Pathway Description

Pathway ID hsa04668
Pathway Term TNF signaling pathway
Pathway Source KEGG
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

AKT3

v-akt murine thymoma viral oncogene homolog 3

10000

Q9Y243

chr1: 243,488,233-243,851,079

TAB1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

10454

Q15750

chr22: 39,399,741-39,437,060

CEBPB

CCAAT/enhancer binding protein (C/EBP), beta

1051

P17676

chr20: 50,190,734-50,192,689

MAP3K8

mitogen-activated protein kinase kinase kinase 8

1326

P41279

chr10: 30,433,937-30,461,833

CREB1

cAMP responsive element binding protein 1

1385

P16220

chr2: 207,529,737-207,603,431

MAPK14

mitogen-activated protein kinase 14

1432

Q16539

chr6: 36,027,677-36,111,236

JAG1

jagged 1

182

P78504

chr20: 10,637,684-10,674,107

EDN1

endothelin 1

1906

P05305

chr6: 12,290,363-12,297,194

AKT1

v-akt murine thymoma viral oncogene homolog 1

207

P31749

chr14: 104,769,349-104,795,751

AKT2

v-akt murine thymoma viral oncogene homolog 2

208

P31751

chr19: 40,230,317-40,285,536

FOS

FBJ murine osteosarcoma viral oncogene homolog

2353

P01100

chr14: 75,278,774-75,282,230

TAB3

TGF-beta activated kinase 1/MAP3K7 binding protein 3

257397

Q8N5C8

chrX: 30,827,442-30,975,084

CXCL1

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

2919

P09341

chr4: 73,869,393-73,871,242

CXCL2

chemokine (C-X-C motif) ligand 2

2920

P19875

chr4: 74,097,035-74,099,293

BIRC3

baculoviral IAP repeat containing 3

330

Q13489

chr11: 102,317,450-102,339,403

ICAM1

intercellular adhesion molecule 1

3383

P05362

chr19: 10,270,835-10,286,615

FAS

Fas cell surface death receptor

355

P25445

chr10: 88,990,582-89,015,785

IL1B

interleukin 1 beta

3553

P01584

chr2: 112,829,751-112,836,903

IL6

interleukin 6

3569

P05231

chr7: 22,725,884-22,732,002

JUN

jun proto-oncogene

3725

P05412

chr1: 58,780,788-58,784,327

JUNB

jun B proto-oncogene

3726

P17275

chr19: 12,791,496-12,793,315

LIF

leukemia inhibitory factor

3976

P15018

chr22: 30,240,447-30,246,851

MAP3K5

mitogen-activated protein kinase kinase kinase 5

4217

Q99683

chr6: 136,557,047-136,792,518

MMP9

matrix metallopeptidase 9

4318

P14780

chr20: 46,008,908-46,016,561

MMP14

matrix metallopeptidase 14

4323

P50281

chr14: 22,836,557-22,849,027

ATF4

activating transcription factor 4

468

P18848

chr22: 39,519,695-39,522,685

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

4790

P19838

chr4: 102,501,329-102,617,302

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5290

P42336

chr3: 179,148,114-179,240,093

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5291

P42338

chr3: 138,652,699-138,834,938

PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

5293

O00329

chr1: 9,651,732-9,729,114

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

5295

P27986

chr5: 68,215,720-68,301,821

MAPK1

mitogen-activated protein kinase 1

5594

P28482

chr22: 21,754,500-21,867,680

MAPK3

mitogen-activated protein kinase 3

5595

P27361

chr16: 30,114,105-30,123,506

MAPK8

mitogen-activated protein kinase 8

5599

P45983

chr10: 48,306,639-48,439,360

MAPK9

mitogen-activated protein kinase 9

5601

P45984

chr5: 180,233,143-180,292,099

MAPK13

mitogen-activated protein kinase 13

5603

O15264

chr6: 36,127,809-36,144,524

MAP2K1

mitogen-activated protein kinase kinase 1

5604

Q02750

chr15: 66,386,817-66,492,312

MAP2K6

mitogen-activated protein kinase kinase 6

5608

P52564

chr17: 69,414,698-69,543,331

MAP2K7

mitogen-activated protein kinase kinase 7

5609

O14733

chr19: 7,903,843-7,914,478

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

5743

P35354

chr1: 186,671,791-186,680,427

RELA

v-rel avian reticuloendotheliosis viral oncogene homolog A

5970

Q04206

chr11: 65,653,596-65,663,094

BCL3

B-cell CLL/lymphoma 3

602

P20749

chr19: 44,747,705-44,760,044

CCL2

chemokine (C-C motif) ligand 2

6347

P13500

chr17: 34,255,218-34,257,203

CCL5

chemokine (C-C motif) ligand 5

6352

P13501

chr17: 35,871,491-35,880,793

CCL20

chemokine (C-C motif) ligand 20

6364

P78556

chr2: 227,813,842-227,817,564

CXCL5

chemokine (C-X-C motif) ligand 5

6374

P42830

chr4: 73,995,642-73,998,779

SELE

selectin E

6401

P16581

chr1: 169,722,641-169,764,705

MAP3K7

mitogen-activated protein kinase kinase kinase 7

6885

O43318

chr6: 90,513,573-90,587,045

TNF

tumor necrosis factor

7124

P01375

chr6: 31,575,567-31,578,336

TNFAIP3

TNF alpha induced protein 3

7128

P21580

chr6: 137,867,188-137,883,312

TNFRSF1B

tumor necrosis factor receptor superfamily member 1B

7133

P20333

chr1: 12,167,003-12,209,228

TRAF1

TNF receptor associated factor 1

7185

Q13077

chr9: 120,902,393-120,929,173

VCAM1

vascular cell adhesion molecule 1

7412

P19320

chr1: 100,719,742-100,739,045

VEGFC

vascular endothelial growth factor C

7424

P49767

chr4: 176,683,538-176,792,727

ITCH

itchy E3 ubiquitin protein ligase

83737

Q96J02

chr20: 34,363,235-34,511,393

CASP8

caspase 8

841

Q14790

chr2: 201,233,443-201,287,711

TRADD

TNFRSF1A-associated via death domain

8717

Q15628

chr16: 67,154,180-67,160,298

RIPK1

receptor interacting serine/threonine kinase 1

8737

Q13546

chr6: 3,063,991-3,115,187

FADD

Fas associated via death domain

8772

Q13158

chr11: 70,203,163-70,207,390

IL18R1

interleukin 18 receptor 1

8809

Q13478

chr2: 102,311,529-102,398,775

CFLAR

CASP8 and FADD like apoptosis regulator

8837

O15519

chr2: 201,116,104-201,176,687

SOCS3

suppressor of cytokine signaling 3

9021

O14543

chr17: 78,356,778-78,360,077

CREB3L1

cAMP responsive element binding protein 3-like 1

90993

Q96BA8

chr11: 46,277,661-46,321,422

RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

9252

O75582

chr14: 90,847,862-91,060,636

CREB5

cAMP responsive element binding protein 5

9586

Q02930

chr7: 28,299,321-28,825,894