| Gene Symbol | HADH |
| Entrez ID | 3033 |
| Uniprot ID | Q16836 |
| Description | hydroxyacyl-CoA dehydrogenase |
| Chromosomal Location | chr4: 107,989,714-108,035,175 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006635 | fatty acid beta-oxidation |
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). | IEA|TAS |
BP | GO:0014823 | response to activity |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. | IEA |
BP | GO:0032868 | response to insulin |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. | IEA |
BP | GO:0042493 | response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. | IEA |
BP | GO:0046676 | negative regulation of insulin secretion |
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. | IEA |
CC | GO:0005654 | nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. | IDA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IDA |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IDA |
CC | GO:0005743 | mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. | IEA |
CC | GO:0005759 | mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. | TAS |
MF | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity |
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). | TAS |
MF | GO:0070403 | NAD+ binding |
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. | IEA |
| Domain ID | Description |
|---|---|
IPR006108 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal |
IPR006176 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding |
IPR006180 | 3-hydroxyacyl-CoA dehydrogenase, conserved site |
IPR008927 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
IPR013328 | 6-phosphogluconate dehydrogenase, domain 2 |
IPR016040 | NAD(P)-binding domain |
IPR022694 | 3-hydroxyacyl-CoA dehydrogenase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00062 | Fatty acid elongation | KEGG |
hsa00071 | Fatty acid degradation | KEGG |
hsa00280 | Valine, leucine and isoleucine degradation | KEGG |
hsa00310 | Lysine degradation | KEGG |
hsa00380 | Tryptophan metabolism | KEGG |
hsa00650 | Butanoate metabolism | KEGG |
hsa01100 | Metabolic pathways | KEGG |
hsa01212 | Fatty acid metabolism | KEGG |
WP368 | Mitochondrial LC-Fatty Acid Beta-Oxidation | WikiPathways |
WP357 | Fatty Acid Biosynthesis | WikiPathways |
WP465 | Tryptophan metabolism | WikiPathways |
WP3925 | Amino Acid metabolism | WikiPathways |
WP143 | Fatty Acid Beta Oxidation | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0028754 | Obesity |
C0032927 | Precancerous Conditions |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
appendix | lymphoid tissue |
bone marrow | hematopoietic cells |
breast | adipocytes |
breast | glandular cells |
breast | myoepithelial cells |
caudate | glial cells |
caudate | neuronal cells |
cerebral cortex | glial cells |
cerebral cortex | neuronal cells |
cervix, uterine | glandular cells |
cervix, uterine | squamous epithelial cells |
colon | endothelial cells |
colon | glandular cells |
duodenum | glandular cells |
endometrium | cells in endometrial stroma |
endometrium | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
kidney | cells in tubules |
liver | bile duct cells |
liver | hepatocytes |
lung | macrophages |
lymph node | germinal center cells |
lymph node | non-germinal center cells |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
pancreas | exocrine glandular cells |
parathyroid gland | glandular cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
skeletal muscle | myocytes |
skin | fibroblasts |
skin | keratinocytes |
skin | Langerhans |
skin | melanocytes |
skin | epidermal cells |
small intestine | glandular cells |
smooth muscle | smooth muscle cells |
soft tissue | adipocytes |
soft tissue | chondrocytes |
soft tissue | fibroblasts |
spleen | cells in white pulp |
stomach | glandular cells |
testis | cells in seminiferous ducts |
testis | Leydig cells |
thyroid gland | glandular cells |
tonsil | germinal center cells |
tonsil | non-germinal center cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
vagina | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
ETFA | 2108 | P13804 | 0.49 |
ETFB | 2109 | P38117 | 0.49 |
FKBP2 | 2286 | P26885 | 0.49 |
PITPNA | 5306 | Q00169 | 0.49 |
PSMA1 | 5682 | P25786 | 0.49 |
PSMA2 | 5683 | P25787 | 0.49 |
PSMB8 | 5696 | P28062 | 0.49 |
RSU1 | 6251 | Q15404 | 0.49 |
UBE2N | 7334 | P61088 | 0.49 |
SF1 | 7536 | Q15637 | 0.49 |
CLIC3 | 9022 | O95833 | 0.49 |
CLIC4 | 25932 | Q9Y696 | 0.49 |
MMAB | 326625 | Q96EY8 | 0.49 |
APP | 351 | P05067 | 0.56 |
HADH | 3033 | Q16836 | 0.63 |
ACAT2 | 39 | Q9BWD1 | 0.49 |
CLK1 | 1195 | P49759 | 0.52 |
ADH1A | 124 | P07327 | 0.63 |
ESR1 | 2099 | P03372 | 0.63 |
MDM2 | 4193 | Q00987 | 0.63 |
MOV10 | 4343 | Q9HCE1 | 0.63 |
NTRK1 | 4914 | P04629 | 0.63 |
MAPK3 | 5595 | P27361 | 0.63 |
STAT1 | 6772 | P42224 | 0.63 |
NXF1 | 10482 | Q9UBU9 | 0.63 |
SLC2A4 | 6517 | P14672 | 0.72 |
UBA5 | 79876 | Q9GZZ9 | 0.72 |