go_id,ontology,go_term,term_definition,evidence
GO:0005509,MF,"calcium ion binding","Interacting selectively and non-covalently with calcium ions (Ca2+).",IDA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0005913,CC,"cell-cell adherens junction","An adherens junction which connects a cell to another cell.",IDA
GO:0007155,BP,"cell adhesion","The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.",IEA
GO:0007156,BP,"homophilic cell adhesion via plasma membrane adhesion molecules","The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.",IEA
GO:0009267,BP,"cellular response to starvation","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.",IDA
GO:0014704,CC,"intercalated disc","A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.",TAS
GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA
GO:0030057,CC,desmosome,"A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.",IEA
GO:0031410,CC,"cytoplasmic vesicle","A vesicle found in the cytoplasm of a cell.",IEA
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA
GO:0086042,BP,"cardiac muscle cell-cardiac muscle cell adhesion","The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.",IMP
GO:0086073,BP,"bundle of His cell-Purkinje myocyte adhesion involved in cell communication","The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.",IMP
GO:0086083,MF,"cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication","Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.",IC
GO:0086091,BP,"regulation of heart rate by cardiac conduction","A cardiac conduction process that modulates the frequency or rate of heart contraction.",ISS
GO:0098911,BP,"regulation of ventricular cardiac muscle cell action potential","Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction.  This typically occurs via modulation of the activity or expression of voltage-gated ion channels.",IMP