| Gene Symbol | HSD17B10 |
| Entrez ID | 3028 |
| Uniprot ID | Q99714 |
| Description | hydroxysteroid (17-beta) dehydrogenase 10 |
| Chromosomal Location | chrX: 53,431,258-53,434,373 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006629 |
lipid metabolic process |
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
TAS |
|
BP |
GO:0009083 |
branched-chain amino acid catabolic process |
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. |
TAS |
|
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
|
BP |
GO:0070901 |
mitochondrial tRNA methylation |
The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. |
TAS |
|
BP |
GO:0090646 |
mitochondrial tRNA processing |
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion. |
TAS |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
TAS |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
ISS |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
|
MF |
GO:0003857 |
3-hydroxyacyl-CoA dehydrogenase activity |
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
EXP |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0008709 |
cholate 7-alpha-dehydrogenase activity |
Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH. |
TAS |
|
MF |
GO:0030283 |
testosterone dehydrogenase [NAD(P)] activity |
Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. |
IEA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:0047015 |
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity |
Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR002347 |
Short-chain dehydrogenase/reductase SDR |
|
IPR016040 |
NAD(P)-binding domain |
|
IPR020904 |
Short-chain dehydrogenase/reductase, conserved site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00280 |
Valine, leucine and isoleucine degradation |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa05010 |
Alzheimer's disease |
KEGG |
|
WP3871 |
Valproic acid pathway |
WikiPathways |
|
WP2059 |
Alzheimers Disease |
WikiPathways |
|
WP465 |
Tryptophan metabolism |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
caudate |
glial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
placenta |
decidual cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
spleen |
cells in white pulp |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
vagina |
squamous epithelial cells |
| Database Name |
|---|
|
DGA |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ALDOA |
226 |
P04075 |
0.49 |
|
ALDOC |
230 |
P09972 |
0.49 |
|
AKR1B1 |
231 |
P15121 |
0.49 |
|
ARHGDIA |
396 |
P52565 |
0.49 |
|
ARHGDIG |
398 |
Q99819 |
0.49 |
|
ATP1B1 |
481 |
P05026 |
0.49 |
|
CALU |
813 |
O43852 |
0.49 |
|
CLIC1 |
1192 |
O00299 |
0.49 |
|
DLD |
1738 |
P09622 |
0.49 |
|
EEF2 |
1938 |
P13639 |
0.49 |
|
ENO1 |
2023 |
P06733 |
0.49 |
|
ENO2 |
2026 |
P09104 |
0.49 |
|
ENO3 |
2027 |
P13929 |
0.49 |
|
FABP5 |
2171 |
Q01469 |
0.49 |
|
FKBP2 |
2286 |
P26885 |
0.49 |
|
GPX4 |
2879 |
P36969 |
0.49 |
|
HNRNPA2B1 |
3181 |
P22626 |
0.49 |
|
HNRNPAB |
3182 |
Q99729 |
0.49 |
|
MYL6 |
4637 |
P60660 |
0.49 |
|
PHB |
5245 |
P35232 |
0.49 |
|
PPIB |
5479 |
P23284 |
0.49 |
|
QDPR |
5860 |
P09417 |
0.49 |
|
SLC12A4 |
6560 |
Q9UP95 |
0.49 |
|
TAGLN |
6876 |
Q01995 |
0.49 |
|
TKT |
7086 |
P29401 |
0.49 |
|
TRIP6 |
7205 |
Q15654 |
0.49 |
|
UBA1 |
7317 |
P22314 |
0.49 |
|
UCHL3 |
7347 |
P15374 |
0.49 |
|
TAGLN2 |
8407 |
P37802 |
0.49 |
|
RUVBL1 |
8607 |
Q9Y265 |
0.49 |
|
VAPA |
9218 |
Q9P0L0 |
0.49 |
|
BZW1 |
9689 |
Q7L1Q6 |
0.49 |
|
ARPC3 |
10094 |
O15145 |
0.49 |
|
ACTR3 |
10096 |
P61158 |
0.49 |
|
ACAA2 |
10449 |
P42765 |
0.49 |
|
STIP1 |
10963 |
P31948 |
0.49 |
|
SEC31A |
22872 |
O94979 |
0.49 |
|
TARDBP |
23435 |
Q13148 |
0.49 |
|
TGDS |
23483 |
O95455 |
0.49 |
|
ARFGAP3 |
26286 |
Q9NP61 |
0.49 |
|
CACYBP |
27101 |
Q9HB71 |
0.49 |
|
BZW2 |
28969 |
Q9Y6E2 |
0.49 |
|
TAGLN3 |
29114 |
Q9UI15 |
0.49 |
|
ISYNA1 |
51477 |
Q9NPH2 |
0.49 |
|
RTN4 |
57142 |
Q9NQC3 |
0.49 |
|
ARFGAP2 |
84364 |
Q8N6H7 |
0.49 |
|
HNRNPA3 |
220988 |
P51991 |
0.49 |
|
AKR1B15 |
441282 |
C9JRZ8 |
0.49 |
|
CHD3 |
1107 |
Q12873 |
0.63 |
|
IGHG1 |
3500 |
P01857 |
0.63 |
|
IGHG2 |
3501 |
P01859 |
0.63 |
|
LAMP1 |
3916 |
P11279 |
0.63 |
|
UBE2D1 |
7321 |
P51668 |
0.63 |
|
FAF1 |
11124 |
Q9UNN5 |
0.63 |
|
KIAA0391 |
9692 |
O15091 |
0.68 |
|
HTRA2 |
27429 |
O43464 |
0.70 |
|
TOMM40 |
10452 |
O96008 |
0.75 |
|
APP |
351 |
P05067 |
0.90 |
|
ADSS |
159 |
P30520 |
0.49 |
|
ATP1B3 |
483 |
P54709 |
0.49 |
|
EEF1A1 |
1915 |
P68104 |
0.49 |
|
FKBP1A |
2280 |
P62942 |
0.49 |
|
FKBP1B |
2281 |
P68106 |
0.49 |
|
HSPA9 |
3313 |
P38646 |
0.49 |
|
RAB8A |
4218 |
P61006 |
0.49 |
|
MSN |
4478 |
P26038 |
0.49 |
|
P4HB |
5034 |
P07237 |
0.49 |
|
PSMB1 |
5689 |
P20618 |
0.49 |
|
PTBP1 |
5725 |
P26599 |
0.49 |
|
RCN1 |
5954 |
Q15293 |
0.49 |
|
RDX |
5962 |
P35241 |
0.49 |
|
TPD52L2 |
7165 |
O43399 |
0.49 |
|
EZR |
7430 |
P15311 |
0.49 |
|
ATP6V1H |
51606 |
Q9UI12 |
0.49 |
|
RAB8B |
51762 |
Q92930 |
0.49 |
|
ELAC2 |
60528 |
Q9BQ52 |
0.49 |
|
SUMF1 |
285362 |
Q8NBK3 |
0.55 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.63 |
|
GRSF1 |
2926 |
Q12849 |
0.63 |
|
HDGF |
3068 |
P51858 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
SOX2 |
6657 |
P48431 |
0.63 |
|
VCAM1 |
7412 |
P19320 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
CUL4B |
8450 |
Q13620 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
|
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
SIRT4 |
23409 |
Q9Y6E7 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
ASB1 |
51665 |
Q9Y576 |
0.63 |
|
WWOX |
51741 |
Q9NZC7 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
FASTKD3 |
79072 |
Q14CZ7 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
TOMM20 |
9804 |
Q15388 |
0.65 |
|
TOMM22 |
56993 |
Q9NS69 |
0.65 |
|
PINK1 |
65018 |
Q9BXM7 |
0.65 |
|
HTT |
3064 |
P42858 |
0.68 |
|
PARK2 |
5071 |
O60260 |
0.71 |
|
H2AFX |
3014 |
P16104 |
0.72 |
|
ICT1 |
3396 |
Q14197 |
0.72 |
|
NOP56 |
10528 |
O00567 |
0.72 |
|
TRMT10C |
54931 |
Q7L0Y3 |
0.75 |