GO:0098703

BP

calcium ion import across plasma membrane

The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.

ATP2B4

GO:0098719

BP

sodium ion import across plasma membrane

The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.

SLC9A6, SLC9A2

GO:0098734

BP

macromolecule depalmitoylation

The removal of palymitoyl groups from a macromolecule.

PPT2

GO:0098735

BP

positive regulation of the force of heart contraction

Any process that increases the force of heart muscle contraction.

RYR2

GO:0098736

BP

negative regulation of the force of heart contraction

Any process that decreases the force of heart muscle contraction.

ATP2B4

GO:0098746

BP

fast, calcium ion-dependent exocytosis of neurotransmitter

The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release.

SYT1

GO:0098749

BP

cerebellar neuron development

The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

NANOS1

GO:0098759

BP

cellular response to interleukin-8

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus.

EGR1

GO:0098779

BP

mitophagy in response to mitochondrial depolarization

The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential.

PARK2, ATG13, SQSTM1, CDC37, PINK1, TOMM7, HDAC6

GO:0098789

BP

pre-mRNA cleavage required for polyadenylation

The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.

NCBP1, CPSF1

GO:0098792

BP

xenophagy

The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents.

LGALS8, CALCOCO2, OPTN

GO:0098829

BP

intestinal folate absorption

Uptake of folic into the blood by absorption from the small intestine.

SLC46A1

GO:0098838

BP

reduced folate transmembrane transport

The directed movement of reduced folate (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) across a membrane.

SLC19A1

GO:0098868

BP

bone growth

The increase in size or mass of a bone that contributes to the shaping of that bone.

LEP, LEPR

GO:0098869

BP

cellular oxidant detoxification

Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.

MGST3, GSTZ1, GSR, HP, APOE, ALB, S100A9, GPX1, GSTA1, GSTP1, MGST1, GPX3, PTGS1, GSTM2, PRDX6, GSTT1, PTGS2, GPX4, SESN2, HBB, HBA1, GSTO1, PRDX4, TXNRD1, AAED1, GPX8, CYGB, IPCEF1, TP53INP1, GPX7, MGST2, VIMP, FAM213A, GSTO2, DUOX2, DUOX1, GSTK1, SESN1

GO:0098883

BP

synapse disassembly

A cellular process that results in the controlled breakdown of synapse.

DKK1

GO:0098901

BP

regulation of cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

CAMK2D

GO:0098903

BP

regulation of membrane repolarization during action potential

Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential.

CACNB3, CACNA2D1, CAV1

GO:0098904

BP

regulation of AV node cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

GJA5, RYR2

GO:0098905

BP

regulation of bundle of His cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

GJA5

GO:0098906

BP

regulation of Purkinje myocyte action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

GJA5

GO:0098907

BP

regulation of SA node cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

ANK2, RYR2

GO:0098908

BP

regulation of neuronal action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

FGF12, FMR1

GO:0098909

BP

regulation of cardiac muscle cell action potential involved in regulation of contraction

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.

ATP2A2, CAV1, CAMK2D

GO:0098910

BP

regulation of atrial cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

GJA5, ANK2, RYR2

GO:0098911

BP

regulation of ventricular cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

JUP, DSP, DSC2, CAV1, CACNA1C, DSG2, RYR2, PKP2

GO:0098912

BP

membrane depolarization during atrial cardiac muscle cell action potential

The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

CACNA1C

GO:0098915

BP

membrane repolarization during ventricular cardiac muscle cell action potential

The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.

KCNH2

GO:0099054

BP

presynapse assembly

The aggregation, arrangement and bonding together of a set of components to form a presynapse.

WNT5A

GO:0099068

BP

postsynapse assembly

The aggregation, arrangement and bonding together of a set of components to form a postsynapse.

WNT5A

GO:0099074

BP

mitochondrion to lysosome transport

Transport from the mitochondrion to the lysosome, mediated by mitochondrion-derived vesicles

PARK2

GO:0099565

BP

chemical synaptic transmission, postsynaptic

The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.

DRD2, AKT1, GSK3B

GO:0099607

BP

lateral attachment of mitotic spindle microtubules to kinetochore

The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate).

CENPE

GO:0099639

BP

neurotransmitter receptor transport, endosome to plasma membrane

The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.

VPS35

GO:0100002

BP

negative regulation of protein kinase activity by protein phosphorylation

Any protein phosphorylation process that negatively_regulates protein kinase activity

AKT1

GO:1900004

BP

negative regulation of serine-type endopeptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.

