WP3925

Amino Acid metabolism

WikiPathways

SRM, PDK4, RARS, PDHA1, AOC3, GLS, OGDH, HMGCL, P4HA2, ACSS1, GOT2, MDH2, MDH1, ALDH7A1, ASS1, PNMT, ALDH18A1, ASNS, CBS, MPST, CTH, PKM, AUH, BCAT1, EPRS, MCCC1, GSR, DLST, MAOA, ALDH1A1, PCK1, FH, HADH, HNMT, IDH1, LARS2, GPT2, ADH7, GCLM, HIBCH, DLD, HIBADH, PC, CAD, SDHA, LDHA, SUCLG1, FAH, TH, ODC1, ACO2

WP3926

ApoE and miR-146 in inflammation and atherosclerosis

WikiPathways

TLR4, RELA, TLR2, IRAK1, APOE

WP3927

BMP Signaling Pathway in Eyelid Development

WikiPathways

JUN, MAPK9, TGFA, EGFR, NOTCH1, FGFR2, BMP4, INHBB, SFRP1, FOXC1, DKK2, MAPK3, SMAD5, SMAD4, PITX2, SMAD1

WP3929

Chemokine signaling pathway

WikiPathways

STAT3, STAT2, CCL3, CCL5, CCL4, PTK2, VAV1, CXCL14, AKT1, AKT2, JAK3, DOCK2, JAK2, CCL20, NRAS, AKT3, TIAM1, STAT5B, NFKB1, RELA, GNG7, KRAS, GNG5, FGR, GNB3, GNB2, PRKX, GNG4, GNAI1, GNAI2, GNG11, ADCY3, CXCL5, CSK, FOXO3, GNAI3, CXCL12, GNB1, CRKL, CDC42, SOS2, ADCY9, PLCB1, RAF1, PRKCB, ADCY7, CXCR4, CXCR2, PRKCD, RAC2, WASL, RASGRP2, MAP2K1, GRB2, MAPK3, CXCL16, RAC1, SOS1, MAPK1, GSK3B, ROCK2, RAP1A, PF4, GRK6, PIK3CA, PIK3CB, PIK3CD, SHC2, ELMO1, PPBP, PARD3, GRK5, PIK3CG, VAV3, LYN, PIK3R1

WP3930

EDA Signalling in Hair Follicle Development

WikiPathways

EDARADD, RELB, BMP1, DKK1, WNT3, PTCH1, SOSTDC1

WP3931

ESC Pluripotency Pathways

WikiPathways

JUN, LRP5, LRP6, STAT3, ELK1, FZD4, SEPP1, FZD6, FZD7, FZD8, PDGFRB, MDM2, WNT2B, JAK1, AKT1, AKT2, AKT3, ACTR2, AXIN1, SMAD5, SMAD9, SMAD7, SMAD6, WNT5B, PDGFA, PDGFB, PDGFRA, ACVR1, APC, PTPN11, RAF1, FGF9, FGF7, HNF1A, FGF2, MAP2K2, MAP2K1, FGFR2, MAP2K5, MAP2K6, FGFR1, FGF14, FGF11, GRB2, FGF12, SMAD4, MAPK7, FGF19, SOS1, SMAD1, MAPK1, EGFR, GSK3B, WNT2, WNT3, WNT5A, WNT6, CTNNB1, FGF18, BMPR2, BMPR1A, PTEN, IL6ST, BMP4, PIK3CD, LIF, GAB1, LIFR, FOS

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

PPARGC1A, HGF, FN1, IGF1, COMP, THBS4, IGF1R, EIF4B, EIF4E, EIF4EBP1, ITGA11, PGF, PTK2, ULK1, HIF1A, FLT4, JAK1, AKT1, JAK3, AKT2, JAK2, NRAS, LAMC1, LAMA4, LAMB1, CSF1R, PRLR, KRAS, PRL, ELAVL1, HSP90B1, MET, FOXO1, CSF3R, FOXO3, COL11A1, LAMC3, COL11A2, OSMR, THBS1, CASP9, TSC2, VWF, FGF9, FGF7, VTN, PDGFD, KITLG, FGF2, BAD, GYS1, GYS2, PHLPP2, NOS3, MAP2K2, PIK3R4, MAP2K1, FGFR2, KIT, FGFR1, FGF14, GRB2, FGF11, CREB5, FGF12, RPS6, ITGA10, STK11, LIPE, PFKFB4, EIF4E2, FGF18, PPP2CB, PFKFB3, PFKFB2, PPP2R1A, PFKFB1, PPP2R1B, PELO, PTEN, TNC, GHR, PPP2R5A, PPP2R3A, PPP2R5D, ATF4, PPP2R5C, PPP2R5B, COL5A3, IRS4, COL6A2, COL5A2, F2R, ITGA9, ANGPT2, ANGPT1, ITGAE, CREB3L1, ITGA3, ITGA5, COL5A1, COL4A6, PDGFRB, COL3A1, RHEB, COL4A2, CDC37, MDM2, ITGB3, CREB1, ITGB4, ITGB5, ITGAV, MLST8, ITGB1, ITGAX, AKT3, SPP1, ITGB2, COL1A1, COL1A2, GNG7, PDGFC, GNG5, GNB3, CHRM2, GNB2, GNG4, GNG11, VEGFA, HSP90AA1, NGF, PRKAA2, VEGFC, ITGB8, VEGFB, NGFR, RAB11B, PDGFA, PDGFB, PDGFRA, IRS2, HSP90AB1, DDIT4, GNB1, HIF3A, RAF1, SLC2A4, SLC2A3, SLC2A1, INS, IL7R, EFNA4, EFNA5, EFNA1, CAB39, MAPK3, INSR, FGF19, SOS1, MAPK1, EPOR, EGFR, EPAS1, GSK3B, TNR, CDKN1B, CDKN1A, TNXB, LAMA3, LAMA2, IFNAR1, IFNAR2, PIK3C2A, ITGA6, RAB2A, IL6R, ITGA2, TEK, PIK3CA, PIK3CB, PIK3CD, IRS1, SREBF1, IL4R, PIK3CG, PIK3R1

