WP2911

miRNA targets in ECM and membrane receptors

WikiPathways

COL6A2, COL6A3, COL5A2, COL6A1, FN1, TNXB, COL5A1, ITGA11, MIR25, COL3A1, COL4A2, ITGB5, SDC2, LAMC1, COL5A3, LAMA4, COL1A2, THBS1

WP2916

Interactome of polycomb repressive complex 2 (PRC2)

WikiPathways

MTF2, THRAP3, EZH2, EZH1, SUZ12, RBBP4, MORC3, STK38, BCLAF1, SETX, TRIM35

WP2942

DDX1 as a regulatory component of the Drosha microprocessor

WikiPathways

MRE11A, NBN, RAD50

WP2943

Hypoxia-mediated EMT and Stemness

WikiPathways

DICER1, ZEB1

WP299

Nuclear Receptors in Lipid Metabolism and Toxicity

WikiPathways

CYP2E1, ABCA1, CYP3A4, PPARA, ABCD3, CYP8B1, VDR, NR1H4, NR1H3, PPARG, PPARD, CYP27B1, CYP26A1, CYP2C9, CYP2B6

WP3

Transcriptional activation by NRF2

WikiPathways

MAPK8, PRKCA, GCLM, GCLC, SLC7A11, PIK3CA, CEBPB, NQO1, HMOX1, MAF, EPHB2

WP304

Kit receptor signaling pathway

WikiPathways

STAT3, PTPN11, PRKCB, RAF1, PRKCA, SNAI2, JUNB, KITLG, BAD, INPP5D, MAP2K2, SOCS6, MAP2K1, VAV1, KIT, AKT1, DOK1, JAK2, GRB10, GRB2, STAT5B, MAPK3, STAT5A, RPS6, SOS1, RPS6KA1, MAPK1, MAPK8, MAPK14, EP300, SOCS1, BCL2, MAPT, FOXO3, CRKL, MITF, FYN, FOS, PIK3R1, LYN

WP306

Focal Adhesion

WikiPathways

JUN, COL6A2, COL5A2, ELK1, HGF, ITGA9, FN1, BIRC3, IGF1, XIAP, ITGAM, COMP, ITGAE, THBS4, IGF1R, ITGA3, SEPP1, ITGA5, COL5A1, COL4A6, ITGA11, PGF, PDGFRB, PTK2, COL3A1, COL4A2, VAV1, ITGB3, ITGB4, AKT1, ITGB5, AKT2, ITGAV, ITGB1, AKT3, ITGAX, ITGB2, SPP1, LAMC1, COL1A1, LAMA4, COL1A2, LAMB1, PDGFC, FLNA, FGR, VEGFA, MYLK, MYL6, VEGFC, VEGFB, ITGB8, PIP5K1C, MET, PAK7, BCL2, PDGFA, PDGFB, PDGFRA, ARHGAP5, COL11A1, LAMC3, COL11A2, CCND2, TNK2, CDC42, THBS1, CCND3, PAK3, RAF1, VWF, ZYX, PAK2, PDGFD, VTN, RHOB, RHOA, PPP1R12A, BAD, ACTN1, MAPK9, RAC2, ERBB2, MAP2K2, RAC3, PIK3R4, MAP2K1, MAP2K5, MAP2K6, ILK, RAPGEF1, GRB2, ACTG1, MAPK7, RAC1, SOS1, MAPK1, ITGA10, MAPK8, EGFR, GSK3B, TNR, TNXB, LAMA3, CTNNB1, LAMA2, FARP2, ACTB, STYK1, ITGA6, ROCK2, PELO, PTEN, RAP1A, ITGA2, TNC, CAV2, CAV1, PIK3CA, PIK3CB, PIK3CD, COL5A3, TLN1, FYN, PIK3CG, PIK3R1

WP311

Synthesis and Degradation of Ketone Bodies

WikiPathways

OXCT1, HMGCL

WP313

Signaling of Hepatocyte Growth Factor Receptor

WikiPathways

JUN, MAPK8, PTPN11, STAT3, RAF1, ELK1, HGF, MET, RAP1A, PTEN, PTK2, MAP2K2, MAP2K1, RASA1, PIK3CA, RAPGEF1, ITGB1, CRKL, GAB1, GRB2, MAPK3, FOS, SOS1, MAPK1

WP314

Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation

WikiPathways

JUN, CASP9, CASP8, MAPK8, MAPKAPK2, TNF, RIPK2, PAK2, LMNA, HSPB1, LMNB1, FADD, CFLAR, ACTB, LMNB2, BCL2, MAP3K7, RB1, CASP6, IL1A, DFFA, CYCS, FAS, ARHGDIB, ACTG1, PRKDC, FAF1, PARP1

