Search Pathways

Pathways

Pathway ID Pathway Term Pathway Source Proteins

h_ErbB3Pathway

Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling

BioCarta

EGFR, ERBB3, NRG1

h_erbB4pathway

g-Secretase mediated ErbB4 Signaling Pathway

BioCarta

ERBB4, PRKCA, PRKCB, PSEN1, ADAM17

h_erk5Pathway

Role of Erk5 in Neuronal Survival

BioCarta

AKT1, CREB1, GRB2, MEF2A, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, MAPK7, RPS6KA1

h_erkPathway

Erk1/Erk2 Mapk Signaling pathway

BioCarta

EGFR, ELK1, GNAS, GNB1, MKNK2, GRB2, IGF1R, ITGB1, KLK2, MYC, NGF, NGFR, PDGFRA, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, RPS6KA1, SOS1, STAT3, MKNK1, RPS6KA5

h_erythPathway

Erythrocyte Differentiation Pathway

BioCarta

IGF1, IL1A, IL6, IL11, KITLG, CCL3, TGFB1, TGFB2

h_etcPathway

Electron Transport Reaction in Mitochondria

BioCarta

CYCS, SLC25A4, GPD2, NDUFA1, SDHA, SDHB, SDHC, UQCRC1

h_etsPathway

METS affect on Macrophage Differentiation

BioCarta

E2F1, ETS1, ETS2, FOS, HDAC2, JUN, NCOR2, HDAC5, CSF1R, RBL1, DDX20, SIN3B

h_extrinsicPathway

Extrinsic Prothrombin Activation Pathway

BioCarta

SERPINC1, F2, F2R, F5, FGA, FGB, FGG, TFPI

h_fasPathway

FAS signaling pathway ( CD95 )

BioCarta

PARP1, FAS, ARHGDIB, CASP6, CASP8, DFFA, JUN, LMNA, LMNB1, PAK2, PRKDC, MAPK8, RB1, MAP3K7, FADD, CFLAR, CEP104, LMNB2, RIPK2, FAF1

h_fbw7Pathway

Cyclin E Destruction Pathway

BioCarta

CDC34, CDK2, E2F1, RB1, SKP1, TFDP1

h_fcer1Pathway

Fc Epsilon Receptor I Signaling in Mast Cells

BioCarta

CALM2, CALM3, ELK1, FOS, GRB2, JUN, LYN, NFATC1, NFATC2, NFATC4, PAK2, PIK3CA, PIK3CG, PIK3R1, PLA2G4A, PPP3CA, PRKCB, MAPK1, MAPK3, MAPK8, MAP2K1, MAP2K7, RAF1, SOS1, SYK, VAV1

h_fibrinolysisPathway

Fibrinolysis Pathway

BioCarta

F2, F2R, FGA, FGB, FGG, SERPINE1, PLAT, PLAU, PLG, CPB2, F13A1

h_flumazenilPathway

Cardiac Protection Against ROS

BioCarta

GABRA5, GPX1

h_fMLPpathway

fMLP induced chemokine gene expression in HMC-1 cells

BioCarta

CALM2, CALM3, MAPK14, ELK1, GNB1, NCF2, NFATC1, NFATC2, NFATC4, NFKB1, PPP3CA, MAPK1, MAPK3, MAP2K1, MAP2K2, MAP2K6, RAC1, RAF1, RELA, CAMK1, PLCB1, FPR1

h_fosbPathway

FOSB gene expression and drug abuse

BioCarta

CDK5, FOSB, JUND

h_freePathway

Free Radical Induced Apoptosis

BioCarta

CXCL8, NFKB1, RELA, TNF, GPX1, GSR, XDH

h_fxrPathway

FXR and LXR Regulation of Cholesterol Metabolism

BioCarta

ABCA1, LDLR, NR0B2, NR1H4, NR1H3, FABP6

h_g1Pathway

Cell Cycle: G1/S Check Point

BioCarta

CDK1, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, SMAD3, SMAD4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TP53, CCNA1

h_g1pPathway

Leloir pathway of galactose metabolism

BioCarta

GALE, GALT

h_g2Pathway

Cell Cycle: G2/M Checkpoint

BioCarta

BRCA1, CCNB1, CDK1, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CHEK1, GADD45A, EP300, MDM2, PLK1, PRKDC, RPS6KA1, TP53, WEE1, YWHAH