SPINK1, CR1

GO:1900005

BP

positive regulation of serine-type endopeptidase activity

Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.

CR1

GO:1900006

BP

positive regulation of dendrite development

Any process that activates or increases the frequency, rate or extent of dendrite development.

OPA1, COBL, CLIP1, IQGAP1, VLDLR, EZH2, PACSIN1, IL1RAP, TMEM106B

GO:1900015

BP

regulation of cytokine production involved in inflammatory response

Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.

PER1, LEP, MAPK14

GO:1900016

BP

negative regulation of cytokine production involved in inflammatory response

Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.

APOD, IL1R2, C5orf30

GO:1900017

BP

positive regulation of cytokine production involved in inflammatory response

Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.

CD6, GPSM3

GO:1900020

BP

positive regulation of protein kinase C activity

Any process that activates or increases the frequency, rate or extent of protein kinase C activity.

WNT5A, CEMIP

GO:1900024

BP

regulation of substrate adhesion-dependent cell spreading

Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.

PTK2, CORO1C

GO:1900025

BP

negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.

ITGB1BP1, ACTN4, MFI2, FBLN1, GBP1, EFNA5, KANK1, POSTN, CORO1C

GO:1900026

BP

positive regulation of substrate adhesion-dependent cell spreading

Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.

ARPC2, APOA1, FGA, FGB, FGG, FLNA, CALR, CRKL, LIMS1, RAC3, S100A10, CDC42, RAC1, C1QBP, ARHGEF7, LRRC16A, OLFM4, NET1, HAS2, MYADM, CIB1, TRIOBP, DOCK5

GO:1900027

BP

regulation of ruffle assembly

Any process that modulates the frequency, rate or extent of ruffle assembly.

ICAM1, RDX, CAV1, SH3YL1, CORO1C

GO:1900028

BP

negative regulation of ruffle assembly

Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.

KANK1, EVL

GO:1900029

BP

positive regulation of ruffle assembly

Any process that activates or increases the frequency, rate or extent of ruffle assembly.

COBL, PFN1, NLGN1

GO:1900034

BP

regulation of cellular response to heat

Any process that modulates the frequency, rate or extent of cellular response to heat.

NUPL2, DNAJB6, HSBP1, NUP155, BAG2, CRYAB, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, TPR, DNAJB1, MAPK3, MAPK1, HSPA1L, RPA3, NUP62, MAPKAPK2, NUP153, RANBP2, GSK3B, NUP107, YWHAE, RAE1, HSF1, FKBP4, EP300, NUP160, CAMK2D, PTGES3, C11orf73, CCAR2, NUP93, NUP43, NUP37, NUP35, NUP210, HSPH1, NUP205, CREBBP, SEH1L, NUP88, DNAJC7, NDC1, MLST8, NUP58, NUP85, CHORDC1, NUP50, BAG5

GO:1900037

BP

regulation of cellular response to hypoxia

Any process that modulates the frequency, rate or extent of cellular response to hypoxia.

AJUBA, CHCHD2

GO:1900041

BP

negative regulation of interleukin-2 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion.

EZR, GBP1

GO:1900042

BP

positive regulation of interleukin-2 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion.

SPTBN1, CD276, VTCN1

GO:1900053

BP

negative regulation of retinoic acid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process.

AKR1C3

GO:1900060

BP

negative regulation of ceramide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.

ORMDL2

GO:1900062

BP

regulation of replicative cell aging

Any process that modulates the frequency, rate or extent of replicative cell aging.

NEK4

GO:1900063

BP

regulation of peroxisome organization

Any process that modulates the frequency, rate or extent of peroxisome organization.

MAVS, MFF

GO:1900076

BP

regulation of cellular response to insulin stimulus

Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.

GPLD1

GO:1900078

BP

positive regulation of cellular response to insulin stimulus

Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.

MYO1C, ESRRA

GO:1900082

BP

negative regulation of arginine catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.

ATP2B4

GO:1900085

BP

negative regulation of peptidyl-tyrosine autophosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.

CAV1

GO:1900086

BP

positive regulation of peptidyl-tyrosine autophosphorylation

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.

GREM1, ACE, VEGFA, IQGAP1

GO:1900087

BP

positive regulation of G1/S transition of mitotic cell cycle

Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle.

DDX3X, PLRG1, ANXA1, CYP1A1, CCND2, RDX, CUL4A, CUL4B, UBE2E2, PLCB1

GO:1900095

BP

regulation of dosage compensation by inactivation of X chromosome

Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome.