WP322

Osteoblast Signaling

WikiPathways

PDGFB, PDGFRA, ITGB3, BGLAP, TNFRSF11B, ITGAV, COL1A1, PTH, TNFSF11, PDGFRB

WP325

Triacylglyceride Synthesis

WikiPathways

LPL, AGPS, GK, DGAT2, LIPE, GPAM, PLPP3, PLPP1, PNPLA2, AGPAT3, AGPAT4, GNPAT

WP3286

Copper homeostasis

WikiPathways

JUN, MT1G, MT1H, MT1E, MT1F, MTF1, SLC31A2, SLC31A1, XIAP, STEAP4, ADAM17, CCS, COX17, COMMD1, SOD3, MDM2, ATOX1, AKT1, SLC11A2, MT2A, MT1X, MT3, GSK3B, XAF1, ADAM10, MTF2, PTEN, MAPT, FOXO1, FOXO3, APC, ADAM9, TP53, APP, PRNP, PIK3CA, COX11

WP3287

Overview of nanoparticle effects

WikiPathways

NFRKB, PTK2, BCL2, PTGS2, BAX, PTGS1, TNF, CRP, FN1, LAMA3, HMOX1, PIK3CD, AKT3, IL6, CCND3, CXCL8

WP3297

EV release from cardiac cells and their functional effects

WikiPathways

ERBB4, CXCL12, KLF2, TNF, PRL

WP3298

Melatonin metabolism and effects

WikiPathways

CALM2, MAOA, CSNK1D, ECE1, PRKCA, CSNK1E, PER1, GSK3B, ADRB1, CYP1A1, MAP2, IRAK1, CYP1B1, CYP2D6, FOXO1, CRY1, EDN1, APOE, ARNTL, NFKB1

WP3300

Dual hijack model of Vif in HIV infection

WikiPathways

RUNX1, CBFB, RBX1, CUL5, TCEB1, TCEB2, APOBEC3G

WP3301

MFAP5-mediated ovarian cancer cell motility and invasiveness

WikiPathways

JUN, ITGAV, PTK2, PRKCQ, ITPR3, CREB5, ITGB3, RYR3, MAPK1, MFAP5

WP3302

eIF5A regulation in response to inhibition of the nuclear export system

WikiPathways

XPO4, XPO1, EIF5A

WP3303

Rac1/Pak1/p38/MMP-2 pathway

WikiPathways

CASP9, STAT3, PTPN11, BIRC5, FN1, ANGPT2, ANGPT1, STMN1, EIF4EBP1, RAD51, BAD, MAPK9, PTK2, ANGPTL1, ERBB2, MAPK13, BAX, AKT1, RASA1, GRB14, ITGB1, NRAS, GRB2, TIE1, STAT5B, MAPK3, STAT5A, NFKB1, RAC1, SOS1, MYC, MAPK1, MAPK8, MAPK14, EGFR, RELA, KRAS, CTNNB1, YAP1, FOXO1, TEK, MSH2, TP53, PIK3CA, PIK3R1

WP334

GPCRs, Class B Secretin-like

WikiPathways

CD97, ADCYAP1R1, PTH2R, ADGRE1, ADGRL2, ADGRL3

WP34

Ovarian Infertility Genes

WikiPathways

PTGER2, EGR1, PRLR, CDKN1B, INHA, NRIP1, CEBPB, VDR, NCOR1, PGR, SYNE2, MLH1, CDK4, CYP19A1, ESR2, ZP3, LHCGR, FSHR, SMAD3, CCND2, GDF9

WP3407

FTO Obesity Variant Mechanism

WikiPathways

FTO, TBX1, PPARGC1A, ARID5B, UCP1, IRX3

WP3408

Evolocumab Mechanism

WikiPathways

LDLR, PCSK9

WP3413

NOTCH1 regulation of human endothelial cell calcification

WikiPathways

CALU, DLL4, GJA5, NOTCH1, MGP, JAG1, VEGFA, SOX6, SAT1, PLAT, ALPL

WP3414

Initiation of transcription and translation elongation at the HIV-1 LTR

WikiPathways

NFATC4, SUPT5H, EP300, RELA, HDAC3, PPP3R2, HDAC8, HDAC5, CREBBP, HEXIM1, HDAC7, HDAC9, HDAC4, PPP3CA, CCNT1, HDAC1, HDAC2, NFATC2, NFATC1, NFKB1

