| Gene Symbol | HADH |
| Entrez ID | 3033 |
| Uniprot ID | Q16836 |
| Description | hydroxyacyl-CoA dehydrogenase |
| Chromosomal Location | chr4: 107,989,714-108,035,175 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006635 |
fatty acid beta-oxidation |
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
IEA|TAS |
|
BP |
GO:0014823 |
response to activity |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. |
IEA |
|
BP |
GO:0032868 |
response to insulin |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
IEA |
|
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
|
BP |
GO:0046676 |
negative regulation of insulin secretion |
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. |
IEA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
IEA |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
|
MF |
GO:0003857 |
3-hydroxyacyl-CoA dehydrogenase activity |
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
TAS |
|
MF |
GO:0070403 |
NAD+ binding |
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR006108 |
3-hydroxyacyl-CoA dehydrogenase, C-terminal |
|
IPR006176 |
3-hydroxyacyl-CoA dehydrogenase, NAD binding |
|
IPR006180 |
3-hydroxyacyl-CoA dehydrogenase, conserved site |
|
IPR008927 |
6-phosphogluconate dehydrogenase C-terminal domain-like |
|
IPR013328 |
6-phosphogluconate dehydrogenase, domain 2 |
|
IPR016040 |
NAD(P)-binding domain |
|
IPR022694 |
3-hydroxyacyl-CoA dehydrogenase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00062 |
Fatty acid elongation |
KEGG |
|
hsa00071 |
Fatty acid degradation |
KEGG |
|
hsa00280 |
Valine, leucine and isoleucine degradation |
KEGG |
|
hsa00310 |
Lysine degradation |
KEGG |
|
hsa00380 |
Tryptophan metabolism |
KEGG |
|
hsa00650 |
Butanoate metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa01212 |
Fatty acid metabolism |
KEGG |
|
WP368 |
Mitochondrial LC-Fatty Acid Beta-Oxidation |
WikiPathways |
|
WP357 |
Fatty Acid Biosynthesis |
WikiPathways |
|
WP465 |
Tryptophan metabolism |
WikiPathways |
|
WP3925 |
Amino Acid metabolism |
WikiPathways |
|
WP143 |
Fatty Acid Beta Oxidation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0028754 |
Obesity |
|
C0032927 |
Precancerous Conditions |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
adipocytes |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ETFA |
2108 |
P13804 |
0.49 |
|
ETFB |
2109 |
P38117 |
0.49 |
|
FKBP2 |
2286 |
P26885 |
0.49 |
|
PITPNA |
5306 |
Q00169 |
0.49 |
|
PSMA1 |
5682 |
P25786 |
0.49 |
|
PSMA2 |
5683 |
P25787 |
0.49 |
|
PSMB8 |
5696 |
P28062 |
0.49 |
|
RSU1 |
6251 |
Q15404 |
0.49 |
|
UBE2N |
7334 |
P61088 |
0.49 |
|
SF1 |
7536 |
Q15637 |
0.49 |
|
CLIC3 |
9022 |
O95833 |
0.49 |
|
CLIC4 |
25932 |
Q9Y696 |
0.49 |
|
MMAB |
326625 |
Q96EY8 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
HADH |
3033 |
Q16836 |
0.63 |
|
ACAT2 |
39 |
Q9BWD1 |
0.49 |
|
CLK1 |
1195 |
P49759 |
0.52 |
|
ADH1A |
124 |
P07327 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
MAPK3 |
5595 |
P27361 |
0.63 |
|
STAT1 |
6772 |
P42224 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
SLC2A4 |
6517 |
P14672 |
0.72 |
|
UBA5 |
79876 |
Q9GZZ9 |
0.72 |