Pathway Description

Pathway ID hsa04650
Pathway Term Natural killer cell mediated cytotoxicity
Pathway Source KEGG
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

MICA

MHC class I polypeptide-related sequence A

100507436

Q29983

chr6: 31,399,784-31,415,315

VAV3

vav guanine nucleotide exchange factor 3

10451

Q9UKW4

chr1: 107,571,160-107,965,144

FCGR3B

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

2215

O75015

chr1: 161,623,196-161,631,963

FYN

FYN proto-oncogene, Src family tyrosine kinase

2534

P06241

chr6: 111,660,332-111,873,452

SHC2

SHC (Src homology 2 domain containing) transforming protein 2

25759

P98077

chr19: 416,583-460,996

GRB2

growth factor receptor bound protein 2

2885

P62993

chr17: 75,318,076-75,405,709

HLA-A

major histocompatibility complex, class I, A

3105

P30443

chr6: 29,941,260-29,945,884

HLA-B

major histocompatibility complex, class I, B

3106

P01889

chr6: 31,269,491-31,357,188

HLA-C

major histocompatibility complex, class I, C

3107

P30499

chr6: 31,268,749-31,272,130

HLA-E

major histocompatibility complex, class I, E

3133

P13747

chr6: 30,489,467-30,494,205

HLA-G

major histocompatibility complex, class I, G

3135

P17693

chr6: 29,826,967-29,831,125

ICAM1

intercellular adhesion molecule 1

3383

P05362

chr19: 10,270,835-10,286,615

IFNA1

interferon, alpha 13

3447

P01562

chr9: 21,367,424-21,368,962

IFNA16

interferon, alpha 16

3449

P05015

chr9: 21,216,373-21,217,311

IFNAR1

interferon (alpha, beta and omega) receptor 1

3454

P17181

chr21: 33,324,477-33,359,862

IFNAR2

interferon (alpha, beta and omega) receptor 2

3455

P48551

chr21: 33,229,901-33,265,675

IFNGR1

interferon gamma receptor 1

3459

P15260

chr6: 137,197,484-137,219,449

IFNGR2

interferon gamma receptor 2 (interferon gamma transducer 1)

3460

P38484

chr21: 33,402,896-33,479,348

FAS

Fas cell surface death receptor

355

P25445

chr10: 88,990,582-89,015,785

ITGB2

integrin subunit beta 2

3689

P05107

chr21: 44,885,953-44,931,989

KIR3DL2

killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

3812

P43630

chr19: 54,850,443-54,867,207

KLRC1

killer cell lectin-like receptor subfamily C, member 1

3821

P26715

chr12: 10,442,264-10,454,685

KRAS

Kirsten rat sarcoma viral oncogene homolog

3845

P01116

chr12: 25,204,789-25,250,936

MICB

MHC class I polypeptide-related sequence B

4277

Q29980

chr6: 31,494,881-31,511,124

NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

4772

O95644

chr18: 79,395,856-79,529,325

NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

4773

Q13469

chr20: 51,386,957-51,562,831

NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog

4893

P01111

chr1: 114,704,469-114,716,894

CD244

CD244 molecule, natural killer cell receptor 2B4

51744

Q9BZW8

chr1: 160,830,160-160,862,855

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5290

P42336

chr3: 179,148,114-179,240,093

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5291

P42338

chr3: 138,652,699-138,834,938

PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

5293

O00329

chr1: 9,651,732-9,729,114

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

5295

P27986

chr5: 68,215,720-68,301,821

PLCG2

phospholipase C gamma 2

5336

P16885

chr16: 81,739,097-81,962,693

PPP3CA

protein phosphatase 3, catalytic subunit, alpha isozyme

5530

Q08209

chr4: 101,023,409-101,348,278

PPP3R2

protein phosphatase 3 regulatory subunit B, beta

5535

Q96LZ3

chr9: 101,591,615-101,595,021

PRKCA

protein kinase C, alpha

5578

P17252

chr17: 66,302,636-66,810,743

PRKCB

protein kinase C, beta

5579

P05771

chr16: 23,836,001-24,220,611

MAPK1

mitogen-activated protein kinase 1

5594

P28482

chr22: 21,754,500-21,867,680

MAPK3

mitogen-activated protein kinase 3

5595

P27361

chr16: 30,114,105-30,123,506

MAP2K1

mitogen-activated protein kinase kinase 1

5604

Q02750

chr15: 66,386,817-66,492,312

MAP2K2

mitogen-activated protein kinase kinase 2

5605

P36507

chr19: 4,090,321-4,124,129

PTPN11

protein tyrosine phosphatase, non-receptor type 11

5781

Q06124

chr12: 112,418,351-112,509,913

RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

5879

P63000

chr7: 6,374,523-6,403,977

RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

5880

P15153

chr22: 37,225,261-37,244,448

RAC3

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

5881

P60763

chr17: 82,031,624-82,034,204

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

5894

P04049

chr3: 12,583,601-12,664,226

BID

BH3 interacting domain death agonist

637

P55957

chr22: 17,734,138-17,774,770

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

6654

Q07889

chr2: 38,981,396-39,124,345

SOS2

SOS Ras/Rho guanine nucleotide exchange factor 2

6655

Q07890

chr14: 50,117,120-50,231,558

SYK

spleen tyrosine kinase

6850

P43405

chr9: 90,801,787-90,898,549

TNF

tumor necrosis factor

7124

P01375

chr6: 31,575,567-31,578,336

TYROBP

TYRO protein tyrosine kinase binding protein

7305

O43914

chr19: 35,904,401-35,908,295

VAV1

vav guanine nucleotide exchange factor 1

7409

P15498

chr19: 6,772,714-6,857,366

ULBP3

UL16 binding protein 3

79465

Q9BZM4

chr6: 150,063,150-150,069,095

ULBP2

UL16 binding protein 2

80328

Q9BZM5

chr6: 149,942,000-149,949,235

TNFSF10

tumor necrosis factor superfamily member 10

8743

P50591

chr3: 172,505,508-172,523,507

TNFRSF10C

tumor necrosis factor receptor superfamily member 10c

8794

O14798

chr8: 23,084,355-23,117,437

CD48

CD48 molecule

962

P09326

chr1: 160,678,746-160,711,851