WP35

G Protein Signaling Pathways

WikiPathways

CALM2, ADCY9, PRKCB, ADCY7, PRKCA, PRKAR2B, AKAP1, RHOA, PRKD1, PRKCI, PRKCD, PRKCQ, NRAS, PDE4C, PDE4D, ITPR1, GNA12, GNG7, KRAS, GNG5, GNA11, PDE7B, GNB3, GNB2, GNG4, AKAP6, GNAI1, RRAS, GNG11, GNAI2, PDE8B, ADCY3, PDE8A, AKAP11, AKAP10, AKAP13, PRKACA, GNAQ, AKAP2, GNAS, GNAI3, PPP3CA, PDE7A, GNB1, PRKAR1A, PRKAR2A, AKAP7

WP3527

Preimplantation Embryo

WikiPathways

ZFP36, SMARCA4, KHSRP, NLRP5, H2AFY2, ESRRA, ZFP36L2, SOX8, MYBL1, HNRNPAB, KLF4, MXD1, TEAD4, EGR1, PBX1, FOSB, DLX2, AQP3, AQP9, DDIT3, ELAVL1, POU5F1, NKX2-1, TCF7L1, HMGA1

WP3529

Zinc homeostasis

WikiPathways

MT1G, MT1H, MT1E, MTF1, MT1F, SLC39A8, SLC39A14, SLC30A9, SLC39A6, SLC30A8, SLC30A1, SLC39A4, MT2A, MT1X, SLC39A10, MT3, MT1M

WP357

Fatty Acid Biosynthesis

WikiPathways

ECHDC1, ACSS2, ECHS1, MECR, ECHDC3, ECHDC2, PC, ACSL1, HADH, SCD, ECH1, FASN, DECR1, ACACB, ACSL6, ACSL4

WP3584

MECP2 and Associated Rett Syndrome

WikiPathways

MEF2C, EZH2, ARHGEF26, E2F1, TET3, MPP1, RBFOX1, FKBP5, IGF2, FGF2, CEBPD, BCL6, NCOR1, CREB1, AKT1, HNRNPH1, NREP, RPS6, DLX5, SMC3, MAG, BDNF, CNP, YBX1, CSRP1, SP3, HDAC1, FUT8

WP3585

Cytosine methylation

WikiPathways

TET3, IDH2, IDH1, DNMT1, MBD3, TDG

WP3593

miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma

WikiPathways

VEGFA, VEGFC, HES1, VEGFB, HIF1A, HEY1

WP3594

Circadian rythm related genes

WikiPathways

STAR, JUN, PPARGC1A, JUND, PRKCDBP, RORA, RORB, NPY2R, KLF10, ARNT, LGR4, ARNTL, DRD2, CSNK1D, CSNK1E, SKP1, ID3, NFIL3, PROX1, UBC, NCOA2, AGRP, SIK1, CST3, TH, HDAC3, GFPT1, NR1H3, MAPK9, NCOR1, NONO, KDM5A, ID2, PSPC1, MTNR1A, MTNR1B, LEP, PPP1CC, PPP1CB, CARTPT, ADORA1, SUV39H2, USP2, HTR7, NRIP1, OPRL1, NKX2-1, ROCK2, NPAS2, PTEN, CRY1, GHRH, ZFHX3, OGT, PTGDS, ATF4, TIMELESS, NAGLU, EZH2, KLF9, NLGN1, HOMER1, TYMS, SFPQ, CREM, NAMPT, CREB1, ID4, RBM4, SETX, RBM4B, RELB, BHLHE40, NR1D1, GNA11, BTRC, CCAR2, PRKAA2, NGFR, ADA, MYBBP1A, ADIPOQ, GNAQ, SERPINE1, NOCT, OPN3, THRAP3, AHR, AHCY, KCNMA1, HNRNPU, NR1D2, PAX4, UBA52, MTA1, HNRNPD, DDX5, PPP1CA, PRKDC, MAPK8, CPT1A, EGR1, SFTPC, EP300, PER1, GSK3B, PPARA, TNFRSF11A, CLDN4, ARNTL2, TOP1, CDK4, TOP2A, PPARG, TP53, RPS27A, EGR3, GHRL, FAS, BTBD9, HDAC1, SREBF1, TPH2, HDAC2, NTRK1, IL6

WP3595

mir-124 predicted interactions with cell cycle and differentiation

WikiPathways

STRADB, CTDSP1, STK11, PTBP1

WP3596

miR-517 relationship with ARCN1 and USP1

WikiPathways

ID1, ID2, ARCN1, CDKN1A, USP1

WP3599

Transcription factor regulation in adipogenesis

WikiPathways

TWIST1, MAPK8, PCK2, PPARGC1A, FOXO1, NR3C1, TNF, ADIPOQ, IRS2, SLC2A4, CREB1, PPARG, LPIN1, NRIP1, CEBPB, LEP, CEBPD, IRS1, INSR, IL6

WP3601

Composition of Lipid Particles

WikiPathways

LDLR, LPL, APOB, APOC3, APOA2, APOE, APOA1

WP3611

Photodynamic therapy-induced AP-1 survival signaling.

