.63

SPINK7

84651

P58062

0.63

IGSF8

93185

Q969P0

0.63

TP53RK

112858

Q96S44

0.63

GDPD1

284161

Q8N9F7

0.63

CTSD

1509

P07339

0.68

APOA1

335

P02647

0.72

HBG2

3048

P69892

0.72

IQCB1

9657

Q15051

0.72

SYNCRIP

10492

O60506

0.72

HBE1

3046

P02100

0.75

VCAM1

7412

P19320

0.82

AHSP

51327

Q9NZD4

0.87