WP3933

Kennedy pathway

WikiPathways

CHKA, PEMT, PCYT2, PTDSS1, CEPT1, CHKB, ETNK1, PCYT1B, PCYT1A

WP3934

Leptin and adiponectin

WikiPathways

LEPR, PRKAG1, CPT1A, LEP, ADIPOQ, ADIPOR2, ADIPOR1

WP3935

Leptin Insulin Overlap

WikiPathways

STAT3, IRS2, SOCS1, AKT1, JAK2, LEPR, SOCS2, LEP, IRS1, DGKZ, SOCS3, INSR, INS, PIK3CG, IRS4

WP3937

Microglia Pathogen Phagocytosis Pathway

WikiPathways

ITGAM, SYK, FCGR1A, PIK3C3, PIK3C2A, TREM1, RAC2, SIGLEC7, NCF4, NCF2, RAC3, VAV1, PIK3CA, PIK3CB, PIK3CD, TYROBP, ITGB2, C1QA, PLCG2, PIK3CG, CYBB, PIK3R1, LYN, RAC1, VAV3

WP3938

miR-222 in Exercise-Induced Cardiac Growth

WikiPathways

HIPK2, CDKN1B

WP3939

Wnt Signaling in Kidney Disease

WikiPathways

LRP5, MAPK8, LRP6, WNT2, WNT3, WNT5A, WNT6, CTNNB1, FZD4, FZD6, FZD7, FZD8, INVS, MAPK9, WNT5B, NPHP3, WNT2B

WP3940

One carbon metabolism and related pathways

WikiPathways

PEMT, TYMS, CEPT1, ETNK1, DMGDH, PCYT1A, SOD2, SOD3, CDO1, SARDH, AHCYL1, PCYT2, MTR, GPX7, CBS, CTH, GSR, GCLC, SHMT1, GPX1, GPX3, GPX4, CHKA, GCLM, CSAD, PLD1, MTHFR, CHKB, MAT2A, PCYT1B

WP3941

Oxidative Damage

WikiPathways

CASP9, TNF, CDKN1C, CDKN1B, CDKN1A, C5AR1, GADD45A, C4B, BAD, PCNA, TRAF1, BCL2, MAPK13, TNFRSF1B, TDP2, C1S, CYCS, C1QA, C1R, TNK2, NFKB1, CDC42

WP3942

PPAR signaling pathway

WikiPathways

SLC27A4, SORBS1, APOA2, APOA1, CD36, FADS2, SLC27A1, CYP8B1, SCD, UCP1, DBI, ACSL6, NR1H3, MMP1, APOA5, RXRB, ILK, APOC3, ACOX2, ACOX3, OLR1, CPT1B, SLC27A2, LPL, CPT1A, PCK2, FABP4, PCK1, SCP2, PPARA, PLIN1, FABP3, FABP5, FABP6, SLC27A6, ADIPOQ, PPARG, PPARD, ACSL1, ACOX1, ACSL4

WP3943

Robo4 and VEGF Signaling Pathways Crosstalk

WikiPathways

VEGFA, SLIT2, RAC1

WP3944

Serotonin and anxiety-related events

WikiPathways

HTR2C, ARC, NLGN1, PRKCB, FOS, PPP3CA

WP3945

TYROBP Causal Network

WikiPathways

SAMSN1, ITGAM, ZFP36L2, NCF2, SFT2D2, TNFRSF1B, SLC7A7, NPC2, ITGAX, TYROBP, SLC1A5, ITGB2, ADAP2, SPP1, STAT5A, CXCL16, RPS6KA1, CD4, CAPG, RUNX3, TMEM106A, IL18, DPYD, GPX1, PYCARD, RBM47, MAF, TGFBR1, SH2B3, ABCC4, HCLS1, TCIRG1, LHFPL2, C3, BIN2

WP3946

White fat cell differentiation

WikiPathways

EGR2, NR2F2, KLF2, KLF15, CEBPB, ZNF423, CEBPD, DDIT3, INS, NR1H3, RORA, TCF7L1, FOXO1, NR3C1, CREB1, PPARG, STAT5B, SREBF1, STAT5A, KLF4, TLE3, CTNNA1

WP3947

Serotonin and anxiety

WikiPathways

ARC, ADRA1A, PRKCB, TRPV1, FMR1, PPP3CA, HTR2C, FOS, POMC

WP395

IL-4 Signaling Pathway

WikiPathways

PTPN11, STAT3, ELK1, BIRC5, CEBPB, BAD, SOCS5, INPP5D, JAK1, AKT1, JAK3, JAK2, GRB2, MAPK3, STAT5B, STAT5A, NFKB1, SOS1, MAPK1, MAPK14, EP300, RELA, FLNA, SOCS1, NFIL3, SOCS3, IRS2, PIK3CA, PIK3CD, IRS1, IL4R, FOS, PIK3R1, HRH1

WP3958

GPR40 Pathway

WikiPathways

PKD1, PLCB1, PLCD1, PLCL1, ITPR3, GNA11, PLCG2

WP3959

DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM

WikiPathways

CASP9, E2F1, RIF1, MCPH1, BLM, RAD51, ACTL6A, TRIM28, MDC1, BRCA2, MRE11A, BID, BRCA1, BAX, RAD9A, MDM2, RASSF1, HSF1, LATS1, PRKDC, EXO1, SMC1A, NBN, SMC3, RNF8, RAD50, FANCD2, PCNA, YAP1, CHEK1, H2AFX, TP53, CDK5, CDC25C, NABP2, DCLRE1C, PARP1

WP3967

miR-509-3p alteration of YAP1/ECM axis

WikiPathways

YAP1, TEAD4, TWIST1, TEAD3, COL3A1, FN1, SNAI2, SPARC, EDNRA, TEAD2, GPC6, COL1A1, COL5A1

WP3968

CTGF-mediated hyperthermia resistance

WikiPathways

CTGF

WP3969

H19 action Rb-E2F1 signaling and CDK-β-catenin activity

WikiPathways

E2F1, CSRP2, SOX4, H2AFY, CDK4, RB1, TULP3, CDK8, PMAIP1, CTNNB1, JAG1, H19

WP399

Wnt Signaling Pathway and Pluripotency

WikiPathways

JUN, LRP5, LRP6, RACGAP1, FZD4, FZD6, FZD7, CREBBP, FZD8, CTBP2, MAP3K7, WNT2B, AXIN1, ZBTB33, MYC, CSNK1E, LDLR, CTNND1, WNT5B, NLK, APC, CCND2, CCND3, PRKCB, PRKCA, PPM1J, RHOA, PRKD1, PRKCI, PRKCD, PLAU, MAPK9, PRKCQ, FOSL1, TCF7L2, EP300, GSK3B, WNT2, CD44, WNT3, WNT5A, CTNNB1, WNT6, PPP2CB, PPP2R1A, POU5F1, PPP2R1B, TCF7L1, PPARD, TP53, PPP2R4, PPP2R3A, PPP2R5C

WP400

p38 MAPK Signaling Pathway

WikiPathways

MEF2D, MAPK14, ELK1, MAPKAPK2, HSPB1, TGFB2, MKNK1, RIPK1, DDIT3, TGFBR1, TRADD, MAP3K5, RPS6KA5, PLA2G4A, MAP3K7, MAP2K6, CREB1, GRB2, RAC1, MYC, CDC42

WP404

Nucleotide Metabolism

WikiPathways

POLG, SRM, MTHFD2, POLD1, RRM1, RRM2, ADSS, PRPS2, ADSL, PRPS1, DHFR, SAT1, POLA1, OAZ1

WP405

Eukaryotic Transcription Initiation

WikiPathways

POLR2G, POLR2E, POLR2I, POLR2J, POLR1D, ERCC2, POLR3K, POLR2K, GTF2B, GTF2A2, TAF12, ILK, GTF2H2, GTF2H1, POLR1E, GTF2F2, CDK7, POLR1A, TAF5, POLR2B, POLR3B, POLR2A, GTF2H4

WP408

Oxidative Stress

WikiPathways

MAOA, GSR, XDH, MAPK14, TXNRD1, GCLC, JUNB, NQO1, GSTT2, TXN2, GPX1, GPX3, CYP1A1, SOD2, SOD3, MGST1, HMOX1, NOX4, NFKB1, MT1X, FOS

WP410

Exercise-induced Circadian Regulation

WikiPathways

KLF9, NCOA4, PER1, RBPMS, PSMA4, PIGF, CEBPB, GSTP1, TUBB3, VAPA, SF3A3, PPP2CB, UCP3, SUMO3, G0S2, HLA-DMA, NR1D2, QKI, AZIN1, BTG1, DNAJA1, ZFR, CRY1, PURA, UGP2, ARNTL, GSTM3, IDI1, CBX3

WP411

mRNA Processing

WikiPathways

CLK2, CSTF3, SREK1, NXF1, SFPQ, RNPS1, NCBP1, SRSF9, PAPOLA, RBM17, PTBP2, SUGP2, SMC1A, CD2BP2, PABPN1, LSM7, RBMX, SF3A3, PRPF40A, SNU13, RBM5, LSM2, POLR2A, PRPF18, NUDT21, SF3B5, SUPT5H, SRP54, PSKH1, SNRNP40, DHX15, RNU2-1 , DICER1, HNRNPL, HNRNPU, CELF2, CPSF1, CPSF2, SRPK1, SRPK2, NONO, HNRNPR, DHX16, CLK4, HNRNPH1, HNRNPH2, PPM1G, RBM39, HNRNPAB, HNRNPC, HNRNPD, HNRNPA2B1, TMED10, SNRPN, SNRPF, SNRPD2, SNRPD3, HNRNPA1, PRPF3, FUS, YBX1, SRSF10, SRSF6, SNRPA, PRMT1, SNRPA1, HNRNPM, SNRPB, PRPF4B, TRA2B, SRSF5, DDX20, PTBP1, SRRM1, SNRPD1, SRSF2, SRSF1

WP422

MAPK Cascade

WikiPathways

JUN, MAPK14, RAF1, ELK1, KRAS, RRAS, MAP2, MAP2K2, MAP2K1, MAP2K7, MAP2K6, RASA3, NRAS, MAPK3, MAPK1

WP428

Wnt Signaling Pathway

WikiPathways

JUN, LRP5, LRP6, PRKCB, PRKCA, FZD6, FZD7, RHOA, FZD8, PRKD1, PRKCI, PRKCD, PLAU, MAPK9, PRKCQ, WNT2B, FOSL1, AXIN1, RAC1, MYC, CSNK1E, GSK3B, WNT2, WNT3, WNT5A, CTNNB1, WNT6, LDLR, WNT5B, APC, PPP2R5C, KREMEN1, ROR1, CCND2, SFRP4, CCND3

