Pathway ID | hsa04650 |
Pathway Term | Natural killer cell mediated cytotoxicity |
Pathway Source | KEGG |
Gene Symbol | Description | Entrez ID | Uniprot ID | Chromosomal Location |
---|---|---|---|---|
MICA |
MHC class I polypeptide-related sequence A |
100507436 |
Q29983 |
chr6: 31,399,784-31,415,315 |
VAV3 |
vav guanine nucleotide exchange factor 3 |
10451 |
Q9UKW4 |
chr1: 107,571,160-107,965,144 |
FCGR3B |
Fc fragment of IgG, low affinity IIIb, receptor (CD16b) |
2215 |
O75015 |
chr1: 161,623,196-161,631,963 |
FYN |
FYN proto-oncogene, Src family tyrosine kinase |
2534 |
P06241 |
chr6: 111,660,332-111,873,452 |
SHC2 |
SHC (Src homology 2 domain containing) transforming protein 2 |
25759 |
P98077 |
chr19: 416,583-460,996 |
GRB2 |
growth factor receptor bound protein 2 |
2885 |
P62993 |
chr17: 75,318,076-75,405,709 |
HLA-A |
major histocompatibility complex, class I, A |
3105 |
P30443 |
chr6: 29,941,260-29,945,884 |
HLA-B |
major histocompatibility complex, class I, B |
3106 |
P01889 |
chr6: 31,269,491-31,357,188 |
HLA-C |
major histocompatibility complex, class I, C |
3107 |
P30499 |
chr6: 31,268,749-31,272,130 |
HLA-E |
major histocompatibility complex, class I, E |
3133 |
P13747 |
chr6: 30,489,467-30,494,205 |
HLA-G |
major histocompatibility complex, class I, G |
3135 |
P17693 |
chr6: 29,826,967-29,831,125 |
ICAM1 |
intercellular adhesion molecule 1 |
3383 |
P05362 |
chr19: 10,270,835-10,286,615 |
IFNA1 |
interferon, alpha 13 |
3447 |
P01562 |
chr9: 21,367,424-21,368,962 |
IFNA16 |
interferon, alpha 16 |
3449 |
P05015 |
chr9: 21,216,373-21,217,311 |
IFNAR1 |
interferon (alpha, beta and omega) receptor 1 |
3454 |
P17181 |
chr21: 33,324,477-33,359,862 |
IFNAR2 |
interferon (alpha, beta and omega) receptor 2 |
3455 |
P48551 |
chr21: 33,229,901-33,265,675 |
IFNGR1 |
interferon gamma receptor 1 |
3459 |
P15260 |
chr6: 137,197,484-137,219,449 |
IFNGR2 |
interferon gamma receptor 2 (interferon gamma transducer 1) |
3460 |
P38484 |
chr21: 33,402,896-33,479,348 |
FAS |
Fas cell surface death receptor |
355 |
P25445 |
chr10: 88,990,582-89,015,785 |
ITGB2 |
integrin subunit beta 2 |
3689 |
P05107 |
chr21: 44,885,953-44,931,989 |
KIR3DL2 |
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 |
3812 |
P43630 |
chr19: 54,850,443-54,867,207 |
KLRC1 |
killer cell lectin-like receptor subfamily C, member 1 |
3821 |
P26715 |
chr12: 10,442,264-10,454,685 |
KRAS |
Kirsten rat sarcoma viral oncogene homolog |
3845 |
P01116 |
chr12: 25,204,789-25,250,936 |
MICB |
MHC class I polypeptide-related sequence B |
4277 |
Q29980 |
chr6: 31,494,881-31,511,124 |
NFATC1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
4772 |
O95644 |
chr18: 79,395,856-79,529,325 |
NFATC2 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
4773 |
Q13469 |
chr20: 51,386,957-51,562,831 |
NRAS |
neuroblastoma RAS viral (v-ras) oncogene homolog |
4893 |
P01111 |
chr1: 114,704,469-114,716,894 |
CD244 |
CD244 molecule, natural killer cell receptor 2B4 |
