hsa01212

Fatty acid metabolism

KEGG

CPT1A, CPT1B, ECHS1, HACD2, ACSL1, ACSL4, FASN, ACSL6, HADHB, HADH, ACADSB, ACADVL, ACAT2, FADS1, HACD4, ACOX1, MECR, HSD17B12, HACD3, PPT1, ELOVL5, SCD, ELOVL6, SCD5, ACOX3, HACD1, PPT2, FADS2

hsa01230

Biosynthesis of amino acids

KEGG

CTH, ENO1, ENO2, ENO3, ALDOA, ALDOC, GAPDH, PHGDH, MAT2B, GOT2, PSAT1, IDH1, IDH2, IDH3B, MAT2A, ASS1, MTR, ACO2, ALDH7A1, PC, PFKL, PGAM1, PGK1, PKM, PRPS1, PRPS2, ALDH18A1, BCAT1, SHMT1, PYCRL, TALDO1, TKT, TPI1, GPT2, CBS

hsa01521

EGFR tyrosine kinase inhibitor resistance

KEGG

AKT3, BCL2L11, EGFR, EIF4E, EIF4EBP1, ERBB2, ERBB3, AKT1, AKT2, FGF2, FGFR2, FOXO3, GAB1, SHC2, GAS6, GRB2, GSK3B, HGF, NRG1, IGF1, IGF1R, IL6, IL6R, JAK1, JAK2, KRAS, MET, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PRKCA, PRKCB, MAPK1, MAPK3, PDGFC, MAP2K1, MAP2K2, BAD, PTEN, BAX, RAF1, BCL2, RPS6, SOS1, SOS2, STAT3, TGFA, VEGFA, PDGFD, EIF4E2

hsa01522

Endocrine resistance

KEGG

AKT3, CDK4, CDKN1A, CDKN1B, CDKN2C, CARM1, ADCY3, ADCY7, ADCY9, MAPK14, CYP2D6, JAG1, HBEGF, E2F1, E2F2, EGFR, ERBB2, AKT1, AKT2, ESR1, ESR2, FOS, SHC2, GNAS, GPER1, GRB2, IGF1, IGF1R, JUN, KRAS, MDM2, MMP2, MMP9, NOTCH1, NOTCH2, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, DLL4, PRKACA, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, BAD, PTK2, BAX, RAF1, RB1, BCL2, SOS1, SOS2, TP53, NCOA3, NCOR1

hsa01523

Antifolate resistance

KEGG

ABCC5, ABCC4, SLC46A1, DHFR, FOLR1, GART, IL1B, IL6, ABCC1, MTHFR, NFKB1, RELA, SHMT1, SLC19A1, TNF, TYMS, GGH

hsa01524

Platinum drug resistance

KEGG

AKT3, CDKN1A, GSTO2, SLC31A1, ERBB2, ERCC1, AKT1, AKT2, BBC3, GSTA1, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTP1, GSTT1, GSTT2, MSH6, BIRC3, XIAP, BIRC5, FAS, MDM2, MAP3K5, MGST1, MGST2, MGST3, MLH1, MSH2, MSH3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PMAIP1, CYCS, POLH, MAPK1, MAPK3, BAD, BAX, BCL2, REV3L, BID, BRCA1, TOP2A, TP53, XPA, CASP8, CASP9, FADD, GSTO1

hsa02010

ABC transporters

KEGG

ABCC5, ABCB6, ABCC4, ABCA8, CFTR, ABCA1, ABCB10, ABCA6, ABCA5, ABCC1, ABCD3, ABCD4, ABCG8, ABCC10

hsa03008

Ribosome biogenesis in eukaryotes

KEGG

RCL1, POP7, EMG1, NXF1, NOP56, RPP30, TBL3, POP4, RPP40, WDR3, WDR36, RPP25L, DKC1, MDN1, REXO2, GNL3, RRP7A, NOB1, NXT1, EIF6, SNU13, FCF1, UTP18, SBDS, POP5, GAR1, XRN1, GNL3L, RPP25, NOP10, REXO1, TCOF1, XPO1, UTP15, UTP4

hsa03010

Ribosome

KEGG

RPL35, RPL22L1, FAU, MRPL21, RPL13A, RPL36, MRPL15, RPSA, RPL10A, RPS27L, MRPL4, MRPS2, MRPL30, MRPL35, MRPS21, MRPL16, MRPS18A, MRPS10, RPL4, RPL5, RPL7, RPL7A, RPL10, RPL11, RPL12, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23A, MRPL23, RPL24, RPL26, RPL27, RPL30, RPL27A, RPL28, RPL29, RPL31, RPL32, RPL34, RPL35A, RPL36AL, RPL37, RPL37A, RPL38, RPL41, RPL36A, RPLP0, RPLP1, RPLP2, MRPL12, MRPS12, RPS2, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS18, RPS20, RPS21, RPS25, RPS26, RPS27, RPS27A, MRPL17, MRPS14, MRPL14, MRPS5, MRPL36, MRPL34, MRPL32, MRPL1, UBA52, RPL14, MRPL33, MRPL19

hsa03013

RNA transport

KEGG

ALYREF, EIF1, POP7, SRRM1, SAP18, EIF1B, TACC3, NXF1, RPP30, PAIP1, NUP50, POP4, RPP40, RNPS1, NUPL2, DDX20, NUP35, RPP25L, EEF1A1, EEF1A2, EIF1AX, EIF2S1, EIF2B1, EIF2S3, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4EBP2, EIF5, NUP205, CYFIP1, NUP210, NUP160, FMR1, NUP62, GEMIN5, UPF2, CYFIP2, NXT1, NUP43, KPNB1, SUMO4, NCBP1, NUP88, PABPC3, GEMIN4, TRNT1, POP5, PHAX, PNN, RPP25, GEMIN8, NDC1, NUP107, THOC2, RANBP2, RANGAP1, ELAC2, SEC13, UPF3A, SUMO3, SUMO2, TPR, UBE2I, XPO1, NUP37, GEMIN6, NUP85, THOC7, PABPC1L, FXR1, SEH1L, THOC3, RAE1, EIF3A, EIF3B, EIF3J, EIF4G3, EIF2B4, EIF2B3, EIF2B5, EIF4E2, NUP155, EIF5B, NUP93, NUP58, RBM8A, NUP153

hsa03015

mRNA surveillance pathway

KEGG

ALYREF, SRRM1, SAP18, NXF1, HBS1L, PAPOLA, RNPS1, NUDT21, MSI2, CSTF3, SMG1, SMG5, UPF2, DAZAP1, SSU72, NXT1, GSPT1, CPSF1, NCBP1, PABPC3, PELO, CPSF2, PNN, PPP1CA, PPP1CB, PPP1CC, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3A, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PAPOLG, UPF3A, PABPC1L, PABPN1, FIP1L1, SYMPK, RBM8A

hsa03018

RNA degradation

KEGG

C1D, TOB2, LSM6, EXOSC8, EXOSC6, NUDT16, DCP2, DHX36, ENO1, ENO2, ENO3, PATL1, DIS3, EXOSC7, CNOT1, EXOSC2, SKIV2L2, LSM5, PAN3, LSM4, LSM3, CNOT7, HSPD1, CNOT3, CNOT4, PABPC3, PARN, EXOSC3, LSM7, LSM8, PFKL, EXOSC9, XRN1, EXOSC4, CNOT6, LSM2, PAPD5, BTG1, BTG2, EDC3, PABPC1L, ZCCHC7, PNPT1

hsa03020

RNA polymerase

KEGG

POLR3F, POLR3G, POLR3C, POLR2J2, POLR1A, ZNRD1, POLR1D, POLR3K, POLR2A, POLR2B, POLR2D, POLR2E, POLR2G, POLR2I, POLR2J, POLR2K, POLR2L, POLR3B, POLR1E, POLR3GL, POLR1C

hsa03022

Basal transcription factors

KEGG

CDK7, GTF2A1L, ERCC2, GTF2A1, GTF2A2, GTF2B, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H4, GTF2I, TAF9B, TAF5, TAF10, TAF11, TAF12, GTF2H2C_2, TAF15

hsa03030

DNA replication

KEGG

RNASEH2A, POLD3, DNA2, FEN1, POLA2, LIG1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, PCNA, POLE3, POLA1, POLD1, POLE, POLE2, PRIM1, PRIM2, POLE4, POLD4, RFC2, RFC3, RFC4, RFC5, RPA3, SSBP1, RNASEH2B

hsa03040

Spliceosome

KEGG

PQBP1, ALYREF, PPIE, PPIH, CHERP, SRSF10, SF3A3, SNRNP27, LSM6, ZMAT2, DDX5, DHX15, HNRNPA3, PUF60, U2SURP, LSM5, LSM4, PRPF31, LSM3, RBMX, PRPF19, TRA2A, HNRNPA1, HNRNPC, HNRNPU, HSPA1A, HSPA1B, HSPA1L, HSPA6, HNRNPM, NCBP1, SNU13, PCBP1, CRNKL1, CWC15, SF3B6, LSM7, LSM8, PLRG1, PRPF40A, RBM22, THOC2, LSM2, RBM25, RP9, SRSF1, SRSF2, SRSF5, SRSF6, TRA2B, SNRPA, SNRPA1, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPF, SF3B5, THOC3, DHX16, RBM17, PRPF18, SRSF9, BUD31, PRPF3, SNRNP40, DDX23, DDX46, CDC5L, RBM8A

hsa03050

Proteasome

KEGG

PSME3, ADRM1, PSME4, POMP, PSMA1, PSMA2, PSMA3, PSMA4, PSMB1, PSMB3, PSMB4, PSMB5, PSMB8, PSMB9, PSMB10, PSMC1, PSMC2, PSMC3, PSMC4, PSMC6, PSMD2, PSMD3, PSMD7, PSMD11, PSMD12, SHFM1