h_gabaPathway

Gamma-aminobutyric Acid Receptor Life Cycle

BioCarta

GABRA5, NSF, GPHN, GABARAP

h_GATA3pathway

GATA3 participate in activating the Th2 cytokine genes expression

BioCarta

MAPK14, NFATC1, NFATC2, PRKAR1A, PRKAR2A, PRKAR2B, JUNB, MAF

h_gcrPathway

Corticosteroids and cardioprotection

BioCarta

ADRB2, AKT1, CALM2, CALM3, GNAS, GNB1, NR3C1, HSP90AA1, NFKB1, NOS3, PIK3CA, PIK3CG, PIK3R1, RELA, ANXA1

h_ghPathway

Growth Hormone Signaling Pathway

BioCarta

GH1, GHR, GRB2, INSR, IRS1, JAK2, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, RAF1, RPS6KA1, SLC2A4, SOS1, STAT5A, STAT5B, HNF1A, SOCS1

h_ghrelinPathway

Ghrelin: Regulation of Food Intake and Energy Homeostasis

BioCarta

GH1, GHRH, IGF1, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, GHRL

h_gleevecpathway

Inhibition of Cellular Proliferation by Gleevec

BioCarta

AKT1, BAD, BCR, CRKL, FOS, GRB2, JAK2, JUN, MYC, PIK3CA, PIK3CG, PIK3R1, MAPK3, MAPK8, MAP2K1, RAF1, SOS1, STAT5A, STAT5B

h_glycolysisPathway

Glycolysis Pathway

BioCarta

GAPDH, PFKL, ENO1, GPI, HK1, PGAM1, PGK1, TPI1

h_gpcrPathway

Signaling Pathway from G-Protein Families

BioCarta

CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, JUN, NFATC1, NFATC2, NFATC4, PPP3CA, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB, MAPK3, MAP2K1, RAF1

h_granulocytesPathway

Adhesion and Diapedesis of Granulocytes

BioCarta

ICAM1, IL1A, CXCL8, ITGAM, ITGB2, PECAM1, SELL, SELPLG, TNF

h_gsk3Pathway

Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages

BioCarta

AKT1, APC, CD14, CTNNB1, GNAI1, GSK3B, IRAK1, NFKB1, PIK3CA, PIK3R1, RELA, TLR4, AXIN1, TOLLIP, TIRAP, GJA1

h_gsPathway

Activation of cAMP-dependent protein kinase, PKA

BioCarta

GNAS, GNB1, PRKAR1A, PRKACA

h_HBxPathway

Calcium Signaling by HBx of Hepatitis B virus

BioCarta

CREB1, GRB2, SOS1

h_hcmvPathway

Human Cytomegalovirus and Map Kinase Pathways

BioCarta

AKT1, CREB1, MAPK14, NFKB1, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, MAP2K1, MAP2K2, MAP2K6, RB1, RELA

h_hdacPathway

Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)

BioCarta

AKT1, CALM2, CALM3, MAPK14, IGF1, IGF1R, INSR, MEF2A, MEF2C, MEF2D, NFATC1, NFATC2, PIK3CA, PIK3CG, PIK3R1, PPP3CA, MAPK7, MAP2K6, YWHAH, CAMK1, HDAC5, CABIN1

h_her2Pathway

Role of ERBB2 in Signal Transduction and Oncology

BioCarta

EGFR, EP300, ERBB2, ESR1, GRB2, IL6, IL6R, IL6ST, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, MAP2K1, RAF1, SOS1, STAT3, CARM1, ERBB3, ERBB4

h_hesPathway

Segmentation Clock

BioCarta

GSK3B, NOTCH1, HNF1A, HES1, NOTCH2

h_hifPathway

Hypoxia-Inducible Factor in the Cardiovascular System

BioCarta

ARNT, CREB1, EDN1, EP300, HIF1A, HSP90AA1, JUN, LDHA, NOS3, P4HB, VEGFA, ASPH

h_HivnefPathway

HIV-I Nef: negative effector of Fas and TNF

BioCarta

ACTG1, PARP1, BIRC3, XIAP, FAS, ARHGDIB, BCL2, BID, CASP6, CASP8, CASP9, CDK11B, DFFA, LMNA, LMNB1, MDM2, MAP3K5, NFKB1, PAK2, PRKCD, PRKDC, MAPK8, MAP2K7, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, TNF, TNFRSF1B, TRAF1, TRADD, RIPK1, CRADD, FADD, CFLAR, CEP104, CYCS, LMNB2, CDK11A

