go_id,ontology,go_term,term_definition,evidence
GO:0005096,MF,"GTPase activator activity","Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.",IEA
GO:0005769,CC,"early endosome","A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.",IDA|ISS
GO:0006897,BP,endocytosis,"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.",IEA
GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA
GO:0016023,CC,"cytoplasmic, membrane-bounded vesicle","A membrane-bounded vesicle found in the cytoplasm of the cell.",IEA
GO:0017112,MF,"Rab guanyl-nucleotide exchange factor activity","Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.",IDA
GO:0017137,MF,"Rab GTPase binding","Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.",IDA
GO:0031410,CC,"cytoplasmic vesicle","A vesicle found in the cytoplasm of a cell.",IEA
GO:0043547,BP,"positive regulation of GTPase activity","Any process that activates or increases the activity of a GTPase.",IEA