hsa05214

Glioma

KEGG

AKT3, CDK4, CDK6, CDKN1A, E2F1, E2F2, EGFR, AKT1, AKT2, SHC2, GRB2, IGF1, IGF1R, KRAS, MDM2, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, MAP2K2, PTEN, RAF1, RB1, SOS1, SOS2, TGFA, TP53, CALM2, CALM3, CAMK2D, CALML4

hsa05215

Prostate cancer

KEGG

AKT3, CDK2, CDKN1A, CDKN1B, CREB1, CREBBP, CTNNB1, E2F1, E2F2, EGFR, EP300, ERBB2, AKT1, AKT2, FGFR1, FGFR2, FOXO1, GRB2, GSK3B, GSTP1, HSP90AA1, HSP90AB1, IGF1, IGF1R, KLK3, INS, AR, KRAS, MDM2, ATF4, NFKB1, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, MAPK1, MAPK3, PDGFC, MAP2K1, MAP2K2, BAD, PTEN, RAF1, RB1, BCL2, RELA, SOS1, SOS2, SRD5A2, TCF7L2, TGFA, TP53, HSP90B1, PDGFD, TCF7L1, CASP9, CREB3L1, CCNE2, CREB5

hsa05216

Thyroid cancer

KEGG

TFG, CTNNB1, KRAS, MYC, NRAS, NTRK1, PPARG, MAPK1, MAPK3, MAP2K1, MAP2K2, RXRB, TCF7L2, TP53, TPM3, TPR, PAX8, CCDC6, NCOA4, TCF7L1

hsa05217

Basal cell carcinoma

KEGG

CTNNB1, GLI2, GLI3, GSK3B, APC, SUFU, PTCH1, HHIP, BMP2, BMP4, TCF7L2, TP53, WNT2, WNT3, WNT5A, WNT6, WNT2B, WNT5B, AXIN1, FZD4, FZD6, FZD7, FZD8, TCF7L1

hsa05218

Melanoma

KEGG

AKT3, CDK4, CDK6, CDKN1A, E2F1, E2F2, EGFR, AKT1, AKT2, FGF2, FGF7, FGF9, FGF11, FGF12, FGF13, FGF14, FGFR1, HGF, IGF1, IGF1R, KRAS, MDM2, MET, MITF, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, MAPK1, MAPK3, PDGFC, MAP2K1, MAP2K2, BAD, PTEN, RAF1, RB1, TP53, PDGFD, FGF18, FGF19

hsa05219

Bladder cancer

KEGG

CDK4, CDKN1A, RASSF1, DAPK1, DAPK3, HBEGF, E2F1, E2F2, TYMP, EGFR, ERBB2, CXCL8, KRAS, MDM2, MMP1, MMP2, MMP9, MYC, NRAS, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, RB1, THBS1, TP53, VEGFA, RPS6KA5

hsa05220

Chronic myeloid leukemia

KEGG

AKT3, CDK4, CDK6, CDKN1A, CDKN1B, CRKL, CTBP2, E2F1, E2F2, AKT1, AKT2, SHC2, GRB2, HDAC1, HDAC2, KRAS, SMAD3, SMAD4, MDM2, MYC, NFKB1, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, MAPK1, MAPK3, MAP2K1, MAP2K2, BAD, PTPN11, RAF1, RB1, RELA, BCR, SOS1, SOS2, STAT5A, STAT5B, TGFB1, TGFB2, TGFBR1, TGFBR2, TP53, RUNX1, CBLB

hsa05221

Acute myeloid leukemia

KEGG

AKT3, EIF4EBP1, AKT1, AKT2, GRB2, JUP, KIT, KRAS, MYC, NFKB1, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PPARD, MAPK1, MAPK3, MAP2K1, MAP2K2, BAD, RAF1, RELA, SOS1, SOS2, STAT3, STAT5A, STAT5B, TCF7L2, ZBTB16, TCF7L1, RUNX1, CCNA1

hsa05222

Small cell lung cancer

KEGG

AKT3, CDK2, CDK4, CDK6, CDKN1B, CDKN2B, LAMC3, CKS1B, CKS2, COL4A2, COL4A3, COL4A6, E2F1, E2F2, AKT1, AKT2, FHIT, FN1, BIRC3, XIAP, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, LAMA2, LAMA3, LAMA4, LAMB1, LAMC1, MYC, NFKB1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, CYCS, PTEN, PTGS2, PTK2, RB1, BCL2, RELA, RXRB, SKP2, TP53, TRAF1, CASP9, CCNE2

hsa05223

Non-small cell lung cancer

KEGG

AKT3, CDK4, CDK6, RASSF1, E2F1, E2F2, EGFR, ERBB2, AKT1, AKT2, FHIT, FOXO3, EML4, GRB2, JAK3, KRAS, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, MAP2K2, BAD, RAF1, RB1, RXRB, SOS1, SOS2, STAT3, STAT5A, STAT5B, STK4, TGFA, TP53, RASSF5, CASP9

