| Gene Symbol | GYS1 |
| Entrez ID | 2997 |
| Uniprot ID | P13807 |
| Description | glycogen synthase 1 |
| Chromosomal Location | chr19: 48,968,125-48,993,310 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0005978 |
glycogen biosynthetic process |
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
IDA|IEA|TAS |
|
BP |
GO:0007507 |
heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
IEA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016234 |
inclusion body |
A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. |
IEA |
|
MF |
GO:0004373 |
glycogen (starch) synthase activity |
Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). |
EXP|IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005536 |
glucose binding |
Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. |
IEA |
|
MF |
GO:0019901 |
protein kinase binding |
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
IPI |
|
MF |
GO:0061547 |
glycogen synthase activity, transferring glucose-1-phosphate |
Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. |
EXP |
| Domain ID | Description |
|---|---|
|
IPR008631 |
Glycogen synthase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00500 |
Starch and sucrose metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
|
hsa04152 |
AMPK signaling pathway |
KEGG |
|
hsa04910 |
Insulin signaling pathway |
KEGG |
|
hsa04922 |
Glucagon signaling pathway |
KEGG |
|
hsa04931 |
Insulin resistance |
KEGG |
|
WP3915 |
Angiopoietin Like Protein 8 Regulatory Pathway |
WikiPathways |
|
WP481 |
Insulin Signaling |
WikiPathways |
|
WP500 |
Glycogen Metabolism |
WikiPathways |
|
WP1403 |
AMP-activated Protein Kinase (AMPK) Signaling |
WikiPathways |
|
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
| Database Name |
|---|
|
DGA |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
PPP1CB |
5500 |
P62140 |
0.00 |
|
APP |
351 |
P05067 |
0.56 |
|
GABARAPL2 |
11345 |
P60520 |
0.56 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.56 |
|
PPP1CC |
5501 |
P36873 |
0.63 |
|
AIMP2 |
7965 |
Q13155 |
0.63 |
|
CCDC36 |
339834 |
Q8IYA8 |
0.63 |
|
NHLRC1 |
378884 |
Q6VVB1 |
0.78 |
|
GYG1 |
2992 |
P46976 |
0.92 |
|
CEP135 |
9662 |
Q66GS9 |
0.49 |
|
CEP152 |
22995 |
O94986 |
0.49 |
|
CEP290 |
80184 |
O15078 |
0.49 |
|
EVC2 |
132884 |
Q86UK5 |
0.49 |
|
CSNK2A1 |
1457 |
P68400 |
0.52 |
|
PRKACA |
5566 |
P17612 |
0.52 |
|
EPM2A |
7957 |
O95278 |
0.52 |
|
MAPKAPK5 |
8550 |
Q8IW41 |
0.52 |
|
MAP1LC3C |
440738 |
Q9BXW4 |
0.56 |
|
GRK5 |
2869 |
P34947 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PPP1R3C |
5507 |
Q9UQK1 |
0.63 |
|
UVRAG |
7405 |
Q9P2Y5 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
BECN1 |
8678 |
Q14457 |
0.63 |
|
STBD1 |
8987 |
O95210 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
SH3GLB1 |
51100 |
Q9Y371 |
0.63 |
|
PPP1R3B |
79660 |
Q86XI6 |
0.63 |
|
SLX4 |
84464 |
Q8IY92 |
0.63 |
|
ZFP41 |
286128 |
Q8N8Y5 |
0.63 |
|
PASK |
23178 |
Q96RG2 |
0.68 |
|
PPP1CA |
5499 |
P62136 |
0.70 |
|
PRKAA2 |
5563 |
P54646 |
0.72 |
|
PRKAB2 |
5565 |
O43741 |
0.72 |
|
SIRT2 |
22933 |
Q8IXJ6 |
0.72 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.72 |
|
PRKAB1 |
5564 |
Q9Y478 |
0.76 |
|
OTUD5 |
55593 |
Q96G74 |
0.76 |
|
GSK3B |
2932 |
P49841 |
0.82 |
|
GYG2 |
8908 |
O15488 |
0.84 |