WP43

Oxidation by Cytochrome P450

WikiPathways

CYP2E1, CYP3A5, CYP4V2, CYP3A4, CYP8B1, CYP11A1, CYB5R3, CYB5A, CYP2D6, CYP19A1, CYP17A1, CYP11B2, CYP11B1, CYP27B1, CYP26A1, CYP2C9, CYP2B6, CYP3A7, CYB5B, CYP26B1, CYP2U1, CYP51A1, CYP2A6, CYP1A1, CYP1B1, CYP3A43, CYP2W1, CYP2R1

WP430

Statin Pathway

WikiPathways

APOB, LPL, ABCA1, SCARB1, APOA2, APOA4, APOA1, LDLR, FDFT1, HMGCR, ACSS1, SOAT1, SQLE, APOA5, APOC1, APOC3, APOE, ABCG8

WP437

EGF/EGFR Signaling Pathway

WikiPathways

MEF2C, JUN, TWIST1, MEF2D, FOXO4, STAT3, MEF2A, ELK1, IQSEC1, JUND, STAMBP, STMN1, EIF4EBP1, RICTOR, PTK2, RPS6KA5, MAP3K4, VAV1, STAM, CREB1, JAK1, AKT1, JAK2, PEBP1, MYBL2, PLSCR1, AP2B1, ABI1, STAT5B, STAT5A, SYNJ1, MAPK14, KRAS, CFL1, STXBP1, CSK, RALB, FOXO1, RALA, RALBP1, ERRFI1, CRKL, PLD1, REPS2, TNK2, ITCH, CDC42, SOS2, E2F1, PTPN11, PRKCB, RAF1, PRKCA, PRKCI, PRKCD, INPP5D, MAPK9, ERBB2, NOS3, MAP2K2, EPS15, MAP2K1, SH3GL2, MAP2K5, USP6NL, RASA1, RPS6KA2, GRB10, GRB2, IQGAP1, MAPK7, RAC1, EPS8, SOS1, RPS6KA1, MAPK1, MAPK8, EGFR, NEDD8, FOSB, CBLB, NCOA3, AURKA, LIMK2, GJA1, PCNA, RAB5A, AP2S1, AP2M1, PTEN, RAP1A, SPRY2, STAM2, CAV2, CAV1, NDUFA13, RALGDS, ATF1, GAB1, FOS, VAV3, PIK3R1, ASAP1

WP438

Non-homologous end joining

WikiPathways

XRCC4, MRE11A, XRCC5, RAD50, PRKDC

WP45

G1 to S cell cycle control

WikiPathways

E2F1, TFDP1, CDK1, CREB3L1, RPA3, POLA2, MDM2, CREB1, RB1, RBL1, MYC, PRIM1, PRIM2, CDKN1C, CDKN1B, CDKN1A, CCNA1, CDKN2B, CDKN2C, GADD45A, PCNA, POLE2, MCM4, ORC6, MCM3, MCM6, MCM5, MCM7, POLE, CDK2, CDK4, WEE1, MCM2, TP53, E2F2, ORC1, CCNE2, CDK6, CDK7, CDC25A, ORC5, CCND2, CCNB1, ORC3, CCNG2, CCND3

WP453

Inflammatory Response Pathway

WikiPathways

CD28, FN1, VTN, CD40LG, COL3A1, TNFRSF1B, LAMC1, COL1A1, IL4R, LAMB1, COL1A2, IL5RA, THBS1

WP455

GPCRs, Class A Rhodopsin-like

WikiPathways

PTGFR, PTGER2, PTGER4, PTGER3, ADRB3, ADRB2, ADRB1, ADRA2B, GPR34, GPR32, GPR27, GPER1, NPY6R, NPY5R, GPR63, NPY1R, NPY2R, DRD2, RABGAP1, SSTR1, NPBWR1, AGTR1, AGTR2, OPN1SW, SSTR5, CXCR4, MC2R, MTNR1A, MTNR1B, MC4R, ACKR4, ADORA1, FPR2, FPR1, ADORA2B, HTR7, OPRL1, HTR2C, HTR2B, AVPR2, ADRA1D, PTGDR, ADRA1B, ADRA1A, PTAFR, GHSR, GPR37, FSHR, LHCGR, HRH1, F2R, OXTR, F2RL1, CCKBR, OR3A3, EDNRA, CHRM2, CHRM3, CNR1, OPN3, HRH3, CXCR2, P2RY14

WP465

Tryptophan metabolism

WikiPathways

CYP2E1, MAOB, ALDH1A1, AOX1, ALDH2, HSD17B10, CYP3A4, HADH, OGDH, CYP1A1, CYP1B1, PRMT1, ALDH1A2, ECHS1, ALDH9A1, ALDH3A2, MDM2, CYP19A1, UBR5, DHCR24, KYNU

WP466

DNA Replication

WikiPathways

CDC7, PRIM1, PRIM2, POLD4, DBF4, RFC4, RFC5, POLA1, POLD3, RPA3, PCNA, POLE2, ORC6, MCM4, MCM3, MCM6, CDT1, MCM5, POLA2, POLD1, MCM7, POLE, CDK2, UBC, RFC3, RFC2, GMNN, MCM2, UBA52, ORC1, MCM10, ORC5, CDC6, ORC3

