Pathway Description

Pathway ID WP710
Pathway Term DNA Damage Response (only ATM dependent)
Pathway Source WikiPathways
Gene Symbol Description Entrez ID Uniprot ID Chromosomal Location

JUN

jun proto-oncogene

3725

P05412

chr1: 58,780,788-58,784,327

HMGB1

high mobility group box 1

3146

P09429

chr13: 30,456,704-30,617,597

PDK1

pyruvate dehydrogenase kinase, isozyme 1

5163

Q15118

chr2: 172,555,373-172,608,669

BCL6

B-cell CLL/lymphoma 6

604

P41182

chr3: 187,721,377-187,745,727

MAP3K4

mitogen-activated protein kinase kinase kinase 4

4216

Q9Y6R4

chr6: 160,991,727-161,117,385

MDM2

MDM2 proto-oncogene, E3 ubiquitin protein ligase

4193

Q00987

chr12: 68,808,176-68,850,686

MAP3K7

mitogen-activated protein kinase kinase kinase 7

6885

O43318

chr6: 90,513,573-90,587,045

WNT2B

wingless-type MMTV integration site family member 2B

7482

Q93097

chr1: 112,466,541-112,530,165

AKT1

v-akt murine thymoma viral oncogene homolog 1

207

P31749

chr14: 104,769,349-104,795,751

AKT2

v-akt murine thymoma viral oncogene homolog 2

208

P31751

chr19: 40,230,317-40,285,536

PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

5366

Q13794

chr18: 59,899,948-59,904,306

NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog

4893

P01111

chr1: 114,704,469-114,716,894

AKT3

v-akt murine thymoma viral oncogene homolog 3

10000

Q9Y243

chr1: 243,488,233-243,851,079

AXIN1

axin 1

8312

O15169

chr16: 287,440-352,673

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

4790

P19838

chr4: 102,501,329-102,617,302

MYC

v-myc avian myelocytomatosis viral oncogene homolog

4609

P01106

chr8: 127,735,434-127,741,434

KRAS

Kirsten rat sarcoma viral oncogene homolog

3845

P01116

chr12: 25,204,789-25,250,936

LDLR

low density lipoprotein receptor

3949

P01130

chr19: 11,089,362-11,133,816

TGFB1

transforming growth factor beta 1

7040

P01137

chr19: 41,301,587-41,353,911

BBC3

BCL2 binding component 3

27113

Q96PG8

chr19: 47,220,822-47,232,766

BCL2L11

BCL2-like 11 (apoptosis facilitator)