h_hopPathway

Hop Pathway in Cardiac Development

BioCarta

GATA4, HOPX

h_hsp27Pathway

Stress Induction of HSP Regulation

BioCarta

FAS, BCL2, CASP9, HSPB1, HSPB2, IL1A, TNF, MAPKAPK2, CYCS

h_hSWI-SNFpathway

Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes

BioCarta

NR3C1, GTF2A1, GTF2B, GTF2F1, POLR2A, SMARCA4, SMARCC1, SMARCC2, SMARCD1, ARID1A, ACTB

h_HuntingtonPathway

Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors

BioCarta

CREB1, CREBBP, HDAC1, HTT

h_ifnaPathway

IFN alpha signaling pathway

BioCarta

IFNAR1, IFNAR2, JAK1, IRF9, STAT2

h_ifngPathway

IFN gamma signaling pathway

BioCarta

IFNGR1, IFNGR2, JAK1, JAK2

h_igf1mtorpathway

Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway

BioCarta

AKT1, EIF2S1, EIF2S3, EIF4E, EIF4EBP1, GSK3B, IGF1, IGF1R, PIK3CA, PIK3R1, PTEN, RPS6, EIF2B5

h_igf1Pathway

IGF-1 Signaling Pathway

BioCarta

ELK1, FOS, GRB2, IGF1, IGF1R, IRS1, JUN, PIK3CA, PIK3CG, PIK3R1, MAPK3, MAPK8, MAP2K1, PTPN11, RAF1, RASA1, SOS1

h_igf1rPathway

Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation

BioCarta

AKT1, BAD, GRB2, IGF1R, IRS1, PIK3CA, PIK3R1, PRKAR1A, PRKAR2A, PRKAR2B, MAPK1, MAPK3, MAP2K1, RAF1, RPS6KA1, SOS1, YWHAH

h_il10Pathway

IL-10 Anti-inflammatory Signaling Pathway

BioCarta

IL1A, IL6, IL10, JAK1, STAT3, STAT5A, TNF, BLVRB, HMOX1, IL10RB

h_IL12Pathway

IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

BioCarta

MAPK14, IL12A, IL12RB1, IL18, JAK2, JUN, MAPK8, MAP2K6, IL18R1, ETV5

h_il17Pathway

IL 17 Signaling Pathway

BioCarta

CD4, IL6, CXCL8, KITLG, CD58

h_il18Pathway

IL 18 Signaling Pathway

BioCarta

IL12A, IL18, CASP1

h_il1rPathway

Signal transduction through IL1R

BioCarta

MAPK14, IL1A, IL1B, IL1R1, IL6, IRAK1, JUN, NFKB1, MAPK8, MAP2K6, RELA, MAP3K7, TGFB1, TGFB2, TNF, TAB1, TOLLIP, IL1RAP, IL1RN, IRAK2, IRAK3

h_il22bppathway

IL22 Soluble Receptor Signaling Pathway

BioCarta

JAK1, JAK2, JAK3, STAT3, STAT5A, STAT5B, SOCS3

h_il2Pathway

IL 2 signaling pathway

BioCarta

ELK1, FOS, GRB2, JAK1, JAK3, JUN, MAPK3, MAPK8, MAP2K1, RAF1, SOS1, STAT5A, STAT5B, SYK

h_il2rbPathway

IL-2 Receptor Beta Chain in T cell Activation

BioCarta

AKT1, FAS, BAD, BCL2, CRKL, E2F1, FOS, GRB2, IRS1, JAK1, JAK3, MYC, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, RAF1, SOS1, STAT5A, STAT5B, SYK, NMI, PPIA, SOCS1, CFLAR, SOCS3

h_il3Pathway

IL 3 signaling pathway

BioCarta

FOS, GRB2, JAK2, MAPK3, MAP2K1, RAF1, SOS1, STAT5A, STAT5B

h_il4Pathway

IL 4 signaling pathway

BioCarta

AKT1, GRB2, IL4R, IRS1, JAK1, JAK3

h_il5Pathway

IL 5 Signaling Pathway

BioCarta

CD4, HLA-DRA, HLA-DRB1, IL1B, IL6, IL5RA

h_il6Pathway

IL 6 signaling pathway

BioCarta

ELK1, FOS, GRB2, IL6, JAK1, JAK2, JAK3, JUN, MAPK3, MAP2K1, PTPN11, RAF1, SOS1, STAT3, CEBPB, IL6R, IL6ST

h_il7Pathway

IL-7 Signal Transduction

BioCarta

BCL2, CREBBP, EP300, FYN, JAK1, JAK3, PIK3CA, PIK3CG, PIK3R1, STAT5A, STAT5B, IL7R, NMI

h_inflamPathway

Cytokines and Inflammatory Response

BioCarta

CD4, HLA-DRA, HLA-DRB1, IL1A, IL6, CXCL8, IL11, IL12A, PDGFA, TGFB1, TGFB2, TNF, IL10

h_insulinPathway

Insulin Signaling Pathway

BioCarta

ELK1, FOS, GRB2, JUN, PIK3CA, PIK3CG, PIK3R1, MAPK3, MAPK8, MAP2K1, PTPN11, RAF1, RASA1, SLC2A4, SOS1, INSR, IRS1

h_integrinPathway

Integrin Signaling Pathway

BioCarta

ACTN1, ACTN2, RHOA, CAV1, CRKL, CSK, FYN, GRB2, RAPGEF1, ITGB1, JUN, PPP1R12B, MAPK1, MAPK3, MAPK8, MAP2K1, MAP2K2, PTK2, RAF1, RAP1A, SOS1, TLN1, BCR, TNS1, ZYX

