h_nkcellsPathway

Ras-Independent pathway in NK cell-mediated cytotoxicity

BioCarta

IL18, ITGB1, PIK3CA, PIK3R1, MAPK3, MAP2K1, RAC1, SYK, VAV1, B2M, HLA-A, KLRC1, KLRC4

h_nktPathway

Selective expression of chemokine receptors during T-cell polarization

BioCarta

CD4, CD28, CD40LG, IFNGR1, IFNGR2, IL4R, IL12A, IL12RB1, TGFB1, TGFB2, CXCR4, IL18R1, CCL3, CCL4

h_no1Pathway

Actions of Nitric Oxide in the Heart

BioCarta

AKT1, CALM2, CALM3, FLT4, HSP90AA1, NOS3, PRKAR1A, PRKAR2A, PRKAR2B, VEGFA, CAV1, KNG1, PDE3A, PDE3B, RYR2

h_no2il12Pathway

NO2-dependent IL 12 Pathway in NK cells

BioCarta

CD4, IL12A, IL12RB1, JAK2

h_nos1Pathway

Nitric Oxide Signaling Pathway

BioCarta

ACADVL, CALM2, CALM3, DLG4, PPP3CA, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB, GRIN2A

h_notchpathway

Proteolysis and Signaling Pathway of Notch

BioCarta

NOTCH1, PSEN1, ADAM17, FURIN

h_npcPathway

Mechanism of Protein Import into the Nucleus

BioCarta

RCC1, KPNB1, KPNA2, RANBP2, RANGAP1, NUP153, NUTF2, NUP210, NUP62

h_npp1Pathway

Regulators of Bone Mineralization

BioCarta

COL4A2, COL4A3, COL4A6, ALPL, ENPP1, SPP1

h_nthiPathway

NFkB activation by Nontypeable Hemophilus influenzae

BioCarta

CREBBP, MAPK14, DUSP1, EP300, NR3C1, CXCL8, SMAD3, SMAD4, NFKB1, MAP2K6, RELA, MAP3K7, TGFBR1, TGFBR2, TLR2, TNF, IL1B

h_nuclearRsPathway

Nuclear Receptors in Lipid Metabolism and Toxicity

BioCarta

PPARA, PPARD, PPARG, VDR, NR0B2, NR1H3, ABCA1, CYP2B6, CYP2C9, CYP2E1, CYP3A4, CYP8B1, CYP26A1, CYP27B1, ABCD3, NR1H4, CYP3A43

h_ox40Pathway

OX40 Signaling Pathway

BioCarta

TNFSF4

h_p27Pathway

Regulation of p27 Phosphorylation during Cell Cycle Progression

BioCarta

CDK2, CDKN1B, E2F1, RB1, SKP1, SKP2, TFDP1, CKS1B, NEDD8, UBE2M, RBX1

h_p35alzheimersPathway

Deregulation of CDK5 in Alzheimers Disease

BioCarta

APP, CDK5, CSNK1A1, CSNK1D, GSK3B, MAPT

h_p38mapkPathway

p38 MAPK Signaling Pathway

BioCarta

CDC42, MAPK14, ELK1, GRB2, MEF2A, MEF2C, MEF2D, MYC, PLA2G4A, MAP2K6, RAC1, MAP3K7, TGFB1, TGFB2, TGFBR1, TRADD, RIPK1, CREB1, DDIT3, HSPB1, HSPB2, MAP3K5, MKNK1, RPS6KA5, MAPKAPK2

h_p53hypoxiaPathway

Hypoxia and p53 in the Cardiovascular system

BioCarta

AKT1, BAX, CDKN1A, CSNK1A1, CSNK1D, GADD45A, EP300, HIF1A, HSPA1A, HSP90AA1, DNAJB1, MDM2, MAPK8, TP53, NQO1, IGFBP3

h_p53Pathway

p53 Signaling Pathway

BioCarta

BCL2, CDK2, CDK4, CDKN1A, E2F1, MDM2, RB1, TIMP3, TP53, BAX, GADD45A, PCNA

h_Par1Pathway

Thrombin signaling and protease-activated receptors

BioCarta

RHOA, F2, F2R, GNAI1, GNAQ, GNB1, PPP1R12B, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, MAP3K7, PLCB1, GNA12