10018

O43521

chr2: 111,119,378-111,168,447

WNT5B

wingless-type MMTV integration site family member 5B

81029

Q9H1J7

chr12: 1,529,891-1,647,243

BCL2

B-cell CLL/lymphoma 2

596

P10415

chr18: 63,123,346-63,320,128

FOXO3

forkhead box O3

2309

O43524

chr6: 108,559,835-108,684,774

APC

adenomatous polyposis coli

324

P25054

chr5: 112,707,498-112,846,239

CCND2

cyclin D2

894

P30279

chr12: 4,273,772-4,305,350

CDC42

cell division cycle 42

998

P60953

chr1: 22,052,627-22,092,946

CCND3

cyclin D3

896

P30281

chr6: 41,934,933-42,050,357

SOS2

SOS Ras/Rho guanine nucleotide exchange factor 2

6655

Q07890

chr14: 50,117,120-50,231,558

RHOA

ras homolog family member A

387

P61586

chr3: 49,359,145-49,412,998

BAD

BCL2 associated agonist of cell death

572

Q92934

chr11: 64,269,830-64,284,704

PLAU

plasminogen activator, urokinase

5328

P00749

chr10: 73,909,177-73,917,497

MAPK9

mitogen-activated protein kinase 9

5601

P45984

chr5: 180,233,143-180,292,099

RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

5880

P15153

chr22: 37,225,261-37,244,448

ERBB2

erb-b2 receptor tyrosine kinase 2

2064

P04626

chr17: 39,687,914-39,730,426

SOD2

superoxide dismutase 2, mitochondrial

6648

P04179

chr6: 159,669,057-159,762,529

RAC3

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

5881

P60763

chr17: 82,031,624-82,034,204

PIK3R4

phosphoinositide-3-kinase regulatory subunit 4

30849

Q99570

chr3: 130,678,935-130,746,829

BAX

BCL2-associated X protein

581

Q07812

chr19: 48,954,815-48,961,798

FOSL1

FOS-like antigen 1

8061

P15407

chr11: 65,892,049-65,900,573

GRB2

growth factor receptor bound protein 2

2885

P62993

chr17: 75,318,076-75,405,709

SMAD3

SMAD family member 3

4088

P84022

chr15: 67,063,763-67,195,195

SMAD4

SMAD family member 4

4089

Q13485

chr18: 51,028,394-51,085,045

INSR

insulin receptor

3643

P06213

chr19: 7,112,255-7,294,034

RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

5879

P63000

chr7: 6,374,523-6,403,977

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

6654

Q07889

chr2: 38,981,396-39,124,345

TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

6934

Q9NQB0

chr10: 112,950,250-113,167,678

MAPK1

mitogen-activated protein kinase 1

5594

P28482

chr22: 21,754,500-21,867,680

MAPK8

mitogen-activated protein kinase 8

5599

P45983

chr10: 48,306,639-48,439,360

PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

5106

Q16822

chr14: 24,094,053-24,110,598

GSK3B

glycogen synthase kinase 3 beta

2932

P49841

chr3: 119,821,323-120,094,417

SCP2

sterol carrier protein 2

6342

P22307

chr1: 52,927,229-53,051,703

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

1027

P46527

chr12: 12,715,058-12,722,371

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

1026

P38936

chr6: 36,676,460-36,687,339

WNT2

wingless-type MMTV integration site family member 2

7472

P09544

chr7: 117,276,631-117,323,289

WNT3

wingless-type MMTV integration site family member 3

7473

P56703

chr17: 46,762,506-46,833,154

WNT5A

wingless-type MMTV integration site family member 5A

7474

P41221

chr3: 55,465,715-55,490,539

CTNNB1

catenin beta 1

1499

P35222

chr3: 41,194,837-41,260,096

WNT6

wingless-type MMTV integration site family member 6

7475

Q9Y6F9

chr2: 218,859,821-218,874,233

PIK3C3

phosphatidylinositol 3-kinase catalytic subunit type 3

5289

Q8NEB9

chr18: 41,955,206-42,087,830

PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

5286

O00443

chr11: 17,077,730-17,207,983

PTEN

phosphatase and tensin homolog

5728

P60484

chr10: 87,863,113-87,971,930

TCF7L1

transcription factor 7-like 1 (T-cell specific, HMG-box)

83439

Q9HCS4

chr2: 85,133,410-85,310,388

TP53

tumor protein p53

7157

P04637

chr17: 7,661,779-7,687,550

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5290

P42336

chr3: 179,148,114-179,240,093

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5291

P42338

chr3: 138,652,699-138,834,938

PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

5293

O00329

chr1: 9,651,732-9,729,114

G6PC

glucose-6-phosphatase, catalytic subunit

2538

P35575

chr17: 42,900,797-42,913,369

PPP2R5C

protein phosphatase 2 regulatory subunit B', gamma

5527

Q13362

chr14: 101,761,798-101,927,989

IRS1

insulin receptor substrate 1

3667

P35568

chr2: 226,731,317-226,799,759

PIK3CG

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

5294

P48736

chr7: 106,865,278-106,907,145

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

5295

P27986

chr5: 68,215,720-68,301,821

CCNG2

cyclin G2

901

Q16589

chr4: 77,157,151-77,433,388