h_intrinsicPathway

Intrinsic Prothrombin Activation Pathway

BioCarta

COL4A2, COL4A3, COL4A6, F2, F2R, KNG1, SERPINC1, SERPING1, F5, F8, FGA, FGB, FGG

h_ionPathway

Ion Channel and Phorbal Esters Signaling Pathway

BioCarta

PRKCA, PRKCB

h_iresPathway

Internal Ribosome entry pathway

BioCarta

EIF4A1, EIF4A2, EIF4E, EIF3A, EIF4G3

h_keratinocytePathway

Keratinocyte Differentiation

BioCarta

FAS, BCL2, MAPK14, EGFR, FOS, JUN, MAP3K5, NFKB1, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK13, MAP2K1, MAP2K6, MAP2K7, RAF1, RELA, TNF, TNFRSF1B, RIPK1, ETS1, ETS2, PRKCD, PRKCQ

h_LairPathway

Cells and Molecules involved in local acute inflammatory response

BioCarta

C3, C6, C7, ICAM1, IL1A, IL6, CXCL8, ITGB1, ITGB2, KNG1, TNF, VCAM1, SELPLG

h_LDLpathway

Low-density lipoprotein (LDL) pathway during atherogenesis

BioCarta

IL6, LDLR, LPL, CCL2

h_lectinPathway

Lectin Induced Complement Pathway,

BioCarta

C3, C4A, C4B, C6, C7, MBL2, MASP2

h_leptinPathway

Reversal of Insulin Resistance by Leptin

BioCarta

CPT1A, LEP, LEPR, PRKAA2, PRKAG1, PRKAG3

h_Lis1Pathway

Lissencephaly gene (LIS1) in neuronal migration and development

BioCarta

CDK5, DCTN1, CLIP1, DYNLL1, DCTN6, DNAH1, NDEL1

h_longevityPathway

The IGF-1 Receptor and Longevity

BioCarta

AKT1, FOXO3, GH1, GHR, IGF1, IGF1R, PIK3CA, PIK3CG, PIK3R1, SOD2, SOD3

h_lympathway

Adhesion and Diapedesis of Lymphocytes

BioCarta

ICAM1, IL1A, CXCL8, ITGB1, ITGB2, PECAM1, SELL, VCAM1

h_lymphocytePathway

Adhesion Molecules on Lymphocyte

BioCarta

CD44, ICAM1, ITGB1, ITGB2, PECAM1, SELE, SELL

h_malatePathway

Malate-aspartate shuttle

BioCarta

MDH1, SLC1A3

h_malatexPathway

Shuttle for transfer of acetyl groups from mitochondria to the cytosol

BioCarta

MDH1, PC, PDHA1, SLC25A1

h_malPathway

Role of MAL in Rho-Mediated Activation of SRF

BioCarta

RHOA, CDC42, MAPK1, MAPK3, MAPK8, MAP2K1, MAP2K2, RAC1, RAF1, HNF1A, MAL

h_mapkPathway

MAPKinase Signaling Pathway

BioCarta

CREB1, MAPK14, ELK1, FOS, GRB2, JUN, MEF2A, MEF2C, MEF2D, MAP3K5, MYC, NFKB1, PAK2, MAPK1, MAPK3, MAPK8, MAPK13, MAP2K1, MAP2K2, MAP2K6, RAC1, RAF1, RELA, RPS6KA1, MAP3K7, TGFB1, TGFB2, TGFBR1, MKNK1, TRADD, RIPK1, RPS6KA5, MAPKAPK2, MAP3K8, MKNK2, MAP3K4, MAPK7, MAPK9, MAP2K5, MAP2K7, RPS6KA2, MAP4K3, MAP3K13, MAP4K4, MAP4K5

h_mCalpainPathway

mCalpain and friends in Cell motility

BioCarta

EGFR, ITGB1, MYLK, PRKAR1A, PRKAR2A, PRKAR2B, PTK2, TLN1, EZR

h_mcmPathway

CDK Regulation of DNA Replication

BioCarta

CDK2, CDKN1B, KITLG, CDC6, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, ORC1, ORC5, ORC6, ORC3, CDT1