hsa03060

Protein export

KEGG

SEC63, SEC61G, SEC61A1, HSPA5, SEC61A2, SRPRB, SRP9, SRP14, SRP54, SRP72, SEC62, SEC11C, SPCS2

hsa03320

PPAR signaling pathway

KEGG

NR1H3, SORBS1, SLC27A4, SLC27A2, APOA5, PLIN2, CPT1A, CPT1B, CYP8B1, DBI, FABP4, FABP3, FABP5, FABP6, ACSL1, ACSL4, ACSL6, GK, SLC27A6, APOA1, APOA2, APOC3, ILK, SLC27A1, LPL, MMP1, PLIN5, OLR1, ACOX1, PCK1, PCK2, PLIN1, PPARA, PPARD, PPARG, RXRB, SCD, SCP2, PLIN4, UBC, UCP1, SCD5, ACOX2, ACOX3, ADIPOQ, FADS2, CD36

hsa03410

Base excision repair

KEGG

PARP2, POLD3, PARP1, FEN1, SMUG1, HMGB1, LIG1, MPG, MUTYH, NTHL1, PCNA, POLE3, POLD1, POLE, POLE2, NEIL3, POLE4, POLD4, TDG, UNG, MBD4

hsa03420

Nucleotide excision repair

KEGG

CDK7, POLD3, ERCC1, ERCC2, ERCC4, GTF2H1, GTF2H2, GTF2H4, LIG1, PCNA, POLE3, POLD1, POLE, POLE2, POLE4, POLD4, RAD23A, RAD23B, RFC2, RFC3, RFC4, RFC5, RPA3, GTF2H2C_2, XPA, XPC, CUL4B, CUL4A, RBX1

hsa03430

Mismatch repair

KEGG

POLD3, MLH3, MSH6, LIG1, MLH1, MSH2, MSH3, PCNA, POLD1, POLD4, RFC2, RFC3, RFC4, RFC5, RPA3, SSBP1, EXO1

hsa03440

Homologous recombination

KEGG

RAD50, POLD3, TOPBP1, EME1, RAD54B, MRE11A, NBN, POLD1, POLD4, BARD1, RAD51, RAD51C, RAD51D, RPA3, BLM, BRCA1, SSBP1, BRCA2, BRCC3, SHFM1, RAD54L

hsa03450

Non-homologous end-joining

KEGG

RAD50, FEN1, MRE11A, PRKDC, DCLRE1C, XRCC4, XRCC5

hsa03460

Fanconi anemia pathway

KEGG

POLI, EME1, EME2, STRA13, ERCC1, ERCC4, FANCD2, FANCE, FANCB, FANCG, FAN1, UBE2T, HES1, APITD1, MLH1, POLK, POLH, FANCI, WDR48, FANCM, RAD51, RAD51C, REV3L, RPA3, BLM, BRCA1, BRCA2, USP1, FAAP100, ATRIP

hsa04010

MAPK signaling pathway

KEGG

AKT3, RASGRP2, TAB1, GADD45G, DUSP10, MAP3K8, CRKL, MAPK14, GADD45A, DDIT3, DUSP1, DUSP2, DUSP3, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, EGFR, ELK1, AKT1, AKT2, FGF2, FGF7, FGF9, FGF11, FGF12, FGF13, FGF14, FGFR1, FGFR2, RRAS2, FLNA, MAPK8IP3, FLNB, FLNC, FOS, MAPK8IP2, GNA12, MKNK2, GRB2, NR4A1, HSPA1A, HSPA1B, HSPA1L, HSPA6, HSPB1, FAS, IL1A, IL1B, IL1R1, JUN, JUND, KRAS, STMN1, MAPT, MEF2C, MAP3K4, MAP3K5, MYC, GADD45B, ATF4, NFATC1, NFKB1, NGF, NRAS, NTRK1, NTRK2, PAK2, TAOK3, PDGFA, PDGFB, PDGFRA, PDGFRB, NLK, ZAK, PLA2G4A, PPM1A, PPM1B, PPP3CA, PPP3R2, PRKACA, PRKCA, PRKCB, MAPK1, MAPK3, MAPK7, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, MAP2K5, MAP2K6, MAP2K7, TAOK1, RAC1, RAC2, RAC3, RAF1, RAP1A, RASA1, RASA2, CACNG8, CACNG6, RELA, RELB, RPS6KA1, RPS6KA2, RRAS, BDNF, SOS1, SOS2, STK4, MAP3K7, TGFB1, TGFB2, TGFBR1, TGFBR2, TNF, TP53, CACNA1C, CACNA1E, CACNA2D1, CACNB3, IL1R2, DUSP16, MAP4K3, MKNK1, PLA2G4C, LAMTOR3, FGF18, CACNA1G, MAP3K13, RPS6KA5, MAPKAPK2, CD14, TAOK2, MAP4K4, MAPK8IP1, CDC25B, FGF19, CDC42

hsa04012

ErbB signaling pathway

KEGG

AKT3, CDKN1A, CDKN1B, CRKL, HBEGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, AKT1, AKT2, GAB1, SHC2, ABL2, GRB2, GSK3B, NRG1, JUN, AREG, KRAS, MYC, NRAS, PAK2, PAK3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK9, MAP2K1, MAP2K2, MAP2K7, PAK7, BAD, PTK2, RAF1, SOS1, SOS2, STAT5A, STAT5B, BTC, TGFA, CAMK2D, CBLB

hsa04014

Ras signaling pathway

KEGG

AKT3, RASA4, RASGRP2, RALBP1, PLA2G16, RASSF1, CSF1R, EFNA1, EFNA4, EFNA5, EGFR, ELK1, AKT1, AKT2, ETS1, ETS2, FGF2, FGF7, FGF9, FGF11, FGF12, FGF13, FGF14, FGFR1, FGFR2, RRAS2, RASA3, RGL1, FLT4, GAB1, SHC2, ABL2, GNB1, GNB2, GNB3, GNG4, GNG5, GNG7, GNG11, ANGPT1, ANGPT2, GRB2, GRIN2A, TBK1, HGF, HTR7, IGF1, IGF1R, INS, INSR, KIT, KRAS, RHOA, MET, KITLG, FOXO4, NFKB1, NGF, NGFR, NRAS, PAK2, PAK3, PLA1A, PDGFA, PDGFB, PDGFRA, PDGFRB, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLA2G2A, PLA2G4A, PLA2G5, PLCG2, PLD1, PRKACA, EXOC2, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK9, PDGFC, MAP2K1, MAP2K2, PAK7, BAD, PTPN11, RAB5A, RAB5B, RAB5C, RAC1, RAC2, RAC3, RAF1, RALA, RALB, RALGDS, RAP1A, RASA1, RASA2, REL, RELA, RRAS, SOS1, SOS2, STK4, TEK, TIAM1, VEGFA, VEGFB, VEGFC, PDGFD, CALM2, CALM3, PLA2G12A, RASSF5, PLA2G4C, FGF18, SYNGAP1, CALML4, RASAL2, FGF19, CDC42

hsa04015

Rap1 signaling pathway

KEGG

AKT3, RASGRP2, ADCY3, RAPGEF4, ADCY7, ADCY9, CNR1, ADORA2B, CRKL, MAPK14, CSF1R, CTNNB1, CTNND1, DRD2, EFNA1, EFNA4, EFNA5, EGFR, AKT1, AKT2, F2R, FGF2, FGF7, FGF9, FGF11, FGF12, FGF13, FGF14, FGFR1, FGFR2, PLCB1, FLT4, FPR1, FYB, PRKD2, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, ANGPT1, ANGPT2, RAPGEF1, GRIN2A, HGF, ID1, IGF1, IGF1R, INS, INSR, ITGAM, ITGB1, ITGB2, ITGB3, KIT, KRAS, RHOA, MET, KITLG, NGF, NGFR, NRAS, PARD6A, PDGFA, PDGFB, PDGFRA, PDGFRB, RAPGEF6, PFN1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PRKCA, PRKCB, PRKCI, PRKD1, MAPK1, MAPK3, MAPK13, PDGFC, MAP2K1, MAP2K2, MAP2K6, PARD3, SIPA1L2, RAC1, RAC2, RAC3, RAF1, RALA, RALB, RALGDS, RAP1A, ACTB, RRAS, ARAP3, TEK, THBS1, TIAM1, TLN1, ACTG1, VEGFA, VEGFB, VEGFC, PDGFD, CALM2, CALM3, RASSF5, PARD6B, FGF18, KRIT1, CALML4, MAGI1, FARP2, MAGI2, FGF19, CDC42

hsa04020

Calcium signaling pathway

KEGG

PPIF, ADCY3, CHRM2, ADCY7, CHRM3, CHRNA7, ADCY9, ADORA2B, ADRA1D, ADRA1B, ADRA1A, ADRB1, ADRB2, ADRB3, AGTR1, EDNRA, EGFR, ERBB2, ERBB3, ERBB4, F2R, PLCB1, GNA11, GNAQ, GNAS, GRIN2A, SLC25A4, SLC25A5, HRH1, HTR2B, HTR2C, HTR7, ITPKA, ITPR1, ITPR2, ITPR3, LHCGR, MYLK, NOS3, ATP2A2, ATP2B1, ATP2B4, OXTR, P2RX4, PDGFRA, PDGFRB, PHKA1, PHKA2, PLCD1, PLCG2, PLN, PPP3CA, PPP3R2, PRKACA, PRKCA, PRKCB, PTAFR, PTGER3, PTGFR, STIM2, RYR2, RYR3, VDAC2, VDAC3, CACNA1C, CACNA1E, ORAI2, CALM2, CALM3, CAMK2D, CCKBR, SPHK1, CACNA1G, CALML4, ORAI3

