pathway_id,pathway_term,pathway_source,proteins
h_ranklPathway,"Bone Remodelling",BioCarta,FOS;NFKB1;MAPK8;RELA;FOSL2;IFNAR1;IFNAR2;FOSL1;TNFSF11;TNFRSF11A;IRF9
hsa04060,"Cytokine-cytokine receptor interaction",KEGG,"TNFSF13B;CSF1R;CSF3R;CTF1;EGFR;EPOR;FLT4;CLCF1;AMH;GH1;AMHR2;GHR;TNFRSF21;CXCL1;CXCL2;HGF;IFNE;IFNA1 ;IFNA16;IFNAR1;IFNAR2;IFNGR1;IFNGR2;FAS;IL1A;IL1B;IL1R1;IL1RAP;IL4R;IL5RA;IL6;IL6R;IL6ST;IL7R;CXCL8;CXCR2;IL9R;IL10;IL10RB;IL11;IL12A;IL12RB1;IL18;INHBA;INHBB;INHBC;KIT;LEP;LEPR;LIF;LIFR;LTBR;MET;KITLG;NGFR;TNFRSF11B;TNFRSF12A;PDGFA;PDGFB;PDGFRA;PDGFRB;PF4;PPBP;TNFRSF19;IL17RB;PDGFC;PRL;PRLR;CXCL16;CCL2;CCL3;CCL4;CCL5;CCL8;CCL20;CXCL6;CXCL5;CXCL12;BMP2;BMPR1A;BMPR2;TGFB1;TGFB2;TGFBR1;TGFBR2;TNF;TNFRSF1B;TNFSF4;VEGFA;VEGFB;VEGFC;IL1R2;CXCR4;GDF5;TNFSF11;TNFRSF25;TNFSF13;TNFSF10;TNFRSF11A;TNFRSF10C;IL18R1;ACVR1;ACVR1B;OSMR;ACVR2A;ACVR2B;CD27;TNFRSF8;CXCL14;CD40LG"
hsa04064,"NF-kappa B signaling pathway",KEGG,TAB1;TNFSF13B;TIRAP;PARP1;ERC1;TAB3;CXCL2;BLNK;CARD10;BIRC3;XIAP;ICAM1;IL1B;IL1R1;CXCL8;IRAK1;LTBR;LYN;GADD45B;NFKB1;PLAU;PLCG2;PRKCB;PRKCQ;PTGS2;BCL2;RELA;RELB;CCL4;CXCL12;SYK;MAP3K7;TLR4;TNF;TNFAIP3;TRAF1;UBE2I;VCAM1;TRIM25;TNFSF11;TRADD;RIPK1;TNFRSF11A;CFLAR;BCL10;CD14;CD40LG
hsa04380,"Osteoclast differentiation",KEGG,AKT3;IRF9;TAB1;LILRB1;CREB1;SIRPA;MAPK14;CSF1R;CTSK;CYLD;AKT1;AKT2;FCGR1A;FCGR2A;FCGR2B;FCGR3B;FOS;FOSB;FOSL2;FYN;GRB2;BLNK;IFNAR1;IFNAR2;IFNGR1;IFNGR2;IL1A;IL1B;IL1R1;ITGB3;JAK1;JUN;JUNB;JUND;MITF;NCF2;NCF4;NFATC1;NFATC2;NFKB1;TNFRSF11B;PIK3CA;PIK3CB;PIK3CD;PIK3R1;PLCG2;PPARG;PPP3CA;PPP3R2;MAPK1;MAPK3;MAPK8;MAPK9;MAPK13;MAP2K1;MAP2K6;MAP2K7;RAC1;RELA;RELB;STAT2;SYK;MAP3K7;TGFB1;TGFB2;TGFBR1;TGFBR2;TNF;TYROBP;FOSL1;TNFSF11;SOCS1;TNFRSF11A;SQSTM1;SOCS3