WP47

Hedgehog Signaling Pathway

WikiPathways

DHH, SUFU, SAP18, GLI2, PTCH1, GLI3, ARNTL

WP474

Endochondral Ossification

WikiPathways

MEF2C, CALM2, ENPP1, ADAMTS1, IGF1, MGP, IGF1R, IGF2, FGF2, PLAT, THRA, ADAMTS5, PTH, ALPL, PLAU, SOX9, PTHLH, MMP9, AKT1, FGFR1, SPP1, SOX6, CAB39, STAT5B, TIMP3, SERPINH1, RUNX2, RUNX3, CDKN1C, ACAN, TGFB2, TGFB1, FGF18, VEGFA, BMPR1A, PRKACA, HMGCS1, HDAC4, GHR, COL10A1, CHST11, GLI3, PTCH1, BMP6, GH1, KIF3A

WP477

Cytoplasmic Ribosomal Proteins

WikiPathways

RPL35, RPL31, RPL4, RPL5, RPL32, RPS10, RPL34, RPS11, RPS13, RPL35A, RPS14, RPL37A, RPL37, RPL38, RPL14, RPS15A, FAU, RPSA, RPS16, RPL27, RPS17, RPL26, RPL24, RPL29, RPL28, RPL27A, RPL30, UBA52, RPS6KA2, RPL36, RPS20, RPS18, RPS4Y1, RPS5, RPS6, RPS6KA1, MRPL19, RPLP2, RPL22, RPL23A, RPL18, RPL18A, RPL19, RPL21, RPS3A, RPL10A, RPS2, RPL17, RPL15, RPL12, RPL36A, RPL13, RPL10, RPL41, RPL11, RPL13A, RPL7A, RPS26, RPS27, RPS25, RPLP1, RPLP0, RPS27A, RPS9, RPS8, RPS21, RPS7, RPL7

WP481

Insulin Signaling

WikiPathways

JUN, XBP1, ENPP1, ELK1, IGF1R, EIF4E, EIF4EBP1, SNAP25, TRIB3, MAP3K5, MAP4K3, RHEB, MAP4K4, RPS6KA5, MAP3K4, MAP3K7, MAP3K8, AKT1, AKT2, MAPK14, SOCS1, TBC1D4, MYO1C, PRKAA2, SOCS3, STXBP1, STX4, FOXO1, FOXO3, STXBP2, IRS2, FLOT1, RHOQ, MAP3K13, KIF3A, SOS2, PTPN11, RAF1, PRKCB, PRKCA, TSC2, SORBS1, SLC2A4, SLC2A1, SNAP23, MINK1, RHOJ, PRKCI, INPP4A, GYS1, GYS2, PRKCD, MAPK9, RAC2, MAP2K2, PRKCQ, PIK3R4, PTPRF, MAPK13, MAP2K1, MAP2K7, MAP2K5, MAP2K6, MAP4K5, GRB14, RPS6KA2, RAPGEF1, PPP1R3A, GRB10, ARF1, ARHGAP33, GRB2, MAPK3, INSR, MAPK7, RAC1, SOS1, MAPK1, RPS6KA1, MAPK8, EGR1, CYTH3, SGK3, GSK3B, CBLB, VAMP2, LIPE, PFKL, PIK3C3, PIK3C2A, PTEN, RRAD, PIK3CA, PIK3CB, PIK3CD, GAB1, SHC2, IRS1, FOS, PIK3CG, PIK3R1, IRS4

WP49

IL-2 Signaling Pathway

WikiPathways

JUN, PTPN11, STAT3, RAF1, SYK, SOCS3, BCL2, MAP2K2, MAPT, FOXO3, MAP2K1, JAK1, AKT1, JAK3, CRKL, GRB2, NMI, MAPK3, STAT5B, STAT5A, FYN, CCND2, FOS, PIK3R1, RPS6, MYC, SOS1, MAPK1

WP496

Steroid Biosynthesis

WikiPathways

HSD17B7, HSD17B4, HSD17B2, HSD3B2, HSD17B1, HSD3B1, F13B, CYP17A1, CPN1

WP497

Urea cycle and metabolism of amino groups

WikiPathways

SRM, PYCRL, GATM, ASS1, ALDH18A1, CKB, ODC1

WP500

Glycogen Metabolism

WikiPathways

CALM2, PHKA2, PHKA1, GSK3B, AGL, PPP2CB, PPP2R1A, PPP2R1B, GYG2, GYS1, GYS2, GBE1, PPP2R5A, PPP2R4, PPP2R3A, UGP2, PYGB, PPP2R5D, PPP2R5C, PYGM, PPP2R5B, PGM1, CALM3

WP501

GPCRs, Class C Metabotropic glutamate, pheromone

WikiPathways

GRM3, GABBR1, GRM8, GRM6, GPRC5B, GABBR2, GPRC5C, GPRC5A

WP51

Regulation of Actin Cytoskeleton

WikiPathways

ABI2, F2, F2R, FN1, ENAH, SSH2, RRAS2, PDGFRB, PIP4K2B, WASF2, PTK2, DIAPH3, ARHGEF7, VAV1, PIP5K1B, CD14, NRAS, PFN1, GNA12, KRAS, CHRM2, CFL1, MYLK, CHRM3, PIP5K1C, RDX, CYFIP2, PAK7, CSK, PDGFA, PDGFB, PDGFRA, TMSB4X, APC, EZR, CDC42, SOS2, PAK3, RAF1, ARHGEF4, FGF9, FGF7, PAK2, FGF2, RHOA, PPP1R12A, ACTN1, RAC2, MAP2K2, RAC3, PIK3R4, MAP2K1, FGFR2, FGFR1, SSH3, FGF14, FGF11, IQGAP1, FGF12, FGF13, MAPK3, ACTG1, FGF19, RAC1, SOS1, MAPK1, EGFR, RRAS, FGF18, PIK3C3, PIP4K2A, ACTB, PIK3C2A, ROCK2, GIT1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1