hsa04022

cGMP-PKG signaling pathway

KEGG

AKT3, PPIF, MYL9, ADCY3, ADCY7, ADCY9, CNGA1, ADORA1, CREB1, ADRA1D, ADRA1B, ADRA1A, ADRA2B, ADRB1, ADRB2, ADRB3, AGTR1, EDNRA, AKT1, AKT2, PLCB1, GATA4, GNA11, GNA12, GNAI1, GNAI2, GNAI3, GNAQ, SLC25A4, SLC25A5, GTF2I, INS, INSR, IRS1, ITPR1, ITPR2, ITPR3, KCNMA1, RHOA, MEF2A, MEF2C, MEF2D, MYLK, PPP1R12A, ATF4, ATP1A2, NFATC1, NFATC2, NFATC4, ATP1B1, ATP1B3, NOS3, NPPB, ATP2A2, NPR2, ATP2B1, ATP2B4, PDE3A, PDE3B, PIK3CG, PLN, PPP1CA, PPP1CB, PPP1CC, PPP3CA, PPP3R2, MAPK1, MAPK3, MAP2K1, MAP2K2, BAD, RAF1, RGS2, TRPC6, VDAC2, VDAC3, CACNA1C, CALM2, CALM3, IRS4, PDE5A, IRS2, CREB3L1, CALML4, ROCK2, CREB5

hsa04024

cAMP signaling pathway

KEGG

AKT3, ABCC4, MYL9, VAV3, CFTR, ADCY3, RAPGEF4, CHRM2, ADCY7, ADCY9, ADCYAP1R1, CNGA1, ADORA1, CREB1, CREBBP, ADRB1, ADRB2, DRD2, EDNRA, EP300, AKT1, AKT2, F2R, RRAS2, FOS, FSHB, FSHR, GABBR1, AMH, GHSR, GLI3, GNAI1, GNAI2, GNAI3, GNAS, GRIA4, GRIN2A, JUN, RHOA, LIPE, MC2R, PPP1R12A, ATP1A2, NFATC1, NFKB1, ATP1B1, ATP1B3, ATP2A2, NPY1R, ATP2B1, ATP2B4, OXTR, ACOX1, PDE3A, PDE3B, PDE4C, PDE4D, GHRL, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLD1, FXYD1, PLN, PPARA, PPP1CA, PPP1CB, PPP1CC, PRKACA, MAPK1, MAPK3, MAPK8, MAPK9, MAP2K1, MAP2K2, BAD, PTCH1, PTGER2, PTGER3, RAC1, RAC2, RAC3, RAF1, RAP1A, RELA, RRAS, RYR2, BDNF, HHIP, ARAP3, SOX9, SSTR1, SSTR5, TIAM1, TNNI3, VAV1, CACNA1C, CALM2, CALM3, CAMK2D, ACOX3, CREB3L1, CALML4, ROCK2, GABBR2, CREB5

hsa04060

Cytokine-cytokine receptor interaction

KEGG

TNFSF13B, CSF1R, CSF3R, CTF1, EGFR, EPOR, FLT4, CLCF1, AMH, GH1, AMHR2, GHR, TNFRSF21, CXCL1, CXCL2, HGF, IFNE, IFNA1 , IFNA16, IFNAR1, IFNAR2, IFNGR1, IFNGR2, FAS, IL1A, IL1B, IL1R1, IL1RAP, IL4R, IL5RA, IL6, IL6R, IL6ST, IL7R, CXCL8, CXCR2, IL9R, IL10, IL10RB, IL11, IL12A, IL12RB1, IL18, INHBA, INHBB, INHBC, KIT, LEP, LEPR, LIF, LIFR, LTBR, MET, KITLG, NGFR, TNFRSF11B, TNFRSF12A, PDGFA, PDGFB, PDGFRA, PDGFRB, PF4, PPBP, TNFRSF19, IL17RB, PDGFC, PRL, PRLR, CXCL16, CCL2, CCL3, CCL4, CCL5, CCL8, CCL20, CXCL6, CXCL5, CXCL12, BMP2, BMPR1A, BMPR2, TGFB1, TGFB2, TGFBR1, TGFBR2, TNF, TNFRSF1B, TNFSF4, VEGFA, VEGFB, VEGFC, IL1R2, CXCR4, GDF5, TNFSF11, TNFRSF25, TNFSF13, TNFSF10, TNFRSF11A, TNFRSF10C, IL18R1, ACVR1, ACVR1B, OSMR, ACVR2A, ACVR2B, CD27, TNFRSF8, CXCL14, CD40LG

hsa04062

Chemokine signaling pathway

KEGG

AKT3, RASGRP2, VAV3, ADCY3, ADCY7, ADCY9, CRKL, ADRBK2, DOCK2, AKT1, AKT2, FGR, FOXO3, PLCB1, SHC2, GNAI1, GNAI2, GNAI3, GNB1, GNB2, GNB3, GNG4, GNG5, GNG7, GNG11, GRK5, GRK6, GRB2, CXCL1, CXCL2, GSK3B, CXCL8, CXCR2, JAK2, JAK3, KRAS, RHOA, LYN, NFKB1, NRAS, PF4, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PPBP, PRKACA, PRKCB, PRKCD, MAPK1, MAPK3, MAP2K1, PARD3, PTK2, CXCL16, RAC1, RAC2, RAF1, RAP1A, RELA, CCL2, CCL3, CCL4, CCL5, CCL8, CCL20, CXCL6, CXCL5, CXCL12, SOS1, SOS2, STAT2, STAT3, STAT5B, TIAM1, VAV1, CXCR4, WASL, ROCK2, ELMO1, CDC42

hsa04064

NF-kappa B signaling pathway

KEGG

TAB1, TNFSF13B, TIRAP, PARP1, ERC1, TAB3, CXCL2, BLNK, CARD10, BIRC3, XIAP, ICAM1, IL1B, IL1R1, CXCL8, IRAK1, LTBR, LYN, GADD45B, NFKB1, PLAU, PLCG2, PRKCB, PRKCQ, PTGS2, BCL2, RELA, RELB, CCL4, CXCL12, SYK, MAP3K7, TLR4, TNF, TNFAIP3, TRAF1, UBE2I, VCAM1, TRIM25, TNFSF11, TRADD, RIPK1, TNFRSF11A, CFLAR, BCL10, CD14, CD40LG

hsa04066

HIF-1 signaling pathway

KEGG

AKT3, CDKN1A, CDKN1B, EGLN3, CREBBP, CYBB, EDN1, EGFR, EIF4E, EIF4EBP1, ENO1, ENO2, ENO3, EP300, ERBB2, AKT1, AKT2, ALDOA, GAPDH, ANGPT1, ANGPT2, MKNK2, HIF1A, HK1, HMOX1, IFNGR1, IFNGR2, IGF1, IGF1R, IL6, IL6R, INS, INSR, LDHA, ARNT, LTBR, NFKB1, NOS3, SERPINE1, PDHA1, PDHB, PDK1, PFKFB3, PFKL, PGK1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, MAP2K2, BCL2, RELA, RPS6, SLC2A1, STAT3, TCEB1, TCEB2, TEK, TF, TFRC, TIMP1, TLR4, VEGFA, HKDC1, CAMK2D, CUL2, MKNK1, EIF4E2, RBX1

hsa04068

FoxO signaling pathway

KEGG

AKT3, BCL2L11, CDK2, CDKN1A, CDKN1B, CDKN2B, KLF2, PLK4, PLK2, GADD45G, GABARAP, GABARAPL2, FBXO32, CREBBP, MAPK14, CSNK1E, GADD45A, S1PR1, EGFR, EP300, AKT1, AKT2, FOXG1, FOXO1, FOXO3, SGK3, GABARAPL1, G6PC, FBXO25, GRB2, PRMT1, IGF1, IGF1R, IL6, IL7R, IL10, INS, INSR, IRS1, KRAS, SMAD2, SMAD3, SMAD4, MDM2, FOXO4, GADD45B, NRAS, PCK1, PCK2, NLK, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLK1, PRKAG3, PRKAA2, PRKAG1, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, PTEN, RAF1, RAG1, BCL6, SKP2, SLC2A4, BNIP3, SOD2, SOS1, SOS2, STAT3, STK4, STK11, TGFB1, TGFB2, TGFBR1, TGFBR2, SETD7, IRS4, IRS2, TNFSF10, CCNB1, CCND2, CCNG2, CCNB2, ATG12, G6PC3, HOMER3, HOMER1

hsa04070

Phosphatidylinositol signaling system

KEGG

CDS1, DGKK, DGKH, PIKFYVE, PLCB1, PIP5K1C, IMPA1, INPP1, INPP4A, INPP5A, INPP5D, ITPK1, ITPKA, ITPR1, ITPR2, ITPR3, MTM1, OCRL, IP6K2, INPP5K, PIK3C2A, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PI4KB, PIP4K2A, PLCD1, PLCG2, PRKCA, PRKCB, INPP5E, PTEN, CALM2, CALM3, PIP5K1B, PIP4K2B, DGKZ, CDS2, MTMR1, INPP4B, SYNJ1, SYNJ2, MTMR2, MTMR4, CALML4, PPIP5K1

hsa04071

Sphingolipid signaling pathway

KEGG

AKT3, SGPP2, ADORA1, MAPK14, CTSD, SGMS2, S1PR1, S1PR3, AKT1, AKT2, PLCB1, FYN, CERS6, SGMS1, GNA12, GNAI1, GNAI2, GNAI3, GNAQ, KRAS, RHOA, MAP3K5, ASAH1, ABCC1, NFKB1, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLD1, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3A, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, PTEN, BAX, RAC1, RAC2, RAC3, RAF1, BCL2, RELA, BID, TNF, TP53, CERS4, NSMAF, TRADD, SPHK1, CERS5, ROCK2, SPTLC2

hsa04072

Phospholipase D signaling pathway

KEGG

AKT3, ADCY3, RAPGEF4, ADCY7, ADCY9, DGKK, DGKH, AGTR1, EGFR, AKT1, AKT2, F2R, RRAS2, PLCB1, PIP5K1C, FYN, GAB1, SHC2, GNA12, GNAS, GRB2, GRM3, GRM6, GRM8, CXCL8, CXCR2, INS, INSR, ARF1, KIT, KRAS, RHOA, KITLG, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PLA2G4A, PLCG2, PLD1, AVPR2, PRKCA, MAPK1, MAPK3, PDGFC, MAP2K1, MAP2K2, AGPAT3, AGPAT4, PTGFR, PTPN11, RAF1, RALA, RALB, RALGDS, RHEB, RRAS, SOS1, SOS2, SYK, TSC2, PDGFD, PIP5K1B, DGKZ, PLA2G4C, PLPP1, PLPP3, SPHK1, CYTH3, CYTH2

hsa04080

Neuroactive ligand-receptor interaction

KEGG

CGA, HRH3, CHRM2, CHRM3, CHRNA5, CHRNA7, CHRNB1, ADCYAP1R1, CNR1, ADORA1, ADORA2B, ADRA1D, ADRA1B, ADRA1A, ADRA2B, ADRB1, ADRB2, ADRB3, DRD2, AGTR1, AGTR2, S1PR1, S1PR3, EDNRA, F2, F2R, F2RL1, FPR1, FPR2, FSHB, FSHR, GABBR1, GABRA5, GH1, GHR, GHSR, GLRB, GNRHR, NPBWR1, P2RY8, GRIA4, GRIN2A, NR3C1, GRM3, GRM6, GRM8, HRH1, HTR2B, HTR2C, HTR7, LEP, LEPR, LHB, LHCGR, MC2R, MC4R, MTNR1A, MTNR1B, NPY1R, NPY2R, NPY5R, OPRL1, OXTR, P2RX4, PLG, AVPR2, PRL, PRLR, PARD3, PRSS1, PRSS3, PTAFR, PTGDR, PTGER2, PTGER3, PTGER4, PTGFR, PTH2R, SSTR1, SSTR5, TSPO, THRA, C5AR1, TRPV1, KISS1R, CCKBR, GABBR2, P2RY14

hsa04110

Cell cycle

KEGG

CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2B, CDKN2C, ANAPC10, GADD45G, DBF4, CHEK1, CREBBP, GADD45A, E2F1, E2F2, EP300, ORC6, ORC3, SFN, GSK3B, ANAPC4, HDAC1, HDAC2, MAD2L1, SMAD2, SMAD3, SMAD4, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MYC, GADD45B, ORC1, ORC5, PCNA, FZR1, ANAPC5, PLK1, PRKDC, RAD21, RB1, RBL1, ANAPC1, SKP1, SKP2, BUB1, BUB1B, TFDP1, TGFB1, TGFB2, TP53, TTK, WEE1, YWHAB, YWHAE, YWHAH, YWHAZ, ZBTB17, SMC1A, CDC7, MAD1L1, CDC14B, CDC14A, CDC23, CCNA2, CCNA1, CCNB1, CCND2, CCND3, PKMYT1, SMC3, CCNB2, CCNE2, BUB3, PTTG1, ESPL1, CDK1, CDC6, CDC20, CDC25A, CDC25B, CDC25C, CDC27, RBX1

hsa04114

Oocyte meiosis

KEGG

CDK2, ANAPC10, ADCY3, ADCY7, ADCY9, CPEB2, SGOL1, CPEB3, FBXO5, ANAPC4, IGF1, IGF1R, INS, AR, ITPR1, ITPR2, ITPR3, MAD2L1, ANAPC5, PGR, PLK1, PPP1CA, PPP1CB, PPP1CC, PPP2CB, PPP2R1A, PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP3CA, PPP3R2, PRKACA, MAPK1, MAPK3, MAP2K1, RPS6KA1, RPS6KA2, ANAPC1, SKP1, AURKA, BUB1, YWHAB, YWHAE, YWHAH, YWHAZ, CPEB4, CALM2, CALM3, CAMK2D, SMC1A, CDC23, CCNB1, BTRC, PKMYT1, SMC3, CCNB2, CCNE2, CALML4, PTTG1, ESPL1, SLK, CDK1, CDC20, CDC25C, CDC27, RBX1

hsa04115

p53 signaling pathway

KEGG

CDK2, CDK4, CDK6, CDKN1A, GADD45G, CHEK1, SESN3, GADD45A, BBC3, SESN1, SFN, IGF1, IGFBP3, FAS, MDM2, MDM4, GADD45B, SERPINE1, GTSE1, SERPINB5, PMAIP1, CYCS, RPRM, PTEN, BAX, RRM2, BID, PERP, SIAH1, THBS1, TP53, TSC2, SESN2, CASP8, CASP9, CCNB1, CCND2, CCND3, CCNG1, CCNG2, CCNB2, CCNE2, CDK1

hsa04120

Ubiquitin mediated proteolysis

KEGG

SAE1, HUWE1, STUB1, UBE4B, ANAPC10, UBE2E3, WWP1, WWP2, UBE2C, UBE2J2, UBE2QL1, NEDD4L, PPIL2, HERC4, UBE2S, PRPF19, ANAPC4, BIRC3, XIAP, MDM2, MID1, TRIM37, PARK2, FZR1, UBR5, ANAPC5, UBE2D4, UBA6, UBE2W, KLHL9, ANAPC1, SMURF2, SIAH1, SKP1, SKP2, UBE2Z, BRCA1, TCEB1, TCEB2, UBA1, UBA7, UBE2A, UBE2B, UBE2D3, UBE2E1, UBE2E2, UBE2H, UBE2I, CUL5, ITCH, SYVN1, CUL4B, CUL4A, CUL3, CUL2, SOCS1, CBLB, CDC23, HERC3, BTRC, SOCS3, KLHL13, UBE2M, UBE3C, CUL7, CDC20, CDC27, CDC34, RBX1

hsa04122

Sulfur relay system

KEGG

MPST

hsa04130

SNARE interactions in vesicular transport

KEGG

STX6, VTI1B, STX2, BET1L, STX3, STX4, VAMP2, VAMP7, STX7, VAMP4, STX11, SNAP23, VAMP3, SNAP29, SEC22B, GOSR2

hsa04136

Autophagy - other

KEGG

GABARAP, GABARAPL2, GABARAPL1, WIPI2, PIK3R4, IGBP1, PIK3C3, WIPI1, ATG2B, PPP2CB, MLST8, ATG10, ATG12, ATG13

hsa04137

Mitophagy - animal

KEGG

OPTN, CALCOCO2, CITED2, GABARAP, GABARAPL2, E2F1, RRAS2, FOXO3, GABARAPL1, TBK1, HIF1A, JUN, KRAS, NBR1, MITF, ATF4, NRAS, PARK2, TOMM7, MAPK8, MAPK9, RELA, RRAS, TBC1D15, PINK1, BNIP3, BNIP3L, TP53, RAB7A, TFEB, ULK1, SQSTM1, TAX1BP1, MFN2, USP15

hsa04140

Autophagy - animal

KEGG

AKT3, GABARAP, GABARAPL2, CTSB, CTSD, CTSL, DAPK1, DAPK3, EIF2S1, AKT1, AKT2, ERN1, RRAS2, GABARAPL1, WIPI2, NRBF2, PIK3R4, HIF1A, HMGB1, IGBP1, IGF1R, INS, IRS1, ITPR1, KRAS, LAMP1, LAMP2, EIF2AK4, NRAS, SH3GLB1, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, ZFYVE1, DDIT4, WIPI1, ATG2B, PPP2CB, PRKAA2, PRKACA, PRKCD, PRKCQ, MAPK1, MAPK3, MAPK8, MAPK9, MAP2K1, MAP2K2, BAD, PTEN, TP53INP2, RRAGD, RAF1, BCL2, RHEB, RRAS, RRAGC, MLST8, DEPTOR, BNIP3, STK11, MAP3K7, TSC2, RAB7A, VMP1, ATG10, ULK1, IRS4, IRS2, CFLAR, ATG16L2, MTMR4, ATG12, SNAP29, ATG13, RB1CC1

hsa04141

Protein processing in endoplasmic reticulum

KEGG

PDIA6, BCAP31, STUB1, UBE4B, DNAJA2, SEC23A, HYOU1, HSPH1, OS9, ERP29, SEC63, MAN1B1, UBE2J2, CRYAB, DAD1, DDIT3, DDOST, EIF2S1, STT3B, ERN1, SEC31A, ATF6, GANAB, SEC61G, PPP1R15A, SVIP, AMFR, PDIA3, SEC61A1, ERO1A, DNAJB2, DNAJA1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA6, HSP90AA1, HSP90AB1, DNAJB1, STT3A, MAN1A1, MAP3K5, ATXN3, EIF2AK4, ATF4, P4HB, PARK2, DERL2, SAR1B, UBE2D4, DNAJC10, SEC61A2, VIMP, PRKCSH, NSFL1C, MAPK8, MAPK9, MAP2K7, DNAJC3, ERO1B, UGGT1, UBQLN4, MAN1C1, BAX, RAD23A, RAD23B, BCL2, RRBP1, SEC13, SEL1L, DNAJC1, SKP1, SSR1, SSR3, SSR4, SEC62, HSP90B1, UBE2D3, UFD1L, VCP, XBP1, EDEM3, UBXN6, CALR, CANX, SYVN1, PLAA, BAG2, PDIA4, EDEM1, SEC24D, RBX1

