go_id,ontology,go_term,term_definition,evidence GO:0001501,BP,"skeletal system development","The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).",IMP GO:0001503,BP,ossification,"The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.",IEA GO:0005509,MF,"calcium ion binding","Interacting selectively and non-covalently with calcium ions (Ca2+).",IDA GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA GO:0007155,BP,"cell adhesion","The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.",IEA GO:0007156,BP,"homophilic cell adhesion via plasma membrane adhesion molecules","The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.",IEA GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA GO:0021957,BP,"corticospinal tract morphogenesis","Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.",IEA GO:0034332,BP,"adherens junction organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.",TAS GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA