Pathway Description

Pathway ID hsa04015
Pathway Term Rap1 signaling pathway
Pathway Source KEGG
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

AKT3

v-akt murine thymoma viral oncogene homolog 3

10000

Q9Y243

chr1: 243,488,233-243,851,079

RASGRP2

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

10235

Q7LDG7

chr11: 64,726,911-64,745,456

ADCY3

adenylate cyclase 3

109

O60266

chr2: 24,819,169-24,919,839

RAPGEF4

Rap guanine nucleotide exchange factor 4

11069

Q8WZA2

chr2: 172,735,274-173,052,893

ADCY7

adenylate cyclase 7

113

P51828

chr16: 50,246,137-50,318,135

ADCY9

adenylate cyclase 9

115

O60503

chr16: 3,953,387-4,116,185

CNR1

cannabinoid receptor 1 (brain)

1268

P21554

chr6: 88,139,864-88,166,359

ADORA2B

adenosine A2b receptor

136

P29275

chr17: 15,944,917-15,975,746

CRKL

v-crk avian sarcoma virus CT10 oncogene homolog-like

1399

P46109

chr22: 20,917,426-20,953,749

MAPK14

mitogen-activated protein kinase 14

1432

Q16539

chr6: 36,027,677-36,111,236

CSF1R

colony stimulating factor 1 receptor

1436

P07333

chr5: 150,053,291-150,113,372

CTNNB1

catenin beta 1

1499

P35222

chr3: 41,194,837-41,260,096

CTNND1

catenin delta 1

1500

O60716

chr11: 57,753,243-57,819,546

DRD2

dopamine receptor D2

1813

P14416

chr11: 113,409,615-113,475,691

EFNA1

ephrin-A1

1942

P20827

chr1: 155,127,460-155,134,857

EFNA4

ephrin-A4

1945

P52798

chr1: 155,063,731-155,069,553

EFNA5

ephrin-A5

1946

P52803

chr5: 107,376,889-107,670,895

EGFR

epidermal growth factor receptor

1956

P00533

chr7: 55,019,021-55,211,628

AKT1

v-akt murine thymoma viral oncogene homolog 1

207

P31749

chr14: 104,769,349-104,795,751

AKT2

v-akt murine thymoma viral oncogene homolog 2

208

P31751

chr19: 40,230,317-40,285,536

F2R

coagulation factor II (thrombin) receptor

2149

P25116

chr5: 76,716,043-76,735,781

FGF2

fibroblast growth factor 2 (basic)

2247

P09038

chr4: 122,826,708-122,898,236

FGF7

fibroblast growth factor 7

2252

P21781

chr15: 49,423,096-49,488,775

FGF9

fibroblast growth factor 9

2254

P31371

chr13: 21,671,383-21,704,498

FGF11

fibroblast growth factor 11

2256

Q92914

chr17: 7,438,273-7,444,937

FGF12

fibroblast growth factor 12

2257

P61328

chr3: 192,139,395-192,767,764

FGF13

fibroblast growth factor 13

2258

Q92913

chrX: 138,614,731-139,222,777

FGF14

fibroblast growth factor 14

2259

Q92915

chr13: 101,710,804-102,402,457

FGFR1

fibroblast growth factor receptor 1

2260

P11362

chr8: 38,411,138-38,468,834

FGFR2

fibroblast growth factor receptor 2

2263

P21802

chr10: 121,478,334-121,598,458

PLCB1

phospholipase C beta 1

23236

Q9NQ66

chr20: 8,077,251-8,968,360

FLT4

fms-related tyrosine kinase 4

2324

P35916

chr5: 180,601,506-180,649,624

FPR1

formyl peptide receptor 1

2357

P21462

chr19: 51,745,172-51,804,110

FYB

FYN binding protein

2533

O15117

chr5: 39,105,236-39,274,528

PRKD2

protein kinase D2

25865

Q9BZL6

chr19: 46,674,275-46,717,127

GNAI1

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

2770

P63096

chr7: 80,133,955-80,219,402

GNAI2

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

2771

P04899

chr3: 50,226,292-50,259,355

GNAI3

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

2773

P08754

chr1: 109,548,611-109,618,321

GNAQ

guanine nucleotide binding protein (G protein), q polypeptide

2776

P50148

chr9: 77,716,087-78,031,458

GNAS

GNAS complex locus

2778

O95467

chr20: 58,839,718-58,911,192

ANGPT1

angiopoietin 1

284

Q15389

chr8: 107,249,482-107,498,055

ANGPT2

angiopoietin 2

285

O15123

chr8: 6,499,651-6,563,409

RAPGEF1

Rap guanine nucleotide exchange factor 1

2889

Q13905

chr9: 131,576,770-131,740,074

GRIN2A

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

2903

Q12879

chr16: 9,753,404-10,182,754

HGF

hepatocyte growth factor (hepapoietin A; scatter factor)

3082

P14210

chr7: 81,699,006-81,770,438

ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

3397

P41134

chr20: 31,605,283-31,606,515

IGF1

insulin like growth factor 1

3479

P05019

chr12: 102,395,867-102,480,645

IGF1R

insulin like growth factor 1 receptor

3480

P08069

chr15: 98,648,971-98,964,530

INS

insulin

3630

P01308

chr11: 2,159,779-2,161,341

INSR

insulin receptor

3643

P06213

chr19: 7,112,255-7,294,034

ITGAM

integrin subunit alpha M

3684

P11215

chr16: 31,259,990-31,332,892

ITGB1

integrin subunit beta 1

3688

P05556

chr10: 32,900,319-33,005,792

ITGB2

integrin subunit beta 2

3689

P05107

chr21: 44,885,953-44,931,989

ITGB3

integrin subunit beta 3

3690

P05106

chr17: 47,253,846-47,311,816

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

3815

P10721

chr4: 54,657,918-54,740,715

KRAS

Kirsten rat sarcoma viral oncogene homolog

3845

P01116

chr12: 25,204,789-25,250,936

RHOA

ras homolog family member A

387

P61586

chr3: 49,359,145-49,412,998

MET

MET proto-oncogene, receptor tyrosine kinase

4233

P08581

chr7: 116,672,390-116,798,386

KITLG

KIT ligand

4254

P21583

chr12: 88,492,793-88,580,851

NGF

nerve growth factor (beta polypeptide)

