go_id,ontology,go_term,term_definition,evidence
GO:0001726,CC,ruffle,"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.",IDA
GO:0003924,MF,"GTPase activity","Catalysis of the reaction: GTP + H2O = GDP + phosphate.",IEA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005525,MF,"GTP binding","Interacting selectively and non-covalently with GTP, guanosine triphosphate.",IEA
GO:0005769,CC,"early endosome","A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.",IDA|ISS
GO:0005770,CC,"late endosome","A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.",IEA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0006897,BP,endocytosis,"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.",IEA
GO:0007032,BP,"endosome organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.",IEA
GO:0007264,BP,"small GTPase mediated signal transduction","Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.",IEA
GO:0010008,CC,"endosome membrane","The lipid bilayer surrounding an endosome.",TAS
GO:0015031,BP,"protein transport","The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",IEA
GO:0015629,CC,"actin cytoskeleton","The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.",ISS
GO:0019003,MF,"GDP binding","Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.",IDA
GO:0030670,CC,"phagocytic vesicle membrane","The lipid bilayer surrounding a phagocytic vesicle.",TAS
GO:0045335,CC,"phagocytic vesicle","A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.",IEA
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA
GO:0097494,BP,"regulation of vesicle size","Any process that modulates the size of a vesicle.",IDA