go_id,ontology,go_term,term_definition,evidence GO:0000122,BP,"negative regulation of transcription from RNA polymerase II promoter","Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.",IDA|ISS GO:0004861,MF,"cyclin-dependent protein serine/threonine kinase inhibitor activity","Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.",IDA GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA GO:0006351,BP,"transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA.",IEA GO:0007507,BP,"heart development","The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.",IMP GO:0017069,MF,"snRNA binding","Interacting selectively and non-covalently with a small nuclear RNA (snRNA).",IDA GO:0045736,BP,"negative regulation of cyclin-dependent protein serine/threonine kinase activity","Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.",IDA GO:0045892,BP,"negative regulation of transcription, DNA-templated","Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.",ISS GO:0097322,MF,"7SK snRNA binding","Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA).",IDA GO:1901798,BP,"positive regulation of signal transduction by p53 class mediator","Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.",IMP