hsa05224

Breast cancer

KEGG

AKT3, CDK4, CDK6, CDKN1A, CSNK1A1, CTNNB1, JAG1, E2F1, E2F2, EGFR, ERBB2, AKT1, AKT2, ESR1, ESR2, FGF2, FGF7, FGF9, FGF11, FGF12, FGF13, FGF14, FGFR1, FLT4, HEY1, FOS, SHC2, HEYL, GRB2, GSK3B, APC, HES1, IGF1, IGF1R, JUN, KIT, KRAS, LRP6, LRP5, MYC, NOTCH1, NOTCH2, NRAS, PGR, PIK3CA, PIK3CB, PIK3CD, PIK3R1, DLL4, MAPK1, MAPK3, MAP2K1, MAP2K2, PTEN, RAF1, RB1, SOS1, SOS2, BRCA1, BRCA2, TCF7L2, TP53, WNT2, WNT3, WNT5A, WNT6, WNT2B, WNT5B, NCOA3, AXIN1, FZD4, FZD6, FZD7, FZD8, TCF7L1, TNFSF11, NCOA1, FGF18, FGF19

hsa05230

Central carbon metabolism in cancer

KEGG

AKT3, EGFR, ERBB2, AKT1, AKT2, FGFR1, FGFR2, G6PD, GLS, HIF1A, HK1, IDH1, KIT, KRAS, LDHA, MET, MYC, NRAS, NTRK1, PDGFRA, PDGFRB, PDHA1, PDHB, PDK1, PFKL, PGAM1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PKM, MAPK1, MAPK3, MAP2K1, MAP2K2, PTEN, RAF1, SLC1A5, SLC2A1, TP53, HKDC1, SLC7A5, SLC16A3

hsa05231

Choline metabolism in cancer

KEGG

AKT3, WASF2, LYPLA1, CHKA, CHKB, SLC44A3, DGKK, DGKH, EGFR, EIF4EBP1, SLC44A5, AKT1, AKT2, PIP5K1C, SLC44A1, FOS, GRB2, HIF1A, JUN, KRAS, NRAS, PCYT1A, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLA2G4A, PLD1, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK9, PDGFC, MAP2K1, MAP2K2, SLC44A2, RAC1, RAC2, RAC3, RAF1, RALGDS, RHEB, SLC22A1, SLC22A3, SLC22A5, SOS1, SOS2, TSC2, PDGFD, PIP5K1B, DGKZ, PLA2G4C, PLPP1, PLPP3, WASL, PCYT1B

hsa05310

Asthma

KEGG

HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL10, PRG2, TNF, CD40LG

hsa05320

Autoimmune thyroid disease

KEGG

CGA, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, IFNA1 , IFNA16, FAS, IL10, CD28, CD40LG

hsa05321

Inflammatory bowel disease (IBD)

KEGG

HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IFNGR1, IFNGR2, IL1A, IL1B, IL4R, IL6, IL10, IL12A, IL12RB1, IL18, JUN, SMAD2, SMAD3, MAF, NFATC1, NFKB1, FOXP3, RELA, RORA, STAT3, TGFB1, TGFB2, TLR2, TLR4, TLR5, TNF, IL18R1

hsa05322

Systemic lupus erythematosus

KEGG

FCGR1A, FCGR2A, FCGR3B, GRIN2A, HIST1H2AD, H2AFX, H2AFZ, HIST1H2BD, HIST1H2BB, H3F3A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL10, H2AFY2, H2AFJ, SNRPB, SNRPD1, SNRPD3, TROVE2, SSB, C1QA, TNF, C1R, C1S, C3, C4A, C4B, HIST2H2AA3, C6, C7, C8G, ACTN4, HIST1H2AC, HIST1H2BH, HIST1H2BC, HIST2H2BE, HIST1H3D, HIST1H4A, HIST1H2BK, ACTN1, HIST1H2AG, HIST3H2A, CD28, H2AFV, H2AFY, CD40LG

hsa05323

Rheumatoid arthritis

KEGG

TCIRG1, TNFSF13B, CTSK, CTSL, FOS, ATP6V1C2, ANGPT1, CXCL1, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, ICAM1, IL1A, IL1B, IL6, CXCL8, IL11, IL18, ITGB2, JUN, MMP1, ATP6V1D, ATP6V1H, ATP6V1B2, ATP6V1C1, ATP6V1G2, ATP6V0A1, CCL2, CCL3, CCL5, CCL20, CXCL6, CXCL5, CXCL12, TEK, TGFB1, TGFB2, TLR2, TLR4, TNF, VEGFA, TNFSF11, TNFSF13, TNFRSF11A, ATP6V0E1, ATP6V0D1, ATP6V1F, CD28, ATP6V1G1

hsa05330

Allograft rejection

KEGG

HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, FAS, IL10, IL12A, TNF, CD28, CD40LG

hsa05332

Graft-versus-host disease

KEGG

HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, FAS, IL1A, IL1B, IL6, KIR3DL2, KLRC1, TNF, CD28

hsa05340

Primary immunodeficiency

KEGG

ADA, BLNK, IL7R, JAK3, PTPRC, RAG1, RFX5, DCLRE1C, UNG, CD4, CD40LG

hsa05410

Hypertrophic cardiomyopathy (HCM)

KEGG

DAG1, ACE, DES, DMD, EMD, ITGA11, IGF1, IL6, ITGA6, ITGA2, ITGA3, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB8, LAMA2, LMNA, ATP2A2, PRKAG3, PRKAA2, PRKAG1, CACNG8, CACNG6, ACTB, RYR2, SGCB, SGCD, ACTC1, TGFB1, TGFB2, ACTG1, TNF, TNNI3, TPM1, TPM2, TPM3, TPM4, TTN, CACNA1C, CACNA2D1, CACNB3, ITGA10

