go_id,ontology,go_term,term_definition,evidence
GO:0000185,BP,"activation of MAPKKK activity","Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).",IDA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0006915,BP,"apoptotic process","A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.",IEA
GO:0006950,BP,"response to stress","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).",IDA
GO:0007275,BP,"multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",IEA
GO:0030154,BP,"cell differentiation","The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.",IEA
GO:0043065,BP,"positive regulation of apoptotic process","Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.",ISS
GO:0046330,BP,"positive regulation of JNK cascade","Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.",IEA
GO:0051726,BP,"regulation of cell cycle","Any process that modulates the rate or extent of progression through the cell cycle.",IEA
GO:1900745,BP,"positive regulation of p38MAPK cascade","Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.",IDA