hsa04142

Lysosome

KEGG

AP3S2, TCIRG1, NPC2, CTSC, AP3M2, AP4S1, AP1S1, TPP1, CLN3, CLN5, CLTA, HGSNAT, CTSB, CTSD, CTSH, CTSK, CTSL, CTSS, CTSZ, AP1B1, GGA2, FUCA1, GAA, MFSD8, GALC, GALNS, GGA1, AP3M1, LAMP3, GM2A, GNS, SUMF1, HEXA, IGF2R, LAMP1, LAMP2, LIPA, ARSA, ARSB, MAN2B1, ASAH1, NAGLU, NEU1, NPC1, SLC11A2, NAGPA, ATP6V1H, ATP6V0A1, LAPTM4B, PPT1, PSAP, SGSH, SLC11A1, LAPTM5, GNPTAB, GNPTG, CTSF, CD164, AP1S2, AP1G2, AP3D1, ATP6V0D1, PPT2, LITAF, CD68

hsa04144

Endocytosis

KEGG

PDCD6IP, WASH1, ARPC4, ARPC3, ARPC2, STAM2, ARFGEF2, STAMBP, RAB31, WWP1, ARAP2, ARAP1, AGAP1, AP2M1, AP2S1, CLTA, CHMP4B, VPS37A, CSF1R, ADRB1, ADRB2, ADRB3, ADRBK2, DAB2, AP2A2, AP2B1, EGFR, EPS15, ERBB3, ERBB4, F2R, FGFR2, RAB11FIP2, SPG20, NEDD4L, PSD3, PIP5K1C, FOLR1, ACAP2, LDLRAP1, ARFGAP3, SNX5, CHMP2A, BIN1, GRK5, GRK6, GIT1, SNX12, EHD4, EHD3, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HSPA1A, HSPA1B, HSPA1L, HSPA6, IGF1R, IGF2R, CXCR2, ARF1, KIF5C, ARF5, KIT, RHOA, LDLR, SMAD2, SMAD3, MDM2, MET, NTRK1, ASAP1, PARD6A, CCDC53, SH3GLB1, VTA1, PDGFRA, VPS29, PLD1, VPS37C, VPS35, PRKCI, PARD3, RAB22A, SNX6, RAB5A, RAB5B, RAB5C, ARAP3, WIPF3, SH3GL2, SMURF2, SNX1, TFRC, TGFB1, TGFB2, TGFBR1, TGFBR2, CXCR4, RAB7A, RAB11FIP1, STAM, CAPZA1, CAPZB, ITCH, PIP5K1B, EEA1, ARFGAP2, PARD6B, CAV1, CAV2, CBLB, SNX4, SNX3, GBF1, RAB11A, ASAP2, WASL, RABEP1, RAB11B, CYTH3, CYTH2, MVB12A, VPS4B, VPS26A, RAB11FIP3, ZFYVE16, IST1, GIT2, IQSEC1, CDC42

hsa04145

Phagosome

KEGG

TCIRG1, TUBA1B, TUBB3, TUBB4A, TUBB4B, CORO1A, TUBA3C, COMP, CTSL, CTSS, CYBB, DYNC1H1, DYNC1I1, DYNC1I2, DYNC1LI2, PIKFYVE, TUBB, FCGR1A, FCGR2A, FCGR2B, FCGR3B, SEC61G, ATP6V1C2, SEC61A1, CD209, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, TUBB2B, ITGA2, ITGA5, ITGAM, ITGAV, ITGB1, ITGB2, ITGB3, ITGB5, LAMP1, LAMP2, MBL2, MPO, MRC1, NCF2, NCF4, OLR1, ATP6V1D, ATP6V1H, ATP6V1B2, ATP6V1C1, PIK3C3, ATP6V1G2, ATP6V0A1, SEC61A2, RAB5A, RAB5B, RAB5C, RAC1, ACTB, CLEC7A, TFRC, THBS1, THBS4, TLR2, TLR4, ACTG1, C1R, C3, TUBA4A, TUBB2A, TUBA1A, RAB7A, TUBB1, COLEC12, CALR, CANX, EEA1, STX7, TUBB6, ATP6V0E1, ATP6V0D1, CD14, ATP6V1F, VAMP3, CD36, SCARB1, ATP6V1G1, SEC22B

hsa04146

Peroxisome

KEGG

ACOT8, ECI2, SLC25A17, DHRS4, SLC27A2, CRAT, AGXT, ECH1, ACSL1, ACSL4, ACSL6, NUDT7, HMGCL, HSD17B4, IDH1, IDH2, GSTK1, NUDT19, MPV17, MVK, PRDX1, ACOX1, HAO2, PIPOX, PEX12, PEX14, CROT, FAR2, ABCD3, ABCD4, SCP2, SOD2, XDH, ACOX2, ACOX3, GNPAT, PEX3, AGPS, PEX11B

hsa04150

mTOR signaling pathway

KEGG

AKT3, SLC38A9, EIF4B, EIF4E, EIF4EBP1, FLCN, AKT1, AKT2, RNF152, LPIN1, ATP6V1C2, RICTOR, GRB2, GRB10, LAMTOR2, GSK3B, IGF1, IGF1R, INS, INSR, IRS1, KRAS, RHOA, LAMTOR4, LRP6, LRP5, NRAS, ATP6V1D, ATP6V1H, CAB39, ATP6V1B2, ATP6V1C1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, ATP6V1G2, DDIT4, LAMTOR1, STRADB, PRKAA2, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, MAP2K2, PTEN, FNIP2, RRAGD, RAF1, RHEB, RPS6, RPS6KA1, RPS6KA2, CLIP1, SEC13, RRAGC, MLST8, DEPTOR, SKP2, SLC3A2, SOS1, SOS2, STK11, TNF, TSC2, WNT2, WNT3, WNT5A, WNT6, WNT2B, MAPKAP1, WNT5B, NPRL3, SLC7A5, SEH1L, FZD4, FZD6, FZD7, FZD8, SESN2, ULK1, LAMTOR3, ATP6V1F, EIF4E2, ATP6V1G1, FNIP1

hsa04151

PI3K-Akt signaling pathway

KEGG

AKT3, BCL2L11, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, LAMC3, CDC37, CHRM2, THEM4, COL1A1, COL1A2, COL4A2, COL4A3, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COMP, CREB1, CSF1R, CSF3R, EFNA1, EFNA4, EFNA5, EGFR, EIF4B, EIF4E, EIF4EBP1, EPOR, AKT1, AKT2, F2R, FGF2, FGF7, FGF9, FGF11, FGF12, FGF13, FGF14, FGFR1, FGFR2, ITGA11, PHLPP2, FOXO3, FLT4, FN1, SGK3, G6PC, GH1, GHR, GNB1, GNB2, GNB3, GNG4, GNG5, GNG7, GNG11, ANGPT1, ANGPT2, GRB2, GSK3B, GYS1, GYS2, HGF, NR4A1, HSP90AA1, HSP90AB1, TNC, IFNA1 , IFNA16, IFNAR1, IFNAR2, IGF1, IGF1R, IL4R, IL6, IL6R, IL7R, INS, INSR, ITGA6, IRS1, ITGA2, ITGA3, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB8, JAK1, JAK2, JAK3, KIT, KRAS, LAMA2, LAMA3, LAMA4, LAMB1, LAMC1, MCL1, MDM2, MET, KITLG, MTCP1, MYC, ATF4, NFKB1, NGF, NGFR, NOS3, NRAS, PCK1, PCK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, DDIT4, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3A, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PRKAA2, PRKCA, PKN1, PKN2, MAPK1, MAPK3, PDGFC, MAP2K1, MAP2K2, PRL, PRLR, BAD, PTEN, PTK2, RAC1, RAF1, BCL2, RELA, RHEB, RPS6, MLST8, SOS1, SOS2, SPP1, BRCA1, STK11, SYK, TEK, THBS1, THBS4, TLR2, TLR4, TNR, TNXB, TP53, HSP90B1, TSC2, VEGFA, VEGFB, VEGFC, VTN, VWF, YWHAB, YWHAE, YWHAH, YWHAZ, PDGFD, CASP9, ITGA10, FGF18, CCND2, CCND3, CREB3L1, CCNE2, OSMR, G6PC3, EIF4E2, CREB5, FGF19

hsa04152

AMPK signaling pathway

KEGG

AKT3, CFTR, PPARGC1A, CPT1A, CPT1B, CREB1, ADRA1A, EEF2, EIF4EBP1, ELAVL1, AKT1, AKT2, FASN, FBP1, FOXO1, FOXO3, G6PC, GYS1, GYS2, HMGCR, ACACB, IGF1, IGF1R, INS, INSR, IRS1, LEP, LEPR, LIPE, PCK1, PCK2, ADIPOR1, CAB39, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PRKAG3, PPARG, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3A, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, STRADB, PRKAA2, PRKAG1, RAB2A, RHEB, SCD, SLC2A4, SREBF1, STK11, MAP3K7, TSC2, ADIPOR2, SCD5, ULK1, IRS4, IRS2, FBP2, CCNA2, CCNA1, CREB3L1, RAB11B, G6PC3, ADIPOQ, CD36, CREB5