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

KEGG

CDH2, CTNNA1, CTNNA2, CTNNB1, DAG1, DES, DMD, DSC2, DSG2, DSP, EMD, ITGA11, GJA1, ITGA6, ITGA2, ITGA3, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB8, JUP, LAMA2, LMNA, ATP2A2, PKP2, CACNG8, CACNG6, ACTB, RYR2, SGCB, SGCD, TCF7L2, ACTG1, CACNA1C, CACNA2D1, CACNB3, TCF7L1, ITGA10, ACTN2

hsa05414

Dilated cardiomyopathy

KEGG

ADCY3, ADCY7, ADCY9, ADRB1, DAG1, DES, DMD, EMD, ITGA11, GNAS, IGF1, ITGA6, ITGA2, ITGA3, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB8, LAMA2, LMNA, ATP2A2, PLN, PRKACA, CACNG8, CACNG6, ACTB, RYR2, SGCB, SGCD, ACTC1, TGFB1, TGFB2, ACTG1, TNF, TNNI3, TPM1, TPM2, TPM3, TPM4, TTN, CACNA1C, CACNA2D1, CACNB3, ITGA10

hsa05416

Viral myocarditis

KEGG

CXADR, CD55, DAG1, DMD, FYN, ABL2, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ITGB2, LAMA2, CYCS, RAC1, RAC2, RAC3, ACTB, BID, SGCB, SGCD, ACTG1, CASP8, CASP9, CAV1, EIF4G3, CD28, CD40LG

hsa05418

Fluid shear stress and atherosclerosis

KEGG

AKT3, CDH5, KLF2, GSTO2, MAPK14, CTNNB1, CTSL, NQO1, DUSP1, EDN1, AKT1, AKT2, FOS, TXN2, GPC1, GSTA1, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTP1, GSTT1, GSTT2, HMOX1, HSP90AA1, HSP90AB1, ICAM1, IL1A, IL1B, IL1R1, ITGAV, ITGB3, JUN, RHOA, SUMO4, MEF2A, MEF2C, MAP3K5, MGST1, MGST2, MGST3, MMP2, MMP9, ASS1, NCF2, NFKB1, NOS3, PDGFA, PDGFB, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLAT, PRKAA2, MAPK7, MAPK8, MAPK9, MAPK13, MAP2K5, MAP2K6, MAP2K7, PTK2, RAC1, RAC2, RAC3, TRPV4, BCL2, RELA, ACTB, CCL2, SDC1, SDC2, SDC4, SELE, BMP4, BMPR1A, BMPR2, SUMO3, SUMO2, MAP3K7, ACTG1, TNF, TP53, HSP90B1, TXN, VCAM1, VEGFA, IL1R2, CALM2, CALM3, CAV1, CAV2, SQSTM1, ACVR1, ARHGEF2, CALML4, ACVR2A, ACVR2B, GSTO1

WP100

Glutathione metabolism

WikiPathways

GSTA1, GSR, GCLM, GCLC, GSTT2, GSTM1, G6PD, GPX1, GPX3, GPX4, IDH1, GSTM2, OPLAH

WP106

Alanine and aspartate metabolism

WikiPathways

ASS1, DARS, GOT2, ABAT, AGXT, PC

WP107

Translation Factors

WikiPathways

EEF1D, EEF1B2, EIF1, EEF2, EIF4G3, EIF4A1, EIF4A2, EIF3J, EIF4B, EIF4E, EIF4EBP1, EIF4EBP2, EIF6, EIF5, EIF5A, EEF1A2, EEF1A1, EIF5B, EIF2B4, EIF2B3, EIF2B5, EIF2B1, EIF2S3, EIF3B, EIF2S1, EIF3A, EIF1AX, PAIP1

WP111

Electron Transport Chain

WikiPathways

UQCR10, NDUFA5, NDUFA4, UCP2, UCP3, ATP5O, UCP1, COX5B, ATP5H, NDUFA2, NDUFA1, UQCRQ, ATP5D, ATP5G3, ATP5G2, ATP5E, COX5A, SLC25A5, SLC25A4, ATP5J, ATP5I, SDHA, COX7C, SDHB, SDHC, COX7B, COX6C, COX17, COX6B1, ATP5C1, UQCRB, COX6A1, UQCRH, UQCRFS1, UQCRC2, SLC25A14, UQCRC1, NDUFA10, NDUFAB1, NDUFA7, UQCR11, NDUFV3, ATP5L, NDUFS8, NDUFB10, NDUFV2, NDUFS1, NDUFS4, NDUFB6, NDUFB7, NDUFB8, NDUFS6, NDUFS2, NDUFB4, COX11

WP117

GPCRs, Other

WikiPathways

ADGRG1, PTGFR, GRM8, F2R, ADRB2, OR2A5, CXCR2, CCKBR, GPR176, ADGRD1, S1PR1, OR3A3, ADGRL2, EDNRA, LGR6, CELSR3, CHRM2, HTR7, CHRM3, GPR98, CNR1, OR2A20P, ADRA1D, GNRHR, GPR183, ALG6, FSHR, ADGRL3

WP12

Osteoclast Signaling

WikiPathways

ATP6V1G1, MAPK8, PDGFB, ITGB3, TNFRSF11B, CTSK, TNFRSF11A, SPP1, IFNAR1, TNFSF11

WP127

IL-5 Signaling Pathway

WikiPathways

JUN, STAT3, PTPN11, RAF1, ELK1, GSK3B, KRAS, SYK, BCL2, MAPT, MAP2K2, FOXO3, MAP2K1, JAK1, AKT1, JAK2, GRB2, MAPK3, STAT5B, STAT5A, FOS, IL5RA, PIK3CG, PIK3R1, LYN, MYC, SOS1, SPRED1, RPS6, MAPK1, RPS6KA1

WP129

Matrix Metalloproteinases

WikiPathways

BSG, MMP24, TNF, TCF20, MMP19, MMP16, MMP14, MMP15, MMP2, MMP1, MMP10, MMP9, MMP8, MMP25, TIMP2, TIMP1, TIMP3, MMP26, MMP11

WP134

Pentose Phosphate Pathway

WikiPathways

TALDO1, G6PD, TKT, PGLS, PGD

WP136

Phase I biotransformations, non P450

WikiPathways

LIPA, PON1

WP138

Androgen receptor signaling pathway

WikiPathways

JUN, STAT3, RACK1, FKBP4, RHOB, RHOA, CREBBP, PSMC3IP, ZMIZ1, NCOR2, PTK2, NCOR1, BRCA1, RAD9A, MDM2, RB1, CREB1, AES, AKT1, SMAD3, SMAD4, KDM1A, RAC1, RNF14, ETV5, RUNX2, EP300, EGFR, NCOA4, RELA, GSK3B, FLNA, STUB1, UBE2I, NCOA3, CDKN1A, CTNNB1, LIMK2, DSTN, TGFB1I1, NCOA1, RNF6, AR, ROCK2, CALR, PTEN, KAT2B, FOXO1, CAV1, PRDX1, NCOA2, PLPP1, CARM1, KLK3, NR0B2, HDAC1, PIK3R1, PATZ1, CDC42

WP1403

AMP-activated Protein Kinase (AMPK) Signaling

WikiPathways

STRADB, PLCB1, EEF2, TSC2, SLC2A4, FASN, SLC2A4RG, HMGCR, EIF4EBP1, ADIPOR2, GYS1, GYS2, PRKAG3, ADIPOR1, AKT1, AKT2, PPARGC1B, LEPR, CPT1B, ACACB, LEP, CAB39, INSR, CPT1A, STK11, CDKN1A, LIPE, CCNA1, PFKFB3, PRKAA2, ELAVL1, PIK3C3, ADRA1B, CCNA2, ADRA1A, ADIPOQ, TP53, PIK3CA, PIK3CB, PIK3CD, PRKAG1, SREBF1, CCNB1, PIK3CG, PIK3R1

WP1422

Sphingolipid Metabolism

WikiPathways

SGPP2, SGMS2, CERS6, CERS5, SERINC1, ASAH1, PLPP1, B4GALT6, SPTLC2, SPHK1, CERS4

WP1423

Ganglio Sphingolipid Metabolism

WikiPathways

SLC33A1, ST3GAL2, ST3GAL1, FUT1, B3GALT4

WP1424

Globo Sphingolipid Metabolism

WikiPathways

ST6GALNAC4, ST6GALNAC5, GALNT2, ST6GAL2, ST6GAL1, ST3GAL2, ST3GAL1, FUT2, ST6GALNAC2, FUT1

WP1425

Bone Morphogenic Protein (BMP) Signalling and Regulation

WikiPathways

BMPR2, RUNX2, TOB2, BMPR1A, SMAD4, BMP2, SMAD1, SMAD6

WP143

Fatty Acid Beta Oxidation

WikiPathways

ACSS2, LPL, CPT1A, LIPE, ACADVL, HADH, HADHB, TPI1, DECR1, ACSL6, ECHS1, GK, DLD, CRAT, ACSL1, PNPLA2, CPT1B, CHKB, ECI1, GPD2, ACSL4

WP1433

Nucleotide-binding Oligomerization Domain (NOD) pathway

WikiPathways

CASP9, CASP8, IL18, RELA, RIPK2, XIAP, HSP90AA1, PYCARD, IL1B, COPS6, NDUFA13, CASP1, DUOX2, SUGT1, RAC1

WP1434

Osteopontin Signaling

WikiPathways

ITGAV, MMP9, SPP1, RELA, MAP2K1, MAPK3, ITGB3, NFKB1, PLAU, MAPK1

WP1438

Influenza A virus infection

WikiPathways

BCL2

WP1449

Regulation of toll-like receptor signaling pathway

WikiPathways

JUN, CCL3, CCL5, CCL4, RIPK1, SQSTM1, TREM1, PELI1, PELI2, MAP3K7, MAP3K8, AKT1, AKT2, TRAFD1, CD14, MLST8, CTNNAL1, AKT3, SPP1, NFKB1, TLR5, TIRAP, MAPK14, RELA, SOCS1, TOLLIP, RNF216, PLK1, SARM1, SMAD6, CASP8, TAB3, SIGIRR, TNF, FADD, MBL2, CXCL8, MAPK9, MAP2K2, MAPK13, IL12A, MAP2K1, MAP2K7, MAP2K6, FBXW5, IFNA1 , IFNA16, TNFAIP3, MAPK3, RAC1, MAPK1, MAPK8, SYK, IFNAR1, IFNAR2, CYLD, IRAK2, IL1B, IRAK1, ZMYND11, IRAK3, TBK1, PIK3CA, PIK3CB, PIK3CD, TLR3, TLR4, TAB1, TLR1, FOS, TLR2, PIK3CG, PIK3R1, IL6

WP1455

Serotonin Transporter Activity

WikiPathways

SCAMP2, TGFB1I1, MAOA, PPP2CB, TPH2, IL1B, ITGB3, IL1R1

WP1471

Target Of Rapamycin (TOR) Signaling

WikiPathways

PRKCA, TSC2, PRKAA2, HMGCR, RICTOR, EIF4EBP1, RRAGC, ULK1, RHEB, PRKAG3, DDIT4, MAPKAP1, AKT1, MLST8, PRKAG1, RRAGD, IDI1, RAC1, CDC42

WP15

Selenium Micronutrient Network

WikiPathways

APOB, F2, ALOX5, XDH, TXN, MPO, PRDX4, TNF, CCL2, TXNRD1, SCARB1, ICAM1, APOA1, SEPP1, PLAT, SELM, INS, EPT1, HBA1, SOD2, SOD3, SELENOH, PTGS2, PTGS1, SELENOF, KYNU, MTR, CBS, CTH, INSR, NFKB1, HBB, SAA2, GSR, SELT, SAA1, RFK, ALB, PRDX2, ABCA1, RELA, SERPINA3, SEPN1, LDLR, GPX1, GPX3, GPX4, IL1B, DIO2, KMO, CRP, PRDX1, SERPINE1, PLG, VIMP, MTHFR, IL6

WP1528

Physiological and Pathological Hypertrophy of the Heart

WikiPathways

JUN, CALM2, MAPK8, NFATC4, IL6ST, STAT3, MAPK14, PRKCB, CAMK2D, CTF1, GATA4, EDN1, PPP3CA, AGT, RHOA, LIFR, MYEF2, FOS, RAC1, MAPK1

WP1530

miRNA Regulation of DNA Damage Response

WikiPathways

CASP9, CASP8, SFN, E2F1, CDK1, GADD45B, RAD51, MRE11A, BID, BRCA1, RAD9A, BAX, MDM2, CREB1, RB1, PMAIP1, TLK1, GADD45G, MIR17HG, PRKDC, MYC, SMC1A, MIR21, NBN, ATRIP, CDKN1B, CDKN1A, BBC3, GADD45A, RAD50, FANCD2, MCM7, CDK2, CHEK1, SESN1, CDK4, H2AFX, TP53, CDK5, CYCS, FAS, CDK6, CCNE2, CCNB2, CDC25C, CDC25A, RAD1, CCND2, CCNB1, CCNG1, CCND3

WP1531

Vitamin D Metabolism

WikiPathways

DHCR7, CYP27B1, VDR, CYP2R1, RXRB, GC, PTH

WP1533

Vitamin B12 Metabolism

WikiPathways

APOB, F2, MPO, TNF, CCL2, SCARB1, APOA1, ICAM1, CCL5, PLAT, INS, HBA1, SOD2, SOD3, LRP2, APOE, MTR, CBS, CTH, INSR, NFKB1, HBB, SAA2, SAA1, ABCA1, ALB, RELA, SERPINA3, LDLR, MCEE, IL1B, CRP, MMAB, SERPINE1, PLG, MTHFR, IL6

WP1539

Angiogenesis

WikiPathways

PTK2, NOS3, PDGFB, MAPK14, PDGFRA, MMP9, TEK, HIF1A, FGFR2, AKT1, ANGPT1, PIK3CA, ARNT, VEGFA, FGF2, CREBBP, TIMP2, TIMP3, SMAD1, MAPK1

WP1544

MicroRNAs in cardiomyocyte hypertrophy

WikiPathways

LRP5, CALM2, LRP6, STAT3, NRG1, IGF1, IGF1R, RCAN1, HDAC7, CTF1, AKT1, AKT2, EDN1, NFKB1, MIR21, NFATC4, MAPK14, GATA4, HDAC5, TGFB1, MYLK, CAMK2D, HDAC4, AGT, RAF1, PRKCB, TNF, FGF2, RHOA, PLA2G2A, MAP2K2, MAP2K1, FGFR2, MAP2K7, MAP2K5, MAP2K6, MAPK3, MAPK7, RAC1, MAPK1, MAPK8, NPPB, GSK3B, WNT5A, CTNNB1, EIF2B5, ROCK2, IL6ST, HDAC9, PPP3CA, PIK3CA, PIK3CB, CDK7, PIK3CD, LIF, TAB1, MYEF2, PIK3CG, PIK3R1

WP1545

miRNAs involved in DNA damage response

WikiPathways

E2F1, MIR93, MIR25, CREB1, MYC, MIR21, CDKN1B, CDKN1A, H2AFX, TP53, CDK6, CDC25A, CCND3

WP1559

TFs Regulate miRNAs related to cardiac hypertrophy

WikiPathways

MIR21, STAT3, AKT1, AKT2, TGFB1, MYEF2, NFKB1

WP1584

Type II diabetes mellitus

WikiPathways

MAPK8, GK, PHKA2, ADIPOQ, TNF, SLC2A4, KCNJ11, IRS1, INSR, PRKCD, MAPK1

WP1589

Folate-Alcohol and Cancer Pathway

WikiPathways

CEBPB, CYP2E1, ALDH1A1, MTHFR, CBS, CREB1, ALDH1L1

WP1591

Heart Development

WikiPathways

MEF2C, NFATC4, PTPN11, BHLHE40, NOTCH1, GATA6, HEY1, GATA4, CTNNB1, FOXC1, VEGFA, VEGFC, VEGFB, PITX2, BMPR2, BMPR1A, ERBB3, BMP4, BMP2, BMP10, TBX1, SMAD4, NFATC2, NFATC1, SMAD1, MAPK1