h_parkinPathway

Role of Parkin in the Ubiquitin-Proteasomal Pathway

BioCarta

PARK2, SNCA, GPR37, UBE2E2, SNCAIP

h_ParkinsonsPathway

Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease

BioCarta

PARK2, SNCA

h_pcafpathway

The information-processing pathway at the IFN-beta enhancer

BioCarta

CREBBP, JUN, NFKB1, POLR2A, RELA, KAT2B, HMGB1, IRF1

h_pdgfPathway

PDGF Signaling Pathway

BioCarta

ELK1, FOS, GRB2, JAK1, JUN, PDGFA, PDGFRA, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, MAPK3, MAPK8, MAP2K1, RAF1, RASA1, SOS1, STAT3, STAT5A

h_PDZsPathway

Synaptic Proteins at the Synaptic Junction

BioCarta

ACADVL, DLG1, DLG4, GUK1, NCAM1, SPTBN1, CASK, PCLO

h_pelp1Pathway

Pelp1 Modulation of Estrogen Receptor Activity

BioCarta

CREBBP, EP300, MAPK1, MAPK3, ESR1

h_pepiPathway

Proepithelin Conversion to Epithelin and Wound Repair Control

BioCarta

CXCL8, GRN, SLPI, CELA2B, CELA2A

h_pgc1aPathway

Regulation of PGC-1a

BioCarta

CALM2, CALM3, CAMK2D, PPARA, PPP3CA, YWHAH, PPARGC1A, ESRRA, MEF2A, MEF2C, MEF2D, SLC2A4, CAMK1, HDAC5

h_pitx2Pathway

Multi-step Regulation of Transcription by Pitx2

BioCarta

APC, CREBBP, CTNNB1, EP300, GSK3B, HDAC1, AXIN1, PITX2, TRRAP

h_pkcPathway

Activation of PKC through G protein coupled receptor

BioCarta

GNAQ, NFKB1, PRKCA, PRKCB, RELA, PLCB1

h_plateletAppPathway

Platelet Amyloid Precursor Protein Pathway

BioCarta

COL4A2, COL4A3, COL4A6, F2, APP, SERPINE1, PLAT, PLAU, PLG

h_plcdPathway

Phospholipase C d1 in phospholipid associated cell signaling

BioCarta

PRKCA, PRKCB, ADRA1B, PLCD1, TGM2

h_plcePathway

Phospholipase C-epsilon pathway

BioCarta

GNAS, PRKAR1A, PRKAR2A, PRKAR2B, ADRB2, RAP2B

h_plcPathway

Phospholipase C Signaling Pathway

BioCarta

AKT1, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, VAV1, PLCB1

h_plk3Pathway

Regulation of cell cycle progression by Plk3

BioCarta

CDC25C, CHEK1, TP53, YWHAH

h_pmlPathway

Regulation of transcriptional activity by PML

BioCarta

FAS, CREBBP, RB1, TNF, TNFRSF1B, TP53, SP100

h_pparaPathway

Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

BioCarta

CREBBP, DUSP1, EP300, HSPA1A, HSP90AA1, JUN, LPL, MYC, PIK3CA, PIK3CG, PIK3R1, PPARA, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB, MAPK1, MAPK3, RB1, RELA, STAT5A, STAT5B, TNF, NCOA1, NCOR1, NCOR2, PPARGC1A, ACOX1, APOA1, APOA2, DUT, HSD17B4, PDGFA, NRIP1, NR0B2, SRA1, NR1H3, CITED2

