| Pathway ID | WP710 |
| Pathway Term | DNA Damage Response (only ATM dependent) |
| Pathway Source | WikiPathways |
| Gene Symbol | Description | Entrez ID | Uniprot ID | Chromosomal Location |
|---|---|---|---|---|
|
JUN |
jun proto-oncogene |
3725 |
P05412 |
chr1: 58,780,788-58,784,327 |
|
HMGB1 |
high mobility group box 1 |
3146 |
P09429 |
chr13: 30,456,704-30,617,597 |
|
PDK1 |
pyruvate dehydrogenase kinase, isozyme 1 |
5163 |
Q15118 |
chr2: 172,555,373-172,608,669 |
|
BCL6 |
B-cell CLL/lymphoma 6 |
604 |
P41182 |
chr3: 187,721,377-187,745,727 |
|
MAP3K4 |
mitogen-activated protein kinase kinase kinase 4 |
4216 |
Q9Y6R4 |
chr6: 160,991,727-161,117,385 |
|
MDM2 |
MDM2 proto-oncogene, E3 ubiquitin protein ligase |
4193 |
Q00987 |
chr12: 68,808,176-68,850,686 |
|
MAP3K7 |
mitogen-activated protein kinase kinase kinase 7 |
6885 |
O43318 |
chr6: 90,513,573-90,587,045 |
|
WNT2B |
wingless-type MMTV integration site family member 2B |
7482 |
Q93097 |
chr1: 112,466,541-112,530,165 |
|
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
P31749 |
chr14: 104,769,349-104,795,751 |
|
AKT2 |
v-akt murine thymoma viral oncogene homolog 2 |
208 |
P31751 |
chr19: 40,230,317-40,285,536 |
|
PMAIP1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
5366 |
Q13794 |
chr18: 59,899,948-59,904,306 |
|
NRAS |
neuroblastoma RAS viral (v-ras) oncogene homolog |
4893 |
P01111 |
chr1: 114,704,469-114,716,894 |
|
AKT3 |
v-akt murine thymoma viral oncogene homolog 3 |
10000 |
Q9Y243 |
chr1: 243,488,233-243,851,079 |
|
AXIN1 |
axin 1 |
8312 |
O15169 |
chr16: 287,440-352,673 |
|
NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
4790 |
P19838 |
chr4: 102,501,329-102,617,302 |
|
MYC |
v-myc avian myelocytomatosis viral oncogene homolog |
4609 |
P01106 |
chr8: 127,735,434-127,741,434 |
|
KRAS |
Kirsten rat sarcoma viral oncogene homolog |
3845 |
P01116 |
chr12: 25,204,789-25,250,936 |
|
LDLR |
low density lipoprotein receptor |
3949 |
P01130 |
chr19: 11,089,362-11,133,816 |
|
TGFB1 |
transforming growth factor beta 1 |
7040 |
P01137 |
chr19: 41,301,587-41,353,911 |
|
BBC3 |
BCL2 binding component 3 |
27113 |
Q96PG8 |
chr19: 47,220,822-47,232,766 |
|
BCL2L11 |
BCL2-like 11 (apoptosis facilitator) |
10018 |
O43521 |
chr2: 111,119,378-111,168,447 |
|
WNT5B |
wingless-type MMTV integration site family member 5B |
81029 |
Q9H1J7 |
chr12: 1,529,891-1,647,243 |
|
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
P10415 |
chr18: 63,123,346-63,320,128 |
|
FOXO3 |
forkhead box O3 |
2309 |
O43524 |
chr6: 108,559,835-108,684,774 |
|
APC |
adenomatous polyposis coli |
324 |
P25054 |
chr5: 112,707,498-112,846,239 |
|
CCND2 |
cyclin D2 |
894 |
P30279 |
chr12: 4,273,772-4,305,350 |
|
CDC42 |
cell division cycle 42 |
998 |
P60953 |
chr1: 22,052,627-22,092,946 |
|
CCND3 |
cyclin D3 |
896 |
P30281 |
chr6: 41,934,933-42,050,357 |
|
SOS2 |
SOS Ras/Rho guanine nucleotide exchange factor 2 |
6655 |
Q07890 |
chr14: 50,117,120-50,231,558 |
|
RHOA |
ras homolog family member A |
387 |
P61586 |
chr3: 49,359,145-49,412,998 |
|
BAD |
BCL2 associated agonist of cell death |
572 |
Q92934 |
chr11: 64,269,830-64,284,704 |
|
PLAU |
plasminogen activator, urokinase |
5328 |
P00749 |
chr10: 73,909,177-73,917,497 |
|
MAPK9 |
mitogen-activated protein kinase 9 |
5601 |
P45984 |
chr5: 180,233,143-180,292,099 |
|
RAC2 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
5880 |
P15153 |
chr22: 37,225,261-37,244,448 |
|
ERBB2 |
erb-b2 receptor tyrosine kinase 2 |
2064 |
P04626 |
chr17: 39,687,914-39,730,426 |
|
SOD2 |
superoxide dismutase 2, mitochondrial |
6648 |
P04179 |
chr6: 159,669,057-159,762,529 |
|
RAC3 |