WikiPathways

JUN, MAPK8, MAPK14, ELK1, EGFR, TNF, FGF7, TNFSF10, CDKN1A, JUNB, CFLAR, HSP90AA1, BCL2L11, BCL3, MAP3K5, MMP2, BCL2, BID, CCNA2, PDGFRA, MAPK13, BAX, MAP2K7, RB1, MAP2K6, TP53, MCL1, FAS, HBEGF, FOS, IL6

WP3612

Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

WikiPathways

JUN, ABCC4, MAPK8, MAPK14, MAPK13, GCLM, EPHX1, GCLC, NQO1, NQO2, HMOX1, GSTP1, FOS

WP3613

Photodynamic therapy-induced unfolded protein response

WikiPathways

XBP1, PDIA6, DNAJB9, DNAJC3, EDEM1, BBC3, ATF6, DDIT3, BCL2L11, HSP90B1, TRIB3, CALR, ERN1, SULT1E1, PPP1R15A, HSPA5, UBE2E1, ASNS, ATF3, ATF4

WP3614

Photodynamic therapy-induced HIF-1 survival signaling

WikiPathways

PGK1, BIRC5, PDHA1, BNIP3, ANGPT2, BNIP3L, SLC2A3, ANGPT1, SLC2A1, PFKL, VEGFA, IGFBP1, IGFBP2, IGFBP3, HK1, BID, TGFA, PTGS2, BAX, HIF1A, TP53, SERPINE1, EDN1, PMAIP1, MCL1, LDHA, ARNT, PKM

WP3617

Photodynamic therapy-induced NF-kB survival signaling

WikiPathways

RELB, RELA, BIRC5, TNF, SELE, BIRC3, ICAM1, CFLAR, VEGFA, IL1B, CXCL8, REL, CD40LG, MMP2, MMP1, BCL2L2, MMP9, PTGS2, CXCL2, IL1A, VCAM1, NFKB1, IL6

WP3624

Lung fibrosis

WikiPathways

HGF, TNF, IGF1, CCL2, FGF7, CCL3, OBFC1, CEBPB, CCL5, CCL4, FGF2, SKIL, SERPINA1, PLAU, CXCL8, MMP2, TGFA, MMP9, EDN1, PARN, SPP1, CTGF, TIMP1, MT2A, FAM13A, SFTPC, TGFB1, IL1B, PTX3, SMAD7, PDGFA, PDGFB, CXCL2, GREM1, HMOX1, DSP, IL6

WP3627

Gut-Liver Indole Metabolism

WikiPathways

CYP2E1

WP363

Wnt Signaling Pathway Netpath

WikiPathways

LRP5, LRP6, PRKCB, PRKCA, TSC2, TCF3, RHOA, TCF4, MAPK9, CSNK1G1, MAP3K7, AKT1, PIP5K1B, AXIN1, RAC1, MYC, TCF7L2, MAPK1, MAPK8, CSNK1D, CSNK1A1, CSNK1E, GSK3B, CTNNB1, GJA1, NLK, TEK, APC, PPARG, CDK6, ROR1, NFATC2

WP3630

NAD metabolism, sirtuins and aging

WikiPathways

FOXO1, FOXO3, TFAM, HIF1A, NAMPT, NFKB1, PPARG, PARP1

WP3633

Caffeine and Theobromine metabolism

WikiPathways

CYP2A6, XDH

WP3634

Insulin signalling in human adipocytes (normal condition)

WikiPathways

IRS1, INSR, SLC2A4, TBC1D4, RPS6, AKT2

WP3635

Insulin signalling in human adipocytes (diabetic condition)

WikiPathways

IRS1, INSR, SLC2A4, TBC1D4, RPS6, AKT2

WP364

IL-6 signaling pathway

WikiPathways

PTPN11, STAT3, GSK3B, JUNB, NCOA1, CREBBP, IRF1, BAD, SOCS3, PRKCD, IL6R, NLK, MAP2K2, IL6ST, MAP2K1, CRP, VAV1, MAP3K7, JAK1, AKT1, JAK2, AGT, GAB1, GRB2, HDAC1, MAPK3, TIMP1, IL6, PIK3R1, RAC1, SOS1, MAPK1