hsa04210

Apoptosis

KEGG

AKT3, BCL2L11, PARP2, TUBA1B, CTSC, GADD45G, TUBA3C, PARP1, CTSB, CTSD, CTSH, CTSK, CTSL, CTSS, CTSZ, GADD45A, DDIT3, DFFA, EIF2S1, AKT1, AKT2, ERN1, FOS, BBC3, BIRC3, XIAP, BIRC5, FAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LMNA, LMNB1, MCL1, MAP3K5, GADD45B, ATF4, NFKB1, NGF, NRAS, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PMAIP1, CYCS, MAPK1, MAPK3, MAPK8, MAPK9, MAP2K1, MAP2K2, BAD, BAX, RAF1, BCL2, RELA, ACTB, BID, ACTG1, TNF, TP53, TRAF1, TUBA4A, TUBA1A, CASP6, CASP8, CASP9, LMNB2, TRADD, CTSF, RIPK1, TNFSF10, FADD, TNFRSF10C, CFLAR, AIFM1

hsa04211

Longevity regulating pathway

KEGG

AKT3, PPARGC1A, ADCY3, EHMT2, ADCY7, ADCY9, CREB1, SESN3, EIF4E, EIF4EBP1, AKT1, AKT2, FOXO1, FOXO3, SESN1, IGF1, IGF1R, INS, INSR, IRS1, KRAS, ATF4, NFKB1, NRAS, ADIPOR1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PRKAG3, PPARG, PRKAA2, PRKACA, PRKAG1, BAX, RELA, RHEB, SOD2, STK11, TP53, TSC2, ADIPOR2, SESN2, ULK1, IRS4, IRS2, CREB3L1, KL, ADIPOQ, EIF4E2, CREB5, ATG13, RB1CC1

hsa04213

Longevity regulating pathway - multiple species

KEGG

AKT3, ADCY3, ADCY7, ADCY9, CRYAB, EIF4EBP2, AKT1, AKT2, FOXO1, FOXO3, HDAC1, HDAC2, HSPA1A, HSPA1B, HSPA1L, HSPA6, IGF1, IGF1R, INS, INSR, IRS1, KRAS, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PRKAG3, PRKAA2, PRKACA, PRKAG1, SOD2, IRS4, IRS2

hsa04215

Apoptosis - multiple species

KEGG

BCL2L11, BBC3, BIRC3, XIAP, BIRC5, NGFR, PMAIP1, CYCS, MAPK8, MAPK9, BAX, BCL2, BID, BOK, CASP8, CASP9, FADD

hsa04260

Cardiac muscle contraction

KEGG

SLC9A6, UQCR11, COX5B, COX6A1, COX6B1, COX6C, COX7B, COX7C, CYC1, COX7B2, UQCRQ, UQCR10, UQCRHL, MYL4, ATP1A2, ATP1B1, ATP1B3, ATP2A2, CACNG8, CACNG6, RYR2, ACTC1, TNNI3, TPM1, TPM2, TPM3, TPM4, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, CACNA1C, CACNA2D1, CACNB3, COX5A

hsa04261

Adrenergic signaling in cardiomyocytes

KEGG

AKT3, ADCY3, RAPGEF4, ADCY7, ADCY9, CREB1, CREM, MAPK14, ADRA1D, ADRA1B, ADRA1A, ADRB1, ADRB2, AGTR1, AGTR2, AKT1, AKT2, PLCB1, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, MYL4, ATF4, ATP1A2, ATP1B1, ATP1B3, ATP2A2, ATP2B1, ATP2B4, PIK3CG, PLN, PPP1CA, PPP1CB, PPP1CC, PPP1R1A, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3A, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PRKACA, PRKCA, MAPK1, MAPK3, MAPK13, CACNG8, CACNG6, BCL2, RYR2, ACTC1, TNNI3, TPM1, TPM2, TPM3, TPM4, CACNA1C, CACNA2D1, CACNB3, CALM2, CALM3, CAMK2D, CREB3L1, CALML4, RPS6KA5, CREB5

hsa04270

Vascular smooth muscle contraction

KEGG

RAMP1, RAMP3, MYL9, ADCY3, ADCY7, ADCY9, ADORA2B, MYL6B, ADRA1D, ADRA1B, ADRA1A, AGTR1, EDNRA, PLCB1, GNA11, GNA12, GNAQ, GNAS, ITPR1, ITPR2, ITPR3, KCNMA1, RHOA, MYH11, MYL6, MYLK, PPP1R12A, PPP1R12B, NPR2, PLA2G2A, PLA2G4A, PLA2G5, PPP1CA, PPP1CB, PPP1CC, PRKACA, PRKCA, PRKCB, PRKCD, PRKCQ, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, ACTA2, ACTG2, CACNA1C, CALD1, CALM2, CALM3, PLA2G12A, PLA2G4C, CALML4, PPP1R14A, ROCK2

hsa04310

Wnt signaling pathway

KEGG

WIF1, CREBBP, PRICKLE1, CSNK1A1, CSNK1E, CTBP2, CTNNB1, EP300, GPC4, DKK1, DAAM1, PLCB1, BAMBI, CACYBP, DKK2, INVS, GSK3B, APC, JUN, RHOA, LRP6, LRP5, SMAD3, SMAD4, MYC, NFATC1, NFATC2, NFATC4, SOST, NLK, SERPINF1, PPARD, PPP3CA, PPP3R2, PRKACA, PRKCA, PRKCB, MAPK8, MAPK9, PSEN1, CHD8, RAC1, RAC2, RAC3, SFRP1, SFRP4, SFRP5, SOX17, SIAH1, SKP1, MAP3K7, TBL1X, TCF7L2, TP53, WNT2, WNT3, WNT5A, WNT6, WNT2B, TBL1XR1, FOSL1, WNT5B, CAMK2D, AXIN1, FZD4, FZD6, FZD7, FZD8, TCF7L1, RUVBL1, CCND2, BTRC, CCND3, ROCK2, RBX1

hsa04320

Dorso-ventral axis formation

KEGG

CPEB2, PIWIL4, EGFR, ETS1, ETS2, CPEB3, GRB2, KRAS, NOTCH1, NOTCH2, MAPK1, MAPK3, MAP2K1, FMN2, SOS1, SOS2, CPEB4

hsa04330

Notch signaling pathway

KEGG

CREBBP, CTBP2, PTCRA, JAG1, EP300, HDAC1, HDAC2, HES1, NOTCH1, NOTCH2, APH1A, DLL4, MAML3, PSEN1, PSEN2, RFNG, ADAM17, APH1B, MAML2, NUMB, KAT2B, NCOR2

hsa04340

Hedgehog signaling pathway

KEGG

KIF3A, CSNK1A1, CSNK1D, CSNK1E, CSNK1G3, ADRBK2, EVC, GAS1, GLI2, GLI3, GSK3B, SPOPL, LRP2, DHH, SUFU, CSNK1G1, PRKACA, PTCH1, BCL2, HHIP, SMURF2, CUL3, CCND2, BTRC

hsa04350

TGF-beta signaling pathway

KEGG

CDKN2B, FST, CREBBP, DCN, EP300, BAMBI, AMH, AMHR2, ID1, ID2, ID3, ID4, BMP8A, INHBA, INHBB, INHBC, RHOA, LTBP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, MYC, NBL1, PITX2, PPP2CB, PPP2R1A, PPP2R1B, MAPK1, MAPK3, RBL1, SMURF2, BMP2, SKP1, BMP4, BMP6, BMP8B, BMPR1A, BMPR2, TFDP1, TGFB1, TGFB2, TGFBR1, TGFBR2, THBS1, TNF, GDF5, ACVR1, ACVR1B, ACVR2A, ACVR2B, ZFYVE16, RBX1

hsa04360

Axon guidance

KEGG

PLXNC1, CDK5, SEMA3A, SEMA6B, SEMA3C, CFL1, DPYSL2, EFNA1, EFNA4, EFNA5, EFNB2, EPHA3, EPHA4, EPHA5, EPHB1, EPHB2, EPHB4, UNC5B, SEMA3D, ABLIM3, PLXNB2, FYN, GNAI1, GNAI2, GNAI3, EPHA6, GSK3B, RHOD, ILK, ITGB1, KRAS, RHOA, ABLIM1, LIMK2, MET, NFATC2, NFATC4, NRAS, PAK2, PAK3, PARD6A, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PLXNA1, PLXNA2, SSH3, PPP3CA, PPP3R2, PLXNA3, ENAH, PRKCA, MAPK1, MAPK3, PARD3, PAK7, PTCH1, PTK2, SRGAP1, SEMA6A, PTPN11, RAC1, RAC2, RAC3, RAF1, RASA1, NTN4, RGS3, ROBO2, RRAS, CXCL12, SEMA4A, ROBO3, BMPR2, TRPC1, TRPC3, TRPC6, WNT5A, CXCR4, SEMA3B, SEMA6D, WNT5B, CAMK2D, PARD6B, SEMA7A, SSH2, UNC5C, NRP1, SEMA5A, SLIT2, ROCK2, SEMA3E, CDC42

hsa04370

VEGF signaling pathway

KEGG

AKT3, MAPK14, AKT1, AKT2, SHC2, HSPB1, KRAS, NFATC2, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLA2G4A, PLCG2, PPP3CA, PPP3R2, PRKCA, PRKCB, MAPK1, MAPK3, MAPK13, MAP2K1, MAP2K2, BAD, PTGS2, PTK2, RAC1, RAC2, RAC3, RAF1, VEGFA, CASP9, PLA2G4C, SPHK1, MAPKAPK2, CDC42

hsa04371

Apelin signaling pathway

KEGG

AKT3, HDAC5, KLF2, PPARGC1A, ADCY3, ADCY7, GABARAP, GABARAPL2, ADCY9, CTGF, JAG1, AGTR1, EGR1, AKT1, AKT2, RRAS2, PLCB1, GABARAPL1, GNAI1, GNAI2, GNAI3, GNAQ, GNB1, GNB2, GNB3, GNG4, GNG5, GNG7, GNG11, PIK3R4, ITPR1, ITPR2, ITPR3, KRAS, LIPE, SMAD2, SMAD3, SMAD4, MEF2A, MEF2C, MEF2D, MYL4, MYLK, NOS3, NRAS, SERPINE1, PDE3B, PIK3C3, PIK3CG, PLAT, PLIN1, PRKAG3, PRKAA2, PRKACA, PRKAG1, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, ACTA2, RPS6, RRAS, RYR2, RYR3, SPP1, TFAM, TGFBR1, UCP1, CALM2, CALM3, APLN, SPHK1, CALML4, HDAC4

