go_id,ontology,go_term,term_definition,evidence GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI GO:0005576,CC,"extracellular region","The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",IEA GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA GO:0007275,BP,"multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",IEA GO:0016055,BP,"Wnt signaling pathway","The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.",IEA GO:0017147,MF,"Wnt-protein binding","Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.",IBA|ISS|NAS GO:0030178,BP,"negative regulation of Wnt signaling pathway","Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.",ISS GO:0045600,BP,"positive regulation of fat cell differentiation","Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.",IEA