WP3640

Imatinib and Chronic Myeloid Leukemia

WikiPathways

CSF1R, PDGFRA, FOXO3, KIT, CDKN1B, SKP2, GADD45A, BCR, NOP2, MYC, PDGFRB

WP3644

NAD+ metabolism

WikiPathways

NRK, NMNAT3, NAMPT, SIRT2, NT5E, PARP1

WP3645

NAD+ biosynthetic pathways

WikiPathways

PARP2, TNKS2, SIRT2, NADSYN1, TNKS, QPRT, NAMPT, PARP1

WP3646

Hepatitis C and Hepatocellular Carcinoma

WikiPathways

JUN, CASP9, PTPN11, STAT3, BIRC5, BIRC3, HNF1A, CXCL8, CTTN, MMP1, COL4A2, BRCA1, PTGS2, HIF1A, JAK1, AKT1, UCHL1, GRB2, MAPK3, SMAD3, SMAD4, NFKB1, RAC1, SOS1, MYC, MAPK8, MAPK14, RRM2, CDKN1A, CD44, TGFB1, VEGFA, TGFBR1, IL6R, TP53, E2F2, IL6

WP3651

Pathways Affected in Adenoid Cystic Carcinoma

WikiPathways

SMARCA2, RAF1, CMTR2, NOTCH1, MAGI2, HIST1H1E, MYCN, CREBBP, KAT6A, UHRF1, MYCBP, ERBB2, NCOR1, MAP2K2, BRCA1, MGA, AKT1, KDM6A, BCORL1, TLK1, MYBL1, FOXP2, KMT2C, ATRX, PRKDC, MYC, SMC1A, EP300, MAGI1, ARID5B, ARID1A, NFIB, JMJD1C, PTEN, FOXO3, ARID4B, CHEK1, TP53, PIK3CA, MORF4L1, MAML3

WP3655

Hypothetical Craniofacial Development Pathway

WikiPathways

RHOA, ARHGAP29, IRF6

WP3656

Interleukin-1 Induced Activation of NF-kappa-B

WikiPathways

AJUBA, UBE2V1, SQSTM1, IL1A, IRAK1

WP3657

Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex

WikiPathways

PTEN, GABPA, BCL2, FOXO3, SMARCA4, EP300, DNMT1, MCL1, DNMT3B, CREBBP, FLJ10038, SMAD4, ZFX

WP3658

Wnt/beta-catenin Signaling Pathway in Leukemia

WikiPathways

LRP5, LRP6, ZBTB16, CSNK1A1, GSK3B, DKK1, APC, PPARD, JUP, AKT1, WIF1, CTNNB1, TCF3, FZD6

WP366

TGF-beta Signaling Pathway

WikiPathways

MEF2C, JUN, MEF2A, PDK1, KLF6, FN1, UCHL5, JUND, JUNB, CREBBP, SKIL, SKI, FOXP3, PTK2, MMP1, ITGB3, ITGB4, MAP3K7, AKT1, ITGB1, KLF10, AXIN1, RBL1, COL1A2, MYC, MAPK14, STAMBPL1, BTRC, UBE2I, SKP1, TGFB1I1, TGFB1, EID2, TGFBR3, NEDD4L, RBX1, TGFBR2, TGFBR1, MET, SMAD7, YAP1, CITED1, PRKAR2A, ZFYVE16, SIK1, ITCH, THBS1, CDC42, PARD6A, RAF1, TFDP1, PAK2, CDK1, RHOA, WWP1, NUP153, MAPK9, MAP2K2, MAP2K1, MAP2K6, PPM1A, GRB2, SMAD3, SMAD4, ETS1, RAC1, SOS1, ZEB1, MAPK1, SMAD2, DAB2, SMURF2, RUNX2, MAPK8, EP300, NEDD9, FOSB, CDKN1A, LIMK2, CDKN2B, ITGA2, SPTBN1, TNC, CAV1, TP53, ZEB2, APP, CCNB2, ATF3, RNF111, TAB1, HDAC1, FOS, PIK3R1

WP3664

Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds

WikiPathways

CSNK1A1, GSK3B, APC, CTNNB1, DKK3, TNKS, FZD7, AXIN1, FZD8, SFRP4, TCF4

WP3668

Hypothesized Pathways in Pathogenesis of Cardiovascular Disease

WikiPathways

RUNX2, MAPK8, MAPK14, FLNA, FBN3, ANGPT2, SERPINE1, POSTN, AGTR1, SMAD3, MAPK3, CTGF, TGFBR3, SMAD4, TGFBR2, LTBP1, TGFBR1, FBN2, SMAD2, MAPK1, FBN1