hsa04380

Osteoclast differentiation

KEGG

AKT3, IRF9, TAB1, LILRB1, CREB1, SIRPA, MAPK14, CSF1R, CTSK, CYLD, AKT1, AKT2, FCGR1A, FCGR2A, FCGR2B, FCGR3B, FOS, FOSB, FOSL2, FYN, GRB2, BLNK, IFNAR1, IFNAR2, IFNGR1, IFNGR2, IL1A, IL1B, IL1R1, ITGB3, JAK1, JUN, JUNB, JUND, MITF, NCF2, NCF4, NFATC1, NFATC2, NFKB1, TNFRSF11B, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PPARG, PPP3CA, PPP3R2, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K6, MAP2K7, RAC1, RELA, RELB, STAT2, SYK, MAP3K7, TGFB1, TGFB2, TGFBR1, TGFBR2, TNF, TYROBP, FOSL1, TNFSF11, SOCS1, TNFRSF11A, SQSTM1, SOCS3

hsa04390

Hippo signaling pathway

KEGG

INADL, YAP1, RASSF1, FRMD6, CSNK1D, CSNK1E, CTGF, CTNNA1, CTNNA2, CTNNB1, AMOT, RASSF6, DLG1, DLG4, WWC1, CRB1, LATS2, AMH, BBC3, GLI2, GSK3B, APC, BIRC5, ID1, ID2, BMP8A, ITGB2, AREG, SMAD1, SMAD2, SMAD3, SMAD4, SMAD7, MYC, NF2, SERPINE1, PARD6A, PPP1CA, PPP1CB, PPP1CC, PPP2CB, PPP2R1A, PPP2R1B, MOB1A, PRKCI, PARD3, ACTB, MPP5, BMP2, BMP4, BMP6, BMP8B, BMPR1A, BMPR2, SNAI2, TCF7L2, TEAD4, TEAD3, TGFB1, TGFB2, TGFBR1, TGFBR2, ACTG1, TP53BP2, WNT2, WNT3, WNT5A, WNT6, WNT2B, YWHAB, YWHAE, YWHAH, YWHAZ, WNT5B, GDF5, AXIN1, FZD4, FZD6, FZD7, FZD8, TCF7L1, PARD6B, TEAD2, AJUBA, CCND2, BTRC, CCND3, LIMD1, LATS1

hsa04392

Hippo signaling pathway -multiple species

KEGG

YAP1, RASSF1, FRMD6, CSNK1E, RASSF6, WWC1, LATS2, NF2, MOB1A, TEAD4, TEAD3, RASSF4, TEAD2, AJUBA, LIMD1, LATS1

hsa04510

Focal adhesion

KEGG

AKT3, LAMC3, MYL9, VAV3, MYL12A, COL1A1, COL1A2, COL4A2, COL4A3, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COMP, CRKL, CTNNB1, EGFR, ELK1, ERBB2, AKT1, AKT2, ITGA11, FLNA, FLNB, FLNC, FLT4, FN1, PIP5K1C, FYN, SHC2, GRB2, RAPGEF1, GSK3B, HGF, BIRC3, XIAP, TNC, IGF1, IGF1R, ILK, ITGA6, ITGA2, ITGA3, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB8, JUN, RHOA, LAMA2, LAMA3, LAMA4, LAMB1, LAMC1, ARHGAP5, MET, MYL5, MYLK, PPP1R12A, PPP1R12B, PAK2, PAK3, PDGFA, PDGFB, PDGFRA, PDGFRB, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PPP1CA, PPP1CB, PPP1CC, PARVA, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK9, PDGFC, MAP2K1, PAK7, BAD, PTEN, PTK2, MYL7, RAC1, RAC2, RAC3, RAF1, RAP1A, BCL2, ACTB, SOS1, SOS2, SPP1, THBS1, THBS4, TLN1, ACTG1, TNR, TNXB, VAV1, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX, PDGFD, ACTN4, ITGA10, CAV1, CAV2, ACTN1, CCND2, CCND3, ROCK2, CDC42

hsa04512

ECM-receptor interaction

KEGG

LAMC3, COL1A1, COL1A2, COL4A2, COL4A3, COL4A6, COL6A1, COL6A2, COL6A3, COL9A1, COMP, DAG1, ITGA11, FN1, GP1BB, HMMR, HSPG2, TNC, ITGA6, ITGA2, ITGA3, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB8, LAMA2, LAMA3, LAMA4, LAMB1, LAMC1, SDC1, SDC4, SPP1, THBS1, THBS4, TNR, TNXB, VTN, VWF, ITGA10, CD36, CD44, CD47, SV2B, SV2A

hsa04514

Cell adhesion molecules (CAMs)

KEGG

CDH2, CDH5, OCLN, CDH15, CNTN1, CLDN4, CLDN3, VCAN, ALCAM, NLGN1, CADM1, NECTIN3, GLG1, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ITGA6, ITGA9, ITGAM, ITGAV, ITGB1, ITGB2, ITGB8, MAG, CD99, NCAM1, NCAM2, NRCAM, F11R, PECAM1, NLGN4X, PTPRC, PTPRF, PTPRM, PVR, NECTIN1, JAM2, SDC1, SDC2, SDC4, SELE, SELL, SELPLG, SIGLEC1, VCAM1, VTCN1, CD276, JAM3, MPZL1, CLDN1, CD4, CD6, NRXN1, CD28, CD40LG, CD58, SDC3

hsa04520

Adherens junction

KEGG

WASF2, SORBS1, SSX2IP, CREBBP, CTNNA1, CTNNA2, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FGFR1, FYN, NECTIN3, IGF1R, INSR, RHOA, SMAD2, SMAD3, SMAD4, MET, NLK, MAPK1, MAPK3, PARD3, PTPRB, PTPRF, PTPRJ, PTPRM, NECTIN1, RAC1, RAC2, RAC3, ACTB, SNAI2, MAP3K7, TCF7L2, TGFBR1, TGFBR2, TJP1, ACTG1, ACTN4, TCF7L1, ACTN1, IQGAP1, WASL, FARP2, CDC42

hsa04530

Tight junction

KEGG

OCLN, ACTR3, ACTR2, CDK4, INADL, TUBA1B, MYL9, MYL12A, CFTR, BVES, TUBA3C, CLDN4, CLDN3, MYL6B, AMOT, AMOTL1, DLG1, CTTN, ERBB2, NEDD4L, GATA4, HCLS1, HSPA4, ITGB1, JUN, RHOA, MAP3K5, MYH2, MYH4, MYH9, MYH11, MYL6, NF2, F11R, PARD6A, PCNA, RAPGEF6, RAB8B, PRKAG3, EPB41L4B, PPP2CB, PPP2R1A, PPP2R1B, PRKAA2, PRKACA, PRKAG1, PRKCI, MAPK8, MAPK9, MAP2K7, PARD3, JAM2, RAC1, RAP1A, RDX, ACTB, MPP5, STK11, TIAM1, TJP1, ACTG1, TUBA4A, EZR, TUBA1A, ACTN4, SYMPK, JAM3, PARD6B, RUNX1, ACTN1, WASL, CLDN1, CD1D, ARHGEF2, MARVELD3, MAGI1, TJAP1, TJP2, ROCK2, CDC42

hsa04540

Gap junction

KEGG

TUBA1B, TUBB3, TUBB4A, TUBB4B, ADCY3, ADCY7, TUBA3C, ADCY9, CSNK1D, ADRB1, DRD2, EGFR, TUBB, PLCB1, GJA1, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, HTR2B, HTR2C, TUBB2B, ITPR1, ITPR2, ITPR3, KRAS, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PRKACA, PRKCA, PRKCB, MAPK1, MAPK3, MAPK7, PDGFC, MAP2K1, MAP2K2, MAP2K5, RAF1, SOS1, SOS2, TJP1, TUBA4A, TUBB2A, TUBA1A, PDGFD, TUBB1, TUBB6, CDK1

hsa04550

Signaling pathways regulating pluripotency of stem cells

KEGG

AKT3, PCGF3, MAPK14, CTNNB1, DLX5, DUSP9, AKT1, AKT2, FGF2, FGFR1, FGFR2, GRB2, GSK3B, APC, ID1, ID2, ID3, ID4, IGF1, IGF1R, IL6ST, INHBA, INHBB, INHBC, JAK1, JAK2, JAK3, KRAS, LIF, LIFR, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD9, MEIS1, MYC, ZFHX3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, POU5F1, RIF1, MAPK1, MAPK3, MAPK13, MAP2K1, MAP2K2, SMARCAD1, RAF1, SKIL, BMP4, BMPR1A, BMPR2, STAT3, HNF1A, TCF3, WNT2, WNT3, WNT5A, WNT6, WNT2B, KAT6A, WNT5B, AXIN1, FZD4, FZD6, FZD7, FZD8, PCGF5, ACVR1, ACVR1B, ACVR2A, ACVR2B, KLF4

hsa04610

Complement and coagulation cascades

KEGG

PROCR, MASP2, VSIG4, CLU, CPB2, CR1, CD55, A2M, F2, F2R, F5, F8, F13A1, F13B, FGA, FGB, FGG, CFH, CFI, ITGAM, ITGAX, ITGB2, KNG1, MBL2, CD46, SERPINC1, SERPINE1, SERPINA5, SERPINA1, PLAT, PLAU, PLAUR, PLG, CFB, TFPI, SERPING1, C1QA, C1R, C1S, C3, C4A, C4B, C5AR1, C6, C7, C8G, VTN, VWF

