go_id,ontology,go_term,term_definition,evidence
GO:0000978,MF,"RNA polymerase II core promoter proximal region sequence-specific DNA binding","Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.",IDA
GO:0000982,MF,"transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding","Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.",ISS
GO:0003334,BP,"keratinocyte development","The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.",IEA
GO:0003682,MF,"chromatin binding","Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.",IDA
GO:0003700,MF,"transcription factor activity, sequence-specific DNA binding","Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.",IMP
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0006351,BP,"transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA.",IEA
GO:0006357,BP,"regulation of transcription from RNA polymerase II promoter","Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.",TAS
GO:0008219,BP,"cell death","Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).",IBA
GO:0045944,BP,"positive regulation of transcription from RNA polymerase II promoter","Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.",IMP
GO:0048146,BP,"positive regulation of fibroblast proliferation","Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.",IDA