go_id,ontology,go_term,term_definition,evidence
GO:0000137,CC,"Golgi cis cisterna","The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.",IDA
GO:0000138,CC,"Golgi trans cisterna","The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.",IDA
GO:0000139,CC,"Golgi membrane","The lipid bilayer surrounding any of the compartments of the Golgi apparatus.",IEA
GO:0004175,MF,"endopeptidase activity","Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.",ISS
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005764,CC,lysosome,"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.",IBA
GO:0005765,CC,"lysosomal membrane","The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.",TAS
GO:0005770,CC,"late endosome","A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.",IEA
GO:0005797,CC,"Golgi medial cisterna","The middle Golgi cisterna (or cisternae).",IDA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0006508,BP,proteolysis,"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.",IEA
GO:0006914,BP,autophagy,"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.",TAS
GO:0010508,BP,"positive regulation of autophagy","Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.",ISS
GO:0010955,BP,"negative regulation of protein processing","Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.",IC
GO:0016021,CC,"integral component of membrane","The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.",IEA
GO:0031902,CC,"late endosome membrane","The lipid bilayer surrounding a late endosome.",IEA
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA
GO:0090005,BP,"negative regulation of establishment of protein localization to plasma membrane","Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane.",IMP
GO:0090285,BP,"negative regulation of protein glycosylation in Golgi","Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus.",IDA