h_mef2dPathway

Role of MEF2D in T-cell Apoptosis

BioCarta

CALM2, CALM3, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PRKCA, PRKCB, CABIN1

h_melanocytepathway

Melanocyte Development and Pigmentation Pathway

BioCarta

BCL2, CREB1, EP300, RPS6KA1, KIT, KITLG, MITF

h_methioninepathway

Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine

BioCarta

BCKDHB, CBS, CTH

h_metPathway

Signaling of Hepatocyte Growth Factor Receptor

BioCarta

CRKL, ELK1, FOS, GRB2, ITGB1, JUN, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, MAPK8, MAP2K1, MAP2K2, PTEN, PTK2, RAF1, RASA1, SOS1, STAT3, GAB1, RAPGEF1, HGF, MET, PTPN11, RAP1A

h_mhcPathway

Antigen Processing and Presentation

BioCarta

B2M, HLA-A, HLA-DRA, HLA-DRB1, CD74, PSMB5, PSMB8, PSMB9

h_mitochondriaPathway

Role of Mitochondria in Apoptotic Signaling

BioCarta

BIRC3, BAX, BCL2, CASP8, CASP9, DFFA, CEP104, CYCS, XIAP, BID, CASP6, AIFM1

h_MITRPathway

Signal Dependent Regulation of Myogenesis by Corepressor MITR

BioCarta

MEF2A, MEF2C, MEF2D, YWHAH, CAMK1, HDAC9

h_monocytePathway

Monocyte and its Surface Molecules

BioCarta

CD44, ICAM1, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL

h_mPRPathway

How Progesterone Initiates the Oocyte Maturation

BioCarta

CCNB1, CDK1, CDC25C, GNAI1, GNAS, GNB1, PRKAR1A, PRKAR2A, PRKAR2B, MAPK1, MAPK3, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, PGR, RPS6KA1, PAQR5

h_mrpPathway

Multi-Drug Resistance Factors

BioCarta

GSTP1, ABCC1

h_mspPathway

Msp/Ron Receptor Signaling Pathway

BioCarta

IL1B, TNF, MST1, CCL2

h_mta3Pathway

Downregulated of MTA-3 in ER-negative Breast Tumors

BioCarta

ESR1, HDAC1, HSPB1, HSPB2, ALDOA, CTSD, GAPDH, SNAI2, TUBA4A, TUBA1A, MTA1, GREB1, MBD3

h_mTORPathway

mTOR Signaling Pathway

BioCarta

AKT1, EIF4E, PIK3CA, PIK3R1, PTEN, TSC2, MKNK1, EIF4A1, EIF4A2, EIF4B, EIF4EBP1, RHEB, RPS6, EIF3A, EIF4G3

h_myosinPathway

PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase

BioCarta

ARHGAP5, GNA12, GNAQ, GNB1, MYLK, PPP1R12B, PRKCA, PRKCB, PLCB1, PKN1

h_ndkDynaminPathway

Endocytotic role of NDK, Phosphins and Dynamin

BioCarta

CALM2, CALM3, AP2M1, PPP3CA, EPS15, NME1, PICALM, SYNJ1, SYNJ2

h_neutrophilPathway

Neutrophil and Its Surface Molecules

BioCarta

ICAM1, ITGB2, CD44, ITGAM, PECAM1, SELE, SELL

h_nfatPathway

NFAT and Hypertrophy of the heart (Transcription in the broken heart)

BioCarta

AKT1, CALM2, CALM3, CREBBP, MAPK14, CSNK1A1, F2, GSK3B, MEF2C, NFATC1, NFATC2, NFATC4, PIK3CA, PIK3CG, PIK3R1, PPP3CA, PRKAR1A, PRKAR2A, PRKAR2B, MAPK1, MAPK3, MAPK8, MAP2K1, RAF1, CAMK1, AGT, CALR, CTF1, HBEGF, EDN1, FGF2, GATA4, IGF1, LIF, MYH2

h_nfkbPathway

NF-kB Signaling Pathway

BioCarta

IRAK1, NFKB1, RELA, MAP3K7, TLR4, TNF, TNFAIP3, TNFRSF1B, TRADD, RIPK1, FADD, TAB1, IL1A, IL1R1

h_ngfPathway

Nerve growth factor pathway (NGF)

BioCarta

ELK1, FOS, GRB2, JUN, KLK2, NGF, PIK3CA, PIK3CG, PIK3R1, MAPK3, MAPK8, MAP2K1, RAF1, SOS1, NGFR