go_id,ontology,go_term,term_definition,evidence GO:0002576,BP,"platelet degranulation","The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.",TAS GO:0003677,MF,"DNA binding","Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).",IEA GO:0004867,MF,"serine-type endopeptidase inhibitor activity","Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.",IDA GO:0005515,MF,"protein binding","Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).",IPI GO:0005576,CC,"extracellular region","The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",IEA GO:0005615,CC,"extracellular space","That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.",TAS GO:0005622,CC,intracellular,"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.",IEA GO:0005634,CC,nucleus,"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",IEA GO:0006953,BP,"acute-phase response","An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.",ISS GO:0006954,BP,"inflammatory response","The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.",IBA GO:0010951,BP,"negative regulation of endopeptidase activity","Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.",IEA GO:0019216,BP,"regulation of lipid metabolic process","Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.",NAS GO:0030277,BP,"maintenance of gastrointestinal epithelium","Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.",NAS GO:0031093,CC,"platelet alpha granule lumen","The volume enclosed by the membrane of the platelet alpha granule.",TAS GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA GO:0072562,CC,"blood microparticle","A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.",IBA