WP3670

Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway

WikiPathways

PKD1, LOXL4, CDC37, FN1, FGF7, ANXA5, BMP2, IGFBP7, NQO1, TGFB1, DDR1

WP3672

LncRNA-mediated mechanisms of therapeutic resistance

WikiPathways

HIF1A, CDKN1A, TP53, WNT6, MEG3

WP3674

Tgif disruption of Shh signaling

WikiPathways

FOXG1, GLI3, NKX2-1, SMAD2

WP3676

BDNF-TrkB Signaling

WikiPathways

ARC, HOMER1, DLG4, TSC2, KRAS, MKNK1, BDNF, EIF4EBP1, RHEB, MAP2K1, CREB1, AKT1, NRAS, GAB1, GRB2, TRPC6, NTRK2, PIK3CG, TRPC3, SOS1, MAPK1, RPS6KA1

WP3678

Amplification and Expansion of Oncogenic Pathways as Metastatic Traits

WikiPathways

TCF7L1, EPAS1, NOTCH1, TNC, WNT2, VCAM1, JAG1, VEGFA, POSTN, CXCR4, PIK3CG, TCF7L2

WP3679

Cell-type Dependent Selectivity of CCK2R Signaling

WikiPathways

GNAI1, PLCB1, ITPR1, CCK, GNAQ, CCKBR, RYR2, CNR1, RYR3, TRPC1

WP368

Mitochondrial LC-Fatty Acid Beta-Oxidation

WikiPathways

CPT1A, SCP2, ACADVL, ACSL1, HADH, ECI1, ACSL4

WP3680

Association Between Physico-Chemical Features and Toxicity Associated Pathways

WikiPathways

JUN, RAF1, ELK1, FN1, FZD4, FZD6, FZD7, RHOA, FZD8, ERBB4, ERBB2, PTK2, TGFA, MAP2K1, NEFH, AKT1, ACTR2, ACTR3, GRB2, AXIN1, STAT5A, CAMK1, MYC, SOS1, PFN1, MAPK1, MAPK8, EGFR, GSK3B, CDKN1B, CDKN1A, CTNNB1, MYLK, GPX1, ROCK2, TMSB4X, APC, DAAM1, PIK3CG

WP382

MAPK Signaling Pathway

WikiPathways

MEF2C, JUN, ELK1, TAOK2, PPP3R2, JUND, ZAK, STMN1, PDGFRB, MAP3K5, MAP4K3, MAP4K4, RPS6KA5, MAP3K4, IL1A, MAP3K7, MAP3K8, AKT1, AKT2, CD14, AKT3, NRAS, NFKB1, MYC, MAPK14, FLNA, GNA12, KRAS, HSPB1, HSPB2, TGFB2, DUSP1, TGFB1, LAMTOR3, GADD45A, NGF, DDIT3, BDNF, TGFBR2, DUSP7, TGFBR1, DUSP5, DUSP6, TAOK1, NLK, PDGFB, ACVR1B, PRKACA, CDC25B, CRKL, MAP3K13, NFATC1, CDC42, CASP9, CASP8, SOS2, PRKCB, RAF1, DUSP10, TNF, PAK2, MKNK1, MINK1, IL1R2, PRKCD, MAPK9, RAC2, MAP2K2, MAPK13, HSPA1A, PLA2G5, MAP2K1, MAP2K7, RASA2, MAP2K5, CASP6, MAP2K6, CASP1, HSPA5, MAPK8IP3, FGFR1, RASA1, PPM1A, PPM1B, GRB2, MAPK3, MAPK7, RAC1, MAPK1, MAPK8, TMEM37, EGFR, MAPKAPK2, IL1B, IL1R1, RAP1A, MAPT, TP53, PPP3CA, FAS, NR4A1, ATF4, TAB1, FOS, NTRK1

WP383

Striated Muscle Contraction

WikiPathways

ACTA2, MYL9, TPM2, TPM1, MYL4, TTN, ACTN4, DMD, TMOD1, TNNI3, TNNT1, VIM, MYBPC1, DES, TPM4, ACTC1, ACTG1, TPM3, ACTN2

WP384

Apoptosis Modulation by HSP70

WikiPathways

CASP9, CASP8, BID, HSPA1A, CASP6, FAS, CYCS, FADD, RIPK1, NFKB1, AIFM1

WP3844

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities

WikiPathways

FOXO4, PDK1, TSC2, GSK3B, KRAS, CDKN1B, TFEB, ATG13, EIF4EBP1, RICTOR, BAD, PTEN, ULK1, NOS3, RHEB, FOXO1, FOXO3, AKT1, RB1CC1, PIK3CA, PIK3CB, NRAS, GRB10, PIK3CG, PIK3R1

