Pathway Description

Pathway ID hsa05418
Pathway Term Fluid shear stress and atherosclerosis
Pathway Source KEGG
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

AKT3

v-akt murine thymoma viral oncogene homolog 3

10000

Q9Y243

chr1: 243,488,233-243,851,079

CDH5

cadherin 5, type 2 (vascular endothelium)

1003

P33151

chr16: 66,366,622-66,404,786

KLF2

Kruppel-like factor 2

10365

Q9Y5W3

chr19: 16,324,817-16,327,874

GSTO2

glutathione S-transferase omega 2

119391

Q9H4Y5

chr10: 104,268,873-104,304,945

MAPK14

mitogen-activated protein kinase 14

1432

Q16539

chr6: 36,027,677-36,111,236

CTNNB1

catenin beta 1

1499

P35222

chr3: 41,194,837-41,260,096

CTSL

cathepsin L

1514

P07711

chr9: 87,725,519-87,731,393

NQO1

NAD(P)H dehydrogenase, quinone 1

1728

P15559

chr16: 69,706,996-69,726,951

DUSP1

dual specificity phosphatase 1

1843

P28562

chr5: 172,768,090-172,771,195

EDN1

endothelin 1

1906

P05305

chr6: 12,290,363-12,297,194

AKT1

v-akt murine thymoma viral oncogene homolog 1

207

P31749

chr14: 104,769,349-104,795,751

AKT2

v-akt murine thymoma viral oncogene homolog 2

208

P31751

chr19: 40,230,317-40,285,536

FOS

FBJ murine osteosarcoma viral oncogene homolog

2353

P01100

chr14: 75,278,774-75,282,230

TXN2

thioredoxin 2

25828

Q99757

chr22: 36,467,036-36,482,030

GPC1

glypican 1

2817

P35052

chr2: 240,435,671-240,468,078

GSTA1

glutathione S-transferase alpha 1

2938

P08263

chr6: 52,791,664-52,803,910

GSTA4

glutathione S-transferase alpha 4

2941

O15217

chr6: 52,977,948-52,995,378

GSTM1

glutathione S-transferase mu 1

2944

P09488

chr1: 109,687,814-109,709,039

GSTM2

glutathione S-transferase mu 2 (muscle)

2946

P28161

chr1: 109,668,022-109,709,551

GSTM3

glutathione S-transferase mu 3 (brain)

2947

P21266

chr1: 109,733,932-109,741,038

GSTM4

glutathione S-transferase mu 4

2948

Q03013

chr1: 109,656,081-109,674,836

GSTP1

glutathione S-transferase pi 1

2950

P09211

chr11: 67,583,595-67,586,660

GSTT1

glutathione S-transferase theta 1

2952

P30711

chr22: 24,033,952-24,042,493

GSTT2

glutathione S-transferase theta 2 (gene/pseudogene)