4803

P01138

chr1: 115,285,918-115,338,236

NGFR

nerve growth factor receptor

4804

P08138

chr17: 49,495,293-49,515,017

NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog

4893

P01111

chr1: 114,704,469-114,716,894

PARD6A

par-6 family cell polarity regulator alpha

50855

Q9NPB6

chr16: 67,660,946-67,662,778

PDGFA

platelet-derived growth factor alpha polypeptide

5154

P04085

chr7: 497,258-520,296

PDGFB

platelet-derived growth factor beta polypeptide

5155

P01127

chr22: 39,223,359-39,244,751

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

5156

P16234

chr4: 54,229,097-54,298,247

PDGFRB

platelet-derived growth factor receptor, beta polypeptide

5159

P09619

chr5: 150,113,837-150,155,872

RAPGEF6

Rap guanine nucleotide exchange factor 6

51735

Q8TEU7

chr5: 131,423,921-131,635,236

PFN1

profilin 1

5216

P07737

chr17: 4,945,652-4,949,061

PGF

placental growth factor

5228

P49763

chr14: 74,941,834-74,955,784

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5290

P42336

chr3: 179,148,114-179,240,093

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5291

P42338

chr3: 138,652,699-138,834,938

PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

5293

O00329

chr1: 9,651,732-9,729,114

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

5295

P27986

chr5: 68,215,720-68,301,821

PRKCA

protein kinase C, alpha

5578

P17252

chr17: 66,302,636-66,810,743

PRKCB

protein kinase C, beta

5579

P05771

chr16: 23,836,001-24,220,611

PRKCI

protein kinase C, iota

5584

P41743

chr3: 170,222,365-170,305,981

PRKD1

protein kinase D1

5587

Q15139

chr14: 29,576,479-30,191,898

MAPK1

mitogen-activated protein kinase 1

5594

P28482

chr22: 21,754,500-21,867,680

MAPK3

mitogen-activated protein kinase 3

5595

P27361

chr16: 30,114,105-30,123,506

MAPK13

mitogen-activated protein kinase 13

5603

O15264

chr6: 36,127,809-36,144,524

PDGFC

platelet derived growth factor C

56034

Q9NRA1

chr4: 156,760,454-156,971,394

MAP2K1

mitogen-activated protein kinase kinase 1

5604

Q02750

chr15: 66,386,817-66,492,312

MAP2K2

mitogen-activated protein kinase kinase 2

5605

P36507

chr19: 4,090,321-4,124,129

MAP2K6

mitogen-activated protein kinase kinase 6

5608

P52564

chr17: 69,414,698-69,543,331

PARD3

par-3 family cell polarity regulator

56288

Q8TEW0

chr10: 34,109,560-34,815,325

SIPA1L2

signal-induced proliferation-associated 1 like 2

57568

Q9P2F8

chr1: 232,397,965-232,561,558

RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

5879

P63000

chr7: 6,374,523-6,403,977

RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

5880

P15153

chr22: 37,225,261-37,244,448

RAC3

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

5881

P60763

chr17: 82,031,624-82,034,204

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

5894

P04049

chr3: 12,583,601-12,664,226

RALA

v-ral simian leukemia viral oncogene homolog A (ras related)

5898

P11233

chr7: 39,623,483-39,708,124

RALB

v-ral simian leukemia viral oncogene homolog B

5899

P11234

chr2: 120,240,064-120,294,713

RALGDS

ral guanine nucleotide dissociation stimulator

5900

Q12967

chr9: 133,097,720-133,149,334

RAP1A

RAP1A, member of RAS oncogene family

5906

P62834

chr1: 111,542,218-111,716,691

ACTB

actin, beta

60

P60709

chr7: 5,527,151-5,563,784

RRAS

related RAS viral (r-ras) oncogene homolog

6237

P10301

chr19: 49,635,292-49,640,201

ARAP3

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

64411

Q8WWN8

chr5: 141,653,401-141,682,221

TEK

TEK tyrosine kinase, endothelial

7010

Q02763

chr9: 27,109,141-27,230,175

THBS1

thrombospondin 1

7057

P07996

chr15: 39,581,079-39,599,466

TIAM1

T-cell lymphoma invasion and metastasis 1

7074

Q13009

chr21: 31,118,416-31,559,977

TLN1

talin 1

7094

Q9Y490

chr9: 35,696,948-35,732,395

ACTG1

actin gamma 1

71

P63261

chr17: 81,509,971-81,523,847

VEGFA

vascular endothelial growth factor A

7422

P15692

chr6: 43,770,184-43,786,487

VEGFB

vascular endothelial growth factor B

7423

P49765

chr11: 64,234,538-64,238,793

VEGFC

vascular endothelial growth factor C

7424

P49767

chr4: 176,683,538-176,792,727

PDGFD

platelet derived growth factor D

80310

Q9GZP0

chr11: 103,907,186-104,164,379

CALM2

calmodulin 2

805

P62158

chr2: 47,160,082-47,176,601

CALM3

calmodulin 3

808

P62158

chr14: 90,396,502-90,408,261

RASSF5

Ras association (RalGDS/AF-6) domain family member 5

83593

Q8WWW0

chr1: 206,507,530-206,589,448

PARD6B

par-6 family cell polarity regulator beta

84612

Q9BYG5

chr20: 50,731,544-50,756,795

FGF18

fibroblast growth factor 18

8817

O76093

chr5: 171,419,656-171,457,623

KRIT1

KRIT1, ankyrin repeat containing

889

O00522

chr7: 92,198,969-92,246,166

CALML4

calmodulin like 4

91860

Q96GE6

chr15: 68,190,705-68,206,110

MAGI1

membrane associated guanylate kinase, WW and PDZ domain containing 1

9223

Q96QZ7

chr3: 65,353,525-66,038,834

FARP2

FERM, ARH/RhoGEF and pleckstrin domain protein 2

9855

O94887

chr2: 241,356,243-241,494,841

MAGI2

membrane associated guanylate kinase, WW and PDZ domain containing 2

9863

Q86UL8

chr7: 78,017,057-79,453,574

FGF19

fibroblast growth factor 19

9965

O95750

chr11: 69,698,232-69,704,642

CDC42

cell division cycle 42

998

P60953

chr1: 22,052,627-22,092,946