go_id,ontology,go_term,term_definition,evidence
GO:0000375,BP,"RNA splicing, via transesterification reactions","Splicing of RNA via a series of two transesterification reactions.",TAS
GO:0000389,BP,"mRNA 3'-splice site recognition","Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.",TAS
GO:0000398,BP,"mRNA splicing, via spliceosome","The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.",IGI
GO:0003723,MF,"RNA binding","Interacting selectively and non-covalently with an RNA molecule or a portion thereof.",IEA
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0005681,CC,"spliceosomal complex","Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.",IBA
GO:0006397,BP,"mRNA processing","Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.",IEA
GO:0008270,MF,"zinc ion binding","Interacting selectively and non-covalently with zinc (Zn) ions.",IEA
GO:0008380,BP,"RNA splicing","The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.",IEA
GO:0016607,CC,"nuclear speck","A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.",IEA
GO:0044822,MF,"poly(A) RNA binding","Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.",IDA
GO:0071013,CC,"catalytic step 2 spliceosome","A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.",IDA