WP1600

Nicotine Metabolism

WikiPathways

CYP2A6, AOX1, CYP2B6

WP1601

Fluoropyrimidine Activity

WikiPathways

SMUG1, SLC29A1, RRM1, TYMS, RRM2, ERCC2, CYP2A6, DPYD, TYMP, GGH, UMPS, UCK2, TK1, UPP2, UPP1, ABCC4, ABCC5, TDG, TP53, DHFR, PPAT, MTHFR, UCK1

WP1602

Nicotine Activity on Dopaminergic Neurons

WikiPathways

CHRNA5, PRKACA, GNAI1, CDK5, KCNK3, GNB1, PPP1CA, DRD2, SLC18A2, TH

WP1603

Nicotine Activity on Chromaffin Cells

WikiPathways

CACNA1G, CACNA1C

WP1604

Codeine and Morphine Metabolism

WikiPathways

CYP3A4, CYP2D6

WP167

Eicosanoid Synthesis

WikiPathways

PLA2G2A, ALOX5, PTGS2, PTGES, PTGS1, PNPLA3, PTGDS, PNPLA8, PTGIS, ALOX15

WP170

Nuclear Receptors

WikiPathways

NR2F1, NR2F2, ESR1, NR0B1, PPARA, VDR, NR4A2, AR, THRA, ESRRA, NR1H2, NR1H3, NR1D2, RORA, PGR, NR3C1, RXRB, ESR2, PPARG, PPARD, NR4A1, NR5A2, ROR1

WP1742

TP53 Network

WikiPathways

BCL2, BID, BAX, TNFSF10, MDM2, CDKN1A, BOK, TP53, PMAIP1, OTX2, BBC3, GADD45A, MYC

WP176

Folate Metabolism

WikiPathways

APOB, F2, MTHFD2, MPO, TNF, CCL2, AHCY, SCARB1, ICAM1, APOA1, MTHFS, PLAT, INS, HBA1, SOD2, SOD3, GART, DHFR, MTR, CBS, CTH, INSR, NFKB1, HBB, SAA2, RFK, SAA1, ALB, ABCA1, RELA, SERPINA3, LDLR, SHMT1, GPX1, GPX3, GPX4, IL1B, FOLR1, CRP, TP53, SERPINE1, PLG, SLC46A1, MTHFD1, MTHFR, SLC19A1, IL6

WP1772

Apoptosis Modulation and Signaling

WikiPathways

JUN, CASP9, CASP8, BIRC5, TNFSF10, BIRC3, XIAP, CRADD, FADD, CFLAR, RIPK1, PRKD1, BAD, IL1R2, MAP3K5, BID, HSPA1A, BAX, CASP4, CASP6, TNFRSF1B, CASP1, TNFRSF11B, PMAIP1, PEA15, MAPK3, NFKB1, MAPK8, BNIP3, BOK, TOLLIP, BBC3, TNFRSF10C, HN1, IL1R1, IRAK1, BCL2L11, TRADD, AIFM2, TNFRSF25, BCL2, BCL2L2, TP53, MCL1, FAS, DFFA, CYCS, FOS, AIFM1

WP179

Cell Cycle

WikiPathways

CDC7, DBF4, HDAC7, MDM2, PTTG3P, RBL1, CDC14B, SMC1A, CDC14A, HDAC8, HDAC5, TGFB1, GADD45A, HDAC6, PLK1, TBC1D8, MCM8, ORC6, MCM4, MAD1L1, MCM3, MCM6, YWHAB, MCM5, CCNA2, BUB1, MCM7, CHEK1, HDAC4, APC, MCM2, PTTG1, MCM10, CDC25B, CDC25C, CDC25A, CDC6, BUB3, CDC20, YWHAZ, CCND2, YWHAH, CCNB1, YWHAE, ORC3, CCND3, E2F1, TFDP1, HDAC3, CDK1, ESPL1, KITLG, BUB1B, RB1, SKP2, ARF1, SMAD3, SMAD4, PRKDC, MAD2L1, EP300, GSK3B, CDKN1B, CDKN1A, CCNA1, PCNA, CDK2, PKMYT1, WEE1, CDK4, TP53, E2F2, ORC1, CDK6, CCNE2, CCNB2, ORC5, HDAC1, HDAC2

WP183

Proteasome Degradation

WikiPathways

PSMA1, PSMA4, PSMA3, PSMA2, PSME3, HLA-C, HLA-B, HLA-A, HLA-G, PSMD2, PSMD3, PSMC6, PSMC4, PSMB3, PSMC3, PSMB5, PSMB4, PSMC1, PSMC2, PSMB8, UCHL3, PSMB1, UCHL1, PSMD11, PSMD12, PSMD7, PSMD10, HLA-F, HLA-E, PSMB10, PSMB9, UBA7, UBA1, UBC, H2AFX, H2AFZ, UBE2B, UBE2D3

WP185

Integrin-mediated Cell Adhesion

WikiPathways

ITGA9, ITGAM, ITGAE, ITGA3, SEPP1, ITGA5, ITGA11, PTK2, ARHGEF7, ITGB3, ITGB4, AKT1, ITGB5, AKT2, ITGAV, ITGB1, AKT3, ITGAX, ITGB2, CAPN3, CAPN5, ITGB8, CAPN10, CSK, CDC42, PAK3, RAF1, SORBS1, ZYX, PAK2, RAC2, MAP2K2, RAC3, MAP2K1, MAP2K5, ILK, MAP2K6, GIT2, RAPGEF1, GRB2, MAPK7, RAC1, SOS1, MAPK1, ITGA10, TNS1, ITGA6, ROCK2, RAP1A, ITGA2, CAV2, CAV1, TLN1, FYN, VAV3

WP186

Homologous recombination

WikiPathways

BRCA2, MRE11A, POLD1, NBN, RAD51, POLD3, RAD50, RAD54B, POLD4

WP1941

Peroxisomal beta-oxidation of tetracosanoyl-CoA

WikiPathways

HSD17B4, ACOX1, SCP2

WP1946

Cori Cycle

WikiPathways

HK1, PGAM1, PGK1, SLC2A4, SLC2A1, TALDO1, TPI1, LDHA, G6PD, GAPDH, INS, GPI

WP195

IL-1 signaling pathway

WikiPathways

JUN, PTPN11, TAB3, CCL2, SQSTM1, PELI1, MAPK9, PELI2, MAP2K2, MAP2K1, MAP2K7, MAP3K7, MAP2K6, IL1A, AKT1, MAPK3, NFKB1, MAPK1, MAPK8, MAPK14, RELA, MAPKAPK2, HSPB2, TOLLIP, UBE2V1, IL1RAP, IRAK2, IL1B, IL1R1, IRAK1, REL, IRAK3, TAB1, PIK3R1

WP197

Cholesterol Biosynthesis

WikiPathways

LSS, SQLE, MVK, HMGCS1, CYP51A1, FDPS, DHCR7, MSMO1, FDFT1, SC5D, MVD, HMGCR, NSDHL, IDI1

WP1971

Integrated Cancer Pathway

WikiPathways

MIR21, CASP9, CASP8, E2F1, BACH1, CDKN1B, CDKN1A, CDK1, BLM, CDKN2B, BBC3, PLK1, MSH6, BAD, RAD50, MAP3K5, PTEN, MMP1, BCL2, MRE11A, BARD1, BRCA1, BAX, CDK2, CHEK1, MSH2, MDM2, CDK4, RB1, JAK1, AKT1, TP53, CDC25B, ATF1, CDC25A, SMAD3, POU2F1, NOXA1, MYC, SMAD2

WP1981

Thyroxine (Thyroid Hormone) Production

WikiPathways

TRH, CGA, SLC5A5

WP1982

Sterol Regulatory Element-Binding Proteins (SREBP) signalling

WikiPathways

SREBF2, RBP4, LSS, SEC31A, GPAM, SCARB1, LPIN1, SCD, INSIG1, SEC23A, FASN, HMGCR, SEC13, INS, ACSS1, DBI, MDH1, SEC24D, PRKAG3, CREB1, AKT1, PPARGC1B, SAR1B, MVD, LPL, CYP51A1, CDK8, FDPS, LDLR, FDFT1, PRKAA2, ATF6, NR1H2, AMFR, YY1, MED15, KPNB1, SQLE, PRKACA, HMGCS1, PPARG, PIK3CA, PRKAG1, SREBF1, IDI1

WP1984

Integrated Breast Cancer Pathway

WikiPathways

JUN, LGALS13, ESR1, NUP85, HMGCR, ZMIZ1, MSH6, MYCBP2, MAP3K7CL, BRCA2, MMP1, RHEB, BRCA1, MDM2, CYP19A1, CREB1, JAK1, AKT1, TPR, NFKB1, NOXA1, MYC, RAD54L, MIR21, CSNK1D, KRAS, HIPK2, VEGFA, GADD45A, PLK1, ZNF655, RAD50, TGFBR2, TGFBR1, SMAD7, SMAD6, RALGAPA1, BCL2, FOXO1, RALA, PHB, CHEK1, MSH2, PKIA, CDC25B, MAP3K13, CDC25A, ALKBH1, CDC42, PPP4R3A, ODC1, CASP9, CASP8, E2F1, BACH1, SMARCA4, TSC2, AHR, BLM, FADD, FAU, GRN, RAD51, BAD, USP15, TFPI, MRE11A, BARD1, BID, ANXA1, BAX, RB1, IMPA1, FOSL1, APOBEC3G, GDI1, SMAD4, RAC1, SMAD1, MAPK1, SMAD2, EP300, EGFR, STK11, NCOA3, DAG1, AURKA, CTNNB1, RRAS, AR, TRADD, BMPR2, RAP1A, PTEN, BMPR1A, CDK2, CDK4, WEE1, DCAKD, TP53, CDK7, ATF1, IRS1, HDAC1, TAB1

WP1991

SRF and miRs in Smooth Muscle Differentiation and Proliferation

WikiPathways

MEF2C, MEF2D, MEF2A, ELK1, CAMK2D, KLF4, CCND2

WP1992

TarBasePathway

WikiPathways

TMSB4X, HDAC4, IGF1, GJA1, PTBP2

WP1995

Effects of Nitric Oxide

WikiPathways

HBA1, NOS3, XDH, AOX1

WP2007

Iron metabolism in placenta

WikiPathways

SLC11A2, FTH1, TFR2, TFRC, SLC40A1, TF, HAMP

WP2011

SREBF and miR33 in cholesterol and lipid homeostasis

WikiPathways

SREBF2, MED15, PPARGC1A, ABCA1, HMGCS1, PPARA, LDLR, SCD, FASN, SREBF1, HMGCR, NR1H3

WP2012

miRs in Muscle Cell Differentiation

WikiPathways

MEF2C, EZH2, MEF2D, PRKCB, MEF2A, PRKCA, PRKAR2B, PRKD1, PRKCI, PRKCD, PRKCQ, PRKACA, ID2, PRKAR1A, PRKAR2A

WP2018

RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway

WikiPathways

JUN, ICAM1, SQSTM1, TNFSF11, MAPK9, PTK2, MAP2K1, MAP2K7, PAPSS2, MAP2K6, MAP3K7, AKT1, TNFRSF11B, AKT2, CTSK, VCAM1, MAPK3, NFKB1, RAC1, MAPK1, MAPK8, RELB, MAPK14, RELA, SYK, TNFRSF11A, TRAF1, MITF, TAB1, NFATC1, FOS, PIK3R1, LYN, CDC42

WP2029

Cell Differentiation - Index

WikiPathways

MEF2C, MEF2D, STAT3, MEF2A, HDAC5, MIR155

WP2032

Human Thyroid Stimulating Hormone (TSH) signaling pathway

WikiPathways

PAX8, JUN, PLCB1, E2F1, STAT3, RAF1, IGF1R, MAP2K1, CGA, MAP2K6, RB1, CREB1, JAK1, AKT1, JAK2, TTF2, MAPK3, RPS6, MYC, RPS6KA1, MAPK1, EGR1, MAPK14, PDE4D, GNA12, CDKN1B, GNAI1, GNAI2, ADCY3, RAP1A, CDK2, GNAQ, CDK4, GNAS, GNAI3, RALGDS, PIK3CA, GNB1, PLD1, FOS, PIK3R1, CCND3

WP2034

Leptin signaling pathway

WikiPathways

PTPN11, STAT3, RAF1, ELK1, ESR1, SOCS2, RHOA, EIF4E, EIF4EBP1, BAD, KHDRBS1, ERBB2, PTK2, NOS3, MAP2K2, MAP2K1, BAX, CREB1, JAK1, AKT1, JAK2, LEPR, GRB2, LEP, ACACB, SH2B1, MAPK3, STAT5B, NFKB1, RAC1, SOS1, RPS6, MAPK1, RPS6KA1, PDE3B, MAPK8, MAPK14, RELA, GSK3B, KPNA4, NCOA1, PRKAA2, IL1B, SOCS3, IL1RN, ROCK2, REL, PTEN, FOXO1, PLCG2, IRS1, FYN, PIK3R1, CDC42

WP2035

Follicle Stimulating Hormone (FSH) signaling pathway

WikiPathways

MAPK14, RAF1, PRKCA, TSC2, BDNF, EIF4EBP1, RHEB, FOXO1, PRKACA, CREB1, CGA, FSHB, CYP19A1, GRK6, AKT1, FSHR, AREG, MAPK3, RPS6, MAPK1

WP2036

TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway

WikiPathways

JUN, CASP8, MAPK8, RELB, MAPK14, RAF1, RELA, TNF, GSK3B, BIRC3, CCL2, CTNNB1, CCL5, FADD, RIPK1, TRAF1, MAPK9, MMP9, MAP3K7, AKT1, AKT2, TNFRSF12A, HDAC1, MAPK3, NFKB1, IL6, RAC1, MAPK1

WP2037

Prolactin Signaling Pathway

WikiPathways

JUN, STAT3, PTPN11, RAF1, ELK1, PPIB, NEK3, PPIA, SOCS2, EIF4EBP1, MAPK9, PTK2, ERBB2, MAP2K2, MAP2K1, VAV1, JAK1, AKT1, JAK2, RPS6KA2, ITGB1, GRB2, MAPK3, STAT5B, STAT5A, NFKB1, RAC1, SOS1, MYC, RPS6, MAPK1, MAPK8, MAPK14, PRLR, RELA, FLNA, GSK3B, PRL, SOCS1, IRF1, SOCS3, CTSD, SIRPA, IRS2, PIK3CA, PIK3CB, YWHAZ, IRS1, FYN, FOS, PIK3CG, PIK3R1

WP2038

Regulation of Microtubule Cytoskeleton

WikiPathways

PARD6A, STAT3, PRKCA, TPPP, MAPKAPK2, GSK3B, MAPRE1, CDK1, DPYSL2, STMN1, MAP1B, TAOK1, EPHB2, PTEN, MAPT, MARK1, PRKACA, APC, GNAQ, AKT1, PHLDB2, PIK3CA, AURKB, KIF2C, CLIP1, TIAM1, RAC1, SPRED1, CDC42

WP205

IL-7 Signaling Pathway

WikiPathways

STAT3, GSK3B, CDKN1B, BAD, IL7R, MAP2K2, MAP2K1, JAK1, AKT1, JAK3, STAT5B, MAPK3, STAT5A, FYN, PIK3R1, MYC, MAPK1

WP2059

Alzheimers Disease

WikiPathways

CALM2, NAE1, PPP3R2, ATP2A2, ADAM17, MME, ITPR3, APOE, MIR21, LPL, HSD17B10, APH1A, GAPDH, ATF6, IDE, ADAM10, ERN1, GNAQ, APBB1, CYCS, MIR132, CALM3, CASP9, CASP8, PLCB1, TNF, RYR3, FADD, BAD, GRIN2A, BID, CACNA1C, MAPK3, MAPK1, ITPR1, ITPR2, PSEN2, GSK3B, PSEN1, IL1B, SNCA, MAPT, TP53, PPP3CA, APP, CDK5, FAS, CHP1

WP206

Fatty Acid Omega Oxidation

WikiPathways

ADH1B, CYP2E1, ALDH1A1, ALDH2, CYP3A4, CYP2A6, CYP1A1, ADH7, CYP2D6