go_id,ontology,go_term,term_definition,evidence GO:0004111,MF,"creatine kinase activity","Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).",IDA GO:0005524,MF,"ATP binding","Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.",IEA GO:0005739,CC,mitochondrion,"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.",IEA GO:0005743,CC,"mitochondrial inner membrane","The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.",IEA GO:0006600,BP,"creatine metabolic process","The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.",ISS GO:0016310,BP,phosphorylation,"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.",IEA GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA