| Gene Symbol | HIST1H1E |
| Entrez ID | 3008 |
| Uniprot ID | P10412 |
| Description | histone cluster 1, H1e |
| Chromosomal Location | chr6: 26,156,354-26,157,107 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
|
BP |
GO:0006334 |
nucleosome assembly |
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
IEA |
|
BP |
GO:0016584 |
nucleosome positioning |
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another. |
IEA |
|
BP |
GO:0080182 |
histone H3-K4 trimethylation |
The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. |
IEA |
|
BP |
GO:0098532 |
histone H3-K27 trimethylation |
The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone. |
IEA |
|
CC |
GO:0000786 |
nucleosome |
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
IEA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005720 |
nuclear heterochromatin |
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0031490 |
chromatin DNA binding |
Interacting selectively and non-covalently with DNA that is assembled into chromatin. |
IMP |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR005818 |
Linker histone H1/H5, domain H15 |
|
IPR005819 |
Histone H5 |
|
IPR011991 |
Winged helix-turn-helix DNA-binding domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP3651 |
Pathways Affected in Adenoid Cystic Carcinoma |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0010606 |
Adenoid Cystic Carcinoma |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
kidney |
cells in glomeruli |
|
liver |
hepatocytes |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
adipocytes |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
IL7R |
3575 |
P16871 |
0.49 |
|
MED8 |
112950 |
Q96G25 |
0.49 |
|
CBX1 |
10951 |
P83916 |
0.52 |
|
SUMO1 |
7341 |
P63165 |
0.56 |
|
VPS26A |
9559 |
O75436 |
0.63 |
|
TOM1 |
10043 |
O60784 |
0.63 |
|
EXOSC4 |
54512 |
Q9NPD3 |
0.63 |
|
CBX5 |
23468 |
P45973 |
0.65 |
|
CBX3 |
11335 |
Q13185 |
0.84 |
|
PRKCA |
5578 |
P17252 |
0.52 |
|
PARP2 |
10038 |
Q9UGN5 |
0.52 |
|
EHMT2 |
10919 |
Q96KQ7 |
0.52 |
|
IRAK4 |
51135 |
Q9NWZ3 |
0.52 |
|
HIST1H3A |
8350 |
P68431 |
0.59 |
|
CD81 |
975 |
P60033 |
0.63 |
|
CDK5 |
1020 |
Q00535 |
0.63 |
|
CRK |
1398 |
P46108 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
GSK3B |
2932 |
P49841 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
ICAM1 |
3383 |
P05362 |
0.63 |
|
IFI16 |
3428 |
Q16666 |
0.63 |
|
ILF3 |
3609 |
Q12906 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MCM5 |
4174 |
P33992 |
0.63 |
|
MNDA |
4332 |
P41218 |
0.63 |
|
NCK1 |
4690 |
P16333 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
YBX1 |
4904 |
P67809 |
0.63 |
|
PAK1 |
5058 |
Q13153 |
0.63 |
|
PRKCD |
5580 |
Q05655 |
0.63 |
|
MAPK13 |
5603 |
O15264 |
0.63 |
|
EIF2AK2 |
5610 |
P19525 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
VCAM1 |
7412 |
P19320 |
0.63 |
|
STK24 |
8428 |
Q9Y6E0 |
0.63 |
|
CAMK1 |
8536 |
Q14012 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
PAN2 |
9924 |
Q504Q3 |
0.63 |
|
PTBP3 |
9991 |
O95758 |
0.63 |
|
EBNA1BP2 |
10969 |
Q99848 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
CBX6 |
23466 |
O95503 |
0.63 |
|
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
|
STK26 |
51765 |
Q9P289 |
0.63 |
|
FBXW7 |
55294 |
Q969H0 |
0.63 |
|
PBK |
55872 |
Q96KB5 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
IGSF8 |
93185 |
Q969P0 |
0.63 |
|
HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4 |
121504 |
P62805 |
0.63 |
|
PYHIN1 |
149628 |
Q6K0P9 |
0.63 |
|
PPP2R2B |
5521 |
Q00005 |
0.68 |
|
HDGF |
3068 |
P51858 |
0.72 |
|
MAP3K14 |
9020 |
Q99558 |
0.72 |
|
C10orf12 |
26148 |
Q8N655 |
0.72 |
|
L3MBTL1 |
26013 |
Q9Y468 |
0.78 |