h_ppargPathway

Role of PPAR-gamma Coactivators in Obesity and Thermogenesis

BioCarta

CREBBP, EP300, LPL, PPARG, NCOA1, NCOA2, PPARGC1A

h_pparPathway

Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression

BioCarta

PPARA, PPARD, PPARG

h_prc2Pathway

The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails

BioCarta

HDAC1, EZH1, EZH2, HDAC2, RBBP4, RING1, YY1, SUZ12, SYNC

h_prionPathway

Prion Pathway

BioCarta

BCL2, HSPA5, DNAJB1, LAMB1, LAMC1, RPSA, PRNP, DNAJB6, TMEM135

h_ps1Pathway

Presenilin action in Notch and Wnt signaling

BioCarta

APC, CTNNB1, GSK3B, HNF1A, AXIN1, BTRC, NOTCH1, PSEN1, ADAM17

h_ptc1Pathway

Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle

BioCarta

CCNB1, CDK1, CDC25A, CDC25B, CDC25C, CDK7, PTCH1, XPO1

h_ptdinsPathway

Phosphoinositides and their downstream targets

BioCarta

AKT1, BAD, GSK3B, RAB5A, RAC1, JAG1, ARF1, AP2M1, LYN, PFKL, EEA1, ARHGEF2

h_ptenPathway

PTEN dependent cell cycle arrest and apoptosis

BioCarta

AKT1, CDKN1B, GRB2, ITGB1, PIK3CA, PIK3R1, MAPK1, MAPK3, PTK2, SOS1, FOXO3, ILK, PTEN

h_pyk2Pathway

Links between Pyk2 and Map Kinases

BioCarta

CALM2, CALM3, MAPK14, GNAQ, GRB2, JUN, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAP2K1, RAC1, RAF1, SOS1, CRKL, MAP2K2

h_rabPathway

Rab GTPases Mark Targets In The Endocytotic Machinery

BioCarta

RAB1A, RAB2A, RAB5A, RAB27A, RAB7A, RAB11A, RAB9A

h_rac1Pathway

Rac 1 cell motility signaling pathway

BioCarta

CDK5, CFL1, MYLK, PPP1R12B, PIK3CA, PIK3CG, PIK3R1, PLD1, RAC1, VAV1, RALBP1, CHN1, NCF2, PDGFRA

h_raccPathway

Ion Channels and Their Functional Role in Vascular Endothelium

BioCarta

GNB1, NOS3, GNAS, TRPC3, TRPV4

h_RacCycDPathway

Influence of Ras and Rho proteins on G1 to S Transition

BioCarta

AKT1, RHOA, CDK2, CDK4, E2F1, NFKB1, PIK3CA, PIK3R1, MAPK1, MAPK3, RAC1, RAF1, RB1, RELA, TFDP1, CDK6, CDKN1A, CDKN1B

h_ranbp2Pathway

Sumoylation by RanBP2 Regulates Transcriptional Repression

BioCarta

HDAC1, RANBP2, RANGAP1, MDM2, HDAC9, HDAC4, HDAC6

h_ranklPathway

Bone Remodelling

BioCarta

FOS, NFKB1, MAPK8, RELA, FOSL2, IFNAR1, IFNAR2, FOSL1, TNFSF11, TNFRSF11A, IRF9

h_ranMSpathway

Role of Ran in mitotic spindle regulation

BioCarta

RCC1, RANBP1, RANGAP1, KPNB1, KPNA2, AURKA, TPX2, KIF15

h_ranPathway

Cycling of Ran in nucleocytoplasmic transport

BioCarta

RCC1, RANBP1, RANBP2, RANGAP1

h_rarPathway

Degradation of the RAR and RXR by the proteasome

BioCarta

CDK7

h_rarrxrPathway

Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells

BioCarta

POLR2A, NCOA3, NCOA1, HDAC3, KAT2B, NCOA2, GTF2A1, GTF2B, GTF2F1, NCOR2

h_rasPathway

Ras Signaling Pathway

BioCarta

AKT1, RHOA, BAD, CASP9, CDC42, ELK1, NFKB1, PIK3CA, PIK3CG, PIK3R1, MAPK3, MAP2K1, RAC1, RAF1, RELA, FOXO4, PLD1, RALA, RALGDS, RALBP1

h_rbPathway

RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage

BioCarta

CDK1, CDC25A, CDC25B, CDC25C, CDK2, RB1, TP53, CDK4, CHEK1, WEE1, YWHAH

h_reckPathway

Inhibition of Matrix Metalloproteinases

BioCarta

MMP2, MMP9, MMP14, TIMP1, TIMP2, TIMP3, RECK

h_reelinPathway

Reelin Signaling Pathway

BioCarta

FYN, CDK5, DAB1, VLDLR

h_RELAPathway

Acetylation and Deacetylation of RelA in The Nucleus

BioCarta

CREBBP, EP300, NFKB1, RELA, TNF, TNFRSF1B, TRADD, RIPK1, FADD, HDAC3

h_rhodopsinPathway

Visual Signal Transduction

BioCarta

SLC25A18

h_rhoPathway

Rho cell motility signaling pathway

BioCarta

RHOA, TLN1, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, ARHGAP5, ARHGAP6, CFL1, MYLK, PPP1R12B, PFN1, ARHGEF5, PIP5K1B