51744 |
Q9BZW8 |
chr1: 160,830,160-160,862,855 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5290 |
P42336 |
chr3: 179,148,114-179,240,093 |
PIK3CB |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5291 |
P42338 |
chr3: 138,652,699-138,834,938 |
PIK3CD |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
5293 |
O00329 |
chr1: 9,651,732-9,729,114 |
PIK3R1 |
phosphoinositide-3-kinase regulatory subunit 1 |
5295 |
P27986 |
chr5: 68,215,720-68,301,821 |
PLCG2 |
phospholipase C gamma 2 |
5336 |
P16885 |
chr16: 81,739,097-81,962,693 |
PPP3CA |
protein phosphatase 3, catalytic subunit, alpha isozyme |
5530 |
Q08209 |
chr4: 101,023,409-101,348,278 |
PPP3R2 |
protein phosphatase 3 regulatory subunit B, beta |
5535 |
Q96LZ3 |
chr9: 101,591,615-101,595,021 |
PRKCA |
protein kinase C, alpha |
5578 |
P17252 |
chr17: 66,302,636-66,810,743 |
PRKCB |
protein kinase C, beta |
5579 |
P05771 |
chr16: 23,836,001-24,220,611 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
P28482 |
chr22: 21,754,500-21,867,680 |
MAPK3 |
mitogen-activated protein kinase 3 |
5595 |
P27361 |
chr16: 30,114,105-30,123,506 |
MAP2K1 |
mitogen-activated protein kinase kinase 1 |
5604 |
Q02750 |
chr15: 66,386,817-66,492,312 |
MAP2K2 |
mitogen-activated protein kinase kinase 2 |
5605 |
P36507 |
chr19: 4,090,321-4,124,129 |
PTPN11 |
protein tyrosine phosphatase, non-receptor type 11 |
5781 |
Q06124 |
chr12: 112,418,351-112,509,913 |
RAC1 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
5879 |
P63000 |
chr7: 6,374,523-6,403,977 |
RAC2 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
5880 |
P15153 |
chr22: 37,225,261-37,244,448 |
RAC3 |
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
5881 |
P60763 |
chr17: 82,031,624-82,034,204 |
RAF1 |
Raf-1 proto-oncogene, serine/threonine kinase |
5894 |
P04049 |
chr3: 12,583,601-12,664,226 |
BID |
BH3 interacting domain death agonist |
637 |
P55957 |
chr22: 17,734,138-17,774,770 |
SOS1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
6654 |
Q07889 |
chr2: 38,981,396-39,124,345 |
SOS2 |
SOS Ras/Rho guanine nucleotide exchange factor 2 |
6655 |
Q07890 |
chr14: 50,117,120-50,231,558 |
SYK |
spleen tyrosine kinase |
6850 |
P43405 |
chr9: 90,801,787-90,898,549 |
TNF |
tumor necrosis factor |
7124 |
P01375 |
chr6: 31,575,567-31,578,336 |
TYROBP |
TYRO protein tyrosine kinase binding protein |
7305 |
O43914 |
chr19: 35,904,401-35,908,295 |
VAV1 |
vav guanine nucleotide exchange factor 1 |
7409 |
P15498 |
chr19: 6,772,714-6,857,366 |
ULBP3 |
UL16 binding protein 3 |
79465 |
Q9BZM4 |
chr6: 150,063,150-150,069,095 |
ULBP2 |
UL16 binding protein 2 |
80328 |
Q9BZM5 |
chr6: 149,942,000-149,949,235 |
TNFSF10 |
tumor necrosis factor superfamily member 10 |
8743 |
P50591 |
chr3: 172,505,508-172,523,507 |
TNFRSF10C |
tumor necrosis factor receptor superfamily member 10c |
8794 |
O14798 |
chr8: 23,084,355-23,117,437 |
CD48 |
CD48 molecule |
962 |
P09326 |
chr1: 160,678,746-160,711,851 |