go_id,ontology,go_term,term_definition,evidence GO:0000122,BP,"negative regulation of transcription from RNA polymerase II promoter","Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.",IDA|ISS GO:0001078,MF,"transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding","Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.",IDA GO:0003677,MF,"DNA binding","Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).",IEA GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA GO:0006351,BP,"transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA.",IEA GO:0032728,BP,"positive regulation of interferon-beta production","Any process that activates or increases the frequency, rate, or extent of interferon-beta production.",ISS GO:0032755,BP,"positive regulation of interleukin-6 production","Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.",IDA GO:0032760,BP,"positive regulation of tumor necrosis factor production","Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.",ISS GO:0046872,MF,"metal ion binding","Interacting selectively and non-covalently with any metal ion.",IEA