WP516

Hypertrophy Model

WikiPathways

WDR1, IL18, IFRD1, IL1A, ANKRD1, JUND, NR4A3, CYR61, VEGFA, ATF3, EIF4E, HBEGF, EIF4EBP1, MSTN, IL1R1, ADAM10, ZEB1

WP521

Amino acid conjugation of benzoic acid

WikiPathways

ACSS2

WP524

G13 Signaling Pathway

WikiPathways

CALM2, PAK3, CFL1, CYFIP1, RHOA, PKN1, PIP4K2A, ROCK2, WASL, MAP3K4, PIK3CA, PIK3CB, PIK3CD, IQGAP1, IQGAP2, PPP1CB, ARHGDIB, TNK2, RAC1, CDC42, PFN1

WP528

Acetylcholine Synthesis

WikiPathways

CHKA, PEMT, PDHA1, PCYT1A

WP53

ID signaling pathway

WikiPathways

PAX8, ELK3, ELK1, ID1, CDK2, ID2, RB1, ID3, SREBF1, RBL1

WP530

Cytokines and Inflammatory Response

WikiPathways

CD4, CXCL1, TNF, TGFB1, IL1B, PDGFA, CXCL2, IL1A, IL10, IL6, HLA-DRB1, HLA-DRA, IL11

WP531

Mismatch repair

WikiPathways

POLD1, LIG1, MLH1, MSH2, MSH6, PCNA, EXO1

WP534

Glycolysis and Gluconeogenesis

WikiPathways

PGK1, PDHB, PCK1, PDHA1, SLC2A5, SLC2A4, FBP2, SLC2A3, PFKL, SLC2A1, TPI1, GAPDH, ENO3, ENO2, FBP1, LDHB, HK1, PGAM1, ALDOA, ALDOC, MDH2, GOT2, DLD, MDH1, DLAT, PC, LDHA, G6PC, ENO1, PKM, GPI

WP536

Calcium Regulation in the Cardiac Cell

WikiPathways

CALM2, ADRB3, ADRB2, ATP2A2, ADRB1, ATP1B3, ATP1B1, PKIG, ITPR3, RGS5, CAMK1, GNG7, GNA11, GNG5, GNB3, GNB2, CHRM2, GNG4, PLN, GNAI1, GNAI2, GNG11, CHRM3, ADCY3, RGS7, RGS10, CALR, YWHAB, CAMK2D, PRKACA, GNAQ, GNAS, PKIA, GNAI3, GNB1, PRKAR1A, PRKAR2A, ATP2B1, YWHAZ, CALM3, YWHAH, YWHAE, CACNB3, SFN, ADCY9, ADCY7, PRKCB, GJA5, PRKCA, PRKAR2B, RYR2, RYR3, PRKD1, PRKCD, PRKCQ, CACNA1E, CACNA1C, ANXA6, GJC1, ITPR1, ITPR2, GJA1, ADRA1D, ADRA1B, ADRA1A, GRK6, RGS2, RGS3, RGS4, GRK5

WP545

Complement Activation

WikiPathways

CFP, CD55, C1S, C6, C3, C1QA, C1R, C4B, C4A, MASP2, C7, CFB, C8G

WP550

Biogenic Amine Synthesis

WikiPathways

MAOA, COMT, PNMT, TH

WP554

ACE Inhibitor Pathway

WikiPathways

NOS3, KNG1, CYP11B2, TGFB1, AGT, AGTR1, AGTR2, ACE, ATP6AP2

WP558

Complement and Coagulation Cascades

WikiPathways

F2, F2R, CLU, KNG1, VWF, FGB, PLAT, F5, SERPINA1, PLAUR, PLAU, TFPI, F8, CR1, F13B, C7, C8G, SERPINA5, CD55, C6, C5AR1, C4B, CFH, CFB, CPB2, CD46, SERPINE1, PLG, SERPINC1, C1S, C3, C1QA, C1R, CFI, SERPING1, MASP2

WP560

TGF-beta Receptor Signaling

WikiPathways

JUN, STAT3, TNF, INHBA, CREBBP, SKIL, SKI, MAPK9, JAK1, SPP1, MAPK3, SMAD3, SMAD4, NFKB1, SMAD1, SMAD2, RUNX2, RUNX3, EP300, CTNNB1, BAMBI, TGFB1, ZNF423, SMAD5, FST, TGFBR3, TGFBR2, LTBP1, TGFBR1, SMAD9, SMAD7, SMAD6, BMP4, ZEB2, SERPINE1, LIF, FOS, THBS1

WP561

Heme Biosynthesis

WikiPathways

ALAD, CPOX, UROD

WP58

Monoamine GPCRs

WikiPathways

CHRM2, HTR7, ADRB3, ADRB2, ADRB1, HTR2C, ADRA2B, HTR2B, CHRM3, ADRA1D, ADRA1B, ADRA1A, DRD2, HRH1

WP581

EPO Receptor Signaling

WikiPathways

STAT3, RAF1, PDK1, SOCS1, MAP2K2, MAP2K1, IRS2, AKT1, RASA1, JAK2, GRB2, IRS1, MAPK3, STAT5B, STAT5A, PIK3CG, PTPRC, SOS1, MAPK1, EPOR

WP585

Interferon type I signaling pathways

WikiPathways

PTPN11, STAT3, STAT2, RACK1, EIF4A1, EIF4B, EIF4E, EIF4EBP1, RPS6KA5, VAV1, IRF9, MAP2K6, CREB1, JAK1, RAPGEF1, MLST8, STAT5A, RAC1, PTPRC, RPS6, MAPK14, SOCS1, PDCD4, IFNAR1, IFNAR2, SOCS3, REL, PRMT1, RAP1A, IRS2, MAPKAP1, CRKL, PIK3CD, IRS1, FYN, PIK3R1

WP61

Notch Signaling Pathway

WikiPathways

STAT3, NOTCH2, HES1, NOTCH1, HEY1, ADAM17, HES6, NCOR2, NCOR1, MAML2, DLL4, HIF1A, AKT1, JAK2, RING1, NFKB1, MYC, EP300, GSK3B, PSEN2, NUMB, PSEN1, CDKN1A, PTCRA, APH1A, SKP1, SPEN, FHL1, APH1B, TLE1, MAPT, JAG1, MAML3, HDAC1, HDAC2, ITCH, PIK3R1

WP615

Senescence and Autophagy in Cancer

WikiPathways

JUN, MAP1LC3B, FN1, IGF1, CCL3, GABARAPL1, ATG12, IGF1R, IGFBP3, SQSTM1, LAMP2, COL3A1, RSL1D1, ULK1, CXCL14, MDM2, IGFBP5, IL1A, MLST8, IGFBP7, LAMP1, COL1A1, GABARAP, MAPK14, SH3GLB1, SPARC, TGFB1, ATG13, GABARAPL2, BCL2, ATG10, COL10A1, SERPINE1, CDC25B, IFI16, THBS1, E2F1, CXCL1, RAF1, INHBA, VTN, CEBPB, PLAT, INS, CXCL8, PLAU, MAP2K1, RB1, RB1CC1, SMAD3, SMAD4, MAPK1, MAP1LC3A, GSK3B, CDKN1B, CDKN1A, CD44, PIK3C3, IRF1, IL1B, PCNA, RNASEL, MMP14, PTEN, IL6R, IL6ST, HMGA1, BMP2, TP53, CREG1, SLC39A4, IL6

WP619

Type II interferon signaling (IFNG)

WikiPathways

PTPN11, STAT2, SOCS1, IFNGR2, ICAM1, IFNGR1, IRF1, HLA-B, IL1B, SOCS3, PRKCD, PSMB9, ISG15, GBP1, IRF9, JAK1, JAK2, CYBB

WP623

Oxidative phosphorylation

WikiPathways

NDUFA5, NDUFA4, ATP6AP2, ATP5O, ATP5H, NDUFA2, NDUFA10, NDUFAB1, NDUFA7, NDUFV3, ATP5D, ATP5L, NDUFA11, ATP5G3, ATP5G2, ATP5E, NDUFS8, NDUFB10, NDUFV2, NDUFS1, NDUFB6, NDUFS4, NDUFB7, NDUFB8, NDUFS6, NDUFS2, NDUFB4, ATP5J, ATP5I

WP661

Glucose Homeostasis

WikiPathways

INS

WP673

ErbB Signaling Pathway

WikiPathways

JUN, PRKCA, BTC, NRG1, ELK1, PDK1, EIF4EBP1, BAD, ERBB4, PTK2, ERBB2, ERBB3, TGFA, MAP2K1, MAP2K7, MDM2, AKT3, AREG, GRB2, STAT5A, SOS1, MYC, MAPK1, MIR21, MAPK8, EGFR, GSK3B, KRAS, CDKN1B, CDKN1A, EREG, BCL2L11, FOXO1, TP53, GAB1, SHC2, HBEGF

WP678

Arachidonate Epoxygenase / Epoxide Hydrolase

WikiPathways

COX5A, GSTP1, CYP2C9

WP688

Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs)

WikiPathways

FMO4, FMO2

WP69

T-Cell antigen Receptor (TCR) Signaling Pathway

WikiPathways

JUN, PTPN11, RAF1, CD28, RIPK2, PRKCD, MAPK9, MAP2K2, PRKCQ, CD83, MAP2K1, VAV1, IL1A, MAP3K7, MAP3K8, CREB1, DBNL, AKT1, GRB2, MAPK3, NFKB1, SOS1, MAPK1, CD4, MAPK8, MAPK14, ITPR1, RELA, CBLB, TGFB1, IL1B, SH2B3, REL, VIM, LHB, FAS, CRKL, BCL10, FYN, NFATC2, NFATC1, FOS, IL6, PIK3R1, VAV3, FYB, CDC42