WP3845

Canonical and Non-canonical Notch signaling

WikiPathways

NOTCH2, HES1, DNER, NOTCH1, PSEN2, PSEN1, HEY1, RRAS, ADAM10, MFAP2, MAML2, DLL4, JAG1, DLK1, MAML3

WP3849

MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ

WikiPathways

RRAS, RAF1, NFKB1, MAP2K6, MAPK1

WP3850

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

WikiPathways

MAP1LC3A, PPARGC1A, PDK1, GSK3B, FBXO32, IGF1, IGF1R, EIF4E, JKAMP, PTEN, WASL, ACVR2B, IGFBP5, ILK, AKT1, ITGB1, PLD1, IRS1, SMAD3, MSTN, NFKB1, PIK3CG, SMAD2

WP3851

TLR4 Signaling and Tolerance

WikiPathways

TIRAP, TNF, RIPK1, IRAK1, INPP5D, CXCL8, IRAK3, MAP3K7, TBK1, TLR4, TAB1, NFKB1, IL6

WP3853

ERK Pathway in Huntington's Disease

WikiPathways

RPS6KA5, RAF1, EGFR, ELK1, MAP2K7, CREB1, BDNF, NTRK2, MAPK1

WP3858

Toll-like Receptor Signaling

WikiPathways

TLR5, RELB, TIRAP, RELA, TOLLIP, IRAK1, REL, TBK1, TLR3, TLR4, TLR1, TLR2, NFKB1, MAPK1

WP3859

TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition

WikiPathways

CDH6, RUNX2, TNC, ID1, FN1, SNAI2, AKT1, VIM, TGFB1, MAPK3, SMAD3, SMAD4, CDH2, SMAD2, MAPK1

WP3863

T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection

WikiPathways

JUN, CALM2, RAF1, CD28, PDK1, TNF, MAPK9, MAP2K2, PRKCQ, MAP2K1, MAP2K7, MAP3K7, MAP3K8, AKT1, GRB2, MAPK3, NFKB1, IL10, SOS1, PTPRC, CD4, GSK3B, RRAS, CD40LG, CDK4, DLG1, PIK3CA, BCL10, FYN, NFATC2, FOS, CHP1

WP3865

RIG-I-like Receptor Signaling

WikiPathways

CASP8, TRIM25, TNF, ATG12, FADD, RIPK1, CXCL8, MAPK9, ISG15, MAPK13, MAP3K7, TKFC, DDX3X, NFKB1, MAPK8, MAPK14, RELA, DDX17, IFNE, TANK, CYLD, TRADD, MAVS, TBK1, CXCL12, AZI2

WP3871

Valproic acid pathway

WikiPathways

CYP2A6, HADHB, CYP2C9, HDAC1, ACADSB, ABAT, CYP2B6, HSD17B10

WP3872

Regulation of Apoptosis by Parathyroid Hormone-related Protein

WikiPathways

BCL2, BID, BCL2L2, PTHLH, BAX, GSK3B, ITGB4, BCL2L15, BCL2L12, AKT1, BOK, MCL1, PIK3CG, ITGA6, MYC

WP3874

Canonical and Non-Canonical TGF-B signaling

WikiPathways

BMPR2, MAPK9, BMPR1A, MAPK8, MAPK14, LOXL4, BMP1, GREM1, TGFB1, SMAD3, SMAD4, TGFBR2, LOXL2, TGFBR1, LOX, LOXL1, SMAD2

WP3875

ATR Signaling

WikiPathways

TOPBP1, RAD9B, RAD9A, RAD1, ATRIP, CHEK1

WP3876

BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation

WikiPathways

FOXO1, DKK1, BMP2, SFRP1, CTNNB1, SMAD5, DCN, BCL2L11, SMAD9, SMAD1

WP3877

Simplified Depiction of MYD88 Distinct Input-Output Pathway

WikiPathways

JUN, TLR5, IL1A, TLR4, UBE2V1, TLR1, NFKB1, TLR2, IRAK1

WP3878

ATM Signaling Network in Development and Disease

WikiPathways

SMC1A, NBN, TSC2, RIF1, STK11, HSPB1, CDK1, RNF8, RAD50, TRIM28, MDC1, MAP3K5, MRE11A, BUB1, CHEK1, HDAC4, H2AFX, CDK5, PPP2R4, AURKB, G6PD, NFKB1, PRKDC, DCLRE1C

