go_id,ontology,go_term,term_definition,evidence
GO:0000118,CC,"histone deacetylase complex","A protein complex that possesses histone deacetylase activity.",TAS
GO:0000381,BP,"regulation of alternative mRNA splicing, via spliceosome","Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.",IDA|IMP
GO:0003714,MF,"transcription corepressor activity","Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.",ISS
GO:0004407,MF,"histone deacetylase activity","Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.",TAS
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0006351,BP,"transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA.",IEA
GO:0006357,BP,"regulation of transcription from RNA polymerase II promoter","Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.",TAS
GO:0006397,BP,"mRNA processing","Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.",IEA
GO:0008380,BP,"RNA splicing","The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.",IEA
GO:0016575,BP,"histone deacetylation","The modification of histones by removal of acetyl groups.",IEA
GO:0016607,CC,"nuclear speck","A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.",IEA
GO:0035145,CC,"exon-exon junction complex","A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.",IDA
GO:0043065,BP,"positive regulation of apoptotic process","Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.",ISS
GO:0044822,MF,"poly(A) RNA binding","Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.",IDA
GO:0048025,BP,"negative regulation of mRNA splicing, via spliceosome","Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.",IDA
GO:0061574,CC,"ASAP complex","A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.",IDA
GO:1903507,BP,"negative regulation of nucleic acid-templated transcription","Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.",IEA