go_id,ontology,go_term,term_definition,evidence
GO:0004871,MF,"signal transducer activity","Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.",IMP
GO:0005085,MF,"guanyl-nucleotide exchange factor activity","Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.",IEA
GO:0005089,MF,"Rho guanyl-nucleotide exchange factor activity","Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.",IDA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0005911,CC,"cell-cell junction","A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.",IDA
GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA
GO:0030027,CC,lamellipodium,"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.",IEA
GO:0030139,CC,"endocytic vesicle","A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.",TAS
GO:0035023,BP,"regulation of Rho protein signal transduction","Any process that modulates the frequency, rate or extent of Rho protein signal transduction.",IEA
GO:0035767,BP,"endothelial cell chemotaxis","The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).",IMP
GO:0043065,BP,"positive regulation of apoptotic process","Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.",ISS
GO:0043123,BP,"positive regulation of I-kappaB kinase/NF-kappaB signaling","Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.",IMP
GO:0043547,BP,"positive regulation of GTPase activity","Any process that activates or increases the activity of a GTPase.",IEA
GO:0048471,CC,"perinuclear region of cytoplasm","Cytoplasm situated near, or occurring around, the nucleus.",IDA
GO:0051056,BP,"regulation of small GTPase mediated signal transduction","Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.",TAS