WP3879

4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression

WikiPathways

MAP3K5, MAP2K2, PBK, RAF1, MAP2K1, MAP2K6, AKT1, MKNK2, MKNK1, MAPK3, EIF4E, EIF4EBP1, MAPK1

WP3888

VEGFA-VEGFR2 Signaling Pathway

WikiPathways

MEF2C, JUN, STAT3, ELK1, CCL2, NR4A3, EIF4E, RICTOR, PGF, RCAN1, HDAC7, MAP3K5, PTK2, PTGS2, OCLN, STAM, AKT1, IGFBP7, TXNIP, ACACB, CTGF, EEA1, NFKB1, CTNNA1, PFN1, MAPK14, FLNB, KCNC3, CFL1, RAB11A, ATF6, CSK, PBK, FOXO1, FOXO3, JAG1, MYH9, HBEGF, NFATC2, NFATC1, TRPC1, SMARCA2, ICAM1, FGB, RHOJ, PLAUR, PLAU, MAPK9, NOS3, MAP2K2, PLA2G4A, ANXA1, PLA2G5, MAP2K1, MAP2K7, MAP2K6, RAPGEF1, GRB10, NRP2, GRB2, IQGAP1, MYO6, ETS1, RPS6, INPP4B, CTNNB1, GJA1, MMP14, ROCK2, RAP1A, HDAC9, CAV1, MAPKAP1, FGA, PPP3CA, GAB1, ATF4, CDH5, AMOT, FRS2, FOXO4, TXN, NR4A2, MMP2, MMP10, NCF2, RPS6KA5, ITGB3, CREB1, ITGB5, DOK1, BIN1, ITGAV, ITGB1, MLST8, KL, DNAJB9, RELA, SELE, FGG, HSPB1, HDAC5, VEGFA, HSP90AA1, CTNND1, PRKAA2, TPCN2, BCL2, ERN1, HDAC4, BMP10, EZR, YWHAE, ITCH, FAF1, CDC42, SHB, PTPN11, PTPN9, RAF1, PRKCB, PRKCA, ADAMTS1, RACK1, GPC1, PAK2, NDRG1, MKNK1, FADD, PRKD2, RHOA, PRKD1, PRKCI, PRKCD, CXCL8, PTPRJ, SOD2, DLL4, HSPA1A, EPS15, DKK1, MAPK3, RAC1, MAPK1, TEAD4, MAPK8, EGR1, MAPKAPK2, GSK3B, TNXB, TNFRSF10C, RAB5A, EGR3, PIK3CA, FAS, NR4A1, SHC2, HDAC1, FYN, PIK3R1

WP3891

Benzene metabolism

WikiPathways

NQO1, CYP2E1, GSTM1, MPO, EPHX1

WP3892

Development of pulmonary dendritic cells and macrophage subsets

WikiPathways

IKZF1, RUNX2, STAT3, ID2, TCF4

WP3893

Development and heterogeneity of the ILC family

WikiPathways

ZBTB16, IL18, TNF, AHR, HNF1A, IL33, NFIL3, IL1B, RORA, IL12A, ID2, TOX, AREG, IL6

WP391

Mitochondrial Gene Expression

WikiPathways

GABPA, PPARGC1A, MTERF1, CREB1, PPP3CA, PPARGC1B, MYEF2, TFAM, FLJ10038, ESRRA

WP3915

Angiopoietin Like Protein 8 Regulatory Pathway

WikiPathways

CYP3A4, EIF4E, THRA, RICTOR, EIF4EBP1, FBP1, MAP3K5, MAP4K3, MAP4K4, RHEB, RPS6KA5, MAP3K4, MAP3K8, MAP3K7, EXOC7, AKT1, AKT2, MLST8, LPL, MAPK14, PRKAA2, FOXO1, FOXO3, IRS2, FLOT1, PRKAG1, RHOQ, MAP3K13, SREBF2, SOS2, RAF1, TSC2, SLC2A4, SLC2A1, SCD, FASN, MINK1, INS, NR1H3, GYS1, MAPK9, MAP2K2, MAPK13, PIK3R4, MAP2K1, MAP2K7, MAP2K5, PRKAG3, MAP2K6, MAP4K5, RPS6KA2, RAPGEF1, MAPK3, INSR, CYP2B6, MAPK7, SESN3, SOS1, RPS6KA1, MAPK1, MAPK8, PCK1, GSK3B, CBLB, TRIP10, PIK3C3, PIK3C2A, DIO2, MAPKAP1, PIK3CA, PIK3CB, PIK3CD, G6PC, SHC2, SREBF1, IRS1, ABCG8, PIK3CG, PIK3R1, IRS4

WP3924

Hfe effect on hepcidin production

WikiPathways

ID1, HAMP, HFE, SMAD7, BMP6, TMPRSS6