hsa04917,"Prolactin signaling pathway",KEGG,AKT3;CGA;MAPK14;CYP17A1;ELF5;AKT1;AKT2;ESR1;ESR2;FOXO3;FOS;SHC2;GALT;GRB2;GSK3B;INS;IRF1;JAK2;KRAS;LHB;LHCGR;NFKB1;NRAS;PIK3CA;PIK3CB;PIK3CD;PIK3R1;MAPK1;MAPK3;MAPK8;MAPK9;MAPK13;MAP2K1;MAP2K2;PRL;PRLR;RAF1;RELA;SOS1;SOS2;STAT3;STAT5A;STAT5B;TH;TNFSF11;SOCS1;TNFRSF11A;SOCS2;CCND2;SOCS3;SOCS6;SOCS5
hsa05323,"Rheumatoid arthritis",KEGG,TCIRG1;TNFSF13B;CTSK;CTSL;FOS;ATP6V1C2;ANGPT1;CXCL1;HLA-DMA;HLA-DMB;HLA-DOB;HLA-DPA1;HLA-DQA1;HLA-DQA2;HLA-DQB1;HLA-DRA;HLA-DRB1;HLA-DRB3;HLA-DRB4;HLA-DRB5;ICAM1;IL1A;IL1B;IL6;CXCL8;IL11;IL18;ITGB2;JUN;MMP1;ATP6V1D;ATP6V1H;ATP6V1B2;ATP6V1C1;ATP6V1G2;ATP6V0A1;CCL2;CCL3;CCL5;CCL20;CXCL6;CXCL5;CXCL12;TEK;TGFB1;TGFB2;TLR2;TLR4;TNF;VEGFA;TNFSF11;TNFSF13;TNFRSF11A;ATP6V0E1;ATP6V0D1;ATP6V1F;CD28;ATP6V1G1
WP12,"Osteoclast Signaling",WikiPathways,ATP6V1G1;MAPK8;PDGFB;ITGB3;TNFRSF11B;CTSK;TNFRSF11A;SPP1;IFNAR1;TNFSF11
WP2018,"RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway",WikiPathways,JUN;ICAM1;SQSTM1;TNFSF11;MAPK9;PTK2;MAP2K1;MAP2K7;PAPSS2;MAP2K6;MAP3K7;AKT1;TNFRSF11B;AKT2;CTSK;VCAM1;MAPK3;NFKB1;RAC1;MAPK1;MAPK8;RELB;MAPK14;RELA;SYK;TNFRSF11A;TRAF1;MITF;TAB1;NFATC1;FOS;PIK3R1;LYN;CDC42
WP3594,"Circadian rythm related genes",WikiPathways,STAR;JUN;PPARGC1A;JUND;PRKCDBP;RORA;RORB;NPY2R;KLF10;ARNT;LGR4;ARNTL;DRD2;CSNK1D;CSNK1E;SKP1;ID3;NFIL3;PROX1;UBC;NCOA2;AGRP;SIK1;CST3;TH;HDAC3;GFPT1;NR1H3;MAPK9;NCOR1;NONO;KDM5A;ID2;PSPC1;MTNR1A;MTNR1B;LEP;PPP1CC;PPP1CB;CARTPT;ADORA1;SUV39H2;USP2;HTR7;NRIP1;OPRL1;NKX2-1;ROCK2;NPAS2;PTEN;CRY1;GHRH;ZFHX3;OGT;PTGDS;ATF4;TIMELESS;NAGLU;EZH2;KLF9;NLGN1;HOMER1;TYMS;SFPQ;CREM;NAMPT;CREB1;ID4;RBM4;SETX;RBM4B;RELB;BHLHE40;NR1D1;GNA11;BTRC;CCAR2;PRKAA2;NGFR;ADA;MYBBP1A;ADIPOQ;GNAQ;SERPINE1;NOCT;OPN3;THRAP3;AHR;AHCY;KCNMA1;HNRNPU;NR1D2;PAX4;UBA52;MTA1;HNRNPD;DDX5;PPP1CA;PRKDC;MAPK8;CPT1A;EGR1;SFTPC;EP300;PER1;GSK3B;PPARA;TNFRSF11A;CLDN4;ARNTL2;TOP1;CDK4;TOP2A;PPARG;TP53;RPS27A;EGR3;GHRL;FAS;BTBD9;HDAC1;SREBF1;TPH2;HDAC2;NTRK1;IL6