WP690

Polyol Pathway

WikiPathways

AKR1B1, SORD

WP691

Tamoxifen metabolism

WikiPathways

CYP2E1, SULT1E1, CYP3A5, SULT2A1, CYP3A4, CYP2A6, CYP2C9, CYP1A1, CYP1B1, CYP2D6

WP692

Sulfation Biotransformation Reaction

WikiPathways

GSR, SULT1E1, PAPSS2, SULT2A1, G6PD

WP696

Benzo(a)pyrene metabolism

WikiPathways

AKR1C3, EPHX1, AKR1C2, AKR1C1, CYP1A1, CYP1B1, CYP3A4

WP697

Estrogen metabolism

WikiPathways

GSTA1, SULT1E1, COMT, CYP3A4, NQO1, GSTM1, CYP1A1, ARSD, CYP1B1, STS

WP698

Glucuronidation

WikiPathways

PGM2, UGDH, HK1, UGP2, PGM1, UGT2B4, UGT2A3

WP699

Aflatoxin B1 metabolism

WikiPathways

GSTM1, EPHX1, AKR7A2, CYP3A4

WP702

Metapathway biotransformation

WikiPathways

GSTCD, CYP3A5, COMT, CYP4V2, CYP3A4, CYP8B1, NDST1, GSTP1, CYP11A1, GSTT2, GSTZ1, HS2ST1, FMO4, SULT1E1, NAT9, GSTO1, CYP21A2, CYP19A1, CYP17A1, FMO2, CYP11B2, CYP11B1, CHST7, CYP27B1, CYP26A1, NAA50, GSTM1, GSTA4, GSTM4, TPMT, GSTM3, GSTM2, CHST4, UGT2A3, NNMT, CHST2, CYP51A1, GSTK1, NAA30, AKR1C2, AKR1C1, CYP3A43, CYP2E1, EPHX1, AKR7A2, SULT2A1, AKR1C3, HS6ST2, CYP2D6, HS3ST1, HS6ST1, MGST2, MGST1, MGST3, CYP2C9, AKR1B1, CYP2B6, CHST6, CYP3A7, CYP2U1, CYP26B1, GSR, GPX3, HNMT, GPX4, HS3ST3B1, CYP1A1, CYP1B1, CHST11, CYP2W1, CHST5, NAT14, GSTO2, CYP2R1, CHST3, UGT2B4

WP704

Methylation Pathways

WikiPathways

PNMT, MAT2B, HNMT, TPMT, MAT2A, NNMT, COMT

WP706

Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

WikiPathways

JUN, MEF2C, PPARGC1A, HES1, CREM, CREBBP, SNAP25, RORA, HIF1A, IL1A, CREB1, PPARGC1B, NFKB1, SSTR1, BHLHE40, PLP1, GNB3, CHRM2, HADHB, VEGFA, NGF, GAPDH, BDNF, C4B, C4A, HSP90B1, YWHAB, ALDOA, PRKACA, FOXM1, ESR2, SLC25A4, HSPD1, ASCL1, PRKAR1A, SP3, PRKAR2A, YWHAZ, YWHAH, CDCA7L, YWHAE, TH, ADCYAP1R1, PRKAR2B, TNF, RYR2, CEBPB, TCF3, TF, MAZ, CXCL8, CHRNA7, NR3C1, SLC1A3, IL10, CPT1A, MAOA, EGR1, ECE1, PBX1, RUNX3, TPPP, EP300, DLX2, VAMP2, CTNNB1, GJA1, KCNH2, AR, POU5F1, IL1B, MAP2, SNTA1, IL1RN, YBX1, IL6R, SPTBN1, HDAC9, G6PC, HDAC1, TPH2, NTRK2, IL6

WP707

DNA Damage Response

WikiPathways

CASP9, CASP8, SFN, E2F1, CDK1, GADD45B, RAD51, MRE11A, BID, BRCA1, RAD9A, BAX, MDM2, CREB1, RB1, PMAIP1, TLK1, GADD45G, PRKDC, MYC, SMC1A, NBN, ATRIP, CDKN1B, CDKN1A, BBC3, GADD45A, RAD50, FANCD2, CDK2, CHEK1, SESN1, CDK4, H2AFX, TP53, CDK5, CYCS, FAS, CDK6, CCNE2, CCNB2, CDC25C, CDC25A, RAD1, CCND2, CCNB1, CCND3

WP710

DNA Damage Response (only ATM dependent)

WikiPathways

JUN, HMGB1, PDK1, BCL6, MAP3K4, MDM2, MAP3K7, WNT2B, AKT1, AKT2, PMAIP1, NRAS, AKT3, AXIN1, NFKB1, MYC, KRAS, LDLR, TGFB1, BBC3, BCL2L11, WNT5B, BCL2, FOXO3, APC, CCND2, CDC42, CCND3, SOS2, RHOA, BAD, PLAU, MAPK9, RAC2, ERBB2, SOD2, RAC3, PIK3R4, BAX, FOSL1, GRB2, SMAD3, SMAD4, INSR, RAC1, SOS1, TCF7L2, MAPK1, MAPK8, PCK2, GSK3B, SCP2, CDKN1B, CDKN1A, WNT2, WNT3, WNT5A, CTNNB1, WNT6, PIK3C3, PIK3C2A, PTEN, TCF7L1, TP53, PIK3CA, PIK3CB, PIK3CD, G6PC, PPP2R5C, IRS1, PIK3CG, PIK3R1, CCNG2

WP712

Estrogen signaling pathway

WikiPathways

MAPK9, JUN, BCL2, MAPK14, ELK1, MAP2K1, PRKACA, GNAS, CREB1, ESR1, AKT1, PIK3CA, GNB1, FOS, NFKB1, GPER1, MAPK1

WP716

Vitamin A and Carotenoid Metabolism

WikiPathways

RBP4, LPL, CYP2E1, ALDH1A1, SCARB1, DHRS3, CD36, RBP1, ALDH1A3, ALDH1A2, RXRB, RDH10, CYP26A1, ABCG8, MAPK1, CYP26B1

WP727

Monoamine Transport

WikiPathways

SCAMP2, MAPK14, HRH3, FBXO32, TNF, TSC2, TGFB1I1, PPP2CB, IL1B, IL1R1, ITGB3, SYN1, SLC6A1, TNFRSF11B, CDC25C, AGT, TPH2, TH

WP732

Serotonin Receptor 2 and ELK-SRF/GATA4 signaling

WikiPathways

MAP2K2, RAF1, ELK1, ITPR1, MAP2K1, MAPKAPK2, KRAS, GNAQ, GATA4, HTR2C, NRAS, HTR2B, MAPK3, MAPK1

WP733

Serotonin Receptor 2 and STAT3 Signaling

WikiPathways

STAT3, GNAQ, JAK2

WP734

Serotonin Receptor 4/6/7 and NR3C Signaling

WikiPathways

RAP1A, EGR1, MAP2K2, RPS6KA5, ELK1, NR3C1, MAP2K1, MAPKAPK2, CREB1, GNAS, HTR7, ATF1, MAPK3, MAPK1