go_id,ontology,go_term,term_definition,evidence
GO:0000139,CC,"Golgi membrane","The lipid bilayer surrounding any of the compartments of the Golgi apparatus.",IEA
GO:0005789,CC,"endoplasmic reticulum membrane","The lipid bilayer surrounding the endoplasmic reticulum.",IEA
GO:0006621,BP,"protein retention in ER lumen","The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.",IEA
GO:0006890,BP,"retrograde vesicle-mediated transport, Golgi to ER","The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.",IBA|TAS
GO:0015031,BP,"protein transport","The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",IEA
GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA
GO:0030133,CC,"transport vesicle","Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.",TAS
GO:0036498,BP,"IRE1-mediated unfolded protein response","A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.",TAS
GO:0046923,MF,"ER retention sequence binding","Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.",IEA