go_id,ontology,go_term,term_definition,evidence
GO:0003779,MF,"actin binding","Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.",IEA
GO:0005516,MF,"calmodulin binding","Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.",IEA
GO:0005523,MF,"tropomyosin binding","Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.",IPI
GO:0005829,CC,cytosol,"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.",IBA
GO:0005856,CC,cytoskeleton,"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.",IBA
GO:0005886,CC,"plasma membrane","The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",IEA
GO:0005913,CC,"cell-cell adherens junction","An adherens junction which connects a cell to another cell.",IDA
GO:0006928,BP,"movement of cell or subcellular component","The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.",TAS
GO:0006936,BP,"muscle contraction","A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.",TAS
GO:0015629,CC,"actin cytoskeleton","The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.",ISS
GO:0017022,MF,"myosin binding","Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.",IPI
GO:0030016,CC,myofibril,"The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.",ISS
GO:0030478,CC,"actin cap","Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.",IEA
GO:0098609,BP,"cell-cell adhesion","The attachment of one cell to another cell via adhesion molecules.",IEA
GO:0098641,MF,"cadherin binding involved in cell-cell adhesion","Any cadherin binding that occurs as part of the process of cell-cell adhesion.",IDA