go_id,ontology,go_term,term_definition,evidence
GO:0004222,MF,"metalloendopeptidase activity","Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.",IMP|NAS|TAS
GO:0005578,CC,"proteinaceous extracellular matrix","A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.",IEA
GO:0005615,CC,"extracellular space","That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.",TAS
GO:0005783,CC,"endoplasmic reticulum","The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).",IDA
GO:0006508,BP,proteolysis,"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.",IEA
GO:0006516,BP,"glycoprotein catabolic process","The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.",TAS
GO:0007275,BP,"multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",IEA
GO:0008237,MF,"metallopeptidase activity","Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.",IDA|IMP|TAS
GO:0008270,MF,"zinc ion binding","Interacting selectively and non-covalently with zinc (Zn) ions.",IEA
GO:0009986,CC,"cell surface","The external part of the cell wall and/or plasma membrane.",IDA
GO:0015031,BP,"protein transport","The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",IEA
GO:0016192,BP,"vesicle-mediated transport","A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.",IMP
GO:0031012,CC,"extracellular matrix","A structure lying external to one or more cells, which provides structural support for cells or tissues.",IDA|ISS
GO:0045636,BP,"positive regulation of melanocyte differentiation","Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.",ISS