2953

P0CG29

chr22: 23,980,058-23,983,915

HMOX1

heme oxygenase 1

3162

P09601

chr22: 35,380,361-35,394,214

HSP90AA1

heat shock protein 90kDa alpha family class A member 1

3320

P07900

chr14: 102,080,738-102,139,699

HSP90AB1

heat shock protein 90kDa alpha family class B member 1

3326

P08238

chr6: 44,246,166-44,253,888

ICAM1

intercellular adhesion molecule 1

3383

P05362

chr19: 10,270,835-10,286,615

IL1A

interleukin 1 alpha

3552

P01583

chr2: 112,773,915-112,784,590

IL1B

interleukin 1 beta

3553

P01584

chr2: 112,829,751-112,836,903

IL1R1

interleukin 1 receptor, type I

3554

P14778

chr2: 102,064,544-102,179,874

ITGAV

integrin subunit alpha V

3685

P06756

chr2: 186,590,065-186,680,901

ITGB3

integrin subunit beta 3

3690

P05106

chr17: 47,253,846-47,311,816

JUN

jun proto-oncogene

3725

P05412

chr1: 58,780,788-58,784,327

RHOA

ras homolog family member A

387

P61586

chr3: 49,359,145-49,412,998

SUMO4

small ubiquitin-like modifier 4

387082

Q6EEV6

chr6: 149,400,227-149,401,292

MEF2A

myocyte enhancer factor 2A

4205

Q02078

chr15: 99,565,417-99,716,466

MEF2C

myocyte enhancer factor 2C

4208

Q06413

chr5: 88,717,117-88,904,257

MAP3K5

mitogen-activated protein kinase kinase kinase 5

4217

Q99683

chr6: 136,557,047-136,792,518

MGST1

microsomal glutathione S-transferase 1

4257

P10620

chr12: 16,347,142-16,609,259

MGST2

microsomal glutathione S-transferase 2

4258

Q99735

chr4: 139,665,768-139,740,745

MGST3

microsomal glutathione S-transferase 3

4259

O14880

chr1: 165,630,861-165,661,796

MMP2

matrix metallopeptidase 2

4313

P08253

chr16: 55,389,700-55,506,691

MMP9

matrix metallopeptidase 9

4318

P14780

chr20: 46,008,908-46,016,561

ASS1

argininosuccinate synthase 1

445

P00966

chr9: 130,444,929-130,501,274

NCF2

neutrophil cytosolic factor 2

4688

P19878

chr1: 183,555,563-183,590,876

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

4790

P19838

chr4: 102,501,329-102,617,302

NOS3

nitric oxide synthase 3

4846

P29474

chr7: 150,990,995-151,014,588

PDGFA

platelet-derived growth factor alpha polypeptide

5154

P04085

chr7: 497,258-520,296

PDGFB

platelet-derived growth factor beta polypeptide

5155

P01127

chr22: 39,223,359-39,244,751

PECAM1

platelet/endothelial cell adhesion molecule 1

5175

P16284

chr17: 64,319,415-64,413,776

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5290

P42336

chr3: 179,148,114-179,240,093

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5291

P42338

chr3: 138,652,699-138,834,938

PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

5293

O00329

chr1: 9,651,732-9,729,114

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

5295

P27986

chr5: 68,215,720-68,301,821

PLAT

plasminogen activator, tissue

5327

P00750

chr8: 42,175,233-42,207,724

PRKAA2

protein kinase, AMP-activated, alpha 2 catalytic subunit

5563

P54646

chr1: 56,645,322-56,715,335

MAPK7

mitogen-activated protein kinase 7

5598

Q13164

chr17: 19,377,721-19,383,544

MAPK8

mitogen-activated protein kinase 8

5599

P45983

chr10: 48,306,639-48,439,360

MAPK9

mitogen-activated protein kinase 9

5601

P45984

chr5: 180,233,143-180,292,099

MAPK13

mitogen-activated protein kinase 13

5603

O15264

chr6: 36,127,809-36,144,524

MAP2K5

mitogen-activated protein kinase kinase 5

5607

Q13163

chr15: 67,542,709-67,807,123

MAP2K6

mitogen-activated protein kinase kinase 6

5608

P52564

chr17: 69,414,698-69,543,331

MAP2K7

mitogen-activated protein kinase kinase 7

5609

O14733

chr19: 7,903,843-7,914,478

PTK2

protein tyrosine kinase 2

5747

Q05397

chr8: 140,657,900-141,002,216

RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

5879

P63000

chr7: 6,374,523-6,403,977

RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

5880

P15153

chr22: 37,225,261-37,244,448

RAC3

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

5881

P60763

chr17: 82,031,624-82,034,204

TRPV4

transient receptor potential cation channel, subfamily V, member 4

59341

Q9HBA0

chr12: 109,783,085-109,833,401

BCL2

B-cell CLL/lymphoma 2

596

P10415

chr18: 63,123,346-63,320,128

RELA

v-rel avian reticuloendotheliosis viral oncogene homolog A

5970

Q04206

chr11: 65,653,596-65,663,094

ACTB

actin, beta

60

P60709

chr7: 5,527,151-5,563,784

CCL2

chemokine (C-C motif) ligand 2

6347

P13500

chr17: 34,255,218-34,257,203

SDC1

syndecan 1

6382

P18827

chr2: 20,200,797-20,225,433

SDC2

syndecan 2

6383

P34741

chr8: 96,493,351-96,611,780

SDC4

syndecan 4

6385

P31431

chr20: 45,325,288-45,348,424

SELE

selectin E

6401

P16581

chr1: 169,722,641-169,764,705

BMP4

bone morphogenetic protein 4

652

P12644

chr14: 53,949,736-53,958,761

BMPR1A

bone morphogenetic protein receptor type IA

657

P36894

chr10: 86,756,601-86,932,838

BMPR2

bone morphogenetic protein receptor type II

659

Q13873

chr2: 202,376,936-202,567,751

SUMO3

small ubiquitin-like modifier 3

6612

P55854

chr21: 44,805,617-44,818,779

SUMO2

small ubiquitin-like modifier 2

6613

P61956

chr17: 75,165,586-75,182,983

MAP3K7

mitogen-activated protein kinase kinase kinase 7

6885

O43318

chr6: 90,513,573-90,587,045

ACTG1

actin gamma 1

71

P63261

chr17: 81,509,971-81,523,847

TNF

tumor necrosis factor

7124

P01375

chr6: 31,575,567-31,578,336

TP53

tumor protein p53

7157

P04637

chr17: 7,661,779-7,687,550

HSP90B1

heat shock protein 90kDa beta family member 1

7184

P14625

chr12: 103,930,107-103,953,645

TXN

thioredoxin

7295

P10599

chr9: 110,243,811-110,256,640

VCAM1

vascular cell adhesion molecule 1

7412

P19320

chr1: 100,719,742-100,739,045

VEGFA

vascular endothelial growth factor A

7422

P15692

chr6: 43,770,184-43,786,487

IL1R2

interleukin 1 receptor, type II

7850

P27930

chr2: 101,991,844-102,028,544

CALM2

calmodulin 2

805

P62158

chr2: 47,160,082-47,176,601

CALM3

calmodulin 3

808

P62158

chr14: 90,396,502-90,408,261

CAV1

caveolin 1

857

Q03135

chr7: 116,524,785-116,561,184

CAV2

caveolin 2

858

P51636

chr7: 116,287,380-116,508,541

SQSTM1

sequestosome 1

8878

Q13501

chr5: 179,806,398-179,838,078

ACVR1

activin A receptor type I

90

Q04771

chr2: 157,736,444-157,875,862

ARHGEF2

Rho/Rac guanine nucleotide exchange factor 2

9181

Q92974

chr1: 155,946,851-156,007,070

CALML4

calmodulin like 4

91860

Q96GE6

chr15: 68,190,705-68,206,110

ACVR2A

activin A receptor type IIA

92

P27037

chr2: 147,844,517-147,930,826

ACVR2B

activin A receptor type IIB

93

Q13705

chr3: 38,453,851-38,493,142

GSTO1

glutathione S-transferase omega 1

9446

P78417

chr10: 104,235,356-104,267,459