go_id,ontology,go_term,term_definition,evidence GO:0000775,CC,"chromosome, centromeric region","The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.",TAS GO:0000784,CC,"nuclear chromosome, telomeric region","The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.",IDA GO:0000785,CC,chromatin,"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.",IEA GO:0001939,CC,"female pronucleus","The pronucleus originating from the ovum that is being fertilized.",IEA GO:0001940,CC,"male pronucleus","The pronucleus originating from the spermatozoa that was involved in fertilization.",IEA GO:0003682,MF,"chromatin binding","Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.",IDA GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA GO:0005720,CC,"nuclear heterochromatin","A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.",IDA GO:0005721,CC,"pericentric heterochromatin","Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.",IDA GO:0005819,CC,spindle,"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.",TAS GO:0010369,CC,chromocenter,"A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure.",IEA GO:0019899,MF,"enzyme binding","Interacting selectively and non-covalently with any enzyme.",IPI GO:0042803,MF,"protein homodimerization activity","Interacting selectively and non-covalently with an identical protein to form a homodimer.",IEA GO:0045892,BP,"negative regulation of transcription, DNA-templated","Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.",ISS GO:1990226,MF,"histone methyltransferase binding","Interacting selectively and non-covalently with a histone methyltransferase enzyme.",IPI