h_rnaPathway

Double Stranded RNA Induced Gene Expression

BioCarta

EIF2S1, NFKB1, RELA, TP53, DNAJC3

h_RNApol3Pathway

RNA polymerase III transcription

BioCarta

SSB, GTF3C4

h_s1pPathway

SREBP control of lipid synthesis,

BioCarta

HMGCS1, LDLR, SREBF1, SREBF2, LIMA1

h_salmonellaPathway

How does salmonella hijack a cell

BioCarta

RAC1, CDC42, WASL, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2

h_sam68Pathway

Regulation of Splicing through Sam68

BioCarta

CDK1, MAPK1, MAPK3, RASA1, KHDRBS1

h_SARSpathway

SARS Coronavirus Protease

BioCarta

MAPK14, EIF4E, LDHA, LDHB

h_setPathway

Granzyme A mediated Apoptosis Pathway

BioCarta

CREBBP, DFFA, CEP104, HMGB2, SET, ANP32A

h_shhPathway

Sonic Hedgehog (Shh) Pathway

BioCarta

GSK3B, PRKAR1A, PRKAR2A, PRKAR2B, GLI2, GLI3, PTCH1, SUFU

h_skp2e2fPathway

E2F1 Destruction Pathway

BioCarta

RB1, CDC34, CDK2, E2F1, SKP1, SKP2, TFDP1, CCNA1

h_slrp2Pathway

Function of SLRP in Bone: An Integrated View

BioCarta

TGFB1, TGFB2, TGFBR1

h_slrpPathway

Small Leucine-rich Proteoglycan (SLRP) molecules,

BioCarta

BGN, DCN, EPYC, FMOD, LUM

h_smPathway

Spliceosomal Assembly

BioCarta

SRSF2, SNRPA, SNRPA1, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPF

h_soddPathway

SODD/TNFR1 Signaling Pathway

BioCarta

CASP8, TNF, TNFRSF1B, TRADD, RIPK1, FADD, BIRC3

h_sppaPathway

Aspirin Blocks Signaling Pathway Involved in Platelet Activation

BioCarta

GNB1, ITGB1, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, PTK2, RAF1, PLCB1, F2, F2R, GNAI1, PLA2G4A, PTGS1, SYK

h_spryPathway

Sprouty regulation of tyrosine kinase signals

BioCarta

EGFR, GRB2, MAPK1, MAPK3, MAP2K1, RAF1, RASA1, SOS1, PTPRB, SPRY1, SPRY2, SPRY4

h_srcRPTPPathway

Activation of Src by Protein-tyrosine phosphatase alpha

BioCarta

CCNB1, CDK1, GRB2, PRKCA, PRKCB, CDC25A, CDC25B, CDC25C, CSK

h_stat3Pathway

Stat3 Signaling Pathway

BioCarta

JAK2, MAPK1, MAPK3, STAT3, JAK1, JAK3

h_stathminPathway

Stathmin and breast cancer resistance to antimicrotubule agents

BioCarta

PRKAR1A, PRKAR2A, PRKAR2B, CAMK2D, CCNB1, CDK1, HSPA5, STMN1, MAPK13, RB1CC1, UHMK1

h_stemPathway

Regulation of hematopoiesis by cytokines

BioCarta

CD4, IL6, CXCL8, IL11

h_stressPathway

TNF/Stress Related Signaling

BioCarta

MAPK14, JUN, NFKB1, MAPK8, MAP2K6, RELA, TNF, TRADD, RIPK1, CRADD, TANK, ATF1

h_sumoPathway

Basic Mechanisms of SUMOylation

BioCarta

SUMO3, SUMO2, UBE2I, SAE1

h_tall1Pathway

TACI and BCMA stimulation of B cell immune responses

BioCarta

MAPK14, NFKB1, MAPK8, RELA, TNFSF13, TNFSF13B

h_tcapoptosisPathway

HIV Induced T Cell Apoptosis

BioCarta

CD4, CD28, FAS

h_tcraPathway

Lck and Fyn tyrosine kinases in initiation of TCR Activation

BioCarta

CD4, FYN, HLA-DRA, HLA-DRB1, PTPRC

h_tcrPathway

T Cell Receptor Signaling Pathway

BioCarta

CALM2, CALM3, ELK1, FOS, FYN, GRB2, JUN, NFATC1, NFATC2, NFKB1, PIK3CA, PIK3CG, PIK3R1, PPP3CA, PRKCA, PRKCB, MAPK3, MAPK8, MAP2K1, RAC1, RAF1, RASA1, RELA, SOS1, NFATC4, VAV1

h_tcytotoxicPathway

T Cytotoxic Cell Surface Molecules

BioCarta

CD28, ICAM1, ITGB2, PTPRC

h_telPathway

Telomeres, Telomerase, Cellular Aging, and Immortality

BioCarta

AKT1, EGFR, MYC, PRKCA, RB1, TP53, BCL2, HSP90AA1, IGF1R, KRAS, POLR2A, TEP1, TERF1, XRCC5, TNKS

h_tercPathway

Overview of telomerase RNA component gene hTerc Transcriptional Regulation

BioCarta

RB1, SP3, NFYB, NFYC

h_tertpathway

Overview of telomerase protein component gene hTert Transcriptional Regulation

BioCarta

HDAC1, MYC, TP53, WT1, SP3, MZF1

h_tffPathway

Trefoil Factors Initiate Mucosal Healing

BioCarta

AKT1, RHOA, CASP9, CTNNB1, GRB2, ITGB1, PIK3CA, PIK3CG, PIK3R1, MAPK3, PTK2, SOS1, BAD, EGFR, ERBB2, GH1, GHR, MAPK1, CYCS

h_tgfbPathway

TGF beta signaling pathway

BioCarta

APC, CREBBP, EP300, SMAD3, SMAD4, MAPK3, MAP2K1, MAP3K7, TGFB1, TGFB2, TGFBR1, TGFBR2, TAB1, SMAD2, SMAD7, SKIL

h_th1th2Pathway

Th1/Th2 Differentiation

BioCarta

CD28, IFNGR1, IFNGR2, CD40LG, HLA-DRA, HLA-DRB1, IL4R, IL12A, IL12RB1, IL18, IL18R1

h_thelperPathway

T Helper Cell Surface Molecules

BioCarta

CD4, CD28, ICAM1, ITGB2, PTPRC

h_tidPathway

Chaperones modulate interferon Signaling Pathway

BioCarta

JAK2, NFKB1, RB1, RELA, TNF, TNFRSF1B, HSPA1A, IFNGR1, IFNGR2, TP53, WT1, TAX1BP3

h_tnfr1Pathway

TNFR1 Signaling Pathway

BioCarta

JUN, MAPK8, MAP3K7, TNF, RIPK1, PARP1, ARHGDIB, CASP8, DFFA, LMNA, LMNB1, PAK2, PRKDC, RB1, TRADD, CRADD, FADD, CEP104, LMNB2

h_tnfr2Pathway

TNFR2 Signaling Pathway

BioCarta

NFKB1, RELA, DUSP1, TNFAIP3, TNFRSF1B, TRAF1, IKBKAP, RIPK1, TANK

h_tob1Pathway

Role of Tob in T-cell activation

BioCarta

SMAD4, CD28, SMAD3, TGFB1, TGFB2, TGFBR1, TGFBR2, TGFBR3, TOB2

h_tollPathway

Toll-Like Receptor Pathway

BioCarta

MAPK14, FOS, JUN, NFKB1, RELA, MAP3K7, TAB1, CD14, ELK1, IRAK1, PPARA, MAPK8, MAP2K6, TLR2, TLR3, TLR4, TOLLIP, TIRAP

h_TPOPathway

TPO Signaling Pathway

BioCarta

FOS, GRB2, JUN, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, SOS1, JAK2, MAPK3, MAP2K1, RAF1, RASA1, STAT3, STAT5A, STAT5B

h_trkaPathway

Trka Receptor Signaling Pathway

BioCarta

PIK3CA, PIK3R1, PRKCA, PRKCB, AKT1, GRB2, KLK2, NGF, NTRK1, SOS1