go_id,ontology,go_term,term_definition,evidence
GO:0001504,BP,"neurotransmitter uptake","The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.",TAS
GO:0004872,MF,"receptor activity","Combining with an extracellular or intracellular messenger to initiate a change in cell activity.",TAS
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005783,CC,"endoplasmic reticulum","The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).",IDA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0005911,CC,"cell-cell junction","A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.",IDA
GO:0006874,BP,"cellular calcium ion homeostasis","Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.",IEA
GO:0008021,CC,"synaptic vesicle","A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.",IDA
GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA
GO:0019901,MF,"protein kinase binding","Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.",IEA
GO:0022857,MF,"transmembrane transporter activity","Enables the transfer of a substance from one side of a membrane to the other.",IC
GO:0030672,CC,"synaptic vesicle membrane","The lipid bilayer surrounding a synaptic vesicle.",IEA
GO:0031594,CC,"neuromuscular junction","The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.",ISS
GO:0043005,CC,"neuron projection","A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.",IEA
GO:0043195,CC,"terminal bouton","Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.",IEA
GO:0048786,CC,"presynaptic active zone","A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.",IEA
GO:0055085,BP,"transmembrane transport","The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other",IEA