go_id,ontology,go_term,term_definition,evidence
GO:0005102,MF,"receptor binding","Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.",IPI
GO:0005125,MF,"cytokine activity","Functions to control the survival, growth, differentiation and effector function of tissues and cells.",TAS
GO:0005164,MF,"tumor necrosis factor receptor binding","Interacting selectively and non-covalently with the tumor necrosis factor receptor.",NAS
GO:0005576,CC,"extracellular region","The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",IEA
GO:0005615,CC,"extracellular space","That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.",TAS
GO:0005654,CC,nucleoplasm,"That part of the nuclear content other than the chromosomes or the nucleolus.",IDA
GO:0005737,CC,cytoplasm,"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",IDA
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0006955,BP,"immune response","Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.",TAS
GO:0007165,BP,"signal transduction","The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",IEA
GO:0008284,BP,"positive regulation of cell proliferation","Any process that activates or increases the rate or extent of cell proliferation.",IMP
GO:0016020,CC,membrane,"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.",IDA
GO:0033209,BP,"tumor necrosis factor-mediated signaling pathway","A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.",TAS
GO:0043488,BP,"regulation of mRNA stability","Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.",TAS
GO:0048298,BP,"positive regulation of isotype switching to IgA isotypes","Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes.",IDA
GO:0070062,CC,"extracellular exosome","A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.",IDA