go_id,ontology,go_term,term_definition,evidence
GO:0000307,CC,"cyclin-dependent protein kinase holoenzyme complex","Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.",IDA
GO:0000785,CC,chromatin,"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.",IEA
GO:0001934,BP,"positive regulation of protein phosphorylation","Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.",IDA
GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI
GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0005730,CC,nucleolus,"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.",IEA
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0007049,BP,"cell cycle","The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.",NAS
GO:0008284,BP,"positive regulation of cell proliferation","Any process that activates or increases the rate or extent of cell proliferation.",IMP
GO:0019901,MF,"protein kinase binding","Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.",IEA
GO:0031965,CC,"nuclear membrane","Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.",IEA
GO:0043066,BP,"negative regulation of apoptotic process","Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.",IMP
GO:0045737,BP,"positive regulation of cyclin-dependent protein serine/threonine kinase activity","Any process that activates or increases the frequency, rate or extent of CDK activity.",IBA
GO:0051301,BP,"cell division","The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.",IEA
GO:1900087,BP,"positive regulation of G1/S transition of mitotic cell cycle","Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle.",IMP