hsa04611

Platelet activation

KEGG

AKT3, RASGRP2, MYL12A, ADCY3, ADCY7, ADCY9, COL1A1, COL1A2, COL3A1, MAPK14, AKT1, AKT2, F2R, FCGR2A, FGA, FGB, FGG, PLCB1, FYN, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GP1BB, ITGA2, ITGB1, ITGB3, ITPR1, ITPR2, ITPR3, RHOA, LYN, MYLK, PPP1R12A, NOS3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PLA2G4A, PLCG2, PPP1CA, PPP1CB, PPP1CC, PRKACA, PRKCI, MAPK1, MAPK3, MAPK13, PTGS1, RAP1A, ACTB, SYK, TLN1, ACTG1, VWF, PLA2G4C, SNAP23, ROCK2

hsa04612

Antigen processing and presentation

KEGG

PSME3, CREB1, CTSB, CTSL, CTSS, PDIA3, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSPA1A, HSPA1B, HSPA1L, HSPA4, HSPA5, HSPA6, HSP90AA1, HSP90AB1, KIR3DL2, KLRC1, NFYB, NFYC, B2M, RFX5, TNF, CALR, CANX, KLRC4, CD4, CD74

hsa04614

Renin-angiotensin system

KEGG

ATP6AP2, ACE, AGT, AGTR1, AGTR2, KLK2, LNPEP, MME, PREP, NLN, THOP1

hsa04620

Toll-like receptor signaling pathway

KEGG

AKT3, TAB1, TIRAP, MAP3K8, MAPK14, CTSK, AKT1, AKT2, FOS, TBK1, IFNA1 , IFNA16, IFNAR1, IFNAR2, IL1B, IL6, CXCL8, IL12A, IRAK1, JUN, NFKB1, PIK3CA, PIK3CB, PIK3CD, PIK3R1, TOLLIP, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, MAP2K6, MAP2K7, RAC1, RELA, CCL3, CCL4, CCL5, SPP1, MAP3K7, TLR1, TLR2, TLR3, TLR4, TLR5, TNF, CASP8, RIPK1, FADD, CD14

hsa04621

NOD-like receptor signaling pathway

KEGG

TANK, NAMPT, IRF9, TAB1, TXNIP, SUGT1, GABARAP, GABARAPL2, CARD16, ANTXR2, NEK7, MAPK14, CTSB, CYBB, PLCB1, GABARAPL1, PANX1, TAB3, TXN2, GBP1, GBP2, GBP3, PYCARD, TBK1, CXCL1, CXCL2, BIRC3, XIAP, HSP90AA1, HSP90AB1, IFI16, IFNA1 , IFNA16, IFNAR1, IFNAR2, IL1B, IL6, CXCL8, IL18, ITPR1, ITPR2, ITPR3, JAK1, JUN, RHOA, NFKB1, TRPV2, TRPM7, PRKCD, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAVS, BCL2, RELA, RNASEL, CCL2, CCL5, STAT2, MAP3K7, TLR4, TNF, TNFAIP3, TRIP6, TXN, VDAC2, VDAC3, BRCC3, CASP1, CASP4, CASP8, RIPK1, RIPK2, FADD, ATG12, MFN2

hsa04622

RIG-I-like receptor signaling pathway

KEGG

TANK, MAPK14, CYLD, DDX3X, TKFC, TBK1, IFNE, IFNA1 , IFNA16, CXCL8, IL12A, NFKB1, MAPK8, MAPK9, MAPK13, MAVS, RELA, AZI2, MAP3K7, TNF, TRIM25, CASP8, TRADD, RIPK1, FADD, ATG12, ISG15

hsa04623

Cytosolic DNA-sensing pathway

KEGG

POLR3F, POLR3G, POLR3C, PYCARD, TBK1, IFNA1 , IFNA16, IL1B, IL6, IL18, NFKB1, POLR1D, POLR3K, POLR2E, POLR2K, POLR2L, POLR3B, MAVS, RELA, CCL4, CCL5, CASP1, POLR3GL, RIPK1, IL33, POLR1C

hsa04630

Jak-STAT signaling pathway

KEGG

AKT3, STAM2, CDKN1A, IRF9, CREBBP, CSF3R, CTF1, EP300, EPOR, AKT1, AKT2, FHL1, GH1, GHR, GRB2, AOX1, IFNE, IFNA1 , IFNA16, IFNAR1, IFNAR2, IFNGR1, IFNGR2, IL4R, IL5RA, IL6, IL6R, IL6ST, IL7R, IL9R, IL10, IL10RB, IL11, IL12A, IL12RB1, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MCL1, MYC, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PRL, PRLR, PTPN2, PTPN11, RAF1, BCL2, SOS1, SOS2, STAT2, STAT3, STAT5A, STAT5B, STAM, SOCS1, SOCS2, CCND2, CCND3, SOCS3, OSMR, SOCS6, SOCS5

hsa04640

Hematopoietic cell lineage

KEGG

CD24, CR1, CSF1R, CSF3R, CD55, EPOR, FCGR1A, GP1BB, GYPA, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL1A, IL1B, IL1R1, IL4R, IL5RA, IL6, IL6R, IL7R, IL9R, IL11, ITGA6, ITGA2, ITGA3, ITGA5, ITGAM, ITGB3, KIT, KITLG, MME, TFRC, TNF, IL1R2, CD1D, CD4, CD9, CD14, CD33, CD36, CD44

hsa04650

Natural killer cell mediated cytotoxicity

KEGG

MICA, VAV3, FCGR3B, FYN, SHC2, GRB2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, ICAM1, IFNA1 , IFNA16, IFNAR1, IFNAR2, IFNGR1, IFNGR2, FAS, ITGB2, KIR3DL2, KLRC1, KRAS, MICB, NFATC1, NFATC2, NRAS, CD244, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PPP3CA, PPP3R2, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, MAP2K2, PTPN11, RAC1, RAC2, RAC3, RAF1, BID, SOS1, SOS2, SYK, TNF, TYROBP, VAV1, ULBP3, ULBP2, TNFSF10, TNFRSF10C, CD48

hsa04657

IL-17 signaling pathway

KEGG

CEBPB, TRAF3IP2, MAPK14, ELAVL1, FOS, FOSB, TAB3, TBK1, CXCL1, CXCL2, GSK3B, USP25, HSP90AA1, HSP90AB1, IL1B, IL6, CXCL8, JUN, JUND, LCN2, MMP1, MMP9, MUC5AC, NFKB1, ANAPC5, IL17RB, MAPK1, MAPK3, MAPK7, MAPK8, MAPK9, MAPK13, PTGS2, RELA, S100A7, S100A8, S100A9, CCL2, CCL20, CXCL6, CXCL5, SRSF1, MAP3K7, TNF, TNFAIP3, HSP90B1, FOSL1, CASP8, TRADD, FADD

hsa04658

Th1 and Th2 cell differentiation

KEGG

MAPK14, JAG1, FOS, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IFNGR1, IFNGR2, IL4R, IL12A, IL12RB1, JAK1, JAK2, JAK3, JUN, MAF, NFATC1, NFATC2, NFKB1, NOTCH1, NOTCH2, DLL4, PPP3CA, PPP3R2, MAML3, PRKCQ, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, RELA, STAT5A, STAT5B, MAML2, RUNX3, CD4

hsa04659

Th17 cell differentiation

KEGG

MAPK14, AHR, FOS, HIF1A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HSP90AA1, HSP90AB1, IFNGR1, IFNGR2, IL1B, IL1R1, IL1RAP, IL4R, IL6, IL6R, IL6ST, IL12RB1, JAK1, JAK2, JAK3, JUN, SMAD2, SMAD3, SMAD4, NFATC1, NFATC2, NFKB1, FOXP3, PPP3CA, PPP3R2, PRKCQ, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, RELA, RORA, RXRB, STAT3, STAT5A, STAT5B, TGFB1, TGFBR1, TGFBR2, RUNX1, CD4

hsa04660

T cell receptor signaling pathway

KEGG

AKT3, CDK4, VAV3, MAP3K8, MAPK14, DLG1, AKT1, AKT2, FOS, FYN, GRB2, GSK3B, IL10, JUN, KRAS, RHOA, NFATC1, NFATC2, NFKB1, NRAS, PAK2, PAK3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PPP3CA, PPP3R2, PRKCQ, MAPK1, MAPK3, MAPK9, MAPK13, MAP2K1, MAP2K2, MAP2K7, PAK7, PTPRC, RAF1, RELA, SOS1, SOS2, MAP3K7, TNF, VAV1, CBLB, BCL10, CD4, CD28, CD40LG, CDC42

hsa04662

B cell receptor signaling pathway

KEGG

AKT3, VAV3, AKT1, AKT2, FCGR2B, FOS, GRB2, GSK3B, BLNK, INPP5D, JUN, KRAS, LYN, NFATC1, NFATC2, NFKB1, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PPP3CA, PPP3R2, PRKCB, MAPK1, MAPK3, MAP2K1, MAP2K2, RAC1, RAC2, RAC3, RAF1, RELA, SOS1, SOS2, SYK, VAV1, IFITM1, BCL10, CD81

hsa04664

Fc epsilon RI signaling pathway

KEGG

AKT3, VAV3, MAPK14, AKT1, AKT2, ALOX5, FYN, GRB2, INPP5D, KRAS, LYN, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLA2G4A, PLCG2, PRKCA, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, MAP2K6, MAP2K7, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, PLA2G4C