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
5881 |
P60763 |
chr17: 82,031,624-82,034,204 |
|
PIK3R4 |
phosphoinositide-3-kinase regulatory subunit 4 |
30849 |
Q99570 |
chr3: 130,678,935-130,746,829 |
|
BAX |
BCL2-associated X protein |
581 |
Q07812 |
chr19: 48,954,815-48,961,798 |
|
FOSL1 |
FOS-like antigen 1 |
8061 |
P15407 |
chr11: 65,892,049-65,900,573 |
|
GRB2 |
growth factor receptor bound protein 2 |
2885 |
P62993 |
chr17: 75,318,076-75,405,709 |
|
SMAD3 |
SMAD family member 3 |
4088 |
P84022 |
chr15: 67,063,763-67,195,195 |
|
SMAD4 |
SMAD family member 4 |
4089 |
Q13485 |
chr18: 51,028,394-51,085,045 |
|
INSR |
insulin receptor |
3643 |
P06213 |
chr19: 7,112,255-7,294,034 |
|
RAC1 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
5879 |
P63000 |
chr7: 6,374,523-6,403,977 |
|
SOS1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
6654 |
Q07889 |
chr2: 38,981,396-39,124,345 |
|
TCF7L2 |
transcription factor 7-like 2 (T-cell specific, HMG-box) |
6934 |
Q9NQB0 |
chr10: 112,950,250-113,167,678 |
|
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
P28482 |
chr22: 21,754,500-21,867,680 |
|
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
P45983 |
chr10: 48,306,639-48,439,360 |
|
PCK2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
5106 |
Q16822 |
chr14: 24,094,053-24,110,598 |
|
GSK3B |
glycogen synthase kinase 3 beta |
2932 |
P49841 |
chr3: 119,821,323-120,094,417 |
|
SCP2 |
sterol carrier protein 2 |
6342 |
P22307 |
chr1: 52,927,229-53,051,703 |
|
CDKN1B |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
1027 |
P46527 |
chr12: 12,715,058-12,722,371 |
|
CDKN1A |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
1026 |
P38936 |
chr6: 36,676,460-36,687,339 |
|
WNT2 |
wingless-type MMTV integration site family member 2 |
7472 |
P09544 |
chr7: 117,276,631-117,323,289 |
|
WNT3 |
wingless-type MMTV integration site family member 3 |
7473 |
P56703 |
chr17: 46,762,506-46,833,154 |
|
WNT5A |
wingless-type MMTV integration site family member 5A |
7474 |
P41221 |
chr3: 55,465,715-55,490,539 |
|
CTNNB1 |
catenin beta 1 |
1499 |
P35222 |
chr3: 41,194,837-41,260,096 |
|
WNT6 |
wingless-type MMTV integration site family member 6 |
7475 |
Q9Y6F9 |
chr2: 218,859,821-218,874,233 |
|
PIK3C3 |
phosphatidylinositol 3-kinase catalytic subunit type 3 |
5289 |
Q8NEB9 |
chr18: 41,955,206-42,087,830 |
|
PIK3C2A |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha |
5286 |
O00443 |
chr11: 17,077,730-17,207,983 |
|
PTEN |
phosphatase and tensin homolog |
5728 |
P60484 |
chr10: 87,863,113-87,971,930 |
|
TCF7L1 |
transcription factor 7-like 1 (T-cell specific, HMG-box) |
83439 |
Q9HCS4 |
chr2: 85,133,410-85,310,388 |
|
TP53 |
tumor protein p53 |
7157 |
P04637 |
chr17: 7,661,779-7,687,550 |
|
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5290 |
P42336 |
chr3: 179,148,114-179,240,093 |
|
PIK3CB |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5291 |
P42338 |
chr3: 138,652,699-138,834,938 |
|
PIK3CD |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
5293 |
O00329 |
chr1: 9,651,732-9,729,114 |
|
G6PC |
glucose-6-phosphatase, catalytic subunit |
2538 |
P35575 |
chr17: 42,900,797-42,913,369 |
|
PPP2R5C |
protein phosphatase 2 regulatory subunit B', gamma |
5527 |
Q13362 |
chr14: 101,761,798-101,927,989 |
|
IRS1 |
insulin receptor substrate 1 |
3667 |
P35568 |
chr2: 226,731,317-226,799,759 |
|
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
5294 |
P48736 |
chr7: 106,865,278-106,907,145 |
|
PIK3R1 |
phosphoinositide-3-kinase regulatory subunit 1 |
5295 |
P27986 |
chr5: 68,215,720-68,301,821 |
|
CCNG2 |
cyclin G2 |
901 |
Q16589 |
chr4: 77,157,151-77,433,388 |