RLIM

GO:1900100

BP

positive regulation of plasma cell differentiation

Any process that activates or increases the frequency, rate or extent of plasma cell differentiation.

XBP1

GO:1900102

BP

negative regulation of endoplasmic reticulum unfolded protein response

Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.

RACK1

GO:1900103

BP

positive regulation of endoplasmic reticulum unfolded protein response

Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response.

ERN1, XBP1, PIK3R1, BAX

GO:1900112

BP

regulation of histone H3-K9 trimethylation

Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.

ATRX, ZNF274

GO:1900116

BP

extracellular negative regulation of signal transduction

Any negative regulation of signal transduction that takes place in extracellular region.

DKK1, LRPAP1, ADH7, AGTR2, ESR2

GO:1900118

BP

negative regulation of execution phase of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.

DFFA, GCG

GO:1900119

BP

positive regulation of execution phase of apoptosis

Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.

TP53, TP53BP2, PTGIS, SIRT2, DLC1, BOK

GO:1900121

BP

negative regulation of receptor binding

Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.

ANXA2, PTPRF, B2M, ADIPOQ, HFE, CRTAC1

GO:1900122

BP

positive regulation of receptor binding

Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.

MMP9, B2M, PLCL1, HFE, PLCL2

GO:1900126

BP

negative regulation of hyaluronan biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.

TGFB1

GO:1900127

BP

positive regulation of hyaluronan biosynthetic process

Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.

PDGFB, NFKB1, HAS2

GO:1900133

BP

regulation of renin secretion into blood stream

Any process that modulates the frequency, rate or extent of renin secretion into blood stream.

GJA5

GO:1900134

BP

negative regulation of renin secretion into blood stream

Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream.

F2R

GO:1900135

BP

positive regulation of renin secretion into blood stream

Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.

F2RL1, OR51E2

GO:1900138

BP

negative regulation of phospholipase A2 activity

Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity.

ANXA1

GO:1900142

BP

negative regulation of oligodendrocyte apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process.

GAS6

GO:1900153

BP

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.

CNOT1, ZFP36, ZFP36L2, ZFP36L1, CPEB3, NANOS1, TNRC6C, CNOT7, AGO2, TNRC6B

GO:1900155

BP

negative regulation of bone trabecula formation

Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation.

GREM1

GO:1900158

BP

negative regulation of bone mineralization involved in bone maturation

Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.

GREM1, FAM101A, FAM101B

GO:1900163

BP

positive regulation of phospholipid scramblase activity

Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity.

PRKCD

GO:1900164

BP

nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves.

CITED2

GO:1900165

BP

negative regulation of interleukin-6 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.

GAS6, SYT11, C1QTNF3, RABGEF1, PTPN22

GO:1900168

BP

positive regulation of glial cell-derived neurotrophic factor secretion

Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor secretion.

DRD2

GO:1900169

BP

regulation of glucocorticoid mediated signaling pathway

Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway.

AKAP13

GO:1900170

BP

negative regulation of glucocorticoid mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway.

CREBRF

GO:1900180

BP

regulation of protein localization to nucleus

Any process that modulates the frequency, rate or extent of protein localization to nucleus.

LMNA, NF2, RASSF5

GO:1900181

BP

negative regulation of protein localization to nucleus

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.

DCLK1, GSK3B, OTUD7B, FLCN

GO:1900182

BP

positive regulation of protein localization to nucleus

Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.

F2, INS, FYN, CDK1, NGFR, LIF, AKT1, PLK1, SESN2, TGFB2, STK11, TRIM8, GTSE1

GO:1900186

BP

negative regulation of clathrin-dependent endocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis.

UNC119

GO:1900194

BP

negative regulation of oocyte maturation

Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.

NPR2, SHB

GO:1900195

BP

positive regulation of oocyte maturation

Any process that activates or increases the frequency, rate or extent of oocyte maturation.

AURKA, SIRT2

GO:1900212

BP

negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development.

PAX8

GO:1900215

BP

negative regulation of apoptotic process involved in metanephric collecting duct development

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development.

PAX8

GO:1900218

BP

negative regulation of apoptotic process involved in metanephric nephron tubule development

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development.

PAX8

GO:1900221

BP

regulation of beta-amyloid clearance

Any process that modulates the frequency, rate or extent of beta-amyloid clearance.

APOE, CLU

GO:1900222

BP

negative regulation of beta-amyloid clearance

Any process that stops, prevents or reduces the frequency, rate or extent of beta-amyloid clearance.

LRPAP1

GO:1900224

BP

positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry.

SMAD2